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51. 发明申请

US20140314867A1 VITAMIN K2 MICROSPHERES 审中-公开
标题翻译：维生素K2 MICROSPHERES
公开(公告)号：US20140314867A1
公开(公告)日：2014-10-23
申请号：US14258860
申请日：2014-04-22
申请人： Medical and Pharmaceutical Industry Technology and Development Center
发明人： Shu-Wen Whu , Chung-Chih Cheng , Chih-Chiang Yang
IPC分类号： A61K9/16 , A61K31/122
CPC分类号： A61K9/1647 , A61K31/122
摘要： A vitamin K2 microsphere. The microsphere includes a poly(lactide-co-glycolide) acid (PLGA) particle, in which the Mw of PLGA is between 1000 and 300000, and the molar ratio between the lactide repeat units and the glycolide repeate unit is 1-9:9-1; and one or more vitamin K2 molecules are embedded in the PLGA particle, wherein the vitamin K2 is present in an amount of 0.005-75 wt %, based on the weight of the microsphere. Also disclosed are a method of preparing the vitamin K2 microsphere, a method of treating osteoporosis using this microsphere, and a pharmaceutical composition containing the microsphere.
摘要翻译：维生素K2微球。微球包括聚（丙交酯 - 共 - 乙交酯）酸（PLGA）颗粒，其中PLGA的Mw为1000至300000，丙交酯重复单元与乙交酯重复单元之间的摩尔比为1-9:9 -1; 并且一种或多种维生素K2分子嵌入PLGA颗粒中，其中基于微球的重量，维生素K2以0.005-75重量％的量存在。还公开了制备维生素K2微球的方法，使用该微球治疗骨质疏松症的方法和含有微球的药物组合物。

52. 发明授权

US08470379B2 Use of a potent product extracted from rhizomes of zingiber officinale in treating a disease associated with Helicobacter pylori 有权
标题翻译：使用从姜黄根茎提取的有效产品治疗与幽门螺杆菌相关的疾病
公开(公告)号：US08470379B2
公开(公告)日：2013-06-25
申请号：US12911143
申请日：2010-10-25
申请人： Feng-Nien Ko , Mo-Chi Cheng , Cheng-Ko Liu , Jen-Wei Chen , Fen Chen , Chao-Chi Yei
发明人： Feng-Nien Ko , Mo-Chi Cheng , Cheng-Ko Liu , Jen-Wei Chen , Fen Chen , Chao-Chi Yei
IPC分类号： A61K36/9068
CPC分类号： A61K36/9068
摘要： A new use of a potent product extracted from rhizomes of Zingiber officinale in treating a disease associated with Helicobacter pylori such as gastritis, gastric ulcer or duodenal ulcer in a patient. The potent product is prepared by a process including the steps of a) preparing a crude extract from rhizomes of Zingiber officinale, said crude extract comprising 6-gingerol and 6-shogaol; b) introducing the crude extract to a normal phase chromatography column, and eluting the column with a first eluent having a polarity lower than that of a mixture of n-hexane and ethyl acetate in a weight ratio of 6:4 to obtain a potent fraction. Preferably, the potent fraction is substantially free of both 6-gingerol and 6-shogaol.
摘要翻译：从姜黄根茎提取的有效产品的新用途，用于治疗与幽门螺杆菌相关的疾病，如胃炎，胃溃疡或十二指肠溃疡。所述有效产物通过以下步骤制备，所述方法包括以下步骤：a）从姜黄根茎制备粗提取物，所述粗提物包含6-姜醇和6-shogaol; b）将粗提取物引入正相色谱柱，并用具有极性低于正己烷和乙酸乙酯的混合物的第一洗脱液以6:4的重量比洗脱柱，以获得有效分数。优选地，有效部分基本上不含6-姜醇和6-硫醇。

53. 发明授权

US08071142B2 Anti-bacterial use of extract from Morus australis poir. and compound kuwanon h 有权
标题翻译：抗菌使用来自澳大利亚野草的提取物。和复合kuwanon h
公开(公告)号：US08071142B2
公开(公告)日：2011-12-06
申请号：US12345254
申请日：2008-12-29
申请人： Yuan-Ling Ku , Shih-Tsun Liang , Yu-Hsuan Lin , Liang-Hua Chen , Ying-Yu Kuo , Feng-Nien Ko
发明人： Yuan-Ling Ku , Shih-Tsun Liang , Yu-Hsuan Lin , Liang-Hua Chen , Ying-Yu Kuo , Feng-Nien Ko
IPC分类号： A61K36/00 , A61K36/605
CPC分类号： A61K31/352
摘要： An extract prepared from the root barks of Morus australis Poir. and its use as an anti-bacteria agent, and use of a compound Kuwanon H having the following formula (I) separated from the extract as an anti-bacteria agent:
摘要翻译：从桑the的根皮制备的提取物。及其作为抗菌剂的用途，以及使用具有下述式（I）的化合物Kuwanon H作为抗菌剂从提取物中分离出来：

54. 发明申请

US20090082373A1 Uses of 2-[piperidinyl]methyl-2, 3-dihydroimidazo[1,2-c]quinazolin-5(6H)-one for providing an analgesic effect, anti-allergic effect and histamine H1 receptor antagonism effect 审中-公开
标题翻译：使用2- [哌啶基]甲基-2,3-二氢咪唑并[1,2-c]喹唑啉-5（6H） - 酮，用于提供镇痛作用，抗过敏作用和组胺H1受体拮抗作用
公开(公告)号：US20090082373A1
公开(公告)日：2009-03-26
申请号：US11907853
申请日：2007-10-18
申请人： Feng-Nien Ko , Yuan-Ling Ku
发明人： Feng-Nien Ko , Yuan-Ling Ku
IPC分类号： A61K31/519 , A61P25/04
CPC分类号： A61K31/519
摘要： The present invention discloses new uses of 2-[piperidinyl]methyl-2,3-dihydroimidazo[1,2-c]quinazolin-5(6H)-one in providing an analgesic effect in a patient, treating passive cutaneous anaphylaxis in a patient, and in eliciting a histamine H1 receptor antagonism effect in a patient to treat a disease or disorder, such as allergy.
摘要翻译：本发明公开了在患者中提供镇痛作用的2- [哌啶基]甲基-2,3-二氢咪唑并[1,2-c]喹唑啉-5（6H） - 酮的新用途，治疗患者的被动皮肤过敏反应并且在患者中引发组胺H1受体拮抗作用以治疗诸如过敏的疾病或病症。

55. 发明授权

US07175861B2 Anti-depression pharmaceutical composition containing Polygala extract 有权
公开(公告)号：US07175861B2
公开(公告)日：2007-02-13
申请号：US10915445
申请日：2004-08-11
申请人： Feng-Nien Ko , Cheng-Ko Liu , Yu-Feng Han , Pin-Fun Chen
发明人： Feng-Nien Ko , Cheng-Ko Liu , Yu-Feng Han , Pin-Fun Chen
IPC分类号： A61K35/78
CPC分类号： A61K36/69 , A61K2300/00
摘要： A pharmaceutical composition contains a therapeutically effective amount of an active ingredient, in admixture with a pharmaceutically acceptable carrier or diluent for the active ingredient, in which the active ingredient is i) a polar solvent extract of Polygala, the polar solvent being water or a mixture of water and methanol or ethanol; ii) an aqueous fraction resulting from an extraction of the polar solvent extract with an organic solvent; iii) an organic eluate by introducing the polar solvent extract or the aqueous fraction into a reverse phase chromatography column, and eluting the column with water and an organic solvent; or iv) a filtrate having a molecular mass less than 30000 in the organic eluate.

56. 发明授权

US06991815B2 Anti-ulcer pharmaceutical composition and the preparation thereof 有权
公开(公告)号：US06991815B2
公开(公告)日：2006-01-31
申请号：US10850217
申请日：2004-05-20
申请人： Feng-Nien Ko , Chien-Jen Shih , Je-Yie Lin , Pey-Chyi Wu , Mo-Chi Cheng
发明人： Feng-Nien Ko , Chien-Jen Shih , Je-Yie Lin , Pey-Chyi Wu , Mo-Chi Cheng
IPC分类号： A61K35/78
CPC分类号： A61K36/258
摘要： The invention discloses a pharmaceutical composition for preventing and/or treating peptic ulcer, including American ginseng or the extract thereof, and a method for preparing American ginseng extract, said method including extracting American ginseng with water or ethanol aqueous solution, and then ultrafiltrating, dialyzing, precipitating with ethanol, or performing reverse phase chromatography to obtain various fractions of extract with anti-peptic ulcer effect.

57. 发明申请

US20100166898A1 ANTI-BACTERIAL USE OF EXTRACT FROM MORUS AUSTRALIS POIR. AND COMPOUND KUWANON H 有权
标题翻译：从MORUS AUSTRALIS POIR提取物的抗细菌使用。和化合物KUWANON H
公开(公告)号：US20100166898A1
公开(公告)日：2010-07-01
申请号：US12345254
申请日：2008-12-29
申请人： Yuan-Ling Ku , Shih-Tsun Liang , Yu-Hsuan Lin , Liang-Hua Chen , Ying-Yu Kuo
发明人： Yuan-Ling Ku , Shih-Tsun Liang , Yu-Hsuan Lin , Liang-Hua Chen , Ying-Yu Kuo
IPC分类号： A61K36/605 , A61K31/352 , A61P31/04
CPC分类号： A61K31/352
摘要： An extract prepared from the root barks of Morus australis Poir. and its use as an anti-bacteria agent, and use of a compound Kuwanon H having the following formula (I) separated from the extract as an anti-bacteria agent:
摘要翻译：从桑the的根皮制备的提取物。及其作为抗菌剂的用途，以及使用具有下述式（I）的化合物Kuwanon H作为抗菌剂从提取物中分离出来：

58. 发明申请

US20090053287A1 POROUS DRESSING 审中-公开
标题翻译：多孔连接
公开(公告)号：US20090053287A1
公开(公告)日：2009-02-26
申请号：US11926575
申请日：2007-10-29
申请人： Ching-Cheng HUANG , Quang-Wei CHANG , Yung-Sheng LIN , Ting-Kai LEUNG
发明人： Ching-Cheng HUANG , Quang-Wei CHANG , Yung-Sheng LIN , Ting-Kai LEUNG
IPC分类号： A61L15/00
CPC分类号： A61L15/44 , A61L15/20 , A61L15/425 , A61L2300/41
摘要： A porous dressing is provided. The porous dressing includes a polymeric layer, a pharmaceutically active ingredient and a metal oxide. The polymeric layer has a porosity and a bio-compatibility, and the pharmaceutically active ingredient and the metal oxide distribute in one selected from a group consisting of in the polymeric layer, on a surface of the polymeric layer and a combination thereof.
摘要翻译：提供多孔敷料。多孔敷料包括聚合物层，药物活性成分和金属氧化物。聚合物层具有孔隙率和生物相容性，并且药物活性成分和金属氧化物分布在聚合物层中的聚合物层，聚合物层的表面及其组合中的一个中。

59. 发明申请

US20090043235A1 Composite dressing 有权
标题翻译：复合敷料
公开(公告)号：US20090043235A1
公开(公告)日：2009-02-12
申请号：US12001291
申请日：2007-12-11
申请人： Ching-Cheng Huang , Su-Huei Lai , Yung-Sheng Lin , Ting-Kai Leung
发明人： Ching-Cheng Huang , Su-Huei Lai , Yung-Sheng Lin , Ting-Kai Leung
IPC分类号： A61F13/02 , A61L15/16
CPC分类号： A61L15/18 , A61F13/0209 , A61F13/0213 , A61F13/022 , A61L15/22 , A61L15/44 , A61L2300/41 , A61L2300/608
摘要： A composite dressing including a first polymeric layer, a second polymeric layer, a metal oxide, and a pharmaceutical active material is provided. The second polymeric layer is biocompatible and is disposed on a surface of the first polymeric layer. The metal oxide is distributed inside or on at least one surface of the first polymeric layer, while the pharmaceutical active material is distributed inside or on at least one surface of the second polymeric layer.
摘要翻译：提供包括第一聚合物层，第二聚合物层，金属氧化物和药物活性材料的复合敷料。第二聚合物层是生物相容的并且设置在第一聚合物层的表面上。金属氧化物分布在第一聚合物层的内部或至少一个表面上，而药物活性物质分布在第二聚合物层的内部或至少一个表面上。

60. 发明授权

US06946153B2 Anti-fungal pharmaceutical compositions comprising an active ingredient prepared from Zingiber officinale 失效
标题翻译：抗真菌药物组合物，其包含由姜科药剂制备的活性成分
公开(公告)号：US06946153B2
公开(公告)日：2005-09-20
申请号：US10438233
申请日：2003-05-14
申请人： Tian-Shung Wu , Sheng-Chu Kuo , Che-Ming Teng , Feng-Nien Ko
发明人： Tian-Shung Wu , Sheng-Chu Kuo , Che-Ming Teng , Feng-Nien Ko
IPC分类号： A61K36/9066 , A61K35/78
CPC分类号： A61K36/9068 , A61K36/9066 , Y10S514/864
摘要： A method of treating a patient suffering a disease associated with Trichophyton mentagrophytes or Pityrosporum ovale by applying topically an anti-fungal pharmaceutical composition which is prepared from Zingiber officinale, includes the following steps: preparing a crude liquid from rhizomes of ginger by extraction with an organic solvent or supercritical CO2, or by distillation with steam; introducing the crude liquid to a reverse phase chromatography column, and eluting the column with water, a first eluent and a second eluent having a polarity weaker than that of the first eluent but stronger than that of chloroform, so that a first eluate resulting from elution of the first eluent and a second eluate resulting from elution of the second eluent are obtained; removing the first eluent and the second eluent from the first eluate and the second eluate by evaporation, respectively, so that a first concentrated eluate and a second concentrated eluate are obtained as the potent extract.
摘要翻译：通过局部施用由姜科药剂制备的抗真菌药物组合物治疗患有与毛癣菌相关的疾病的患者的方法包括以下步骤：通过用有机物提取从姜的根茎制备粗液体溶剂或超临界CO 2，或通过蒸汽蒸馏; 将粗液体引入反相色谱柱，并用水洗脱柱，第一洗脱液和第二洗脱液，其极性弱于第一洗脱液的极性，但比氯仿强烈，使得从洗脱产生的第一洗脱液的第一洗脱液和由第二洗脱液洗脱产生的第二洗脱液; 通过蒸发分别从第一洗脱液和第二洗脱液除去第一洗脱液和第二洗脱液，使得获得第一浓缩洗脱液和第二浓缩洗脱液作为有效提取物。

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