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51. 发明申请

US20150306167A1 ALPINIA SPP. EXTRACTS FOR TREATING IRRITABLE BOWEL SYNDROME 审中-公开
标题翻译：阿尔皮尼亚SPP 用于治疗有用的牙刷综合征的提取物
公开(公告)号：US20150306167A1
公开(公告)日：2015-10-29
申请号：US14650745
申请日：2013-12-30
申请人： MEDICAL AND PHARMACEUTICAL INDUSTRY TECHNOLOGY AND DEVELOPMENT CENTER
发明人： Jui-Ching CHEN , Che-Yi LIN , Chih-Sheng HUNG , Pei-Fan WU , Fen CHEN
IPC分类号： A61K36/9062 , A61K31/352 , A61K31/122
CPC分类号： A61K36/9062 , A61K31/122 , A61K31/352
摘要： Disclosed herein is the use of an extract from Alpinia spp. for the preparation of a medicament for the treatment of irritable bowel syndrome (IBS). The extract is prepared by extracting fresh and/or dried fruits of Alpinia spp. plant with a solvent such as a supercritical fluid, water, 10-95% (v/v) ethanol, acetone, ethyl acetate or n-hexane, to obtain an extract suitable for the preparation of IBS medicaments. In some embodiments, active compounds with anti-abnormal defecation activity and/or analgesia effect are isolated from the water extract of Alpinia spp.; these compounds are therefore potential lead compounds for use as medicaments for treating IBS.
摘要翻译：本文公开了使用来自Alpinia spp的提取物。用于制备用于治疗肠易激综合征（IBS）的药物。提取物是通过提取新鲜和/或干果实的Alpinia spp来制备的。用溶剂如超临界流体，水，10-95％（v / v）乙醇，丙酮，乙酸乙酯或正己烷进行处理，得到适于制备IBS药物的提取物。在一些实施方案中，具有抗异常排便活性和/或镇痛作用的活性化合物从高山ia属的水提取物中分离出来。因此，这些化合物是用作治疗IBS的药物的潜在的铅化合物。

52. 发明授权

US09144590B2 Use of aster extract in the treatment of opioid-induced constipation 有权
标题翻译：使用燕麦提取物治疗阿片样物质诱发便秘
公开(公告)号：US09144590B2
公开(公告)日：2015-09-29
申请号：US13336633
申请日：2011-12-23
申请人： Jui-Ching Chen , Che-Yi Lin , Chien-Chang Wu , Cheng-Po Huang , Yuan-Ling Ku , Yueh-Chu Chen , Yu-Hsuan Lin , Chih-Sheng Hung
发明人： Jui-Ching Chen , Che-Yi Lin , Chien-Chang Wu , Cheng-Po Huang , Yuan-Ling Ku , Yueh-Chu Chen , Yu-Hsuan Lin , Chih-Sheng Hung
IPC分类号： A61K36/28
CPC分类号： A61K36/28 , A61K2236/39
摘要： Disclosed herein is the use of an extract from an Aster species for the preparation of a medicament for the treatment of opioid-induced constipation. The extract is extracted from fresh and/or dried roots and rhizomes of a Tatarian aster (Aster tartaricus) plant, in which the extraction uses water or 40-95% (v/v) ethanol as an extractant to obtain an extraction mixture. In some embodiments, the extraction mixture is then eluted with water followed by at least one eluent.
摘要翻译：本文公开了使用来自Aster物质的提取物来制备用于治疗阿片样物质诱导的便秘的药物。提取物从新鲜和/或干燥的根状和根状星体提取，其中提取使用水或40-95％（v / v）乙醇作为萃取剂，以获得提取混合物。在一些实施方案中，然后将萃取混合物用水洗脱，然后用至少一种洗脱液洗脱。

53. 发明授权

US08257759B2 Antitussive composition and method for making the same 有权
标题翻译：镇咳药组合物及其制备方法
公开(公告)号：US08257759B2
公开(公告)日：2012-09-04
申请号：US12344219
申请日：2008-12-25
申请人： Yuan-Ling Ku , Chien-Jen Shih , Hsiao-Chu Huang , Chun-Hung Kuo , Yi-Chen Lin , Yueh-Chu Chen , Feng-Nien Ko
发明人： Yuan-Ling Ku , Chien-Jen Shih , Hsiao-Chu Huang , Chun-Hung Kuo , Yi-Chen Lin , Yueh-Chu Chen , Feng-Nien Ko
IPC分类号： A61K36/00
CPC分类号： A61K36/605
摘要： An antitussive composition is provided. A pharmaceutical composition for relieving, preventing and/or treating a cough includes a sufficient amount of the Morus australis Poir extract as an active component. The effective Morus australis Poir extract is prepared by extracting the root-bark of the Morus australis Poir with water, ethanol, acetone, ethyl acetate, or a combination thereof. The crude extract can be further fractioned by ultrafiltration or reverse phase column.
摘要翻译：提供镇咳药物。用于缓解，预防和/或治疗咳嗽的药物组合物包括足量的作为活性成分的桑alis ir提取物。通过用水，乙醇，丙酮，乙酸乙酯或它们的组合提取桑alis的根皮来制备有效的南极ir提取物。粗提物可以通过超滤或反相柱进一步分级。

54. 发明授权

US07645915B2 Composite dressing 有权
标题翻译：复合敷料
公开(公告)号：US07645915B2
公开(公告)日：2010-01-12
申请号：US12001291
申请日：2007-12-11
申请人： Ching-Cheng Huang , Su-Huei Lai , Yung-Sheng Lin , Ting-Kai Leung
发明人： Ching-Cheng Huang , Su-Huei Lai , Yung-Sheng Lin , Ting-Kai Leung
IPC分类号： A61F13/00
CPC分类号： A61L15/18 , A61F13/0209 , A61F13/0213 , A61F13/022 , A61L15/22 , A61L15/44 , A61L2300/41 , A61L2300/608
摘要： A composite dressing including a first polymeric layer, a second polymeric layer, a metal oxide, and a pharmaceutical active material is provided. The second polymeric layer is biocompatible and is disposed on a surface of the first polymeric layer. The metal oxide is distributed inside or on at least one surface of the first polymeric layer, while the pharmaceutical active material is distributed inside or on at least one surface of the second polymeric layer.
摘要翻译：提供包括第一聚合物层，第二聚合物层，金属氧化物和药物活性材料的复合敷料。第二聚合物层是生物相容的并且设置在第一聚合物层的表面上。金属氧化物分布在第一聚合物层的内部或至少一个表面上，而药物活性物质分布在第二聚合物层的内部或至少一个表面上。

55. 发明申请

US20090104293A1 Use of a potent product extracted from rhizomes of Zingiber officinale in treating a disease associated with Helicobacter pylori 有权
标题翻译：使用从姜黄根茎提取的有效产品治疗与幽门螺杆菌相关的疾病
公开(公告)号：US20090104293A1
公开(公告)日：2009-04-23
申请号：US11907854
申请日：2007-10-18
申请人： Feng-Nien Ko , Mo-Chi Cheng , Cheng-Ko Liu , Jen-Wei Chen , Fen Chen , Chao-Chi Yei
发明人： Feng-Nien Ko , Mo-Chi Cheng , Cheng-Ko Liu , Jen-Wei Chen , Fen Chen , Chao-Chi Yei
IPC分类号： A61K36/9068 , A61P43/00
CPC分类号： A61K36/9068
摘要： The present invention discloses a new use of a potent product extracted from rhizomes of Zingiber officinale in treating a disease associated with Helicobacter pylori such as gastritis, gastric ulcer or duodenal ulcer in a patient. The potent product is prepared by a process including the steps of a) preparing a crude extract from rhizomes of Zingiber officinale, said crude extract comprising 6-gingerol and 6-shogaol; b) introducing the crude extract to a reverse phase chromatography column, and eluting the column with a first eluent having a polarity lower than water to obtain a first potent fraction or a second eluent having a polarity lower than that of the first eluent to obtain a second potent fraction. Preferably, the second potent fraction is substantially free of both 6-gingerol and 6-shogaol.
摘要翻译：本发明公开了一种从姜黄根提取的有效产品在治疗与幽门螺杆菌相关的疾病如胃炎，胃溃疡或十二指肠溃疡中的新用途。所述有效产物通过以下步骤制备，所述方法包括以下步骤：a）从姜黄根茎制备粗提取物，所述粗提物包含6-姜醇和6-shogaol; b）将粗提取物引入反相层析柱，并用极性低于水的第一洗脱液洗脱柱，以获得极性低于第一洗脱液的第一有效级分或第二洗脱液，从而获得第二有效分数。优选地，第二有效级分基本上不含6-姜醇和6-shogaol。

56. 发明授权

US07179496B2 Anti-depression pharmaceutical composition containing Polygala extract 有权
标题翻译：抗抑郁药物组合物含有Polygala提取物
公开(公告)号：US07179496B2
公开(公告)日：2007-02-20
申请号：US10915464
申请日：2004-08-11
申请人： Feng-Nien Ko , Cheng-Ko Liu , Yu-Feng Han , Pin-Fun Chen
发明人： Feng-Nien Ko , Cheng-Ko Liu , Yu-Feng Han , Pin-Fun Chen
IPC分类号： A61K35/78
CPC分类号： A61K36/69 , A61K2300/00
摘要： A pharmaceutical composition contains a therapeutically effective amount of an active ingredient, in admixture with a pharmaceutically acceptable carrier or diluent for the active ingredient, in which the active ingredient is i) a polar solvent extract of Polygala, the polar solvent being water or a mixture of water and methanol or ethanol; ii) an aqueous fraction resulting from an extraction of the polar solvent extract with an organic solvent; iii) an organic eluate by introducing the polar solvent extract or the aqueous fraction into a reverse phase chromatography column, and eluting the column with water and an organic solvent; or iv) a filtrate having a molecular mass less than 30000 in the organic eluate.
摘要翻译：药物组合物含有治疗有效量的活性成分，与活性成分的药学上可接受的载体或稀释剂混合，其中活性成分是i）Polygala的极性溶剂提取物，极性溶剂是水或混合物的水和甲醇或乙醇; ii）由有机溶剂萃取极性溶剂提取物得到的水性级分; iii）通过将极性溶剂提取物或水性级分引入反相色谱柱中，并用水和有机溶剂洗脱柱来进行有机洗脱液; 或iv）在有机洗脱液中分子量小于30000的滤液。

57. 发明申请

US20100166898A1 ANTI-BACTERIAL USE OF EXTRACT FROM MORUS AUSTRALIS POIR. AND COMPOUND KUWANON H 有权
标题翻译：从MORUS AUSTRALIS POIR提取物的抗细菌使用。和化合物KUWANON H
公开(公告)号：US20100166898A1
公开(公告)日：2010-07-01
申请号：US12345254
申请日：2008-12-29
申请人： Yuan-Ling Ku , Shih-Tsun Liang , Yu-Hsuan Lin , Liang-Hua Chen , Ying-Yu Kuo
发明人： Yuan-Ling Ku , Shih-Tsun Liang , Yu-Hsuan Lin , Liang-Hua Chen , Ying-Yu Kuo
IPC分类号： A61K36/605 , A61K31/352 , A61P31/04
CPC分类号： A61K31/352
摘要： An extract prepared from the root barks of Morus australis Poir. and its use as an anti-bacteria agent, and use of a compound Kuwanon H having the following formula (I) separated from the extract as an anti-bacteria agent:
摘要翻译：从桑the的根皮制备的提取物。及其作为抗菌剂的用途，以及使用具有下述式（I）的化合物Kuwanon H作为抗菌剂从提取物中分离出来：

58. 发明申请

US20090053287A1 POROUS DRESSING 审中-公开
标题翻译：多孔连接
公开(公告)号：US20090053287A1
公开(公告)日：2009-02-26
申请号：US11926575
申请日：2007-10-29
申请人： Ching-Cheng HUANG , Quang-Wei CHANG , Yung-Sheng LIN , Ting-Kai LEUNG
发明人： Ching-Cheng HUANG , Quang-Wei CHANG , Yung-Sheng LIN , Ting-Kai LEUNG
IPC分类号： A61L15/00
CPC分类号： A61L15/44 , A61L15/20 , A61L15/425 , A61L2300/41
摘要： A porous dressing is provided. The porous dressing includes a polymeric layer, a pharmaceutically active ingredient and a metal oxide. The polymeric layer has a porosity and a bio-compatibility, and the pharmaceutically active ingredient and the metal oxide distribute in one selected from a group consisting of in the polymeric layer, on a surface of the polymeric layer and a combination thereof.
摘要翻译：提供多孔敷料。多孔敷料包括聚合物层，药物活性成分和金属氧化物。聚合物层具有孔隙率和生物相容性，并且药物活性成分和金属氧化物分布在聚合物层中的聚合物层，聚合物层的表面及其组合中的一个中。

59. 发明申请

US20090043235A1 Composite dressing 有权
标题翻译：复合敷料
公开(公告)号：US20090043235A1
公开(公告)日：2009-02-12
申请号：US12001291
申请日：2007-12-11
申请人： Ching-Cheng Huang , Su-Huei Lai , Yung-Sheng Lin , Ting-Kai Leung
发明人： Ching-Cheng Huang , Su-Huei Lai , Yung-Sheng Lin , Ting-Kai Leung
IPC分类号： A61F13/02 , A61L15/16
CPC分类号： A61L15/18 , A61F13/0209 , A61F13/0213 , A61F13/022 , A61L15/22 , A61L15/44 , A61L2300/41 , A61L2300/608
摘要： A composite dressing including a first polymeric layer, a second polymeric layer, a metal oxide, and a pharmaceutical active material is provided. The second polymeric layer is biocompatible and is disposed on a surface of the first polymeric layer. The metal oxide is distributed inside or on at least one surface of the first polymeric layer, while the pharmaceutical active material is distributed inside or on at least one surface of the second polymeric layer.
摘要翻译：提供包括第一聚合物层，第二聚合物层，金属氧化物和药物活性材料的复合敷料。第二聚合物层是生物相容的并且设置在第一聚合物层的表面上。金属氧化物分布在第一聚合物层的内部或至少一个表面上，而药物活性物质分布在第二聚合物层的内部或至少一个表面上。

60. 发明授权

US06946153B2 Anti-fungal pharmaceutical compositions comprising an active ingredient prepared from Zingiber officinale 失效
标题翻译：抗真菌药物组合物，其包含由姜科药剂制备的活性成分
公开(公告)号：US06946153B2
公开(公告)日：2005-09-20
申请号：US10438233
申请日：2003-05-14
申请人： Tian-Shung Wu , Sheng-Chu Kuo , Che-Ming Teng , Feng-Nien Ko
发明人： Tian-Shung Wu , Sheng-Chu Kuo , Che-Ming Teng , Feng-Nien Ko
IPC分类号： A61K36/9066 , A61K35/78
CPC分类号： A61K36/9068 , A61K36/9066 , Y10S514/864
摘要： A method of treating a patient suffering a disease associated with Trichophyton mentagrophytes or Pityrosporum ovale by applying topically an anti-fungal pharmaceutical composition which is prepared from Zingiber officinale, includes the following steps: preparing a crude liquid from rhizomes of ginger by extraction with an organic solvent or supercritical CO2, or by distillation with steam; introducing the crude liquid to a reverse phase chromatography column, and eluting the column with water, a first eluent and a second eluent having a polarity weaker than that of the first eluent but stronger than that of chloroform, so that a first eluate resulting from elution of the first eluent and a second eluate resulting from elution of the second eluent are obtained; removing the first eluent and the second eluent from the first eluate and the second eluate by evaporation, respectively, so that a first concentrated eluate and a second concentrated eluate are obtained as the potent extract.
摘要翻译：通过局部施用由姜科药剂制备的抗真菌药物组合物治疗患有与毛癣菌相关的疾病的患者的方法包括以下步骤：通过用有机物提取从姜的根茎制备粗液体溶剂或超临界CO 2，或通过蒸汽蒸馏; 将粗液体引入反相色谱柱，并用水洗脱柱，第一洗脱液和第二洗脱液，其极性弱于第一洗脱液的极性，但比氯仿强烈，使得从洗脱产生的第一洗脱液的第一洗脱液和由第二洗脱液洗脱产生的第二洗脱液; 通过蒸发分别从第一洗脱液和第二洗脱液除去第一洗脱液和第二洗脱液，使得获得第一浓缩洗脱液和第二浓缩洗脱液作为有效提取物。

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