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41. 发明授权

KR100486730B1 교류 전압과 Ｔ 채널을 이용하여 제타 포텐셜을 측정하는방법 失效
标题翻译：一种通过使用替代电位和T通道测量ζ电位的方法
公开(公告)号：KR100486730B1
公开(公告)日：2005-05-03
申请号：KR1020030004108
申请日：2003-01-21
申请人： 삼성전자주식회사
发明人： 조윤경 , 신상민 , 강인석 , 임근배
IPC分类号： G01N33/50
CPC分类号： B01F13/0076 , B01L3/50273 , B01L3/502769 , B01L2400/0418 , G01N27/44752 , Y10T436/11
摘要： 본 발명은 고체 벽면과 용액 사이의 제타 포텐셜을 측정하는 방법에 관한 것으로, 구체적으로는 (a) 제1 및 제2 입구 전극과 접지된 출구 전극을 갖는 T 채널의 제1 주입구로는 전해 용액을 주입하고, 상기 T 채널의 제2 주입구로는 상기 전해질 용액과 형광물질의 혼합 용액을 주입하여 정상 상태에 도달시키는 단계; (b) 상기 제1 입구 전극과 제2 입구 전극으로부터 상기 출구 전극으로 직류 전압을 가하여 상기 전해질 용액의 흐름과 상기 전해질 용액과 형광물질의 혼합 용액의 흐름의 경계면을 형성시키는 단계; (c) 상기 두 개의 입구 전극 중 어느 하나의 전극으로부터 상기 접지된 출구 전극으로 교류 전압을 가하여 상기 경계면을 진동시키는 단계; 및 (d) 상기 경계면의 진폭 값을 측정하고, 제타 포텐셜과 경계면의 진폭과의 표준 관계로부터 제타 포텐셜을 계산하는 단계;를 포함하는 채널 벽과 전해액 사이의 제타 포텐셜을 측정하는 방법을 제공하는 것이다.

42. 发明公开

KR1020130029277A 미세유동장치　및 그 제어방법 无效
标题翻译：微流体装置及其控制方法
公开(公告)号：KR1020130029277A
公开(公告)日：2013-03-22
申请号：KR1020110092616
申请日：2011-09-14
申请人： 삼성전자주식회사
发明人： 박상범 , 김나희 , 이상현
IPC分类号： C12M1/38 , C12M1/34 , C12M1/30 , C12Q1/68
CPC分类号： B01L3/502769 , B01L2200/0605 , B01L2200/0673 , B01L2200/141 , B01L2300/0803 , B01L2300/0864 , B01L2400/0409 , B01L2400/0677
摘要： PURPOSE: A microfluidic device is provided to prevent cross contamination between a plurality of reaction chambers and to improve biochemical reaction efficiency and reproducibility. CONSTITUTION: A microfluidic device comprises: a sample chamber(10) which contains a sample; a plurality of reaction chambers(13) which contains a reactant; a distribution channel(12) which distributes the sample to each reaction chamber; a mixing preventing chamber(11) which is connected to the distribution channel and contains a material which prevents each reactant in the reaction chamber from being mixed each other; and valves(16,17) which are placed in the distribution channel and opens and closes the distribution channel.
摘要翻译：目的：提供微流体装置以防止多个反应室之间的交叉污染并提高生化反应效率和再现性。构成：微流体装置包括：样品室（10），其包含样品; 多个反应室（13），其包含反应物; 分配通道（12），其将样品分配到每个反应室; 混合防止室（11），其连接到分配通道并且包含防止反应室中的每个反应物彼此混合的材料; 以及放置在分配通道中并打开和关闭分配通道的阀（16,17）。

43. 发明授权

KR100965667B1 현탁액에서 상의 부피분율을 결정하는 장치 및 방법 失效
标题翻译：用于确定悬架中相的体积部分的装置和方法
公开(公告)号：KR100965667B1
公开(公告)日：2010-06-24
申请号：KR1020087006848
申请日：2006-10-05
申请人： 알베르트-루드빅스-유니베르지텟 푸라이부르그
发明人： 구루만마르쿠스 , 두크리옌스 , 젠저레롤란드 , 리꺼루쯔
IPC分类号： B01J19/00 , B01L3/00 , G01N33/49 , G01F25/00
CPC分类号： B01L3/502753 , B01L3/502746 , B01L3/502769 , B01L2200/0621 , B01L2200/0642 , B01L2200/0684 , B01L2300/028 , B01L2300/0803 , B01L2300/089 , B01L2300/161 , B01L2400/0406 , B01L2400/0409 , B01L2400/088 , Y10T436/11 , Y10T436/111666 , Y10T436/25 , Y10T436/25375 , Y10T436/2575
摘要： 현탁액에서 상의 부피분율을 결정하는 장치가 몸체와, 몸체에 형성된 채널 구조와, 입구 영역(30)과, 입구영역과 유체 유동가능하게 연결되고 그를 통해 충진될 수 있는 블라인드 채널(32)을 포함한다. 또한 몸체에 회전을 부여함으로써, 블라인드 채널(32) 내의 현탁액의 상 분리가 발생하도록 하는 구동 수단이 구비된다. 블라인드 채널(32)의 채널 단면 및/또는 습윤 특성은, 입구 영역을 통하여 상기 현탁액을 블라인드 채널을 충진할 때, 제2 단면 영역보다 제1 단면 영역에서 더 강한 모세관 힘이 작용하여 먼저 제1 단면 영역이 입구 영역에서 블라인드 채널의 막힌 단부 쪽 방향으로 충진되고 나서 제2 단면 영역이 막힌 단부에서 입구 영역 쪽 방향으로 충진되도록 이루어진다.
부피분율, 적혈구용적율, 헤마토크리트

44. 发明申请

WO2011160071A3 DEVICE FOR SORTING, CLASSIFYING, AND ASSAYING PARTITION BEHAVIOR OF CELL MEMBRANE BIOMOLECULES AND METHODS BASED THEREON 审中-公开
标题翻译：用于分类，分类和测定细胞膜生物分子的分离行为的装置及其方法
公开(公告)号：WO2011160071A3
公开(公告)日：2012-04-19
申请号：PCT/US2011040962
申请日：2011-06-17
申请人： UNIV CORNELL , DANIEL SUSAN , CHAO LING
发明人： DANIEL SUSAN , CHAO LING
IPC分类号： G01N33/483 , G01N15/14 , G01N27/00 , G01N35/08
CPC分类号： G01N33/6842 , B01L3/502761 , B01L3/502769 , B82Y30/00 , G01N15/1404 , G01N27/44782 , G01N27/44791 , G01N33/54366
摘要： A biomolecule partitioning device (BPD) is provided that can be used to separate and sort membrane species into raft-like membrane regions without using detergent or crosslinkers. The BPD can comprise one or more microfluidic channels coated with coexistent lipid phases (raft-like and fluid-like lipid compositions) as a contiguous supported lipid bilayer (SLB). The geometry of the phases can be patterned with spatial and temporal control within each channel. Methods for the separation and sorting are also provided. The method can comprise the steps of introducing cell membrane species into an SLB; patterning coexistent phases; applying an electric field or hydrodynamic flow to move the species; sorting migrating species into regions based on their partitioning preference; and collecting sorted species in a quantification area. The BPD can also be used to measure partitioning kinetics or to assay for activity changes of biomolecules as a function of local lipid environment.
摘要翻译：提供生物分子分配装置（BPD），其可用于将膜物质分离和分类为筏状膜区域，而不使用洗涤剂或交联剂。 BPD可以包含作为连续支持的脂质双层（SLB）涂覆有共存的脂质相（筏状和流体状的脂质组合物）的一个或多个微流体通道。可以在每个通道内对空间和时间控制进行图案化。还提供了分离和分选的方法。该方法可以包括将细胞膜物种引入SLB的步骤; 形成共存阶段; 施加电场或流体动力流来移动物种; 根据其分配偏好将迁移物种分类到区域; 并在量化区域收集排序的物种。 BPD还可用于测量分配动力学或测定作为局部脂质环境的函数的生物分子的活性变化。

45. 发明申请

WO2011113563A1 VORRICHTUNG UND VERFAHREN ZUR MANIPULATION EINER FLÜSSIGKEIT 审中-公开
标题翻译：装置和方法用于处理液体
公开(公告)号：WO2011113563A1
公开(公告)日：2011-09-22
申请号：PCT/EP2011/001242
申请日：2011-03-14
申请人： BOEHRINGER INGELHEIM INTERNATIONAL GMBH , RODENFELS, Tobias
发明人： RODENFELS, Tobias
IPC分类号： B01L3/00
CPC分类号： F16K99/0017 , B01L3/5027 , B01L3/50273 , B01L3/502769 , B01L2200/0647 , B01L2300/0636 , B01L2400/043 , B01L2400/0475 , B01L2400/0688 , G01N33/5304 , G01N33/54326 , G01N33/54366 , Y10T137/2202 , Y10T137/2218 , Y10T137/2224
摘要： Es werden eine Vorrichtung und ein Verfahren zur Manipulation einer Flüssigkeit in einem Kanal vorgeschlagen, wobei in dem Kanal ein Körper bewegt wird, der einen kapillaren Zwischenraum zur Kanalwandung bildet und der Kanal immer nur bis zu dem Körper mit Flüssigkeit gefüllt wird. Vorzugsweise kann der Körper auch einen nichtbenetzbaren Bereich des Kanals für die Flüssigkeit überbrücken.
摘要翻译：已提出了用于在信道，其中一个体是在所述信道，其形成用于所述管道壁的毛细管间隙和信道总是充满仅达到主体液体移动操纵的液体的装置和方法。优选地，主体还可以桥接用于液体的通道的非润湿区域。

46. 发明申请

WO2010101926A2 MICROFLUIDIC SYSTEM FOR HIGH-THROUGHPUT, DROPLET-BASED SINGLE MOLECULE ANALYSIS WITH LOW REAGENT CONSUMPTION 审中-公开
标题翻译：微量流动系统，用于高渗透，基于滴液的单分子分析，低试剂消耗
公开(公告)号：WO2010101926A2
公开(公告)日：2010-09-10
申请号：PCT/US2010025933
申请日：2010-03-02
申请人： UNIV JOHNS HOPKINS , WANG JEFF TZA-HUEI , LIU KELVIN J , PULEO CHRISTOPHER M , RANE TUSHAR D
发明人： WANG JEFF TZA-HUEI , LIU KELVIN J , PULEO CHRISTOPHER M , RANE TUSHAR D
IPC分类号： G01N35/08 , G01N21/64 , G01N33/48
CPC分类号： C12Q1/6825 , B01L3/502753 , B01L3/502769 , B01L7/52 , B01L2200/0678 , B01L2200/10 , B01L2300/088 , B01L2400/0481 , B01L2400/0655 , G01N1/38 , G01N15/1484 , G01N21/6458 , G01N2001/4027 , G01N2015/0038 , G01N2015/1493 , G01N2021/6419 , G01N2021/6421 , Y10T436/143333
摘要： A microfluidic device for a confocal fluorescence detection system has an input channel defined by a body of the microfluidic device, a sample concentration section defined by the body of the microfluidic device and in fluid connection with the input channel, a mixing section defined by the body of the microfluidic device and in fluid connection with the concentration section, and a detection region that is at least partially transparent to illumination light of the confocal fluorescence detection system and at least partially transparent to fluorescent light when emitted from a sample under observation as the sample flows through the detection region.
摘要翻译：用于共焦荧光检测系统的微流体装置具有由微流体装置的主体限定的输入通道，由微流体装置的主体限定并与输入通道流体连接的样品浓度部分，由身体限定的混合部分的微流体装置，并且与浓缩部分流体连接;以及检测区域，其对于共聚焦荧光检测系统的照明光至少部分透明，并且当从作为样品的观察样品发射时对荧光至少部分透明流过检测区域。

47. 发明申请

WO2008115916A1 MICROFLUIDIC DEVICE FOR INDUCING SEPARATIONS BY FREEZING AND ASSOCIATED METHOD 审中-公开
标题翻译：用于通过冷冻诱导分离的微流体装置和相关方法
公开(公告)号：WO2008115916A1
公开(公告)日：2008-09-25
申请号：PCT/US2008/057347
申请日：2008-03-18
申请人： THE AEROSPACE CORPORATION , WELLE, Richard P.
发明人： WELLE, Richard P.
IPC分类号： G01N30/00
CPC分类号： B01D17/00 , B01D9/004 , B01D9/04 , B01L3/502769 , B01L2200/0631 , B01L2300/0887 , B01L2300/1822 , B01L2300/1827 , B01L2400/0677 , Y10T137/2196 , Y10T436/25375
摘要： A microfluidic device is provided for inducing the separation of constituent elements from a microfluidic sample by inroducing phase changes in the microfluidic sample while contained in a microfluidic channel in the device. At least a portion of the microfluidic sample is frozen to cause fractional exclusion of the constituent element from the frozen portion of the microfluidic sample. Different portions of the microfluidic sample may be frozen in different sectors and at different times in order to cause movement in a desired direction of the separated constituent element. Portions of the microfluidic sample may be frozen in a sequential order of adjacent sectors within the microfluidic channel in order to cause sequential movement of the excluded constituent element toward one portion of the microfluidic channel. The frozen portion of the microfluidic sample is then thawed, wherein the separated constituent element remains substantially separated from the thawed, purified microfluidic sample.
摘要翻译：提供了一种微流体装置，用于通过在装置中的微流体通道中包含微流体样品中的相变而引起构成元件与微流体样品的分离。将微流体样品的至少一部分冷冻以引起构成元件从微流体样品的冷冻部分的分级排除。微流体样品的不同部分可以在不同的扇区中被冷冻，并且在不同的时间被冷冻以引起在所分离的构成元件的期望方向上的移动。微流体样品的部分可以以微流体通道内的相邻扇区的顺序冷冻，以便排除构成元件朝着微流体通道的一部分顺序移动。然后将微流体样品的冷冻部分解冻，其中分离的构成元件基本上与解冻的纯化的微流体样品分离。

48. 发明申请

WO2007006033A2 MICROFLUIDIC SEPARATORS FOR MULTIPHASE FLUID-FLOW BASED ON MEMBRANES 审中-公开
标题翻译：基于膜的多相流体流动微流体分离器
公开(公告)号：WO2007006033A2
公开(公告)日：2007-01-11
申请号：PCT/US2006/026464
申请日：2006-07-05
申请人： MASSACHUSETTS INSTITUTE OF TECHNOLOGY , JENSEN, Klavs, F. , KRALJ, Jason, G. , SAHOO, Hemantkumar, Ramesh
发明人： JENSEN, Klavs, F. , KRALJ, Jason, G. , SAHOO, Hemantkumar, Ramesh
IPC分类号： B01D69/12
CPC分类号： B01D63/087 , B01D63/088 , B01L3/502723 , B01L3/50273 , B01L3/502753 , B01L3/502769 , B01L2200/0684 , B01L2300/0816 , B01L2300/0864 , B01L2400/0406 , B01L2400/0487 , B01L2400/0688 , Y10T29/49826
摘要： One aspect of the invention relates to fluid-phase separators and devices containing them. Another aspect of the invention relates to the use of said fluid-phase separators and devices containing them for separating individual phases from gas-liquid and liquid-liquid two-phase mixtures for a range of flow regimes. The present invention also relates to methods of making said fluid-phase separators and devices containing them.
摘要翻译：本发明的一个方面涉及含有它们的流体相分离器和装置。本发明的另一方面涉及使用所述流体相分离器和包含它们的装置用于在一系列流动状态下将气相和液 - 液两相混合物分离出各相。本发明还涉及制造所述流体相分离器和包含它们的装置的方法。

49. 发明申请

WO2003038436A2 MICROFLUIDIC SER(R)S DETECTION 审中-公开
标题翻译：微流感检测
公开(公告)号：WO2003038436A2
公开(公告)日：2003-05-08
申请号：PCT/GB2002/005025
申请日：2002-11-04
申请人： UNIVERSITY OF STRATHCLYDE , THE UNIVERSITY COURT OF THE UNIVERSITY OF GLASGOW , SMITH, William, Ewen , GRAHAM, Duncan , COOPER, Jonathan, Mark , KEIR, Ruth , IGATA, Eishi
发明人： SMITH, William, Ewen , GRAHAM, Duncan , COOPER, Jonathan, Mark , KEIR, Ruth , IGATA, Eishi
IPC分类号： G01N33/58
CPC分类号： B01F13/0059 , B01F5/0603 , B01F5/0606 , B01L3/502769 , B01L2300/0654 , B01L2300/0867 , B01L2400/086 , G01N33/582 , G01N33/585
摘要： The present invention relates to a microfluidic method of generating in situ a colloid for use in detecting an analyte using for example SER(R)S, as well as a method of detecting an analyte using SER(R)S in a microfluidic system. The invention also relates to microfluidic devices for use in detecting analytes such as by way of SER(R)S signals.
摘要翻译：本发明涉及使用例如SER（S）S检测分析物的原位产生胶体的微流体方法，以及使用SER（R）S检测分析物的方法， S在微流体系统中。本发明还涉及用于检测分析物例如通过SER（S）信号的微流体装置。

50. 发明公开

KR1020130126350A ＰＣＲ 전처리 칩, 이를 이용한 ＰＣＲ 전처리 방법, 이를 이용한 ＰＣＲ 장치 및 방법 无效
标题翻译： PCR预处理芯片，使用该PCR的PCR预处理方法，PCR装置及其使用方法
公开(公告)号：KR1020130126350A
公开(公告)日：2013-11-20
申请号：KR1020120050412
申请日：2012-05-11
申请人： 한국과학기술원
发明人： 서태석
IPC分类号： C12Q1/68 , C12M1/38 , C12M1/10
CPC分类号： B01L3/502715 , B01L3/502769 , C12M1/10 , C12Q1/686
摘要： A PCR pretreatment chip, a method for PCR pretreatment using the same, a PCR apparatus, and a method using the same are provided. The PCR pretreatment chip according to the embodiment of the present invention has a sample chamber storing sample solutions, a wash buffer solution chamber storing wash buffer solutions, and an eluent chamber storing eluents comprising: a first, a second, and a third microfluid channel which is connected to the sample chamber, the wash buffer solution chamber, and the eluent chamber respectively in which the respective sample solutions, wash buffer solutions, and eluents from the sample chamber, the wash buffer solution chamber, and the eluent chamber flow; a collection chamber in which solutions are supplied from the first, second, and third microfluid channels; a fourth microfluid channel in which the solution from the collection chamber flows by rotation of the PCR pretreatment chip; a first chamber which is connected to the end of the fourth microfluid channel and which stores the solution from the collection chamber; a fifth microfluid channel connected between the fourth microfluid channel and the first chamber;, and a second chamber connected to the end of the fifth microfluid channel. The first, second, and third microfluid channels are made up of hydrophobic paths having different cross section, and the fourth microfluid channel has a wider cross section than the fifth microfluid channel. [Reference numerals] (AA) Trapped bead
摘要翻译：提供PCR预处理芯片，使用其的PCR预处理方法，PCR装置及其使用方法。根据本发明的实施方案的PCR预处理芯片具有存储样品溶液的样品室，存储洗涤缓冲溶液的洗涤缓冲溶液室和储存洗脱液的洗脱液室，其包含：第一，第二和第三微流体通道，分别连接到来自样品室，洗涤缓冲溶液室和洗脱液室的相应样品溶液，洗涤缓冲液和洗脱液的样品室，洗涤缓冲溶液室和洗脱液室; 收集室，其中从第一，第二和第三微流体通道提供溶液; 第四微流体通道，其中来自收集室的溶液通过PCR预处理芯片的旋转而流动; 第一室，其连接到第四微流体通道的端部并且存储来自收集室的溶液; 连接在所述第四微流体通道和所述第一室之间的第五微流体通道;以及连接到所述第五微流体通道的端部的第二室。第一，第二和第三微流体通道由具有不同横截面的疏水路径组成，并且第四微流体通道具有比第五微流体通道更宽的横截面。（附图标记）（AA）捕获的珠

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