专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明申请

WO2008050109A1 FUNCTIONALISED POLYMERS FOR BINDING METAL SURFACES 审中-公开
标题翻译：用于结合金属表面的功能聚合物
公开(公告)号：WO2008050109A1
公开(公告)日：2008-05-02
申请号：PCT/GB2007/004038
申请日：2007-10-23
申请人： UNIVERSITY OF STRATHCLYDE , CORMACK, Peter , GRAHAM, Duncan , HERNANDEZ-SANTANA, Aaron , RAMASWAMY, Arun Prasath , SMITH, William Ewen
发明人： CORMACK, Peter , GRAHAM, Duncan , HERNANDEZ-SANTANA, Aaron , RAMASWAMY, Arun Prasath , SMITH, William Ewen
IPC分类号： C08F8/30 , C08F222/08 , C08F212/08 , B22F1/02 , C23F11/173 , G01N21/65
CPC分类号： B22F1/0018 , B22F1/0062 , B22F1/0096 , B22F2998/00 , B82Y30/00 , C08F8/32 , C08F2800/20 , G01N21/65 , G01N21/658 , Y10T428/2998 , Y10T428/31678 , C08F212/08 , B22F1/0022 , C08F222/06
摘要： The invention relates generally to polyvalent macromolecules comprising: (a) a polymer backbone and (b) pendent groups attached to said polymer backbone, wherein some or all of said pendent groups comprise: (i) optionally a linker, (ii) a surface-seeking group, which is capable of binding strongly to a metal surface, (iii) optionally a chromophore, which is detectable by at least one spectroscopic method. Such molecules can modify metal surfaces and have a variety of uses including (without limitation) appending chromophores to metal surfaces without the need to establish complex chemistry; for the stabilisation and labelling of metal nanoparticles; and for preparing and aggregating nanoparticles in a controlled fashion.
摘要翻译：本发明一般涉及多价大分子，其包含：（a）聚合物主链和（b）与所述聚合物主链连接的侧基，其中所述侧基中的一些或全部包括：（i）任选的连接体，（ii）能够与金属表面强结合的寻找组，（iii）任选的发色团，其可通过至少一种光谱法检测。这样的分子可以改变金属表面并具有各种用途，包括（但不限于）将发色团附着在金属表面上，而不需要建立复杂的化学物质; 用于稳定和标记金属纳米粒子; 并以可控制的方式制备和聚集纳米颗粒。

2. 发明申请

WO2003038436A3 MICROFLUIDIC SER(R)S DETECTION 审中-公开
公开(公告)号：WO2003038436A3
公开(公告)日：2003-05-08
申请号：PCT/GB2002/005025
申请日：2002-11-04
申请人： UNIVERSITY OF STRATHCLYDE , THE UNIVERSITY COURT OF THE UNIVERSITY OF GLASGOW , SMITH, William, Ewen , GRAHAM, Duncan , COOPER, Jonathan, Mark , KEIR, Ruth , IGATA, Eishi
发明人： SMITH, William, Ewen , GRAHAM, Duncan , COOPER, Jonathan, Mark , KEIR, Ruth , IGATA, Eishi
IPC分类号： G01N33/58
摘要： The present invention relates to a microfluidic method of generating in situ a colloid for use in detecting an analyte using for example SER(R)S, as well as a method of detecting an analyte using SER(R)S in a microfluidic system. The invention also relates to microfluidic devices for use in detecting analytes such as by way of SER(R)S signals.

3. 发明申请

WO2005019812A1 NUCLEIC ACID SEQUENCE IDENTIFICATION 审中-公开
标题翻译：核酸序列鉴定
公开(公告)号：WO2005019812A1
公开(公告)日：2005-03-03
申请号：PCT/GB2004/003671
申请日：2004-08-26
申请人： UNIVERSITY OF STRATHCLYDE , GRAHAM, Duncan , SMITH, William, Ewen , FRUK, Ljiljana
发明人： GRAHAM, Duncan , SMITH, William, Ewen , FRUK, Ljiljana
IPC分类号： G01N21/65
CPC分类号： G01N21/658 , G01J3/44 , G01N2021/653
摘要： The invention provides modified molecular beacons detectable by surface enhanced Raman spectroscopy (SERS) and related materials, processes, and methods of use. Examples methods provide for the determination of the presence or absence of a target nucleotide sequence in a sample nucleic acid by (a) providing a detection agent, which agent comprises: (i) a probe comprising a target complement sequence (TCS) being complementary to the target sequence and flanking the TCS, first and second oligonucleotide arms, said first and second oligonucleotide arms forming a stem duplex, and said first arm incorporating a first label moiety being detectable by SERS (e.g. a fluoroscein dye) and said second arm terminating in a second label moiety being detectable by SERS, which second arm further includes a surface seeking group (SSG - e.g. an azo-benzotriazole) capable of promoting association of the second label onto an enhancing surface ii) associated with said probe via said SSG, an enhancing surface, such that said first and second label moieties are in close proximity to each other and to the enhancing surface (b) exposing the sample to the detection agent, (c) detecting hybridisation of the TCS to any target sequence present in the sample by a change in the SERS spectra of said agent.
摘要翻译：本发明提供通过表面增强拉曼光谱（SERS）和相关材料，方法和使用方法可检测的修饰分子信标。实例方法通过（a）提供检测剂来确定样品核酸中靶核苷酸序列的存在或不存在，所述检测剂包括：（i）包含与SEQ ID NO：1的互补序列的靶互补序列（TCS）的探针所述靶序列和所述TCS第一和第二寡核苷酸臂的侧翼，所述第一和第二寡核苷酸臂形成茎双相，并且所述第一臂结合第一标记部分，可被SERS（例如氟代染料染料）检测，所述第二臂终止于第二标签部分可由SERS检测，该第二臂还包括能够促进第二标记与经由所述SSG与所述探针相关联的增强表面ii）的表面寻找组（SSG-例如偶氮 - 苯并三唑），使得所述第一和第二标签部分彼此靠近并且与增强表面（b）将样品暴露于检测年龄（c）通过所述试剂的SERS光谱的变化来检测TCS与样品中存在的任何靶序列的杂交。

4. 发明申请

WO2008050109A8 FUNCTIONALISED POLYMERS FOR BINDING METAL SURFACES 审中-公开
标题翻译：用于结合金属表面的功能化聚合物
公开(公告)号：WO2008050109A8
公开(公告)日：2008-07-03
申请号：PCT/GB2007004038
申请日：2007-10-23
申请人： UNIV STRATHCLYDE , CORMACK PETER , GRAHAM DUNCAN , HERNANDEZ-SANTANA AARON , RAMASWAMY ARUN PRASATH , SMITH WILLIAM EWEN
发明人： CORMACK PETER , GRAHAM DUNCAN , HERNANDEZ-SANTANA AARON , RAMASWAMY ARUN PRASATH , SMITH WILLIAM EWEN
IPC分类号： C08F8/30 , B22F1/02 , C08F212/08 , C08F222/08 , C23F11/173 , G01N21/65
CPC分类号： B22F1/0018 , B22F1/0062 , B22F1/0096 , B22F2998/00 , B82Y30/00 , C08F8/32 , C08F2800/20 , G01N21/65 , G01N21/658 , Y10T428/2998 , Y10T428/31678 , C08F212/08 , B22F1/0022 , C08F222/06
摘要： The invention relates generally to polyvalent macromolecules comprising: (a) a polymer backbone and (b) pendent groups attached to said polymer backbone, wherein some or all of said pendent groups comprise: (i) optionally a linker, (ii) a surface-seeking group, which is capable of binding strongly to a metal surface, (iii) optionally a chromophore, which is detectable by at least one spectroscopic method. Such molecules can modify metal surfaces and have a variety of uses including (without limitation) appending chromophores to metal surfaces without the need to establish complex chemistry; for the stabilisation and labelling of metal nanoparticles; and for preparing and aggregating nanoparticles in a controlled fashion.
摘要翻译：本发明一般涉及多价大分子，其包含：（a）聚合物主链和（b）连接到所述聚合物主链上的侧基，其中一些或所有所述侧基包含：（i）任选的连接基团，（ii）寻找基团，其能够强烈地与金属表面结合，（iii）任选的可通过至少一种光谱方法检测的发色团。这种分子可以修饰金属表面并具有多种用途，包括（但不限于）将发色团附加到金属表面而不需要建立复杂的化学反应; 用于金属纳米粒子的稳定和标记; 并以受控方式制备和聚集纳米颗粒。

5. 发明申请

WO2004007767A3 SERRS REACTIVE PARTICLES 审中-公开
公开(公告)号：WO2004007767A3
公开(公告)日：2004-01-22
申请号：PCT/GB2003/003009
申请日：2003-07-11
申请人： UNIVERSITY OF STRATHCLYDE , SMITH, William, Ewen , GRAHAM, Duncan , CORMACK, Peter , McCABE, Ailie
发明人： SMITH, William, Ewen , GRAHAM, Duncan , CORMACK, Peter , McCABE, Ailie
IPC分类号： C12Q1/68
摘要： The present invention relates to the provision of SERRS active polymer beads and a method of their production for use in detecting target molecules, as well as methods of detecting target molecules.

6. 发明申请

WO2004007767A2 SERRS REACTIVE PARTICLES 审中-公开
标题翻译： SERRS反应性颗粒
公开(公告)号：WO2004007767A2
公开(公告)日：2004-01-22
申请号：PCT/GB0303009
申请日：2003-07-11
申请人： UNIV STRATHCLYDE , SMITH WILLIAM EWEN , GRAHAM DUNCAN , CORMACK PETER , MCCABE AILIE
发明人： SMITH WILLIAM EWEN , GRAHAM DUNCAN , CORMACK PETER , MCCABE AILIE
IPC分类号： G01N21/65 , B01J13/14 , C07B61/00 , C12M1/00 , C12M1/34 , C12N15/09 , C12Q1/68 , G01N33/53 , G01N33/543 , G01N33/553 , G01N33/566 , G01N33/58 , G01N33/531
CPC分类号： G01N33/587 , B01J13/14 , B82Y15/00 , C07B2200/11 , C12Q1/6816 , C40B20/04 , G01N21/658 , C12Q2563/149 , C12Q2563/137
摘要： The present invention relates to the provision of SERRS active polymer beads and a method of their production for use in detecting target molecules, as well as methods of detecting target molecules.
摘要翻译：本发明涉及提供SERRS活性聚合物珠粒及其制备用于检测靶分子的方法以及检测靶分子的方法。

7. 发明申请

WO2003038436A2 MICROFLUIDIC SER(R)S DETECTION 审中-公开
标题翻译：微流感检测
公开(公告)号：WO2003038436A2
公开(公告)日：2003-05-08
申请号：PCT/GB2002/005025
申请日：2002-11-04
申请人： UNIVERSITY OF STRATHCLYDE , THE UNIVERSITY COURT OF THE UNIVERSITY OF GLASGOW , SMITH, William, Ewen , GRAHAM, Duncan , COOPER, Jonathan, Mark , KEIR, Ruth , IGATA, Eishi
发明人： SMITH, William, Ewen , GRAHAM, Duncan , COOPER, Jonathan, Mark , KEIR, Ruth , IGATA, Eishi
IPC分类号： G01N33/58
CPC分类号： B01F13/0059 , B01F5/0603 , B01F5/0606 , B01L3/502769 , B01L2300/0654 , B01L2300/0867 , B01L2400/086 , G01N33/582 , G01N33/585
摘要： The present invention relates to a microfluidic method of generating in situ a colloid for use in detecting an analyte using for example SER(R)S, as well as a method of detecting an analyte using SER(R)S in a microfluidic system. The invention also relates to microfluidic devices for use in detecting analytes such as by way of SER(R)S signals.
摘要翻译：本发明涉及使用例如SER（S）S检测分析物的原位产生胶体的微流体方法，以及使用SER（R）S检测分析物的方法， S在微流体系统中。本发明还涉及用于检测分析物例如通过SER（S）信号的微流体装置。

8. 发明申请

WO1996027370A1 FREE RADICAL SCAVENGER MOLECULES 审中-公开
标题翻译：免费射线扫描仪分子
公开(公告)号：WO1996027370A1
公开(公告)日：1996-09-12
申请号：PCT/GB1996000451
申请日：1996-02-29
申请人： BRITISH TECHNOLOGY GROUP LIMITED , DEMIRYUREK, Abdullah, Tuncay , KANE, Kathleen, Ann , KERR, William, John , KHALAF, Abedawan, Ibrahim , NONHEBEL, Derek, Charles , SMITH, William, Ewen , WADSWORTH, Roger , WAINWRIGHT, Cherry, Lindsey
发明人： BRITISH TECHNOLOGY GROUP LIMITED
IPC分类号： A61K31/195
CPC分类号： C07K5/06191 , A61K31/495 , A61K38/05 , C07D241/08 , C07K5/06026 , C07K5/0606 , C07K5/06078
摘要： Use of a compound comprising one or more alpha -amino acid residues of general formula (I), wherein R is selected from the group consisting of hydrogen, optionally substituted C1-C20 alkyl, C1-C20 alkenyl, aryl and aralkyl groups and a group R -OCO- where R is selected from C1-C20, C1-C20 alkenyl, aryl and aralkyl groups; R and R are independently selected from the group consisting of hydrogen and optionally substituted C1-C6 alkyl, C1-C6 alkenyl, C7-C12 arylalkyl and aryl groups; or R and R together represent a group =CR R , wherein R and R are independently selected from hydrogen, halogen, and optionally substituted C1-C6 alkyl and aryl groups; wherein the compound does not contain free thiol groups; or a pharmaceutically acceptable salt thereof in the preparation of a medicament suitable for the treatment of a disease state caused by production of free radical species or in which free radical species are produced is provided, together with formulations and methods for their preparation.
摘要翻译：包含一种或多种通式（I）的α-氨基酸残基的化合物在其中R选自氢，任选取代的C 1 -C 20烷基，C 1 -C 20烯基，芳基和芳烷基和 R 5 -OCO-，其中R 5选自C 1 -C 20，C 1 -C 20烯基，芳基和芳烷基; R 1和R 2独立地选自氢和任选取代的C 1 -C 6烷基，C 1 -C 6烯基，C 7 -C 12芳烷基和芳基; 或R 1和R 2一起表示基团= CR 6 R 7，其中R 6和R 7独立地选自氢，卤素和任选取代的C 1 -C 6烷基和芳基; 其中所述化合物不含有游离硫醇基团; 或其药学上可接受的盐在制备适于治疗由产生自由基物质或其中产生自由基物质引起的疾病状态的药物的同时，以及其制备方法和制备方法。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式