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1. 发明申请

WO2008115916A1 MICROFLUIDIC DEVICE FOR INDUCING SEPARATIONS BY FREEZING AND ASSOCIATED METHOD 审中-公开
标题翻译：用于通过冷冻诱导分离的微流体装置和相关方法
公开(公告)号：WO2008115916A1
公开(公告)日：2008-09-25
申请号：PCT/US2008/057347
申请日：2008-03-18
申请人： THE AEROSPACE CORPORATION , WELLE, Richard P.
发明人： WELLE, Richard P.
IPC分类号： G01N30/00
CPC分类号： B01D17/00 , B01D9/004 , B01D9/04 , B01L3/502769 , B01L2200/0631 , B01L2300/0887 , B01L2300/1822 , B01L2300/1827 , B01L2400/0677 , Y10T137/2196 , Y10T436/25375
摘要： A microfluidic device is provided for inducing the separation of constituent elements from a microfluidic sample by inroducing phase changes in the microfluidic sample while contained in a microfluidic channel in the device. At least a portion of the microfluidic sample is frozen to cause fractional exclusion of the constituent element from the frozen portion of the microfluidic sample. Different portions of the microfluidic sample may be frozen in different sectors and at different times in order to cause movement in a desired direction of the separated constituent element. Portions of the microfluidic sample may be frozen in a sequential order of adjacent sectors within the microfluidic channel in order to cause sequential movement of the excluded constituent element toward one portion of the microfluidic channel. The frozen portion of the microfluidic sample is then thawed, wherein the separated constituent element remains substantially separated from the thawed, purified microfluidic sample.
摘要翻译：提供了一种微流体装置，用于通过在装置中的微流体通道中包含微流体样品中的相变而引起构成元件与微流体样品的分离。将微流体样品的至少一部分冷冻以引起构成元件从微流体样品的冷冻部分的分级排除。微流体样品的不同部分可以在不同的扇区中被冷冻，并且在不同的时间被冷冻以引起在所分离的构成元件的期望方向上的移动。微流体样品的部分可以以微流体通道内的相邻扇区的顺序冷冻，以便排除构成元件朝着微流体通道的一部分顺序移动。然后将微流体样品的冷冻部分解冻，其中分离的构成元件基本上与解冻的纯化的微流体样品分离。

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