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41. 发明申请

US20050142115A1 Papilloma pseudovirus and preparation 失效
标题翻译：乳糜假病毒及其制备
公开(公告)号：US20050142115A1
公开(公告)日：2005-06-30
申请号：US11060034
申请日：2005-02-17
申请人： Liang Qiao , Wei Shi , Yujun Huang , Jianzhong Liu
发明人： Liang Qiao , Wei Shi , Yujun Huang , Jianzhong Liu
IPC分类号： C12N15/09 , A61K31/711 , A61K35/76 , A61K48/00 , A61P9/00 , A61P31/18 , A61P35/00 , A61P35/02 , C12N7/00 , C12N7/01 , C12N7/04 , A61K39/12
CPC分类号： C12N7/00 , A61K2039/525 , C12N2710/20023 , C12N2710/20061
摘要： The invention involves a papilloma pseudovirus that can induce immune response after oral intake as well as its preparation. It is characterized in that HPV or BPV pseudovirus are made by disrupting HPV-VLP or BPV-VLP, mixing them with plasmids (plasmids or DNA vaccine), and reassembling them into the pseudoviruses (VLPs with plasmids inside). Oral administration of the pseudoviruses will result in delivery to mucosal and systemic lymphoid tissues and induce immune responses for disease prevention and treatment. The pseudovirus induces stronger immune response than DNA vaccines. Additionally, the pseudovirus can be applied in gene therapy by bringing the therapeutic genes into lymphoid tissues in the human body.
摘要翻译：本发明涉及一种乳头状假性假病毒，可在口服摄入后诱导免疫反应及其制备。其特征在于HPV或BPV假病毒通过破坏HPV-VLP或BPV-VLP，与质粒（质粒或DNA疫苗）混合并将其重新组装成假病毒（其中具有质粒的VLP）而制备。假性病毒的口服给药将导致输送到粘膜和系统性淋巴组织，并诱导用于疾病预防和治疗的免疫应答。假DNA病毒诱导比DNA疫苗更强的免疫应答。此外，假病毒可以通过将治疗基因引入人体的淋巴组织来应用于基因治疗。

42. 发明授权

US06878541B2 Papilloma pseudo-virus and preparation 失效
标题翻译：乳头瘤病毒和准备
公开(公告)号：US06878541B2
公开(公告)日：2005-04-12
申请号：US10294087
申请日：2002-11-14
申请人： Liang Qiao , Wei Shi , Yujun Huang , Jianzhong Liu
发明人： Liang Qiao , Wei Shi , Yujun Huang , Jianzhong Liu
IPC分类号： C12N15/09 , A61K31/711 , A61K35/76 , A61K48/00 , A61P9/00 , A61P31/18 , A61P35/00 , A61P35/02 , C12N7/00 , C12N7/01 , C12N7/04 , C12N15/00
CPC分类号： C12N7/00 , A61K2039/525 , C12N2710/20023 , C12N2710/20061
摘要： The invention involves a papilloma pseudo-virus that can induce immune response after oral intake as well as its preparation. It is characterized in that HPV or BPV pseudo-virus are made by disrupting HPV-VLP or BPV-VLP, mixing them with plasmids (plasmids or DNA vaccine), and reassembling them into the pseudo-viruses (VLPs with plasmids inside). Oral administration of the pseudo-viruses will result in delivery to mucosal and systemic lymphoid tissues and induce immune responses for disease prevention and treatment. The pseudo-virus induces stronger immune response than DNA vaccines. Additionally, the pseudo-virus can be applied in gene therapy by bringing the therapeutic genes into lymphoid tissues in the human body.
摘要翻译：本发明涉及一种乳头状假病毒，其能够在口服摄入后引起免疫应答及其制备。其特征在于通过破坏HPV-VLP或BPV-VLP，将其与质粒（质粒或DNA疫苗）混合并将其重新组装成伪病毒（内质体VLP）而制备HPV或BPV伪病毒。假病毒的口服给药将导致粘膜和全身性淋巴组织的传递，并诱导疾病预防和治疗的免疫应答。伪病毒诱导比DNA疫苗更强的免疫应答。此外，假病毒可以通过将治疗基因引入人体的淋巴组织来应用于基因治疗。

43. 发明授权

US06605531B1 Hole-filling technique using CVD aluminum and PVD aluminum integration 失效
标题翻译：使用CVD铝和PVD铝整合的填孔技术
公开(公告)号：US06605531B1
公开(公告)日：2003-08-12
申请号：US09127010
申请日：1998-07-31
申请人： Ted Guo , Wei Shi , Liang-Yuh Chen
发明人： Ted Guo , Wei Shi , Liang-Yuh Chen
IPC分类号： H01L214763
CPC分类号： H01L21/2855 , H01L21/28556 , H01L21/76882
摘要： The present invention provides a method for filling an aperture on a substrate by depositing a metal film on the substrate of insufficient thickness to fill the sub half-micron aperture and then annealing the substrate in a low pressure chamber at a temperature below a melting point of the deposited metal film. The present invention further provides forming a planarized film over the void-free aperture by physical vapor depositing a metal film over the annealed film.
摘要翻译：本发明提供了一种通过在基板上沉积不足厚度的金属膜来填充基板上的孔的方法，以填充次半微米孔径，然后在低压室内在低于熔点的温度下将基板退火沉积金属膜。本发明还提供了通过在退火膜上物理气相沉积金属膜而在无空隙孔上形成平坦化膜。

44. 发明申请

US20140161836A1 CARIOUS TOOTH VACCINE AND PREPARATION METHOD 审中-公开
标题翻译：重要的真菌疫苗和制备方法
公开(公告)号：US20140161836A1
公开(公告)日：2014-06-12
申请号：US14234145
申请日：2011-12-29
申请人： Huimin Yan , Wei Shi , Ying Sun , Jingyi Yang
发明人： Huimin Yan , Wei Shi , Ying Sun , Jingyi Yang
IPC分类号： A61K39/09
CPC分类号： A61K39/092 , A61K39/09 , A61K2039/543 , A61K2039/55594
摘要： The present invention provides a vaccine composition for dental caries caused by S. mutans infection, where the vaccine composition comprises an antigen derived from a surface protein PAc of S. mutans and an adjuvant derived from flagellin. The present invention further provides methods for preparing the vaccine composition. The present invention also provides methods for preventing or curing dental caries caused by S. mutans by administrating to a subject the vaccine composition.
摘要翻译：本发明提供了由变形链球菌感染引起的用于龋齿的疫苗组合物，其中疫苗组合物包含衍生自变形链球菌的表面蛋白PAc的抗原和源自鞭毛蛋白的佐剂。本发明还提供了制备疫苗组合物的方法。本发明还提供了通过向受试者施用疫苗组合物来预防或治愈由变形链球菌引起的龋齿的方法。

45. 发明申请

US20130296527A1 Novel Curcumin and Tetrahydrocurcumin Derivatives 有权
标题翻译：新型姜黄素和四氢姜黄素衍生物
公开(公告)号：US20130296527A1
公开(公告)日：2013-11-07
申请号：US13942606
申请日：2013-07-15
申请人： Krishnaswami Raja , Probal Banerjee , Andrew Auerbach , Wei Shi , William L'Amoreaux
发明人： Krishnaswami Raja , Probal Banerjee , Andrew Auerbach , Wei Shi , William L'Amoreaux
IPC分类号： C07C229/12 , C07C69/602 , C07C69/52 , C07C49/248
CPC分类号： C07C229/12 , A61K8/37 , A61K8/39 , A61K8/496 , A61K8/8147 , A61K2800/522 , A61K2800/56 , A61Q19/02 , C07C49/248 , C07C49/255 , C07C69/52 , C07C69/602 , C07C247/04 , C07D249/04
摘要： The invention relates to novel curcumin and tetrahydrocurcumin derivatives, which have been modified at one phenolic group to incorporate more-reactive groups. The curcumin and tetrahydrocurcumin derivatives are in the form of monomers, dimmers, and polymers.
摘要翻译：本发明涉及新的姜黄素和四氢姜黄素衍生物，它们已经在一个酚基团被修饰以引入更多的反应性基团。姜黄素和四氢姜黄素衍生物是单体，二聚体和聚合物的形式。

46. 发明授权

US08314552B2 Phosphor layer arrangement for use with light emitting diodes 有权
公开(公告)号：US08314552B2
公开(公告)日：2012-11-20
申请号：US12978913
申请日：2010-12-27
申请人： Wei Shi
发明人： Wei Shi
IPC分类号： H05B33/04
CPC分类号： H01L33/507 , F21K9/23 , F21K9/64 , F21L4/027 , F21S8/08 , F21W2131/103 , F21Y2115/10 , H01L25/0753 , H01L33/58 , H01L2224/48091 , H01L2224/48137 , H01L2224/73265 , H01L2924/00014 , H01L2924/00
摘要： Phosphor layer arrangement for use with light emitting diodes. In an aspect, a light emitting diode apparatus is provided that includes a least one light emitting diode, an encapsulation covering the at least one light emitting diode, a lens having a phosphor layer formed upon a bottom surface, the lens positioned to cover at least part of the encapsulation, and an air gap between the phosphor layer and the encapsulation. In an aspect, a light emitting diode lamp is provided that includes a package, a least one light emitting diode, an encapsulation covering the at least one light emitting diode, a lens having a phosphor layer formed upon a bottom surface, wherein the lens is positioned to cover at least part of the encapsulation, and an air gap between the phosphor layer and the encapsulation.

47. 发明授权

US08098011B2 Phosphor layer arrangement for use with light emitting diodes 有权
标题翻译：用于发光二极管的磷光体层布置
公开(公告)号：US08098011B2
公开(公告)日：2012-01-17
申请号：US12819544
申请日：2010-06-21
申请人： Wei Shi
发明人： Wei Shi
IPC分类号： H01L33/00
CPC分类号： H01L33/507 , F21K9/23 , F21K9/64 , F21L4/027 , F21S8/08 , F21W2131/103 , F21Y2115/10 , H01L25/0753 , H01L33/58 , H01L2224/48091 , H01L2224/48137 , H01L2224/73265 , H01L2924/00014 , H01L2924/00
摘要： Phosphor layer arrangement for use with light emitting diodes. In an aspect, a light emitting diode apparatus is provided that includes a least one light emitting diode, an encapsulation covering the at least one light emitting diode, a lens having a phosphor layer formed upon a bottom surface, the lens positioned to cover at least part of the encapsulation, and an air gap between the phosphor layer and the encapsulation. In an aspect, a light emitting diode lamp is provided that includes a package, a least one light emitting diode, an encapsulation covering the at least one light emitting diode, a lens having a phosphor layer formed upon a bottom surface, wherein the lens is positioned to cover at least part of the encapsulation, and an air gap between the phosphor layer and the encapsulation.
摘要翻译：用于发光二极管的磷光体层布置。一方面，提供了一种发光二极管装置，其包括至少一个发光二极管，覆盖至少一个发光二极管的封装，具有形成在底表面上的荧光体层的透镜，所述透镜被定位成至少覆盖封装的一部分，以及荧光体层和封装之间的气隙。一方面，提供一种发光二极管灯，其包括封装，至少一个发光二极管，覆盖所述至少一个发光二极管的封装，具有形成在底表面上的荧光体层的透镜，其中所述透镜是定位成覆盖至少一部分封装，以及荧光体层和封装之间的气隙。

48. 发明授权

US08089085B2 Heat sink base for LEDS 有权
标题翻译： LEDS散热器底座
公开(公告)号：US08089085B2
公开(公告)日：2012-01-03
申请号：US12393559
申请日：2009-02-26
申请人： Wei Shi
发明人： Wei Shi
IPC分类号： H01L29/22 , H01L29/227 , H01L33/00 , H01L23/10 , H01L23/34 , H01L23/28
CPC分类号： H01L33/648 , F21K9/64 , F21Y2115/10 , H01L33/483 , H01L33/507 , H01L33/58 , H01L2924/0002 , H01L2924/19107 , H01L2924/00
摘要： An LED assembly can include a heat sink base, at least one LED die attached to the heat sink base, and a lens. One or more layers of phosphor can be formed upon the lens. A heat sink, such as a finned heat sink, can attach the heat sink base to the lens. Heat from the LED die can flow through the heat sink base to the heat sink, from which the heat can be dissipated. Similarly, heat from phosphors can flow through the lens to the heat sink, from which the heat can be dissipated. By removing heat from the LED die, more current can be used to drive the LED die, thus providing brighter light. By removing heat from the phosphors, desired colors can be more reliably provided.
摘要翻译： LED组件可以包括散热器基座，附接到散热器基座的至少一个LED管芯和透镜。可以在透镜上形成一层或多层磷光体。诸如散热片的散热器可以将散热器底座附接到透镜。来自LED模具的热量可以通过散热器底座流到散热器，从而散热。类似地，来自磷光体的热可以通过透镜流到散热器，热量可从该散热器消散。通过从LED芯片去除热量，可以使用更多的电流来驱动LED管芯，从而提供更亮的光线。通过从磷光体去除热量，可以更可靠地提供所需的颜色。

49. 发明授权

US08076693B2 Transparent heat spreader for LEDs 有权
标题翻译： LED透明散热器
公开(公告)号：US08076693B2
公开(公告)日：2011-12-13
申请号：US12893422
申请日：2010-09-29
申请人： Wei Shi
发明人： Wei Shi
IPC分类号： H01L33/00
CPC分类号： H01L33/644 , H01L25/0753 , H01L33/38 , H01L33/507 , H01L33/58 , H01L33/62 , H01L33/642 , H01L2924/0002 , H01L2924/00
摘要： A heat spreader for an LED can include a thermally conductive and optically transparent member. The bottom side of the heat spreader can be configured to attach to a light emitting side of the LED. The top and/or bottom surface of the heat spreader can have a phosphor layer formed thereon. The heat spreader can be configured to conduct heat from the LED to a package. The heat spreader can be configured to conduct heat from the phosphors to the package. By facilitating the removal of heat from the LED and phosphors, more current can be used to drive the LED. The use of more current facilitates the construction of a brighter LED, which can be used in applications such as flashlights, displays, and general illumination. By facilitating the removal of heat from the phosphors, desired colors can be better provided.
摘要翻译：用于LED的散热器可以包括导热和光学透明构件。散热器的底侧可以被配置为附着到LED的发光侧。散热器的顶表面和/或底表面可以在其上形成荧光体层。散热器可以被配置为将热量从LED传导到包装。散热器可以被配置为将热量从磷光体传导到封装。通过促进从LED和磷光体去除热量，可以使用更多的电流来驱动LED。使用更多的电流有助于构建更亮的LED，其可以用于诸如手电筒，显示器和一般照明的应用中。通过促进从磷光体去除热量，可以更好地提供所需的颜色。

50. 发明授权

US07980865B2 Substrate with raised edge pads 有权
标题翻译：基片与凸起的边缘垫
公开(公告)号：US07980865B2
公开(公告)日：2011-07-19
申请号：US11315854
申请日：2005-12-22
申请人： Wei Shi , Daoqiang Lu , Qing Zhou , Jiangqi He
发明人： Wei Shi , Daoqiang Lu , Qing Zhou , Jiangqi He
IPC分类号： H01R12/00
CPC分类号： H05K7/1061 , Y10T29/49117
摘要： A separable electrical connection may be provided with a landside pad on one of two electrical components to be joined. The landside pad may be made up of two parts, including a flat portion and a raised edge formed on the flat portion. In some embodiments, the raised edge may have a closed geometric shape. Then, a socket contact engaging the junction between the flat portion and the raised edge is prevented from sliding off of the landside pad by the raised edge. In addition, dual areas of electrical connection can be established between both the flat portion and raised edge of the landside pad and the correspondingly shaped pair of portions on the socket. This increases the electrical efficiency of the connection and its security.
摘要翻译：可分离的电连接可以在待连接的两个电气部件之一上设置有陆侧焊盘。侧面垫可以由两部分组成，包括平坦部分和形成在平坦部分上的凸起边缘。在一些实施例中，凸起边缘可以具有闭合的几何形状。然后，通过凸起边缘防止接合平坦部分和凸起边缘之间的连接处的插座触点从边缘垫片滑出。此外，可以在陆侧衬垫的平坦部分和凸起边缘以及插座上的相应形状的一对部分之间建立双重电连接区域。这增加了连接的电效率及其安全性。

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