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1. 发明申请

US20050142115A1 Papilloma pseudovirus and preparation 失效
标题翻译：乳糜假病毒及其制备
公开(公告)号：US20050142115A1
公开(公告)日：2005-06-30
申请号：US11060034
申请日：2005-02-17
申请人： Liang Qiao , Wei Shi , Yujun Huang , Jianzhong Liu
发明人： Liang Qiao , Wei Shi , Yujun Huang , Jianzhong Liu
IPC分类号： C12N15/09 , A61K31/711 , A61K35/76 , A61K48/00 , A61P9/00 , A61P31/18 , A61P35/00 , A61P35/02 , C12N7/00 , C12N7/01 , C12N7/04 , A61K39/12
CPC分类号： C12N7/00 , A61K2039/525 , C12N2710/20023 , C12N2710/20061
摘要： The invention involves a papilloma pseudovirus that can induce immune response after oral intake as well as its preparation. It is characterized in that HPV or BPV pseudovirus are made by disrupting HPV-VLP or BPV-VLP, mixing them with plasmids (plasmids or DNA vaccine), and reassembling them into the pseudoviruses (VLPs with plasmids inside). Oral administration of the pseudoviruses will result in delivery to mucosal and systemic lymphoid tissues and induce immune responses for disease prevention and treatment. The pseudovirus induces stronger immune response than DNA vaccines. Additionally, the pseudovirus can be applied in gene therapy by bringing the therapeutic genes into lymphoid tissues in the human body.
摘要翻译：本发明涉及一种乳头状假性假病毒，可在口服摄入后诱导免疫反应及其制备。其特征在于HPV或BPV假病毒通过破坏HPV-VLP或BPV-VLP，与质粒（质粒或DNA疫苗）混合并将其重新组装成假病毒（其中具有质粒的VLP）而制备。假性病毒的口服给药将导致输送到粘膜和系统性淋巴组织，并诱导用于疾病预防和治疗的免疫应答。假DNA病毒诱导比DNA疫苗更强的免疫应答。此外，假病毒可以通过将治疗基因引入人体的淋巴组织来应用于基因治疗。

2. 发明授权

US06878541B2 Papilloma pseudo-virus and preparation 失效
标题翻译：乳头瘤病毒和准备
公开(公告)号：US06878541B2
公开(公告)日：2005-04-12
申请号：US10294087
申请日：2002-11-14
申请人： Liang Qiao , Wei Shi , Yujun Huang , Jianzhong Liu
发明人： Liang Qiao , Wei Shi , Yujun Huang , Jianzhong Liu
IPC分类号： C12N15/09 , A61K31/711 , A61K35/76 , A61K48/00 , A61P9/00 , A61P31/18 , A61P35/00 , A61P35/02 , C12N7/00 , C12N7/01 , C12N7/04 , C12N15/00
CPC分类号： C12N7/00 , A61K2039/525 , C12N2710/20023 , C12N2710/20061
摘要： The invention involves a papilloma pseudo-virus that can induce immune response after oral intake as well as its preparation. It is characterized in that HPV or BPV pseudo-virus are made by disrupting HPV-VLP or BPV-VLP, mixing them with plasmids (plasmids or DNA vaccine), and reassembling them into the pseudo-viruses (VLPs with plasmids inside). Oral administration of the pseudo-viruses will result in delivery to mucosal and systemic lymphoid tissues and induce immune responses for disease prevention and treatment. The pseudo-virus induces stronger immune response than DNA vaccines. Additionally, the pseudo-virus can be applied in gene therapy by bringing the therapeutic genes into lymphoid tissues in the human body.
摘要翻译：本发明涉及一种乳头状假病毒，其能够在口服摄入后引起免疫应答及其制备。其特征在于通过破坏HPV-VLP或BPV-VLP，将其与质粒（质粒或DNA疫苗）混合并将其重新组装成伪病毒（内质体VLP）而制备HPV或BPV伪病毒。假病毒的口服给药将导致粘膜和全身性淋巴组织的传递，并诱导疾病预防和治疗的免疫应答。伪病毒诱导比DNA疫苗更强的免疫应答。此外，假病毒可以通过将治疗基因引入人体的淋巴组织来应用于基因治疗。

3. 发明授权

US08129144B2 Papilloma pseudovirus and preparation 失效
标题翻译：乳糜假病毒及其制备
公开(公告)号：US08129144B2
公开(公告)日：2012-03-06
申请号：US11784626
申请日：2007-04-09
申请人： Liang Qiao , Wei Shi , Yujun Huang , Jianzhong Liu
发明人： Liang Qiao , Wei Shi , Yujun Huang , Jianzhong Liu
IPC分类号： C12P21/06
CPC分类号： C12N7/00 , A61K2039/525 , C12N2710/20023 , C12N2710/20061
摘要： The invention involves a papilloma pseudovirus that can induce immune response after oral intake as well as its preparation. It is characterized in that HPV or BPV pseudovirus are made by disrupting HPV-VLP or BPV-VLP, mixing them with plasmids (plasmids or DNA vaccine), and reassembling them into the pseudoviruses (VLPs with plasmids inside). Oral administration of the pseudoviruses will result in delivery to mucosal and systemic lymphoid tissues and induce immune responses for disease prevention and treatment. The pseudovirus induces stronger immune response than DNA vaccines. Additionally, the pseudovirus can be applied in gene therapy by bringing the therapeutic genes into lymphoid tissues in the human body.
摘要翻译：本发明涉及一种乳头状假性假病毒，可在口服摄入后诱导免疫反应及其制备。其特征在于HPV或BPV假病毒通过破坏HPV-VLP或BPV-VLP，与质粒（质粒或DNA疫苗）混合并将其重新组装成假病毒（其中具有质粒的VLP）而制备。假性病毒的口服给药将导致输送到粘膜和系统性淋巴组织，并诱导用于疾病预防和治疗的免疫应答。假DNA病毒诱导比DNA疫苗更强的免疫应答。此外，假病毒可以通过将治疗基因引入人体的淋巴组织来应用于基因治疗。

4. 发明授权

US07205126B2 Papilloma pseudovirus and preparation 失效
标题翻译：乳糜假病毒及其制备
公开(公告)号：US07205126B2
公开(公告)日：2007-04-17
申请号：US11060034
申请日：2005-02-17
申请人： Liang Qiao , Wei Shi , Yujun Huang , Jianzhong Liu
发明人： Liang Qiao , Wei Shi , Yujun Huang , Jianzhong Liu
IPC分类号： C12P21/06
CPC分类号： C12N7/00 , A61K2039/525 , C12N2710/20023 , C12N2710/20061
摘要： The invention involves a papilloma pseudovirus that can induce immune response after oral intake as well as its preparation. It is characterized in that HPV or BPV pseudovirus are made by disrupting HPV-VLP or BPV-VLP, mixing them with plasmids (plasmids or DNA vaccine), and reassembling them into the pseudoviruses (VLPs with plasmids inside). Oral administration of the pseudoviruses will result in delivery to mucosal and systemic lymphoid tissues and induce immune responses for disease prevention and treatment. The pseudovirus induces stronger immune response than DNA vaccines. Additionally, the pseudovirus can be applied in gene therapy by bringing the therapeutic genes into lymphoid tissues in the human body.
摘要翻译：本发明涉及一种乳头状假性假病毒，可在口服摄入后诱导免疫反应及其制备。其特征在于HPV或BPV假病毒通过破坏HPV-VLP或BPV-VLP，与质粒（质粒或DNA疫苗）混合并将其重新组装成假病毒（其中具有质粒的VLP）而制备。假性病毒的口服给药将导致输送到粘膜和系统性淋巴组织，并诱导用于疾病预防和治疗的免疫应答。假DNA病毒诱导比DNA疫苗更强的免疫应答。此外，假病毒可以通过将治疗基因引入人体的淋巴组织来应用于基因治疗。

5. 发明申请

US20100255027A1 Papilloma pseudovirus and preparation 失效
标题翻译：乳糜假病毒及其制备
公开(公告)号：US20100255027A1
公开(公告)日：2010-10-07
申请号：US11784626
申请日：2007-04-09
申请人： Liang Qiao , Wei Shi , Yujun Huang , Jianzhong Liu
发明人： Liang Qiao , Wei Shi , Yujun Huang , Jianzhong Liu
IPC分类号： A61K39/12 , A61P31/12
CPC分类号： C12N7/00 , A61K2039/525 , C12N2710/20023 , C12N2710/20061
摘要： The invention involves a papilloma pseudovirus that can induce immune response after oral intake as well as its preparation. It is characterized in that HPV or BPV pseudovirus are made by disrupting HPV-VLP or BPV-VLP, mixing them with plasmids (plasmids or DNA vaccine), and reassembling them into the pseudoviruses (VLPs with plasmids inside). Oral administration of the pseudoviruses will result in delivery to mucosal and systemic lymphoid tissues and induce immune responses for disease prevention and treatment. The pseudovirus induces stronger immune response than DNA vaccines. Additionally, the pseudovirus can be applied in gene therapy by bringing the therapeutic genes into lymphoid tissues in the human body.
摘要翻译：本发明涉及一种乳头状假性假病毒，可在口服摄入后诱导免疫反应及其制备。其特征在于HPV或BPV假病毒通过破坏HPV-VLP或BPV-VLP，与质粒（质粒或DNA疫苗）混合并将其重新组装成假病毒（其中具有质粒的VLP）而制备。假性病毒的口服给药将导致输送到粘膜和系统性淋巴组织，并诱导用于疾病预防和治疗的免疫应答。假DNA病毒诱导比DNA疫苗更强的免疫应答。此外，假病毒可以通过将治疗基因引入人体的淋巴组织来应用于基因治疗。

6. 发明申请

US20120164173A1 Papilloma Pseudovirus and Preparation 审中-公开
标题翻译：乳糜假假病毒及其制备
公开(公告)号：US20120164173A1
公开(公告)日：2012-06-28
申请号：US13413386
申请日：2012-03-06
申请人： Liang Qiao , Wei Shi , Yujun Huang , Jianzhong Liu
发明人： Liang Qiao , Wei Shi , Yujun Huang , Jianzhong Liu
IPC分类号： A61K39/12 , A61K39/00 , A61P31/04 , A61P37/04 , A61P31/00 , A61P31/12 , A61K48/00 , A61K39/02
CPC分类号： C12N7/00 , A61K2039/525 , C12N2710/20023 , C12N2710/20041 , C12N2710/20051 , C12N2710/20061
摘要： The invention involves a papilloma pseudovirus that can induce immune response after oral intake as well as its preparation. It is characterized in that HPV or BPV pseudovirus are made by disrupting HPV-VLP or BPV-VLP, mixing them with plasmids (plasmids or DNA vaccine), and reassembling them into the pseudoviruses (VLPs with plasmids inside). Oral administration of the pseudoviruses will result in delivery to mucosal and systemic lymphoid tissues and induce immune responses for disease prevention and treatment. The pseudovirus induces stronger immune response than DNA vaccines. Additionally, the pseudovirus can be applied in gene therapy by bringing the therapeutic genes into lymphoid tissues in the human body.
摘要翻译：本发明涉及一种乳头状假性假病毒，可在口服摄入后诱导免疫反应及其制备。其特征在于HPV或BPV假病毒通过破坏HPV-VLP或BPV-VLP，与质粒（质粒或DNA疫苗）混合并将其重新组装成假病毒（其中具有质粒的VLP）而制备。假性病毒的口服给药将导致输送到粘膜和系统性淋巴组织，并诱导用于疾病预防和治疗的免疫应答。假DNA病毒诱导比DNA疫苗更强的免疫应答。此外，假病毒可以通过将治疗基因引入人体的淋巴组织来应用于基因治疗。

7. 发明授权

US09346791B2 Itraconazole analogs and use thereof 有权
标题翻译：伊曲康唑类似物及其用途
公开(公告)号：US09346791B2
公开(公告)日：2016-05-24
申请号：US14343040
申请日：2012-09-07
申请人： Jun O. Liu , Wei Shi , Kalyan Kumar Pasunooti
发明人： Jun O. Liu , Wei Shi , Kalyan Kumar Pasunooti
IPC分类号： C07D405/14 , A61K31/496 , A61K31/506
CPC分类号： C07D405/14 , A61K31/496 , A61K31/506
摘要： Provided herein are Itraconazole analogs. Also provided herein are methods of inhibition of Hedgehog pathway, vascular endothelial growth factor receptor 2 (VEGFR2) glycosylation, angiogenesis and treatment of disease with Itraconazole analogs.
摘要翻译：本文提供伊曲康唑类似物。本文还提供了抑制Hedgehog途径，血管内皮生长因子受体2（VEGFR2）糖基化，血管生成和伊曲康唑类似物治疗疾病的方法。

8. 发明申请

US20130301625A1 AGGREGATION OF INFORMATION UNITS IN A WIRELESS NETWORK 审中-公开
标题翻译：在无线网络中聚合信息单元
公开(公告)号：US20130301625A1
公开(公告)日：2013-11-14
申请号：US13470035
申请日：2012-05-11
申请人： Alexander Thoukydides , Fei Tong , Wei Shi
发明人： Alexander Thoukydides , Fei Tong , Wei Shi
IPC分类号： H04W84/12 , H04W84/02
CPC分类号： H04W28/06
摘要： The present application relates to a method for transmitting information from a wireless access point to one or more wireless stations. The method comprises aggregating a plurality of information units of compatible types, such as MAC protocol data units (MPDUs) or acknowledgements into a single data frame, modulating the single data frame and transmitting the modulated data frame containing the plurality of information units to the one or more wireless stations.
摘要翻译：本申请涉及一种从无线接入点向一个或多个无线站发送信息的方法。该方法包括将多个兼容类型的信息单元（例如MAC协议数据单元（MPDU）或确认）聚合到单个数据帧中，调制单个数据帧并将包含多个信息单元的调制数据帧发送到一个或更多的无线电台。

9. 发明授权

US08049236B2 Non-global solder mask LED assembly 有权
标题翻译：非全局焊接面罩LED组件
公开(公告)号：US08049236B2
公开(公告)日：2011-11-01
申请号：US12239494
申请日：2008-09-26
申请人： Wei Shi , Alex Shaikevitch
发明人： Wei Shi , Alex Shaikevitch
IPC分类号： H01L33/00 , H01L21/00
CPC分类号： H01L33/62 , H01L25/0753 , H01L33/54 , H01L33/60 , H01L2224/48091 , H01L2224/48137 , H01L2224/48227 , H01L2224/49175 , H05K1/0274 , H05K3/28 , H05K2201/0989 , H05K2201/10106 , H05K2201/2054 , H01L2924/00 , H01L2924/00014
摘要： A substrate for an LED assembly can have a plurality of cups formed therein. At least one cup can be formed within another cup. The cups can be co-axial with respect to one another, for example. A machined surface of the substrate can enhance reflectivity of the LED assembly. A transparent and/or non-global solder mask can enhance reflectivity of the LED assembly. A transparent ring can enhance reflectivity of the LED assembly. By enhancing reflectivity of the LED assembly, the brightness of the LED assembly can be increased. Brighter LED assemblies can be used in applications such as flashlights, displays, and general illumination.
摘要翻译：用于LED组件的基板可以具有形成在其中的多个杯。至少一杯可以在另一杯内形成。例如，杯可以相对于彼此共轴。衬底的加工表面可以增强LED组件的反射率。透明和/或非全局焊接掩模可以增强LED组件的反射率。透明环可以增强LED组件的反射率。通过提高LED组件的反射率，可以提高LED组件的亮度。较亮的LED组件可用于手电筒，显示屏和一般照明等应用中。

10. 发明授权

US07972881B2 Method for cooling light-emitting diode 有权
标题翻译：冷却发光二极管的方法
公开(公告)号：US07972881B2
公开(公告)日：2011-07-05
申请号：US12700556
申请日：2010-02-04
申请人： Wei Shi
发明人： Wei Shi
IPC分类号： H01L21/00
CPC分类号： H01L33/644 , H01L25/0753 , H01L33/38 , H01L33/507 , H01L33/58 , H01L33/62 , H01L33/642 , H01L2924/0002 , H01L2924/00
摘要： A heat spreader for an LED can include a thermally conductive and optically transparent member. The bottom side of the heat spreader can be configured to attach to a light emitting side of the LED. The top and/or bottom surface of the heat spreader can have a phosphor layer formed thereon. The heat spreader can be configured to conduct heat from the LED to a package. The heat spreader can be configured to conduct heat from the phosphors to the package. By facilitating the removal of heat from the LED and phosphors, more current can be used to drive the LED. The use of more current facilitates the construction of a brighter LED, which can be used in applications such as flashlights, displays, and general illumination. By facilitating the removal of heat from the phosphors, desired colors can be better provided.
摘要翻译：用于LED的散热器可以包括导热和光学透明构件。散热器的底侧可以被配置为附着到LED的发光侧。散热器的顶表面和/或底表面可以在其上形成荧光体层。散热器可以被配置为将热量从LED传导到包装。散热器可以被配置为将热量从磷光体传导到封装。通过促进从LED和磷光体去除热量，可以使用更多的电流来驱动LED。使用更多的电流有助于构建更亮的LED，其可以用于诸如手电筒，显示器和一般照明的应用中。通过促进从磷光体去除热量，可以更好地提供所需的颜色。

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