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    • 1. 发明授权
    • Papilloma pseudovirus and preparation
    • 乳糜假病毒及其制备
    • US08129144B2
    • 2012-03-06
    • US11784626
    • 2007-04-09
    • Liang QiaoWei ShiYujun HuangJianzhong Liu
    • Liang QiaoWei ShiYujun HuangJianzhong Liu
    • C12P21/06
    • C12N7/00A61K2039/525C12N2710/20023C12N2710/20061
    • The invention involves a papilloma pseudovirus that can induce immune response after oral intake as well as its preparation. It is characterized in that HPV or BPV pseudovirus are made by disrupting HPV-VLP or BPV-VLP, mixing them with plasmids (plasmids or DNA vaccine), and reassembling them into the pseudoviruses (VLPs with plasmids inside). Oral administration of the pseudoviruses will result in delivery to mucosal and systemic lymphoid tissues and induce immune responses for disease prevention and treatment. The pseudovirus induces stronger immune response than DNA vaccines. Additionally, the pseudovirus can be applied in gene therapy by bringing the therapeutic genes into lymphoid tissues in the human body.
    • 本发明涉及一种乳头状假性假病毒,可在口服摄入后诱导免疫反应及其制备。 其特征在于HPV或BPV假病毒通过破坏HPV-VLP或BPV-VLP,与质粒(质粒或DNA疫苗)混合并将其重新组装成假病毒(其中具有质粒的VLP)而制备。 假性病毒的口服给药将导致输送到粘膜和系统性淋巴组织,并诱导用于疾病预防和治疗的免疫应答。 假DNA病毒诱导比DNA疫苗更强的免疫应答。 此外,假病毒可以通过将治疗基因引入人体的淋巴组织来应用于基因治疗。
    • 2. 发明授权
    • Papilloma pseudovirus and preparation
    • 乳糜假病毒及其制备
    • US07205126B2
    • 2007-04-17
    • US11060034
    • 2005-02-17
    • Liang QiaoWei ShiYujun HuangJianzhong Liu
    • Liang QiaoWei ShiYujun HuangJianzhong Liu
    • C12P21/06
    • C12N7/00A61K2039/525C12N2710/20023C12N2710/20061
    • The invention involves a papilloma pseudovirus that can induce immune response after oral intake as well as its preparation. It is characterized in that HPV or BPV pseudovirus are made by disrupting HPV-VLP or BPV-VLP, mixing them with plasmids (plasmids or DNA vaccine), and reassembling them into the pseudoviruses (VLPs with plasmids inside). Oral administration of the pseudoviruses will result in delivery to mucosal and systemic lymphoid tissues and induce immune responses for disease prevention and treatment. The pseudovirus induces stronger immune response than DNA vaccines. Additionally, the pseudovirus can be applied in gene therapy by bringing the therapeutic genes into lymphoid tissues in the human body.
    • 本发明涉及一种乳头状假性假病毒,可在口服摄入后诱导免疫反应及其制备。 其特征在于HPV或BPV假病毒通过破坏HPV-VLP或BPV-VLP,与质粒(质粒或DNA疫苗)混合并将其重新组装成假病毒(其中具有质粒的VLP)而制备。 假性病毒的口服给药将导致输送到粘膜和系统性淋巴组织,并诱导用于疾病预防和治疗的免疫应答。 假DNA病毒诱导比DNA疫苗更强的免疫应答。 此外,假病毒可以通过将治疗基因引入人体的淋巴组织来应用于基因治疗。
    • 5. 发明申请
    • Papilloma pseudovirus and preparation
    • 乳糜假病毒及其制备
    • US20100255027A1
    • 2010-10-07
    • US11784626
    • 2007-04-09
    • Liang QiaoWei ShiYujun HuangJianzhong Liu
    • Liang QiaoWei ShiYujun HuangJianzhong Liu
    • A61K39/12A61P31/12
    • C12N7/00A61K2039/525C12N2710/20023C12N2710/20061
    • The invention involves a papilloma pseudovirus that can induce immune response after oral intake as well as its preparation. It is characterized in that HPV or BPV pseudovirus are made by disrupting HPV-VLP or BPV-VLP, mixing them with plasmids (plasmids or DNA vaccine), and reassembling them into the pseudoviruses (VLPs with plasmids inside). Oral administration of the pseudoviruses will result in delivery to mucosal and systemic lymphoid tissues and induce immune responses for disease prevention and treatment. The pseudovirus induces stronger immune response than DNA vaccines. Additionally, the pseudovirus can be applied in gene therapy by bringing the therapeutic genes into lymphoid tissues in the human body.
    • 本发明涉及一种乳头状假性假病毒,可在口服摄入后诱导免疫反应及其制备。 其特征在于HPV或BPV假病毒通过破坏HPV-VLP或BPV-VLP,与质粒(质粒或DNA疫苗)混合并将其重新组装成假病毒(其中具有质粒的VLP)而制备。 假性病毒的口服给药将导致输送到粘膜和系统性淋巴组织,并诱导用于疾病预防和治疗的免疫应答。 假DNA病毒诱导比DNA疫苗更强的免疫应答。 此外,假病毒可以通过将治疗基因引入人体的淋巴组织来应用于基因治疗。
    • 10. 发明授权
    • Method for cooling light-emitting diode
    • 冷却发光二极管的方法
    • US07972881B2
    • 2011-07-05
    • US12700556
    • 2010-02-04
    • Wei Shi
    • Wei Shi
    • H01L21/00
    • H01L33/644H01L25/0753H01L33/38H01L33/507H01L33/58H01L33/62H01L33/642H01L2924/0002H01L2924/00
    • A heat spreader for an LED can include a thermally conductive and optically transparent member. The bottom side of the heat spreader can be configured to attach to a light emitting side of the LED. The top and/or bottom surface of the heat spreader can have a phosphor layer formed thereon. The heat spreader can be configured to conduct heat from the LED to a package. The heat spreader can be configured to conduct heat from the phosphors to the package. By facilitating the removal of heat from the LED and phosphors, more current can be used to drive the LED. The use of more current facilitates the construction of a brighter LED, which can be used in applications such as flashlights, displays, and general illumination. By facilitating the removal of heat from the phosphors, desired colors can be better provided.
    • 用于LED的散热器可以包括导热和光学透明构件。 散热器的底侧可以被配置为附着到LED的发光侧。 散热器的顶表面和/或底表面可以在其上形成荧光体层。 散热器可以被配置为将热量从LED传导到包装。 散热器可以被配置为将热量从磷光体传导到封装。 通过促进从LED和磷光体去除热量,可以使用更多的电流来驱动LED。 使用更多的电流有助于构建更亮的LED,其可以用于诸如手电筒,显示器和一般照明的应用中。 通过促进从磷光体去除热量,可以更好地提供所需的颜色。