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    • 1. 发明申请
    • Papilloma pseudovirus and preparation
    • 乳糜假病毒及其制备
    • US20100255027A1
    • 2010-10-07
    • US11784626
    • 2007-04-09
    • Liang QiaoWei ShiYujun HuangJianzhong Liu
    • Liang QiaoWei ShiYujun HuangJianzhong Liu
    • A61K39/12A61P31/12
    • C12N7/00A61K2039/525C12N2710/20023C12N2710/20061
    • The invention involves a papilloma pseudovirus that can induce immune response after oral intake as well as its preparation. It is characterized in that HPV or BPV pseudovirus are made by disrupting HPV-VLP or BPV-VLP, mixing them with plasmids (plasmids or DNA vaccine), and reassembling them into the pseudoviruses (VLPs with plasmids inside). Oral administration of the pseudoviruses will result in delivery to mucosal and systemic lymphoid tissues and induce immune responses for disease prevention and treatment. The pseudovirus induces stronger immune response than DNA vaccines. Additionally, the pseudovirus can be applied in gene therapy by bringing the therapeutic genes into lymphoid tissues in the human body.
    • 本发明涉及一种乳头状假性假病毒,可在口服摄入后诱导免疫反应及其制备。 其特征在于HPV或BPV假病毒通过破坏HPV-VLP或BPV-VLP,与质粒(质粒或DNA疫苗)混合并将其重新组装成假病毒(其中具有质粒的VLP)而制备。 假性病毒的口服给药将导致输送到粘膜和系统性淋巴组织,并诱导用于疾病预防和治疗的免疫应答。 假DNA病毒诱导比DNA疫苗更强的免疫应答。 此外,假病毒可以通过将治疗基因引入人体的淋巴组织来应用于基因治疗。
    • 3. 发明授权
    • Papilloma pseudovirus and preparation
    • 乳糜假病毒及其制备
    • US08129144B2
    • 2012-03-06
    • US11784626
    • 2007-04-09
    • Liang QiaoWei ShiYujun HuangJianzhong Liu
    • Liang QiaoWei ShiYujun HuangJianzhong Liu
    • C12P21/06
    • C12N7/00A61K2039/525C12N2710/20023C12N2710/20061
    • The invention involves a papilloma pseudovirus that can induce immune response after oral intake as well as its preparation. It is characterized in that HPV or BPV pseudovirus are made by disrupting HPV-VLP or BPV-VLP, mixing them with plasmids (plasmids or DNA vaccine), and reassembling them into the pseudoviruses (VLPs with plasmids inside). Oral administration of the pseudoviruses will result in delivery to mucosal and systemic lymphoid tissues and induce immune responses for disease prevention and treatment. The pseudovirus induces stronger immune response than DNA vaccines. Additionally, the pseudovirus can be applied in gene therapy by bringing the therapeutic genes into lymphoid tissues in the human body.
    • 本发明涉及一种乳头状假性假病毒,可在口服摄入后诱导免疫反应及其制备。 其特征在于HPV或BPV假病毒通过破坏HPV-VLP或BPV-VLP,与质粒(质粒或DNA疫苗)混合并将其重新组装成假病毒(其中具有质粒的VLP)而制备。 假性病毒的口服给药将导致输送到粘膜和系统性淋巴组织,并诱导用于疾病预防和治疗的免疫应答。 假DNA病毒诱导比DNA疫苗更强的免疫应答。 此外,假病毒可以通过将治疗基因引入人体的淋巴组织来应用于基因治疗。
    • 4. 发明授权
    • Papilloma pseudovirus and preparation
    • 乳糜假病毒及其制备
    • US07205126B2
    • 2007-04-17
    • US11060034
    • 2005-02-17
    • Liang QiaoWei ShiYujun HuangJianzhong Liu
    • Liang QiaoWei ShiYujun HuangJianzhong Liu
    • C12P21/06
    • C12N7/00A61K2039/525C12N2710/20023C12N2710/20061
    • The invention involves a papilloma pseudovirus that can induce immune response after oral intake as well as its preparation. It is characterized in that HPV or BPV pseudovirus are made by disrupting HPV-VLP or BPV-VLP, mixing them with plasmids (plasmids or DNA vaccine), and reassembling them into the pseudoviruses (VLPs with plasmids inside). Oral administration of the pseudoviruses will result in delivery to mucosal and systemic lymphoid tissues and induce immune responses for disease prevention and treatment. The pseudovirus induces stronger immune response than DNA vaccines. Additionally, the pseudovirus can be applied in gene therapy by bringing the therapeutic genes into lymphoid tissues in the human body.
    • 本发明涉及一种乳头状假性假病毒,可在口服摄入后诱导免疫反应及其制备。 其特征在于HPV或BPV假病毒通过破坏HPV-VLP或BPV-VLP,与质粒(质粒或DNA疫苗)混合并将其重新组装成假病毒(其中具有质粒的VLP)而制备。 假性病毒的口服给药将导致输送到粘膜和系统性淋巴组织,并诱导用于疾病预防和治疗的免疫应答。 假DNA病毒诱导比DNA疫苗更强的免疫应答。 此外,假病毒可以通过将治疗基因引入人体的淋巴组织来应用于基因治疗。