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41. 发明公开

EP3347093A1 KNOWLEDGE-BASED SPATIAL DOSE METRICS AND METHODS TO GENERATE BEAM ORIENTATIONS IN RADIOTHERAPY 审中-公开
公开(公告)号：EP3347093A1
公开(公告)日：2018-07-18
申请号：EP16766783.1
申请日：2016-09-08
申请人： Varian Medical Systems, Inc. , Varian Medical Systems International AG
发明人： ZANKOWSKI, Corey , NORD, Janne , MARCOS, Maria Isabel Cordero , HARTMAN, Joona , PELTOLA, Jarkko , KUUSELA, Esa
IPC分类号： A61N5/10
CPC分类号： A61N5/1031
摘要： A system for estimating a dose from a radiation therapy plan includes a memory that stores machine-readable instructions and a processor communicatively coupled to the memory, the processor operable to execute the instructions to subdivide a representation of a volume of interest into voxels. The processor also determines distances between a planned radiation field origin and each respective voxel. The processor further computes geometry-based expected (GED) metrics based on the distances, a plan parameter, and a field strength parameter. The processor sums the metrics to yield an estimated dose received by the volume of interest from the planned radiation field.

42. 发明公开

EP3342461A1 SELECTING A DOSE PREDICTION MODEL BASED ON CLINICAL GOALS 有权转让
公开(公告)号：EP3342461A1
公开(公告)日：2018-07-04
申请号：EP17206345.5
申请日：2017-12-11
申请人： Varian Medical Systems International AG
发明人： LAAKSONEN, Hannu , KUUSELA, Esa , NORD, Janne , PYYRY, Joakim , NIEMELA, Perttu
IPC分类号： A61N5/10
CPC分类号： A61N5/1031 , A61N5/1077 , A61N2005/1041
摘要： A clinical goal for radiation treatment of a patient is set. A dose prediction model 150 is selected from a number of dose prediction models based on the clinical goal. A radiation treatment plan is then generated for the patient using the dose prediction model that was selected based on the clinical goal.

43. 发明公开

EP3052188A1 PREDICTING ACHIEVABLE DOSE DISTRIBUTION USING 3D INFORMATION AS AN INPUT 有权转让
标题翻译： VERHERSAGE DER ERREICHBAREN DOSISVERTEILUNG MIT 3D-INFORMATIONEN ALS EINGABE
公开(公告)号：EP3052188A1
公开(公告)日：2016-08-10
申请号：EP14781047.7
申请日：2014-09-30
申请人： Varian Medical Systems International AG
发明人： KUUSELA, Esa , HARTMAN, Joona , NORD, Janne , BAGHAIE, Ramin
IPC分类号： A61N5/10
CPC分类号： A61N5/1039 , A61N5/1031 , A61N5/1045 , A61N5/1065 , A61N5/1071 , A61N2005/1041 , G06T7/344 , G06T2207/10104 , G06T2207/30096
摘要： Knowledge-based radiotherapy treatment planning is expanded to include spatial information from, for example, positron emission tomography (PET). Information that is specific to a patient is accessed. A prediction of a spatial dose distribution inside a target volume in the patient is determined using the patient-specific information as an input to a prediction model. The prediction model is established using training data that includes data resulting from applying other radiation treatment plans to other patients. The training data includes spatially distributed information indicating a level of activity in target volumes in the other patients (e.g., PET image data). A dose-volume histogram and associated three-dimensional dose distribution information based on the prediction are produced. The dose-volume histogram and the three-dimensional dose distribution information can be used to develop a radiation treatment plan for the patient.
摘要翻译：基于知识的放射治疗计划扩大到包括例如正电子发射断层扫描（PET）的空间信息。访问特定于患者的信息。使用患者特定信息作为预测模型的输入来确定患者中目标体积内的空间剂量分布的预测。使用训练数据建立预测模型，训练数据包括将其他辐射治疗计划应用于其他患者所产生的数据。训练数据包括指示其他患者的目标体积的活动水平的空间分布信息（例如，PET图像数据）。产生基于预测的剂量 - 体积直方图和相关联的三维剂量分布信息。剂量体积直方图和三维剂量分布信息可用于为患者制定放射治疗计划。

44. 发明授权

EP3146998B1 APPARATUS TO EMPLOY A MULTI-LAYER MULTI-LEAF COLLIMATOR WHEN ADMINISTERING A RADIATION THERAPY TREATMENT 有权转让
公开(公告)号：EP3146998B1
公开(公告)日：2020-11-04
申请号：EP16187121.5
申请日：2016-09-02
申请人： Varian Medical Systems International AG , Varian Medical Systems, Inc.
发明人： NORD, Janne , PELTOLA, Jarkko , KUUSELA, Esa , PRINCE, Steven
IPC分类号： A61N5/10 , G21K1/04

45. 发明公开

EP3658232A1 THERAPEUTIC RADIATION TREATMENT 有权转让
公开(公告)号：EP3658232A1
公开(公告)日：2020-06-03
申请号：EP18755714.5
申请日：2018-07-20
申请人： Varian Medical Systems International AG
发明人： NORD, Janne , KUUSELA, Esa , PYYRY, Joakim , NIEMELA, Perttu
IPC分类号： A61N5/10

46. 发明授权

EP2968975B8 RADIATION THERAPY PLANNING USING INTEGRATED MODEL 有权转让
公开(公告)号：EP2968975B8
公开(公告)日：2018-09-05
申请号：EP14712561.1
申请日：2014-03-14
申请人： Varian Medical Systems International AG
发明人： KUUSELA, Esa , MARIA, Cordero Marcos , HARTMAN, Joona , PELTOLA, Jarkko , NORD, Janne
IPC分类号： A61N5/10
CPC分类号： G16H50/50 , A61N5/103 , A61N2005/1041 , G06F19/00 , G06N5/00 , G06N5/022
摘要： System and method for automatically generate therapy plan parameters by use of an integrate model with extended applicable regions. The integrated model integrates multiple predictive models from which a suitable predictive model can be selected automatically to perform prediction for a new patient case. The integrated model may operate to evaluate prediction results generated by each predictive model and the associated prediction reliabilities and selectively output a satisfactory prediction. Alternatively, the integrated model may select a suitable predictive model by a decision hierarchy in which each level corresponds to divisions of a patient data feature set and divisions on a subordinate level are nested with divisions on a superordinate level.

47. 发明公开

EP3347094A1 KNOWLEDGE BASED MULTI-CRITERIA OPTIMIZATION FOR RADIOTHERAPY TREATMENT PLANNING 有权转让
公开(公告)号：EP3347094A1
公开(公告)日：2018-07-18
申请号：EP16778188.9
申请日：2016-09-12
申请人： Varian Medical Systems International AG
发明人： NORD, Janne , KUUSELA, Esa , PYYRY, Joakim , PELTOLA, Jarkko , SABEL, Martin
IPC分类号： A61N5/10
摘要： A method of generating a treatment plan for treating a patient with radiotherapy, the method includes obtaining a plurality of sample plans, which are generated by use of a knowledge base comprising historical treatment plans and patient data. The method also includes performing a multi-criteria optimization based on the plurality of sample plans to construct a Pareto frontier, where the plurality of sample plans are evaluated with at least two objectives measuring qualities of the plurality of sample plans such that treatment plans on the constructed Pareto frontier are Pareto optimal with respect to the objectives. The method further includes identifying a treatment plan by use of the constructed Pareto frontier.

48. 发明公开

EP3146998A1 METHOD AND APPARATUS TO EMPLOY A MULTI-LAYER MULTI-LEAF COLLIMATOR WHEN ADMINISTERING A RADIATION THERAPY TREATMENT 有权转让
标题翻译：方法和装置采用多涂层片更多准直器在辐射给药的治疗手段
公开(公告)号：EP3146998A1
公开(公告)日：2017-03-29
申请号：EP16187121.5
申请日：2016-09-02
申请人： Varian Medical Systems International AG , Varian Medical Systems, Inc.
发明人： NORD, Janne , PELTOLA, Jarkko , KUUSELA, Esa , PRINCE, Steven
IPC分类号： A61N5/10 , G21K1/04
摘要： A control circuit 201 administers a radiation treatment plan that specifies a planned total radiation dose for a radiation treatment session for a given patient 207 by modulating a radiation beam 203 with at least one high-resolution aperture that is formed using one of a plurality of linearly-sequential high-resolution aperture possibilities. By one approach the foregoing comprises modulating the radiation beam using at least substantially only high-resolution apertures that are formed using a plurality of the linearly-sequential high-resolution aperture possibilities. In some cases the foregoing can comprise administering the radiation treatment plan using at least two separate radiation exposures for only a single treatment field, in which case, by one approach, each of the separate radiation exposures for the single treatment field can comprise modulating the radiation beam using at least substantially only high-resolution apertures.
摘要翻译：控制电路201管理一个辐射处置计划并指定用于给定患者207辐射治疗会话通过调制的辐射束203与至少一个高分辨率孔径的计划总辐射剂量并使用的线性多个之一形成 -sequential高分辨率孔径的可能性。根据一个方案，前述的包括使用至少基本上仅高分辨率孔径并使用的线性顺序高分辨率孔径的可能性形成的多个调制的辐射束。在一些情况下，前述可包括施用使用至少两个分开的辐射照射只对单个处理场的辐射治疗计划，在这种情况下,,通过一种方法中，每一个用于所述单个处理场的单独的辐射照射的可以包括调节辐射光束使用至少基本上仅高分辨率光圈。

49. 发明公开

EP3049976A1 DECISION SUPPORT TOOL FOR CHOOSING TREATMENT PLANS 审中-公开
标题翻译：决策支持工具选择的治疗计划的
公开(公告)号：EP3049976A1
公开(公告)日：2016-08-03
申请号：EP14793309.7
申请日：2014-09-29
申请人： Varian Medical Systems, International AG
发明人： HARTMAN, Joona , MARCOS, Maria, Isabel, Cordero , KUUSELA, Esa , PELTOLA, Jarkko, Yrjana , NORD, Janne, Ilmari
IPC分类号： G06F19/00
CPC分类号： G06F19/345 , A61N5/103 , A61N2005/1041 , G06F19/00 , G16H50/20
摘要： Patient data can be used to determine input values to different estimation functions for different treatment types. The estimation functions can each be used to estimate one or more outcome values for the respective treatment. A quality score can be determined using the outcome value(s). A first treatment plan having an optimal quality score can be identified, e.g., by displaying the treatment plans with the quality scores, which may correspond to the outcome values.

50. 发明公开

EP2968975A2 RADIATION THERAPY PLANNING USING INTEGRATED MODEL 有权转让
标题翻译： STRAHLENTHERAPIEPLANUNG MIT INTEGRIERTEM MODELL
公开(公告)号：EP2968975A2
公开(公告)日：2016-01-20
申请号：EP14712561.1
申请日：2014-03-14
申请人： Varian Medical Systems, International AG
发明人： KUUSELA, Esa , MARIA, Cordero Marcos , HARTMAN, Joona , PELTOLA, Jarkko , NORD, Janne
IPC分类号： A61N5/10
CPC分类号： G06F19/3437 , A61N5/103 , A61N2005/1041 , G06F19/00 , G06N5/00 , G06N5/022 , G16H50/50
摘要： System and method for automatically generate therapy plan parameters by use of an integrate model with extended applicable regions. The integrated model integrates multiple predictive models from which a suitable predictive model can be selected automatically to perform prediction for a new patient case. The integrated model may operate to evaluate prediction results generated by each predictive model and the associated prediction reliabilities and selectively output a satisfactory prediction. Alternatively, the integrated model may select a suitable predictive model by a decision hierarchy in which each level corresponds to divisions of a patient data feature set and divisions on a subordinate level are nested with divisions on a superordinate level.
摘要翻译：通过使用具有扩展适用区域的集成模型自动生成治疗计划参数的系统和方法。集成模型集成了多个预测模型，从中可以自动选择合适的预测模型，以对新的患者病例进行预测。集成模型可以用于评估由每个预测模型和相关预测可靠性产生的预测结果，并选择性地输出令人满意的预测。或者，集成模型可以通过决策层级来选择合适的预测模型，其中每个级别对应于患者数据特征集的分割，并且下级的分割与上级的分割嵌套。

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