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41. 发明申请

US20070292314A1 Bent Microstructures For Sampling, Transporting Or Dispensing A Fluid Media 有权
标题翻译：用于采样，运输或分配流体介质的弯曲微结构
公开(公告)号：US20070292314A1
公开(公告)日：2007-12-20
申请号：US11791251
申请日：2005-11-22
申请人： Carlo Effenhauser , Emad Sarofim , Stephan Korner
发明人： Carlo Effenhauser , Emad Sarofim , Stephan Korner
IPC分类号： B01L3/02
CPC分类号： G01N1/20 , B01L3/0244 , B01L3/502707 , B01L3/502715 , B01L2200/025 , B01L2400/025 , B01L2400/0406 , Y10T29/49826 , Y10T436/110833 , Y10T436/2575
摘要： A device for sampling, transporting and/or disposal of fluid media in the nl and μl-range comprises a substrate with and open or closed capillary-like groove or channel respectively, the substrate with the open or closed groove or capillary respectively is bent or arcuated at least at one location. The substrate comprises at least one end into which the open closed capillary-like groove or channel respectively is extended, which end is shaped according to its application or use as e.g. needle-like, straight-lined cut, tip-like, at least most half circle-shape, rounded, etc.
摘要翻译：用于在n1和m范围内采样，运输和/或处理流体介质的装置包括分别具有和开放或封闭的毛细管状沟槽或通道的基板，分别具有开放或封闭的凹槽或毛细管的基板被弯曲或至少在一个位置弧形。衬底包括至少一个端部，开放或封闭的毛细管状沟槽或沟槽分别延伸到其中，该端部根据其应用或用途被成形为例如形状。针状，直线切割，尖端状，至少半圆形，圆形等

42. 发明授权

US07256035B1 System for thermocycling of fluids in cartridges 失效
标题翻译：墨盒中流体热循环系统
公开(公告)号：US07256035B1
公开(公告)日：2007-08-14
申请号：US10070343
申请日：2000-09-02
申请人： Urban Schnell , Olivier Elsenhans , Thomas Caratsch , Lukas Birrer , Emad Sarofim
发明人： Urban Schnell , Olivier Elsenhans , Thomas Caratsch , Lukas Birrer , Emad Sarofim
IPC分类号： C12M1/34
CPC分类号： B01L7/52 , G01N2035/00366
摘要： System for thermocycling of fluids in cartridges comprising a thermocycling unit in thermal contact with a first substantially planar and heat conducting wall of a cartridge, a light source for transmitting light into the interior of said cartridge through a second light transparent wall of said cartridge which is arranged substantially perpendicular to said first wall, a light detector for detecting light emerging from the interior of the cartridge through said second wall and a fluid providing unit coupled to an inlet of the cartridge for providing the cartridge with fluid and an outlet of the cartridge to drain gas when the cartridge is filled with fluid. The invention further concerns a cartridge for conducting the thermal cycling of fluids.
摘要翻译：包括与筒的第一基本上平面和导热壁热接触的热循环单元的热循环系统，用于通过所述盒的第二透光壁将光透射到所述盒的内部的光源，基本上垂直于所述第一壁布置的光检测器，用于检测通过所述第二壁从所述盒的内部出射的光的光检测器;以及耦合到所述盒的入口的流体供应单元，用于向所述盒提供所述盒的流体和出口，当墨盒充满流体时，排出气体。本发明还涉及用于进行流体热循环的筒。

43. 发明授权

US06882425B1 Method and apparatus for examining fluids of biological origin 失效
标题翻译：用于检查生物来源的流体的方法和装置
公开(公告)号：US06882425B1
公开(公告)日：2005-04-19
申请号：US10018080
申请日：2000-06-07
申请人： Olivier Elsenhans , Emad Sarofim , Urban Georg Schnell
发明人： Olivier Elsenhans , Emad Sarofim , Urban Georg Schnell
IPC分类号： G01N33/483 , G01N21/27 , G01N21/00
CPC分类号： G01N21/274
摘要： A quality test of fluids of biological origin can be performed optically with applying a suitable evaluation method. In case of two components to be determined in a such fluid, an extinction spectrum is approximated in a first wavelength range by a combination of a merely theoretical curve and the spectrum of the pure first substance in a first wavelength range, and this evaluation is repeated in a second wavelength range this time by approximating the measured spectrum (62) by a combination of a hypothetical curve, the spectrum (64) of the first component with the already determined concentration, and the spectrum (65) of the pure second component. Furthermore, it is feasible to subtract the first and second spectrum and analyze the so obtained differential spectrum (66) in view of anomalies. The hypothetical curves are preferably straight lines which are defined by slope and ordinate section. In the praxis of the quality test of blood, bilirubin and hemoglobin may be quantitatively be determined, whilst the background together with the lipid component can be qualitatively examined by means of the differential spectrum.
摘要翻译：可以通过适当的评估方法对生物来源的流体进行质量检验。在这种流体中要确定的两个成分的情况下，通过理论曲线和纯第一物质在第一波长范围内的光谱的组合，在第一波长范围内近似消光光谱，并重复该评价在第二波长范围内，通过将假设曲线，第一分量的光谱（64）与已经确定的浓度组合并与纯第二分量的光谱（65）的组合近似测量光谱（62）。此外，考虑到异常，可以减去第一和第二频谱并分析得到的差分谱（66）。假设曲线优选是由斜率和纵坐标表定义的直线。在对血液进行质量检测的实践中，可以定量测定胆红素和血红蛋白，同时通过差示谱定性检查背景和脂质成分。

44. 发明授权

US09414774B2 Method and system for withdrawing body fluid 有权
标题翻译：取出体液的方法和系统
公开(公告)号：US09414774B2
公开(公告)日：2016-08-16
申请号：US11539675
申请日：2006-10-09
申请人： Stephan Korner , Rainer Jaeggi , Patrick Griss , Emad Sarofim , Irio Guiseppe Calasso
发明人： Stephan Korner , Rainer Jaeggi , Patrick Griss , Emad Sarofim , Irio Guiseppe Calasso
IPC分类号： A61B5/00 , A61B5/15
CPC分类号： A61B5/150068 , A61B5/1411 , A61B5/150022 , A61B5/150358 , A61B5/150419 , A61B5/150816 , A61B5/150954 , A61B5/15113 , A61B5/157
摘要： A system and method for carrying out the withdrawal of body fluid with as little body fluid as possible visible to the user at the end of the process. The present invention provides a pressure piece for exerting pressure on a body part. The pressure piece is moved relative to a support for the body part, and in the final phase of fluid withdrawal, the compressive or resistive force of the pressure piece on the body part is reduced in order to avoid the escape of body fluid from the puncture site. The support results in a defined positioning of the body part that rests against it for the lancing process, whereas the relative movement of the pressure piece enables an additional increase in pressure and thus an improved collection of fluid.
摘要翻译：一种系统和方法，用于在过程结束时用尽可能少的体液抽出体液，以使用户可以看到。本发明提供一种用于在身体部位施加压力的压力片。压片相对于身体部分的支撑件移动，并且在流体抽出的最后阶段中，压力片在身体部分上的压缩或阻力减小，以避免体液从穿刺中逸出现场。支撑件导致身体部分的定位，其靠在其上以用于穿刺过程，而压力片的相对运动使得能够额外增加压力，从而改善流体的收集。

45. 发明授权

US08797526B2 Instrument and method for the automated thermal treatment of liquid samples 有权
标题翻译：用于液体样品自动热处理的仪器和方法
公开(公告)号：US08797526B2
公开(公告)日：2014-08-05
申请号：US13295504
申请日：2011-11-14
申请人： Claudio Cherubini , Roger Iten , Emad Sarofim , Kurt Schildknecht
发明人： Claudio Cherubini , Roger Iten , Emad Sarofim , Kurt Schildknecht
IPC分类号： G01N1/10
CPC分类号： B01L3/50851 , B01L3/50853 , B01L7/52 , B01L2200/022 , B01L2300/041 , B01L2300/0654 , B01L2300/0829 , B01L2300/1805 , C12Q1/686 , G01N21/0332 , G01N21/253 , G01N21/645 , G01N21/6452 , G01N35/028 , G01N2021/6419 , G01N2021/6484 , G01N2035/00346 , G01N2035/00376 , G01N2201/0627
摘要： An instrument and a method for the automated thermal treatment of liquid samples are disclosed. An inter-distance between a temperature-controlled receptacle for loading with a plurality of vessels for containing the samples and end portions of optical fibers can be varied, wherein the receptacle is configured to form a thermal communication with the loaded vessels and wherein the optical fibers have first and second end portions. The first end portion and the second end portion of each optical fiber is fixed with respect to each other for transmitting light, wherein the variation of the inter-distance allows the vessels to be loaded to or unloaded from the receptacle and to enable detection of light from the samples contained in the one or more receptacle-loaded vessels.
摘要翻译：公开了用于液体样品的自动热处理的仪器和方法。用于装载用于容纳样品和光纤的端部的多个容器的温度控制容器之间的距离可以变化，其中容器被配置为与加载的容器形成热连通，并且其中光纤具有第一和第二端部。每个光纤的第一端部和第二端部相对于彼此固定以透射光，其中间距的变化允许容器被装载或从插座卸载并且能够检测光从包含在一个或多个容器加载的容器中的样品。

46. 发明授权

US08241566B2 Bent microstructures for sampling, transporting or dispensing a fluid media 有权
标题翻译：用于采样，运输或分配流体介质的弯曲微结构
公开(公告)号：US08241566B2
公开(公告)日：2012-08-14
申请号：US11791251
申请日：2005-11-22
申请人： Stephan Korner , Patrick Griss , Emad Sarofim , Carlo Effenhauser
发明人： Stephan Korner , Patrick Griss , Emad Sarofim , Carlo Effenhauser
IPC分类号： C12Q1/68
CPC分类号： G01N1/20 , B01L3/0244 , B01L3/502707 , B01L3/502715 , B01L2200/025 , B01L2400/025 , B01L2400/0406 , Y10T29/49826 , Y10T436/110833 , Y10T436/2575
摘要： A device for sampling, transporting and/or disposal of fluid media in the nl and μl-range comprises a substrate with and open or closed capillary-like groove or channel respectively, the substrate with the open or closed groove or capillary respectively is bent or arcuated at least at one location. The substrate comprises at least one end into which the open closed capillary-like groove or channel respectively is extended, which end is shaped according to its application or use as e.g. needle-like, straight-lined cut, tip-like, at least most half circle-shape, rounded, etc.
摘要翻译：用于在nl和μl范围内采样，运输和/或处理流体介质的装置包括分别具有和开放或封闭的毛细管状沟槽或通道的衬底，分别具有开放或封闭的沟槽或毛细管的衬底被弯曲或至少在一个位置弧形。衬底包括至少一个端部，开放或封闭的毛细管状沟槽或沟槽分别延伸到其中，该端部根据其应用或用途被成形为例如形状。针状，直线切割，尖端状，至少半圆形，圆形等

47. 发明申请

US20110028862A1 METHOD AND DEVICE FOR THE EXTRACTION OF A BODY FLUID 有权
标题翻译：用于提取体液的方法和装置
公开(公告)号：US20110028862A1
公开(公告)日：2011-02-03
申请号：US12901290
申请日：2010-10-08
申请人： Heinz-Michael Hein , Reto Abt , Stephan Korner , Irio Giuseppe Calasso , Emad Sarofim , Patrick Griss , Rainer Jaeggi
发明人： Heinz-Michael Hein , Reto Abt , Stephan Korner , Irio Giuseppe Calasso , Emad Sarofim , Patrick Griss , Rainer Jaeggi
IPC分类号： A61B5/151
CPC分类号： A61B5/150503 , A61B5/0531 , A61B5/150022 , A61B5/150068 , A61B5/150167 , A61B5/150175 , A61B5/150358 , A61B5/150435 , A61B5/15107 , A61B5/15117 , A61B5/15123 , A61B5/15186
摘要： The present invention provides a method and a device for piercing a body part and determining whether a sufficient volume of blood has been withdrawn. A lancing element is rapidly inserted into a body part in a forward phase and retracted quickly to a lesser puncturing depth. Subsequently, the lancing element is retracted slower than during the first retraction movement and the distance retracted during the second retraction is shorter than the first retraction movement. During the second retraction movement, body fluid is collected in a collection phase by a capillary structure of the lancing element. Contact between the lancing element and the body fluid is detected after the forward phase at the beginning and the end of a waiting period.
摘要翻译：本发明提供一种用于刺穿身体部位并确定是否已经抽出了足够体积的血液的方法和装置。穿刺元件迅速地插入到前部的身体部位并且迅速地缩回到较小的穿刺深度。随后，穿刺元件缩回比在第一缩回运动期间慢，并且在第二缩回期间缩回的距离比第一缩回运动短。在第二回缩运动期间，体液通过穿刺元件的毛细结构收集在收集阶段。在等待期开始和结束后的正向相位之后检测穿刺元件与体液之间的接触。

48. 发明申请

US20110009774A1 BODY FLUID SAMPLING DEVICE 有权
标题翻译：身体液体取样装置
公开(公告)号：US20110009774A1
公开(公告)日：2011-01-13
申请号：US12879500
申请日：2010-09-10
申请人： Irio Calasso , Patrick Griss , Emad Sarofim , Rainer Jaeggi , Uwe Kraemer , Dave Hasker , Volker Zimmer , Wilifried Schmid , Otto Fuerst , Hans List , Hans-Peter Haar , Theo Arnitz , Steven N. Roe
发明人： Irio Calasso , Patrick Griss , Emad Sarofim , Rainer Jaeggi , Uwe Kraemer , Dave Hasker , Volker Zimmer , Wilifried Schmid , Otto Fuerst , Hans List , Hans-Peter Haar , Theo Arnitz , Steven N. Roe
IPC分类号： A61B5/151
CPC分类号： A61B5/1411 , A61B5/14532 , A61B5/1486 , A61B5/150022 , A61B5/150068 , A61B5/150282 , A61B5/150358 , A61B5/150396 , A61B5/150419 , A61B5/150427 , A61B5/15045 , A61B5/150503 , A61B5/15151 , A61B5/15163
摘要： Body fluid sampling device comprising a skin-piercing element having a collection zone for receiving body fluid. In one embodiment, the collection zone includes a plurality of holes, e.g., 3 or more holes, or 50 to 100 holes. The hole size may be small, e.g., having a diameter of 0.01 to 0.5 mm. The holes may or may not extend through the lancet. In some embodiments, the holes have a depth of 50 to 500 μm. In other embodiments, the collection zone is porous, or is a roughened area. The collection zone can take up a very small volume of body fluid, e.g., 3 to 10 nL, in a very short time period, e.g., less than 0.5 seconds. In other embodiments, the device further comprises a fluid receiving means spaced apart from the collection zone so that body fluid in the collection zone will not contact the fluid receiving means initially.
摘要翻译：体液取样装置包括具有用于接收体液的收集区的皮肤刺穿元件。在一个实施例中，收集区包括多个孔，例如3个或更多个孔，或50至100个孔。孔尺寸可以较小，例如具有0.01至0.5mm的直径。这些孔可以延伸穿过刺血针也可能不延伸穿过刺血针。在一些实施例中，孔的深度为50至500μm。在其它实施方案中，收集区是多孔的，或者是粗糙区域。收集区可以在非常短的时间段（例如小于0.5秒）内占据非常小体积的体液，例如3至10nL。在其他实施例中，该装置还包括与收集区间隔开的流体接收装置，使得收集区中的体液最初不会接触流体接收装置。

49. 发明授权

US07819822B2 Body fluid sampling device 有权
标题翻译：体液取样装置
公开(公告)号：US07819822B2
公开(公告)日：2010-10-26
申请号：US11470368
申请日：2006-09-06
申请人： Irio Guiseppe Calasso , Patrick Griss , Emad Sarofim , Rainer Jaeggi , Uwe Kraemer , Dave Hasker , Volker Zimmer , Wilfried Schmid , Otto Fuerst , Hans List , Hans-Peter Haar , Theo Arnitz , Steven N. Roe
发明人： Irio Guiseppe Calasso , Patrick Griss , Emad Sarofim , Rainer Jaeggi , Uwe Kraemer , Dave Hasker , Volker Zimmer , Wilfried Schmid , Otto Fuerst , Hans List , Hans-Peter Haar , Theo Arnitz , Steven N. Roe
IPC分类号： A61B5/00
CPC分类号： A61B5/1411 , A61B5/14532 , A61B5/1486 , A61B5/150022 , A61B5/150068 , A61B5/150282 , A61B5/150358 , A61B5/150396 , A61B5/150419 , A61B5/150427 , A61B5/15045 , A61B5/150503 , A61B5/15151 , A61B5/15163
摘要： Body fluid sampling device comprising a skin-piercing element having a collection zone for receiving body fluid, and the device further comprising a fluid receiving means remote spaced apart from the collection zone so that body fluid in the collection zone will not contact the fluid receiving means initially. The collection zone takes up a very small volume of body fluid of about 10 to 500 nl in a very short time period of less than 0.5 seconds. The fluid receiving means may have a test zone for performing an analytical reaction. Fluid sample from the collection zone is automatically or manually transported to the fluid receiving means to contact the fluid with the test zone.
摘要翻译：体液取样装置包括具有用于接收体液的收集区的皮肤刺穿元件，并且该装置还包括与收集区间隔开的流体接收装置，使得收集区中的体液不会接触流体接收装置原来。收集区在小于0.5秒的非常短的时间段内占据非常小体积的体液约10至500nl。流体接收装置可以具有用于进行分析反应的测试区域。来自收集区的流体样品被自动或手动地输送到流体接收装置以使流体与测试区接触。

50. 发明申请

US20080108910A1 METHOD AND DEVICE FOR THE EXTRACTION OF A BODY FLUID 有权
标题翻译：用于提取体液的方法和装置
公开(公告)号：US20080108910A1
公开(公告)日：2008-05-08
申请号：US11868505
申请日：2007-10-07
申请人： Heinz-Michael Hein , Reto Abt , Stephan Korner , Irio Calasso , Emad Sarofim , Patrick Griss , Rainer Jaeggi
发明人： Heinz-Michael Hein , Reto Abt , Stephan Korner , Irio Calasso , Emad Sarofim , Patrick Griss , Rainer Jaeggi
IPC分类号： A61B5/00 , A61B5/05 , A61M5/00
CPC分类号： A61B5/150503 , A61B5/0531 , A61B5/150022 , A61B5/150068 , A61B5/150167 , A61B5/150175 , A61B5/150358 , A61B5/150435 , A61B5/15107 , A61B5/15117 , A61B5/15123 , A61B5/15186
摘要： The present invention provides a method and a device for piercing a body part and determining whether a sufficient volume of blood has been withdrawn. A lancing element is rapidly inserted into a body part in a forward phase and retracted quickly to a lesser puncturing depth. Subsequently, the lancing element is retracted slower than during the first retraction movement and the distance retracted during the second retraction is shorter than the first retraction movement. During the second retraction movement, body fluid is collected in a collection phase by a capillary structure of the lancing element. Contact between the lancing element and the body fluid is detected after the forward phase at the beginning and the end of a waiting period.
摘要翻译：本发明提供一种用于刺穿身体部位并确定是否已经抽出了足够体积的血液的方法和装置。穿刺元件迅速地插入到前部的身体部位并且迅速地缩回到较小的穿刺深度。随后，穿刺元件缩回比在第一缩回运动期间慢，并且在第二缩回期间缩回的距离比第一缩回运动短。在第二回缩运动期间，体液通过穿刺元件的毛细结构收集在收集阶段。在等待期开始和结束后的前进阶段之后检测穿刺元件与体液之间的接触。

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