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    • 44. 发明申请
    • Intracellular antibodies
    • 细胞内抗体
    • US20050272107A1
    • 2005-12-08
    • US11127677
    • 2005-05-12
    • Terrence RabbittsTomoyuki Tanaka
    • Terrence RabbittsTomoyuki Tanaka
    • C07K16/32C12N15/13G01N33/53G01N33/537G01N33/543
    • C07K16/32C07K2317/569C07K2317/622C07K2319/00
    • The invention related to intracellular single domain immunoglobulins, and to a method for determining the ability of an immunoglobulin single domain to bind to a target in an intracellular environment, comprising the steps of: a) providing a first molecule and a second molecule, wherein stable interaction of the first and second molecules leads to the generation of a signal; b) providing a single intracellular immunoglobulin domain which is associated with the first molecule, said single immunoglobulin domain being free of complementary immunoglobulin domains; c) providing an intracellular target which is associated with the second molecule, such that association of the immunoglobulin domain and the target leads to stable interaction of the first and second molecules and generation of the signal; and d) assessing the intracellular interaction between the immunoglobulin domain and the target by monitoring the signal.
    • 本发明涉及细胞内单结构域免疫球蛋白,以及用于确定免疫球蛋白单结构域在细胞内环境中与靶结合的能力的方法,包括以下步骤:a)提供第一分子和第二分子,其中稳定 第一和第二分子的相互作用导致信号的产生; b)提供与第一分子缔合的单个细胞内免疫球蛋白结构域,所述单个免疫球蛋白结构域不含互补免疫球蛋白结构域; c)提供与第二分子缔合的细胞内靶,使得免疫球蛋白结构域和靶标的结合导致第一和第二分子的稳定相互作用以及信号的产生; 和d)通过监测信号来评估免疫球蛋白结构域和靶标之间的细胞内相互作用。
    • 49. 发明申请
    • CONSTRUCTION MACHINE
    • 建筑机械
    • US20130322999A1
    • 2013-12-05
    • US13991292
    • 2012-02-08
    • Shogo KimuraTomoyuki Tanaka
    • Shogo KimuraTomoyuki Tanaka
    • E02F9/16E02F3/30
    • E02F9/163B60J5/0487B62D33/0617E02F3/30E02F3/325
    • A cab (8) is provided with a cab box (13) in which a space between each of pillars (14 to 18) is covered by each of surfaces (13A to 13F) and the inside becomes an operator's room (13G) and a door (24) mounted on the left intermediate pillar (16). On a rear surface portion (14D) of the left front pillar (14), a protruding portion (23A1) of a mounting plate (23A) is provided in a state protruding to the door (24) side. On a mounting opening (24E) on the inner surface side of the door (24), a door holding member (28) engaged with an engaging member (23) and holding the door (24) at a closed position is provided. On the door (24), a retreating recessed portion (29) for avoiding interference with the protruding portion (23A1) of the mounting plate (23A) is provided on the front side from the door holding member (28).
    • 驾驶室(8)设置有驾驶室箱(13),每个支柱(14至18)之间的空间被每个表面(13A至13F)覆盖,内部成为操作室(13G),并且 门(24)安装在左中间支柱(16)上。 在左前柱(14)的后表面部分(14D)上,以突出到门(24)侧的状态设置安装板(23A)的突出部分(23A1)。 在门(24)的内表面侧的安装开口(24E)上设置有与接合构件(23)接合并将门(24)保持在关闭位置的门保持构件(28)。 在门(24)上,从门保持构件(28)的前侧设置有用于避免与安装板(23A)的突出部(23A1)的干涉的后退凹部(29)。
    • 50. 发明申请
    • CONSTRUCTION MACHINE
    • 建筑机械
    • US20130285413A1
    • 2013-10-31
    • US13990611
    • 2012-01-06
    • Naoki TakeokaTomoyuki TanakaShogo Kimura
    • Naoki TakeokaTomoyuki TanakaShogo Kimura
    • E02F9/16B62D33/06
    • B62D33/0625B62D25/07B62D33/0617B62D33/0633E02F3/325E02F9/16
    • A canopy (23) is provided to rise in an upper revolving structure (3) for covering an upper side of an operator's seat (19). A bend portion (25B) extending in the left-right direction and projecting upward is provided in a front end side of a roof plate (25) in the canopy (23). A plate-shaped left front lifting bracket (26) is provided in a left front connecting portion (24J), and a plate-shaped right front lifting bracket (27) is provided in a right front connecting portion (24L). The left and right front lifting brackets (26, 27) sandwich the bend portion (25B) from both sides in the left-right direction. Further, the left and right front lifting brackets (26, 27) are provided with lifting holes (26A, 27A) and also discharging notches (26B, 27B).
    • 设置有用于覆盖操作者座椅(19)的上侧的上部旋转结构(3)的顶盖(23)。 在顶盖(23)的顶板(25)的前端侧设置有向左右方向延伸并向上突出的弯曲部(25B)。 在左前连接部(24J)中设置有板状的左前提升支架(26),在右前连接部(24L)中设置有板状的右前提升支架(27)。 左右前提升支架(26,27)从左右方向的两侧夹着弯曲部(25B)。 此外,左右前提升支架(26,27)设置有提升孔(26A,27A),并且还具有排出凹口(26B,27B)。