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    • 47. 发明授权
    • Peptide tumor cell growth inhibitors
    • 肽肿瘤细胞生长抑制剂
    • US06355619B1
    • 2002-03-12
    • US09650438
    • 2000-08-29
    • Edmund J. MillerShinichiro Hayashi
    • Edmund J. MillerShinichiro Hayashi
    • A61K3800
    • C07K7/06A61K38/08C07K14/54C07K14/5421
    • Disclosed are peptide-based compositions and methods for inhibiting and modulating the actions of CXC intercrine molecules. The antileukinate peptides described inhibit IL-8, GRO and MIP2&bgr; binding to neutrophils and neutrophil activation. The peptides are particularly advantageous as they inhibit IL-8-induced enzyme release at a 25 fold lower concentration than is required to inhibit chemotaxis, which makes them ideal for treating various inflammatory diseases and disorders including, amongst others, Adult Respiratory Distress Syndrome (ARDS), cystic fibrosis and chronic bronchitis. The invention further includes methods for inhibiting tumor cell growth by employing selected members of the disclosed group of peptides to inhibit a-chemokine binding to the tumor cell.
    • 本发明公开了基于肽的组合物和用于抑制和调节CXC胞间分子作用的方法。 所述的抗白细胞介素肽抑制IL-8,GRO和MIP2β结合嗜中性粒细胞和嗜中性粒细胞活化。 这些肽是特别有利的,因为它们以比抑制趋化性所需的浓度低25倍抑制IL-8诱导的酶释放,这使得它们是治疗各种炎性疾病和病症的理想选择,包括成人呼吸窘迫综合征(ARDS) ),囊性纤维化和慢性支气管炎。 本发明还包括通过使用所公开的肽组的选定成员来抑制趋化因子与肿瘤细胞的结合来抑制肿瘤细胞生长的方法。
    • 48. 发明授权
    • Peptide tumor cell growth inhibitors
    • 肽肿瘤细胞生长抑制剂
    • US6110889A
    • 2000-08-29
    • US865472
    • 1997-05-29
    • Edmund J. MillerShinichiro Hayashi
    • Edmund J. MillerShinichiro Hayashi
    • A61K38/00A61K38/08A61P35/00C07K7/06C07K14/54
    • C07K7/06A61K38/08C07K14/54C07K14/5421
    • Disclosed are peptide-based compositions and methods for inhibiting and modulating the actions of CXC intercrine molecules. The antileukinate peptides described inhibit IL-8, GRO and MIP2.beta. binding to neutrophils and neutrophil activation. The peptides are particularly advantageous as they inhibit IL-8-induced enzyme release at a 25 fold lower concentration than is required to inhibit chemotaxis, which makes them ideal for treating various inflammatory diseases and disorders including, amongst others, Adult Respiratory Distress Syndrome (ARDS), cystic fibrosis and chronic bronchitis. The invention further includes methods for inhibiting tumor cell growth by employing selected members of the disclosed group of peptides to inhibit .alpha.-chemokine binding to the tumor cell.
    • 本发明公开了基于肽的组合物和用于抑制和调节CXC胞间分子作用的方法。 所描述的抗白细胞介素肽抑制IL-8,GRO和MIP2β与嗜中性粒细胞和嗜中性粒细胞活化的结合。 这些肽是特别有利的,因为它们以比抑制趋化性所需的浓度低25倍抑制IL-8诱导的酶释放,这使得它们是治疗各种炎性疾病和病症的理想选择,包括成人呼吸窘迫综合征(ARDS) ),囊性纤维化和慢性支气管炎。 本发明还包括通过使用所公开的肽组的选定成员来抑制α-细胞因子与肿瘤细胞的结合来抑制肿瘤细胞生长的方法。