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41. 发明授权

US10238361B2 Combination of ultrasound and x-ray systems 有权
公开(公告)号：US10238361B2
公开(公告)日：2019-03-26
申请号：US13513921
申请日：2010-11-30
申请人： Nicolas Pierre Bruno Gogin , Raoul Florent , Pascal Yves Francois Cathier
发明人： Nicolas Pierre Bruno Gogin , Raoul Florent , Pascal Yves Francois Cathier
IPC分类号： A61B6/12 , A61B8/00 , A61B6/00 , A61B8/08
摘要： The invention proposes to detect and track an intervention device in a 2D fluoroscopy image and to steer an ultrasound probe beam towards this device. Therefore, a method and corresponding system is proposed, by which an ultrasound probe is registered in a fluoroscopy image, wherein the registering includes the estimation of the position and of the orientation of the probe relative to the fluoroscopy.

42. 发明授权

US09545237B2 Method and device for recording a vascular struture during intervention 有权
标题翻译：干预期间记录血管结构的方法和装置
公开(公告)号：US09545237B2
公开(公告)日：2017-01-17
申请号：US12527935
申请日：2008-02-22
申请人： Raoul Florent
发明人： Raoul Florent
IPC分类号： A61B6/00 , A61B6/12
CPC分类号： A61B6/504 , A61B6/12 , A61B6/481
摘要： Method and device for recording a vascular structure during intervention comprises steps or elements for detecting S1 an injection of a contrast agent 6 provided to the vicinity of a device landmark 5, monitoring S3 for a predetermined time the vicinity of the device landmark 5, generating S3a time-contrast curves based on the monitored vicinity of the device landmark 5, analyzing S4a the time-contrast curves, and determining S4b a best instant as a visibility optimum based on the time-contrast curves.
摘要翻译：用于在干预期间记录血管结构的方法和装置包括用于检测S1注射设备地标5附近的造影剂6的步骤或元件，监测设备地标5附近的预定时间的S3，产生S3a 基于设备地标5的监视附近的时间对比度曲线，分析S4a时间 - 对比度曲线，并且基于时间 - 对比度曲线确定S4b作为可见度最优的最佳时刻。

43. 发明授权

US09393079B2 Processing of images of interventional instruments with markers 有权
标题翻译：用标记处理介入仪器的图像
公开(公告)号：US09393079B2
公开(公告)日：2016-07-19
申请号：US11573292
申请日：2005-07-21
申请人： Juergen Weese , Sabine Mollus , Raoul Florent , Lucile Nosjean , Pierre Lelong , Peter Maria Johannes Rongen
发明人： Juergen Weese , Sabine Mollus , Raoul Florent , Lucile Nosjean , Pierre Lelong , Peter Maria Johannes Rongen
IPC分类号： A61B5/05 , A61B19/00
CPC分类号： A61B34/20 , A61B90/39 , A61B90/90 , A61B2034/2065 , A61B2090/392
摘要： A method and an image processing system for the evaluation of projection images generated by an X-ray imaging system, wherein the images may show different instruments of a given set of interventional instruments like catheters or guide wires. The instruments are equipped with markers such that their configuration is characteristic of the corresponding instrument. Preferably three markers are arranged on a straight line, the ratio of the distances between them being characteristic for the corresponding instrument. The image processing system may then identify the instruments present in a given projection and provide functionalities for a user that correspond to said instruments. Moreover, the system may be used to locate an instrument of interest in a projection image if the marker configuration of that instrument is known a priori.
摘要翻译：一种用于评估由X射线成像系统产生的投影图像的方法和图像处理系统，其中所述图像可以显示给定的一组介入装置如导管或导丝的不同仪器。这些仪器配有标记，使得它们的配置是相应仪器的特征。优选地，三个标记布置在直线上，它们之间的距离比对于相应的仪器是特征的。然后，图像处理系统可以识别给定投影中存在的工具，并为与用户对应的功能提供功能。此外，如果该仪器的标记配置是先验已知的，则该系统可用于在投影图像中定位感兴趣的仪器。

44. 发明授权

US09256940B2 Vascular outlining with ostia visualization 有权
标题翻译：血管概述与ostia可视化
公开(公告)号：US09256940B2
公开(公告)日：2016-02-09
申请号：US14343132
申请日：2012-09-07
申请人： Bart Carelsen , Maya Ella Barley , Raoul Florent
发明人： Bart Carelsen , Maya Ella Barley , Raoul Florent
IPC分类号： G06T7/00
CPC分类号： G06T7/0012 , G06T7/73 , G06T2207/10016 , G06T2207/10081 , G06T2207/10121 , G06T2207/30101 , G06T2207/30104
摘要： An apparatus and a related method of processing a 2D projection image (110a-b) taken of a tubular structure comprising two or more tubes. One of the tubes branches off from the other at a sidewall opening. The apparatus is configured to estimate a position of the sidewall opening. The estimation is based on a segmentation of the one or more projection images. A marker for the estimated position of the sidewall opening can be displayed overlaid on the projection image.
摘要翻译：一种处理由包括两个或更多个管的管状结构获取的2D投影图像（110a-b）的装置和相关方法。一个管子在侧壁开口处从另一个管分支。该装置被配置为估计侧壁开口的位置。该估计基于一个或多个投影图像的分割。侧壁开口的估计位置的标记可以重叠在投影图像上。

45. 发明授权

US09095308B2 Vascular roadmapping 有权
标题翻译：血管路线图
公开(公告)号：US09095308B2
公开(公告)日：2015-08-04
申请号：US13498162
申请日：2010-09-17
申请人： Raoul Florent , Pierre Lelong
发明人： Raoul Florent , Pierre Lelong
IPC分类号： G06K9/00 , G06K9/40 , A61B5/05 , A61B6/00 , A61B6/02 , A61B6/12 , G06T5/50 , G06T7/00
CPC分类号： A61B6/503 , A61B6/02 , A61B6/12 , A61B6/481 , A61B6/486 , A61B6/488 , A61B6/504 , A61B6/5235 , G06T5/50 , G06T7/0012 , G06T7/194 , G06T2207/10081 , G06T2207/10121 , G06T2207/30021 , G06T2207/30101
摘要： Cardiac roadmapping consists in correctly overlaying a vessel map sequence derived from an angiogram acquisition onto a fluoroscopy sequence used during PTCA intervention. This enhanced fluoroscopy sequence however suffers from several drawbacks such as breathing motion, high noise level, and most of all suboptimal contrast-enhanced mask due to segmentation defaults. This invention proposes to reverse the process and to locally overlay the intervention device as seen in fluoroscopy onto an optimal contrast-enhanced image of a corresponding cycle. This drastically reduces or suppresses the breathing motion, it provides the high image quality standard of angiograms, and avoids segmentation defaults. This proposal could lead to a brand new navigation practice in PCI procedures.
摘要翻译：心脏路线图包括将从血管造影获取导出的血管图谱顺序正确地覆盖在PTCA干预期间使用的荧光检查序列上。然而，这种增强的荧光透视序列具有诸如呼吸运动，高噪声水平以及由于分割默认值而导致的大多数次优对比度增强的掩模的几个缺陷。本发明提出了逆转该过程并将介入装置局部覆盖在荧光透视中观察到相应周期的最佳对比度增强图像上。这大大降低或抑制呼吸运动，提供血管造影图像的高图像质量标准，并避免分割默认值。这个建议可能导致PCI程序中的全新导航实践。

46. 发明申请

US20140050304A1 MEDICAL IMAGING DEVICE WITH SEPARATE BUTTON FOR SELECTING CANDIDATE SEGMENTATION 审中-公开
标题翻译：具有分离按钮的医学成像装置，用于选择候选分类
公开(公告)号：US20140050304A1
公开(公告)日：2014-02-20
申请号：US14114215
申请日：2012-04-17
申请人： Raoul Florent
发明人： Raoul Florent
IPC分类号： A61B6/00
摘要： A medical imaging device (10) allowing easy and robust representation of anatomic structures within a region of interest in a patient body is presented. The imaging device (10) comprises an image acquisition device (12), an image segmentation device (22), a visualization device (24) and a separate selection button (34). In an image of the region of interest, anatomic structures may be automatically identified using image segmentation techniques. Therein, not only one but a plurality of candidate images comprising differently identified anatomic structures is provided. The plurality of candidate images may be visualized on a display (26) sequentially or in an overlying manner. Using the easy accessible and easy to handle separate selection button (34), a physician may cycle through the plurality of candidate images and manually select one candidate image only by activating the selection button (34) for further exploitation. Thereby, automated segmentation techniques may be combined with the physician's experience thereby significantly increasing the robustness of a selected representation of anatomic structures while reducing human interaction to a minimum.
摘要翻译：呈现允许在患者体内感兴趣的区域内的解剖结构容易且鲁棒地表示的医学成像装置（10）。成像装置（10）包括图像获取装置（12），图像分割装置（22），可视化装置（24）和单独的选择按钮（34）。在感兴趣区域的图像中，可以使用图像分割技术自动识别解剖结构。其中，不仅提供包括不同识别的解剖结构的一个但是多个候选图像。多个候选图像可以在显示器（26）上顺序地或以重叠的方式可视化。使用易于访问和容易处理的单独的选择按钮（34），医师可以循环通过多个候选图像，并且仅通过激活选择按钮（34）手动选择一个候选图像以供进一步利用。因此，自动分割技术可以与医师的经验组合，从而显着增加所选择的解剖结构表示的鲁棒性，同时将人类交互作用降至最低。

47. 发明申请

US20130343631A1 MEDICAL IMAGING DEVICE FOR PROVIDING AN IMAGE REPRESENTATION SUPPORTING IN POSITIONING AN INTERVENTION DEVICE 有权
标题翻译：医疗成像装置，用于提供支持定位干预装置的图像表示
公开(公告)号：US20130343631A1
公开(公告)日：2013-12-26
申请号：US14003486
申请日：2012-03-05
申请人： Raoul Florent , Bart Pierre Antoine Jozef Hoornaert , Herman Stegehuis
发明人： Raoul Florent , Bart Pierre Antoine Jozef Hoornaert , Herman Stegehuis
IPC分类号： A61B5/00
CPC分类号： A61B5/0037 , A61B6/06 , A61B6/12 , A61B6/4441 , A61B6/481 , A61B6/487 , A61B6/503 , A61B6/504 , A61B6/5229 , A61B6/542 , A61B90/37
摘要： A medical imaging device and a method for providing an image representation supporting positioning of an intervention device such as a wire tip (4) in a region of interest during an intervention is proposed. Therein, the following process steps are to be performed: (S1) acquiring a pre-live anatomy image (1) including a region of interest; (S2) acquiring a live anatomy image using a live image acquisition device comprising an adjustable collimator device; (S3) identifying a location (5) of the intervention device (4) within the live anatomy image; (S4) adjusting settings of the collimator device based on the identified location of the intervention device for subsequently acquiring a further live anatomy image representing the region of interest using the live image acquisition device with the collimator device being in the adjusted settings; and providing (S5) the image representation by merging information from the live anatomy image into the pre-live anatomy image. Thereby, the intervention device may be continuously tracked and the collimator device may restrict a field of view to a location of the intervention device thereby significantly reducing an applied X-ray dose. Background anatomical information may be introduced into the final image representation using the pre-live anatomy image possibly having a higher image contrast than the live anatomy images.
摘要翻译：提出了一种医疗成像装置和用于在干预期间提供支持在感兴趣区域中的诸如线尖（4）的介入装置的定位的图像表示的方法。其中，执行以下处理步骤：（S1）获取包括感兴趣区域的活体前解剖图像（1）; （S2）使用包括可调准直器装置的实况图像获取装置获取实况解剖图像; （S3）识别所述实况解剖图像内的介入装置（4）的位置（5）; （S4）基于识别的干预装置的位置来调整准直仪装置的设置，用于随后使用准直仪装置处于调整的设置中的实时图像采集装置获取表示感兴趣区域的另外的活体解剖图像; 以及通过将来自实况解剖图像的信息合并到活体前解剖图像中来提供（S5）图像表示。由此，干预装置可以被连续跟踪，并且准直器装置可以将视野限制到干预装置的位置，从而显着地减少施加的X射线剂量。背景解剖信息可以使用可能具有比活体解剖图像更高的图像对比度的活体前解剖图像被引入最终图像表示。

48. 发明申请

US20130308844A1 MEDICAL IMAGING DEVICE FOR PROVIDING AN IMAGE REPRESENTATION SUPPORTING THE ACCURATE POSITIONING OF AN INVENTION DEVICE IN VESSEL INTERVENTION PROCEDURES 有权
标题翻译：用于提供图像表示的医学成像装置，其支持本发明的精确定位装置在血管干预程序中
公开(公告)号：US20130308844A1
公开(公告)日：2013-11-21
申请号：US13983155
申请日：2012-01-31
申请人： Raoul Florent , Pascal Yves Francois Cathier , Olivier Pierre Nempont
发明人： Raoul Florent , Pascal Yves Francois Cathier , Olivier Pierre Nempont
IPC分类号： A61B5/00
CPC分类号： A61B5/0033 , A61B6/12 , A61B6/4441 , A61B6/481 , A61B6/487 , A61B6/488 , A61B6/504 , A61B6/5229 , A61B2017/00778 , A61B2090/364 , A61B2090/376 , G06T7/30 , G06T2207/10121 , G06T2207/20221 , G06T2207/30021 , G06T2207/30101
摘要： A medical imaging device and a method for providing an image representation supporting inaccurate positioning of an intervention device in a vessel intervention procedure is proposed. Therein, an anatomy representation (AR) of a vessel region of interest and at least one angiogram X-ray image (RA) and a live fluoroscopy X-ray image (LI) are acquired. The following steps are performed when a radio-opaque device is fixedly arranged within the vessel region of interest: (a) registering the anatomy representation to the at least one angiogram X-ray image in order to provide an anatomy-angiogram-registration (R1); (b) processing (DP) the at least one angiogram X-ray image and the at least one live fluoroscopy X-ray image in order to identify in each of the X-ray images the radio-opaque device; (c) registering (R2) the at least one angiogram X-ray image to the at least one live fluoroscopy X-ray image based on the identified radio-opaque device in order to provide an angiogram-fluoroscopy-registration; and (d) combining the anatomy-angiogram-registration and the angiogram-fluoroscopy-registration in order to provide an anatomy-fluoroscopy-registration (GTC; RALC). Finally, an image representation resulting from the anatomy-fluoroscopy-registration showing an overlay of live images with the anatomy representation may be output thereby helping a surgeon to accurately position for example a synthetic aortic valve within an aortic root of a heart.
摘要翻译：提出了一种医疗成像装置和用于在血管干预程序中提供支持干预装置的不准确定位的图像表示的方法。其中，获取血管区域的解剖学表示（AR）和至少一个血管造影X射线图像（RA）和活体荧光透视X射线图像（LI）。当无线电不透明设备固定地布置在感兴趣的血管区域内时，执行以下步骤：（a）将解剖学表现注册到至少一个血管造影X射线图像，以便提供解剖 - 血管造影记录（R1 ）; （b）处理（DP）所述至少一个血管造影X射线图像和所述至少一个活体荧光透视X射线图像，以便在每个所述X射线图像中识别所述不透射线装置; （c）基于所识别的不透射线的装置将所述至少一个血管造影X射线图像记录（R2）到所述至少一个活透视X射线图像，以提供血管造影荧光透视注册; 并且（d）结合解剖 - 血管造影照明和血管造影 - 荧光透视注册，以提供解剖 - 透视注册（GTC; RALC）。最后，可以输出从解剖学 - 透视检查对照中产生的图像表示，其显示具有解剖学表示的活体图像的叠加，从而帮助外科医生准确地将合成的主动脉瓣置于心脏的主动脉根部内。

49. 发明授权

US08498463B2 Mask construction for cardiac subtraction 有权
标题翻译：心脏减量的面罩构造
公开(公告)号：US08498463B2
公开(公告)日：2013-07-30
申请号：US13058205
申请日：2009-08-06
申请人： Raoul Florent , Vincent Maurice Andre Auvray , Odile Bonnefous
发明人： Raoul Florent , Vincent Maurice Andre Auvray , Odile Bonnefous
IPC分类号： G06K9/00
CPC分类号： A61B6/504 , A61B6/481 , A61B6/484 , A61B6/507 , A61B6/5264
摘要： To provide an improved method for achieving DSA images where the effect of residual motions in cardiac DSA during the perfusion phase is reduced and in order to display subtracted images containing less motion artefacts, a method of performing digital subtraction angiography DSA in an imaging apparatus comprises the steps of generating a first image sequence of mask images (10) of a subject to be examined, generating at least one first contrast image (22) at a first phase (16) whereby in the first contrast image part of the subject has a different contrast than in said first image sequence, subtracting the mask images (10) from the at least one first contrast image (22) generating a first DSA image sequence (24), subtracting the DSA images of the first DSA image sequence (24) from the first contrast image (22) within the first phase (16) generating a sequence of extended mask images (32); generating a second contrast image (34) with the imaging system at a second phase (18), said second phase (18) being separated from the first phase (16) by a predetermined phase dividing time limit (20), subtracting the images of the sequence of the extended mask images (32) from the second contrast image (34) generating a second DSA image sequence (38), displaying the second DSA image sequence (38) on a display (28).
摘要翻译：为了提供一种用于实现DSA图像的改进方法，其中在灌注阶段期间心脏DSA中的残留运动的影响减小，并且为了显示包含较少运动伪影的减影图像，在成像设备中执行数字减影血管造影DSA的方法包括产生待检查对象的掩模图像（10）的第一图像序列的步骤，在第一阶段（16）产生至少一个第一对比图像（22），由此在对象的第一对比图像部分中具有不同的与所述第一图像序列相比，从产生第一DSA图像序列（24）的至少一个第一对比图像（22）中减去掩模图像（10），从第一DSA图像序列（24）的DSA图像中减去第一DSA图像序列第一相位（16）内的第一对比度图像（22）产生延伸的掩模图像序列（32）; 在第二阶段（18）产生具有成像系统的第二对比度图像（34），所述第二相位（18）与预定的相位分割时间限制（20）从第一相位（16）分离，减去图像来自第二对比度图像（34）的扩展掩模图像（32）的序列生成第二DSA图像序列（38），在显示器（28）上显示第二DSA图像序列（38）。

50. 发明申请

US20130116551A1 3D-ORIGINATED CARDIAC ROADMAPPING 有权
标题翻译： 3D原版CARDIAC ROADMAPPING
公开(公告)号：US20130116551A1
公开(公告)日：2013-05-09
申请号：US13810292
申请日：2011-07-15
申请人： Raoul Florent , Vincent Auvray , Michael Grass , Dirk Schaefer , Gert Schoonenberg
发明人： Raoul Florent , Vincent Auvray , Michael Grass , Dirk Schaefer , Gert Schoonenberg
IPC分类号： A61B6/02
CPC分类号： A61B6/022 , A61B6/12 , A61B6/4441 , A61B6/463 , A61B6/487 , A61B6/504 , A61B6/5223 , A61B6/5235 , A61B2090/364 , A61B2090/367
摘要： The present invention relates to 3D-originated cardiac roadmapping. In order to improve the accuracy of the information provided to the user as navigation information, without any additional burden to the patient such as additional X-ray dose, a method is described comprising the steps of a) providing 3D+t image data of a vascular structure of an object; b) acquiring two-dimensional image data of the object, which object comprises the vascular structure, the 2D image data comprising at least one 2D image; c) projecting the vascular structure, thereby generating a plurality of mask images on the basis of a 3D+t image data; d) registering the at least one 2D image with one of the plurality of the mask images, wherein the registration comprises finding the maximum of a similarity factor between the mask images and the at least one 2D image; e) generating a combination of the at least one 2D image and a projection of the vascular structure on the basis of the 3D+t image data according to the registration; and f) displaying the combination as a guiding vessel tree projection. Thus improved cardiac roadmapping in form of a topographical roadmapping is provided since the roadmapping is based on three-dimensional data.
摘要翻译：本发明涉及3D起源的心脏路线图。为了提高作为导航信息提供给用户的信息的准确性，对病人没有任何额外的负担，例如额外的X射线剂量，描述了一种方法，其包括以下步骤：a）提供一个物体的血管结构; b）获取所述对象的二维图像数据，所述对象包括所述血管结构，所述2D图像数据包括至少一个2D图像; c）投影血管结构，从而基于3D + t图像数据生成多个掩模图像; d）使用所述多个掩模图像之一登记所述至少一个2D图像，其中所述注册包括找到所述掩模图像与所述至少一个2D图像之间的相似性因子的最大值; e）根据所述注册，基于所述3D + t图像数据生成所述至少一个2D图像和所述血管结构的投影的组合; 以及f）将组合显示为引导血管树投影。因此，由于路线图基于三维数据，所以提供了形成路面图的形式的改进的心脏路线图。

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