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1. 发明授权

US08428220B2 Dynamical visualization of coronary vessels and myocardial perfusion information 有权
标题翻译：冠状动脉血管和心肌灌注信息的动态观察
公开(公告)号：US08428220B2
公开(公告)日：2013-04-23
申请号：US13057772
申请日：2009-08-06
申请人： Antonius Johannes Cornelius Buijns , Peter Maria Johannes Rongen , Vincent Maurice Andre Auvray , Odile Bonnefous , Raoul Florent
发明人： Antonius Johannes Cornelius Buijns , Peter Maria Johannes Rongen , Vincent Maurice Andre Auvray , Odile Bonnefous , Raoul Florent
IPC分类号： H05G1/64
CPC分类号： A61B6/504 , A61B6/463 , A61B6/464 , A61B6/481 , A61B6/503 , A61B6/507 , A61B6/5217 , A61B6/5235 , A61B6/5264 , A61B6/541
摘要： A method for dynamically visualizing coronary information and an apparatus adapted to implement such method is described. In a preferred embodiment of the method, first dynamic cardiac data is acquired during a first cardiac stage and second dynamic cardiac data is acquired during a second cardiac stage. Then, the two data sets are visualized continuously the in a superimposed presentation, wherein the first cardiac data and the second cardiac data corresponding to a same phase within the cardiac cycle are visualized simultaneously. In this way for example information about the vessel geometry may be immediately linked with information about the muscle irrigation or perfusion. Furthermore, this useful information may be displayed in a high-contrasted and low-noise presentation.
摘要翻译：描述了用于动态可视化冠状动脉信息的方法和适于实现这种方法的装置。在该方法的优选实施例中，在第一心脏阶段期间获取第一动态心脏数据，并且在第二心脏阶段期间获取第二动态心脏数据。然后，以叠加的呈现连续显示两个数据集，其中与心脏周期内的相同相位相对应的第一心脏数据和第二心脏数据被同时显现。以这种方式，例如关于血管几何的信息可以立即与关于肌肉灌注或灌注的信息相关联。此外，该有用信息可以以高对比度和低噪声的呈现来显示。

2. 发明授权

US08498463B2 Mask construction for cardiac subtraction 有权
标题翻译：心脏减量的面罩构造
公开(公告)号：US08498463B2
公开(公告)日：2013-07-30
申请号：US13058205
申请日：2009-08-06
申请人： Raoul Florent , Vincent Maurice Andre Auvray , Odile Bonnefous
发明人： Raoul Florent , Vincent Maurice Andre Auvray , Odile Bonnefous
IPC分类号： G06K9/00
CPC分类号： A61B6/504 , A61B6/481 , A61B6/484 , A61B6/507 , A61B6/5264
摘要： To provide an improved method for achieving DSA images where the effect of residual motions in cardiac DSA during the perfusion phase is reduced and in order to display subtracted images containing less motion artefacts, a method of performing digital subtraction angiography DSA in an imaging apparatus comprises the steps of generating a first image sequence of mask images (10) of a subject to be examined, generating at least one first contrast image (22) at a first phase (16) whereby in the first contrast image part of the subject has a different contrast than in said first image sequence, subtracting the mask images (10) from the at least one first contrast image (22) generating a first DSA image sequence (24), subtracting the DSA images of the first DSA image sequence (24) from the first contrast image (22) within the first phase (16) generating a sequence of extended mask images (32); generating a second contrast image (34) with the imaging system at a second phase (18), said second phase (18) being separated from the first phase (16) by a predetermined phase dividing time limit (20), subtracting the images of the sequence of the extended mask images (32) from the second contrast image (34) generating a second DSA image sequence (38), displaying the second DSA image sequence (38) on a display (28).
摘要翻译：为了提供一种用于实现DSA图像的改进方法，其中在灌注阶段期间心脏DSA中的残留运动的影响减小，并且为了显示包含较少运动伪影的减影图像，在成像设备中执行数字减影血管造影DSA的方法包括产生待检查对象的掩模图像（10）的第一图像序列的步骤，在第一阶段（16）产生至少一个第一对比图像（22），由此在对象的第一对比图像部分中具有不同的与所述第一图像序列相比，从产生第一DSA图像序列（24）的至少一个第一对比图像（22）中减去掩模图像（10），从第一DSA图像序列（24）的DSA图像中减去第一DSA图像序列第一相位（16）内的第一对比度图像（22）产生延伸的掩模图像序列（32）; 在第二阶段（18）产生具有成像系统的第二对比度图像（34），所述第二相位（18）与预定的相位分割时间限制（20）从第一相位（16）分离，减去图像来自第二对比度图像（34）的扩展掩模图像（32）的序列生成第二DSA图像序列（38），在显示器（28）上显示第二DSA图像序列（38）。

3. 发明申请

US20110305378A1 MASK CONSTRUCTION FOR CARDIAC SUBTRACTION 有权
标题翻译：用于心脏吸收的掩蔽结构
公开(公告)号：US20110305378A1
公开(公告)日：2011-12-15
申请号：US13058205
申请日：2009-08-06
申请人： Raoul Florent , Vincent Maurice Andre Auvray , Odile Bonnefous
发明人： Raoul Florent , Vincent Maurice Andre Auvray , Odile Bonnefous
IPC分类号： G06K9/00
CPC分类号： A61B6/504 , A61B6/481 , A61B6/484 , A61B6/507 , A61B6/5264
摘要： To provide an improved method for achieving DSA images where the effect of residual motions in cardiac DSA during the perfusion phase is reduced and in order to display subtracted images containing less motion artefacts, a method of performing digital subtraction angiography DSA in an imaging apparatus comprises the steps of generating a first image sequence of mask images (10) of a subject to be examined, generating at least one first contrast image (22) at a first phase (16) whereby in the first contrast image part of the subject has a different contrast than in said first image sequence, subtracting the mask images (10) from the at least one first contrast image (22) generating a first DSA image sequence (24), subtracting the DSA images of the first DSA image sequence (24) from the first contrast image (22) within the first phase (16) generating a sequence of extended mask images (32); generating a second contrast image (34) with the imaging system at a second phase (18), said second phase (18) being separated from the first phase (16) by a predetermined phase dividing time limit (20), subtracting the images of the sequence of the extended mask images (32) from the second contrast image (34) generating a second DSA image sequence (38), displaying the second DSA image sequence (38) on a display (28).
摘要翻译：为了提供一种用于实现DSA图像的改进方法，其中在灌注阶段期间心脏DSA中的残留运动的影响减小，并且为了显示包含较少运动伪影的减影图像，在成像设备中执行数字减影血管造影DSA的方法包括产生待检查对象的掩模图像（10）的第一图像序列的步骤，在第一阶段（16）产生至少一个第一对比图像（22），由此在对象的第一对比图像部分中具有不同的与所述第一图像序列相比，从产生第一DSA图像序列（24）的至少一个第一对比图像（22）中减去掩模图像（10），从第一DSA图像序列（24）的DSA图像中减去第一DSA图像序列第一相位（16）内的第一对比度图像（22）产生延伸的掩模图像序列（32）; 在第二阶段（18）产生具有成像系统的第二对比度图像（34），所述第二相位（18）与预定的相位分割时间限制（20）从第一相位（16）分离，减去图像来自第二对比度图像（34）的扩展掩模图像（32）的序列生成第二DSA图像序列（38），在显示器（28）上显示第二DSA图像序列（38）。

4. 发明申请

US20110135064A1 DYNAMICAL VISUALIZATION OF CORONARY VESSELS AND MYOCARDIAL PERFUSION INFORMATION 有权
标题翻译：冠状动脉和心肌灌注信息的动态可视化
公开(公告)号：US20110135064A1
公开(公告)日：2011-06-09
申请号：US13057772
申请日：2009-08-06
申请人： Antonius Johannes Cornelius Buijns , Peter Maria Johannes Rongen , Vincent Maurice Andre Auvray , Odile Bonnefous , Raoul Florent
发明人： Antonius Johannes Cornelius Buijns , Peter Maria Johannes Rongen , Vincent Maurice Andre Auvray , Odile Bonnefous , Raoul Florent
IPC分类号： H05G1/64
CPC分类号： A61B6/504 , A61B6/463 , A61B6/464 , A61B6/481 , A61B6/503 , A61B6/507 , A61B6/5217 , A61B6/5235 , A61B6/5264 , A61B6/541
摘要： A method for dynamically visualizing coronary information and an apparatus adapted to implement such method is described. In a preferred embodiment of the method, first dynamic cardiac data is acquired during a first cardiac stage and second dynamic cardiac data is acquired during a second cardiac stage. Then, the two data sets are visualized continuously the in a superimposed presentation, wherein the first cardiac data and the second cardiac data corresponding to a same phase within the cardiac cycle are visualized simultaneously. In this way for example information about the vessel geometry may be immediately linked with information about the muscle irrigation or perfusion. Furthermore, this useful information may be displayed in a high-contrasted and low-noise presentation.
摘要翻译：描述了用于动态可视化冠状动脉信息的方法和适于实现这种方法的装置。在该方法的优选实施例中，在第一心脏阶段期间获取第一动态心脏数据，并且在第二心脏阶段期间获取第二动态心脏数据。然后，以叠加的呈现连续显示两个数据集，其中与心脏周期内的相同相位相对应的第一心脏数据和第二心脏数据被同时显现。以这种方式，例如关于血管几何的信息可以立即与关于肌肉灌注或灌注的信息相关联。此外，该有用信息可以以高对比度和低噪声的呈现来显示。

5. 发明申请

US20110317881A1 FLOW SOUND IN X-RAY EXAMINATION 审中-公开
标题翻译： X射线检查中的流声
公开(公告)号：US20110317881A1
公开(公告)日：2011-12-29
申请号：US13139322
申请日：2009-12-07
申请人： Odile Bonnefous , Raoul Florent , Vincent Maurice André Auvray
发明人： Odile Bonnefous , Raoul Florent , Vincent Maurice André Auvray
IPC分类号： G06K9/00 , G08B3/00 , G06K9/32
CPC分类号： A61B6/504 , A61B6/463 , A61B6/481 , A61B6/507 , G06T7/30 , G06T2207/10116 , G06T2207/20224 , G06T2207/30104 , G10H1/0008 , G10H2220/371
摘要： The invention relates to the representation of blood flow-related information using an X-ray image acquisition device. In order to provide an improved method in an X-ray imaging system for representing the blood flow, for vessel analysis purposes for example, a device and a method are provided where X-ray images are used to determine the spatial distribution of blood velocity. Using this information it is possible to artificially synthesize a sound defined by the visual spectrum determined by the velocity distribution. Providing sound information based on X-ray imaging technique allows cardiologists and neurologists, for example, an enhanced way of evaluating vascular lesions and a better control on quality of resulting blood flow.
摘要翻译：本发明涉及使用X射线图像获取装置的血流相关信息的表示。为了提供用于表示血流的X射线成像系统中的改进方法，例如，为了容器分析目的，提供了一种装置和方法，其中使用X射线图像来确定血液速度的空间分布。使用该信息可以人为地合成由速度分布确定的视觉谱定义的声音。提供基于X射线成像技术的声音信息可以使心脏病专家和神经科医师，例如，增强评估血管病变的方法，并更好地控制血液流动的质量。

6. 发明授权

US10932739B2 Dynamic normalization of data for perfusion comparison and quantification 有权
公开(公告)号：US10932739B2
公开(公告)日：2021-03-02
申请号：US14004195
申请日：2012-02-28
申请人： Raoul Florent , Cecile Dufour , Vincent Auvray , Odile Bonnefous
发明人： Raoul Florent , Cecile Dufour , Vincent Auvray , Odile Bonnefous
IPC分类号： A61B6/00 , G06T7/00 , A61B6/12 , G06T5/50 , G06T5/00
摘要： The invention relates to x-ray imaging technology as well as image post-processing. Particularly, the present invention relates to post-processing of perfusion image data acquired by an x-ray imaging apparatus by absolutely or relatively normalizing perfusion image data to allow a preferred comparison of the image data, both with regard to different acquisitions as well as different patients. To allow normalization of perfusion image data, it may be desirable to know the amount of contrast agent injected, which remains in a coronary. Subsequently, image parameters may be adapted or normalized based on the known amount of contrast agent within the coronary for normalization of perfusion image data. To obtain a precise amount of injected contrast agent, the injected volume of contrast agent flowing through a defined region or section of a vessel may be estimated. Said injected volume of contrast agent may thus be deduced from the estimation of the total volume flow at this location. Accordingly, a method (10) is provided for dynamic normalization of data for perfusion comparison and quantification, comprising the steps of determining (20) a total volume flow or an amount of a contrast agent in a blood vessel and normalizing (34) perfusion data based on the determined total volume flow or amount of contrast agent.

7. 发明申请

US20140005538A1 DYNAMIC NORMALIZATION OF DATA FOR PERFUSION COMPARISON AD QUANTIFICATION 审中-公开
标题翻译：用于灌注比较的AD数据的数据的动态正规化（DYNAMIC NORMALIZATION OF DATA FOR PERFUSION COMPARISON AD QUANTIFICATION）
公开(公告)号：US20140005538A1
公开(公告)日：2014-01-02
申请号：US14004195
申请日：2012-02-28
申请人： Raoul Florent , Cecile Dufour , Vincent Auvray , Odile Bonnefous
发明人： Raoul Florent , Cecile Dufour , Vincent Auvray , Odile Bonnefous
IPC分类号： A61B6/00
CPC分类号： A61B6/481 , A61B6/12 , A61B6/4441 , A61B6/464 , A61B6/486 , A61B6/503 , A61B6/504 , A61B6/507 , A61B6/5217 , A61B6/5235 , A61B6/583 , G06T5/008 , G06T5/50 , G06T7/0012 , G06T2207/10116 , G06T2207/30104
摘要： The invention relates to x-ray imaging technology as well as image post-processing. Particularly, the present invention relates to post-processing of perfusion image data acquired by an x-ray imaging apparatus by absolutely or relatively normalizing perfusion image data to allow a preferred comparison of the image data, both with regard to different acquisitions as well as different patients. To allow normalization of perfusion image data, it may be desirable to know the amount of contrast agent injected, which remains in a coronary. Subsequently, image parameters may be adapted or normalized based on the known amount of contrast agent within the coronary for normalization of perfusion image data. To obtain a precise amount of injected contrast agent, the injected volume of contrast agent flowing through a defined region or section of a vessel may be estimated. Said injected volume of contrast agent may thus be deduced from the estimation of the total volume flow at this location. Accordingly, a method (10) is provided for dynamic normalization of data for perfusion comparison and quantification, comprising the steps of determining (20) a total volume flow or an amount of a contrast agent in a blood vessel and normalizing (34) perfusion data based on the determined total volume flow or amount of contrast agent.
摘要翻译：本发明涉及X射线成像技术以及图像后处理。特别地，本发明涉及通过绝对或相对规范化灌注图像数据来获得的由X射线成像设备获取的灌注图像数据的后处理，以允许针对不同采集以及不同的采集的图像数据的优选比较耐心。为了允许灌注图像数据的归一化，可能需要知道留在冠状动脉中的造影剂的注入量。随后，可以基于冠状动脉内的已知量的造影剂来调整或归一化图像参数，以用于灌注图像数据的归一化。为了获得精确量的注射造影剂，可以估计流过容器的限定区域或部分的造影剂的注射体积。因此，可以从该位置处的总体积流量的估计推断所述注射量的造影剂。因此，提供了一种用于动态规范用于灌注比较和定量的数据的方法（10），包括以下步骤：确定（20）血管中的总体积流量或造影剂的量并使（34）灌注数据基于确定的总体积流量或造影剂的量。

8. 发明申请

US20080167554A1 Method and Device For Determining the Motion Vector of Tissues in a Biological Medium 有权
标题翻译：用于确定生物介质中组织运动载体的方法和装置
公开(公告)号：US20080167554A1
公开(公告)日：2008-07-10
申请号：US11814087
申请日：2006-01-18
申请人： Odile Bonnefous
发明人： Odile Bonnefous
IPC分类号： A61B8/08
CPC分类号： A61B8/08 , A61B8/0883 , A61B8/488 , Y10S128/916
摘要： The invention relates to a method of determining the motion vector of tissues in a biological medium. This method comprises the steps of:—acquiring a sequence of echographical images at a given repetition rate,—digitalising said echographical images and storing the so-digitalised images,—defining a digital pseudo echographical pulse,—effecting in a plurality of directions a convolution of said digital pseudo echographical pulse with said digitalised images and deducing therefrom at each point of said medium a plurality of pseudo echographical signals associated with said plurality of directions,—determining an estimate over said plurality of directions of the phase shift between two successive pseudo echographical signals and deducing therefrom the magnitude and the direction of said motion vector.
摘要翻译：本发明涉及确定生物培养基中组织的运动矢量的方法。该方法包括以下步骤： - 以给定的重复率获取一系列回波图像， - 对所述回波图像进行数字化并存储所述数字化图像，定义数字伪回波脉冲， - 在多个方向上影响卷积所述数字伪回波脉冲与所述数字化图像一起从所述介质的每个点处推导出与所述多个方向相关联的多个伪回波信号，确定在两个连续的伪超声波相位之间的相移的所述多个方向上的估计信号并从其推导出所述运动矢量的大小和方向。

9. 发明授权

US07347820B2 Phased array acoustic system for 3D imaging of moving parts 失效
标题翻译：用于运动部件3D成像的相控阵声学系统
公开(公告)号：US07347820B2
公开(公告)日：2008-03-25
申请号：US10533029
申请日：2003-10-31
申请人： Odile Bonnefous
发明人： Odile Bonnefous
IPC分类号： A61B8/00
CPC分类号： G01S15/8925 , A61B8/483 , G01S7/52038 , G01S7/5206 , G01S7/52068 , G01S7/52071 , G01S7/52073 , G01S7/52095 , G01S15/8981 , G01S15/8993
摘要： The invention relates to an ultrasound phased array imaging system comprising: probe (10) with a 2-D array of transducer elements (12) for acquiring 3-D ultrasound data of a volume of a body, including moving tissue and fluid flow; a beamforming system (10, 12, 14, 16) for emitting and receiving in real time ultrasound beams in said volume, which provides, in real time and in 3-D, more than one spatial receive beams signals for each transmission beam within an ensemble length of more than two temporal samples, among which the receive flow beam signals and the receive tissue beam signals are substantially temporally uncorrelated but spatially correlated; separation means (30) for processing in real time the receive beams signals, comprising adaptive spatial tissue filtering means using simultaneously more than one spatial receive beam signals acquired in 3-D within the ensemble length of more than two temporal samples, which separation means analyzes temporal variations of the respective successive receive signals and extracts flow receive beam signals from spatial combinations of receive beam signals; processing means (40, 50) and display means (62, 60) for processing flow Doppler signals and for displaying images based on said processed flow Doppler signals.
摘要翻译：本发明涉及一种超声相控阵成像系统，包括：具有用于获取身体体积的三维超声数据的换能器元件（2D）的二维阵列的探针（10），包括运动的组织和流体流动; 波束形成系统（10,12,14,16），用于在所述体积中实时地发射和接收超声波束，其实时地和三维地提供多于一个空间接收波束的信号，每个发射波束在一个多于两个时间样本的集合长度，其中接收流束信号和接收组织束信号基本上在时间上不相关但在空间上相关; 分离装置（30），用于实时处理接收波束信号，所述接收波束信号包括自适应空间组织滤波装置，所述自适应空间组织滤波装置同时使用在多于两个时间样本的整体长度内的3-D中获取的多于一个的空间接收波束信号，各个连续接收信号的时间变化，并从接收波束信号的空间组合中提取流接收波束信号; 处理装置（40,50）和显示装置（62,60），用于处理流动多普勒信号并用于基于所述处理的流量多普勒信号显示图像。

10. 发明授权

US06647135B2 Ultrasonic image processing method and system for displaying a composite image sequence of an artery segment 失效
标题翻译：用于显示动脉段的复合图像序列的超声图像处理方法和系统
公开(公告)号：US06647135B2
公开(公告)日：2003-11-11
申请号：US09732195
申请日：2000-12-07
申请人： Odile Bonnefous
发明人： Odile Bonnefous
IPC分类号： G06K900
CPC分类号： G01S15/8979 , A61B8/06 , A61B8/13 , G01S7/52073 , G01S7/52074 , Y10S128/916
摘要： The invention concerns an ultrasonic image processing method for displaying a composite sequence of images of an artery segment with indication of blood flow velocity and wall movements in function of the cardiac cycle, comprising steps of: forming, at a first rate, a first sequence (131) of blood flow velocity color-coded images and forming, at a second rate, a second sequence (231) of images with wall movement graphics; and constructing said composite image sequence (361) by determining a first set of temporal markers (n1,n2), related to the cardiac cycle, in the first image sequence as the minimum points of a curve (P(n)) of the number of the colored points per image in function of the image instants, determining a second set of temporal markers (k1,k2), related to the same cardiac cycle, in the second image sequence as the minimum points of a curve (D(k)) of the arterial mean dilation in function of the image instants, and by superposing the first and second image sequences by synchronizing the respective markers of said two sets, and displaying the composite image sequence. The invention also relates to an ultrasonic examination imaging system carrying out said method.
摘要翻译：本发明涉及一种超声波图像处理方法，用于显示具有心动周期功能的血流速度和壁运动指示的动脉段的复合序列，包括以下步骤：以第一速率形成第一序列（ 131）和以第二速率形成具有壁移动图形的图像的第二序列（231）;以及通过确定第一组时间标记（n1）来构建所述复合图像序列（361），n2）与第一图像序列相关，作为图像时间函数中每个图像的着色点的数量的曲线（P（n））的最小点，确定第二组时间在第二图像序列中与相同心动周期相关的标记（k1，k2）作为图像时间函数的动脉平均扩张的曲线（D（k））的最小点，并且通过将第一和第二个图像序列同步对所述两组的各个标记进行分组，并显示合成图像序列。本发明还涉及执行所述方法的超声波检查成像系统。

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