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    • 41. 发明授权
    • &agr;-sulfenimino acid derivatives
    • α-亚磺酰亚氨基酸衍生物
    • US06479550B1
    • 2002-11-12
    • US09906374
    • 2001-07-16
    • André JeanguenatMartin ZellerHugo Ziegler
    • André JeanguenatMartin ZellerHugo Ziegler
    • A61K3116
    • C07C313/20A01N37/50A01N41/00A01N41/04A01N41/06A01N41/12A01N43/10A01N43/30A01N47/34
    • &agr;-Sulfenimino acid derivatives of formula I including the optical isomers thereof and mixtures of such isomers, wherein A is cycloalkyl, cycloalkenyl, aryl or heteroaryl, each optionally substituted, B is a direct bond or optionally substituted alkylene, E is hydrogen or optionally substituted aryl, R is hydrogen, alkyl, alkenyl, alkynyl, cycloalkyl, cycloalkylalkyl, aryl or arylalkyl, each optionally substituted, and T is NH or oxygen, have been found to be useful for controlling or preventing the infestation of plants by phytopathogenic microorganisms, especially fungi. The invention relates the novel compounds and also to the preparation thereof and to the use of the compounds for plant protection, and to compositions suitable for applying the novel compounds in agricultural techniques.
    • 式I的亚磺酰亚氨基酸衍生物包括其旋光异构体和这些异构体的混合物,其中A是环烷基,环烯基,芳基或杂芳基,各自任意取代,B是直接键或任选取代的亚烷基,E是氢或任选取代的芳基, 已经发现R是氢,烷基,烯基,炔基,环烷基,环烷基烷基,芳基或芳基烷基,各自任选被取代,并且T是NH或氧,可用于通过植物病原微生物,特别是真菌来控制或防止植物侵染。 本发明涉及新化合物以及其制备方法以及该化合物用于植物保护的用途,以及适于在农业技术中施用新化合物的组合物。
    • 46. 发明授权
    • Dermopharmaceutically and cosmetically active oligopeptides
    • 药物和化妆品活性寡肽
    • US07671009B2
    • 2010-03-02
    • US10493856
    • 2002-10-30
    • Christian LudinMarc HeidlHugo Ziegler
    • Christian LudinMarc HeidlHugo Ziegler
    • A61K38/00
    • C07K14/78A61K38/00C07K5/06086
    • Oligopeptides and derivatives thereof, peptide analogs and derivatives thereof as well as pharmaceutically acceptable salts of these compounds, which correspond to general formula (I) wherein R1 represents H, —C(O)—R7, —SO2—R7, —C(O)—OR7 or —C(O)—N(R7)2 R2 represents, independent of one another, H or —(C1-C4)-alkyl, R3 and R6 represent, independent of one another, —(CH2)q—N(R1)R8 R4 and R5 represent, independent of one another, —CH2—OR2, —CH(CH3)OR8 or —CH2—CH2—OR8 R7 represents hydrogen, optionally substituted (C1-C19)-alkyl; optionally substituted (C1-C19)-alkenyl; phenyl-(C1-C4)-alkyl whose phenyl radical is optionally substituted with amino in the para position R8 represents H, —(C1-C4)-alkyl, —C(O)—R7, —C(O)—OR7, —C(O)—N(R7)2 or —SO2—R7 X represents oxygen (—O—) or —NH—; or XR7, with X=O, also represents the esters of α-tocopherol, tocotrienol or retinol or the carboxylic acid (with R7=H) m, n, p represent, independent of one another, zero or 1 and q in R3 and R6 represent, independent of one another, an integer from 1 to 4, with the provision that the following conditions do not simultaneously occur: R4=—CH(CH3)—OH and R5=—CH(CH3)—OH and R6=—(CH2)4—NH2; dermopharmaceutically and/or cosmetically active compositions containing at least one compound of formula (I).
    • 对应于通式(I)的寡肽及其衍生物,肽类似物及其衍生物以及这些化合物的药学上可接受的盐,其中R 1表示H,-C(O)-R 7,-SO 2 -R 7,-C(O )-OR 7或-C(O)-N(R 7)2 R 2彼此独立地表示H或 - (C 1 -C 4) - 烷基,R 3和R 6彼此独立地表示 - (CH 2)q - N(R 1)R 8 R 4和R 5彼此独立地表示-CH 2 OR 2,-CH(CH 3)OR 8或-CH 2 -CH 2 -OR 8 R 7表示氢,任选取代的(C 1 -C 19) - 烷基; 任选取代的(C 1 -C 19) - 烯基; 苯基 - (C 1 -C 4) - 烷基,其苯基任选被对位R8上的氨基取代,代表H, - (C1-C4) - 烷基,-C(O)-R7,-C(O)-OR7, -C(O)-N(R 7)2或-SO 2 -R 7 X表示氧(-O-)或-NH-; 或具有X = O的XR7也表示α-生育酚,生育三烯酚或视黄醇或羧酸(R7 = H)m,n,p表示彼此独立的零或1和q在R3和 R6代表彼此独立的1至4的整数,条件是不同时发生以下条件:R4 = -CH(CH3)-OH,R5 = -CH(CH3)-OH,R6 = - (CH 2)4 -NH 2; 含有至少一种式(I)化合物的药物和/或化妆品活性组合物。
    • 47. 发明申请
    • Tripeptides and derivatives thereof for cosmetic application in order to improve skin structure
    • 用于化妆品应用的三肽及其衍生物,以改善皮肤结构
    • US20070099842A1
    • 2007-05-03
    • US10555994
    • 2004-05-07
    • Hugo ZieglerMarc HeldiDominik Imfeld
    • Hugo ZieglerMarc HeldiDominik Imfeld
    • A61K38/05C07K5/08
    • C07K7/08A61K8/64A61Q19/08
    • The invention relates to compounds and to the cosmetically acceptable salts thereof, which correspond to general formula (I), wherein: R1 represents H, —C(O)—R6, —SO2—R6 or —C(O)—XR6; R2 and R4, independent of one another, represent (CH2)n—NH2 or (CH2)3—NHC(NH)NH2; n equals 1 4; R3 represents linear or branched C1-C4 alkyl that is optionally substituted by hydroxy; R5 and R6, independent of one another, represent hydrogen, optionally substituted (C1-C24) alkyl, optionally substituted C2-C24 alkenyl, optionally substituted phenyl, optionally substituted phenyl-C1-C4 alkyl or 9-fluorenyl-methyl; X represents oxygen (—O—) or —NH—; or XR5 with X=O also represents the esters of a-tocopherol, tocotrienol or retinol, with the provision that R1 and R5 do not represent hydrogen and X does not represent oxygen at the same time. The invention also relates to the production of the compounds of general formula (I) and to a cosmetically active composition that contains at least one compound of formula (I).
    • 本发明涉及对应于通式(I)的化合物及其化学上可接受的盐,其中:R 1表示H,-C(O)-R 6 O >,-SO 2 -OR 6或-C(O)-XR 6; R 2和R 4彼此独立地表示(CH 2 - )N - 2或(CH 2 2)3 -NHC(NH)NH 2; n等于1 4; R 3表示任选被羟基取代的直链或支链C 1 -C 4烷基; R 5和R 6彼此独立地表示氢,任选被取代的(C 1 -C 24 - )烷基,任选取代的C 2 -C 24链烯基,任选取代的苯基,任选取代的苯基-C 1 -C 4 - 烷基或9-芴基 - 甲基; X表示氧(-O-)或-NH-; 或XR 5,X = O也表示α-生育酚,生育三烯酚或视黄醇的酯,其条件是R 1和R 5, 不表示氢,X不同时代表氧。 本发明还涉及通式(I)的化合物的生产和含有至少一种式(I)化合物的化妆品活性组合物。
    • 48. 发明授权
    • Phenyl-methoxyimino-glyoxylic acid derivatives as pesticides
    • 苯甲氧基亚氨基 - 乙醛酸衍生物作为农药
    • US06372787B1
    • 2002-04-16
    • US09671421
    • 2000-09-27
    • Hugo ZieglerRené Zurflüh
    • Hugo ZieglerRené Zurflüh
    • C07C22940
    • C07C251/58A01N37/50C07C251/48C07C251/86C07C251/88C07C2601/02
    • Compounds of formula I wherein A is a group OCHR4 or N═CR4; Y is O or NH, R1 is C1-C6-alkyl; R2 is C1-C6-alkyl or C1-C6-alkyl substituted by 1 to 5 fluorine atoms; R3 is C1-C6-alkyl, C1-C6-alkoxy, C3-C6-cycloalkyl, C3-C6-cycloalkoxy, C2-C6-alkenyl, C2-C6-alkenyloxy, C2-C6-alkinyl, C2-C6-alkinyloxy, C1-C6-alkoxycarbonyl, CN or halogen, aryl, hetaryl, heterocyclyl, aryloxy, hetaryloxy or heterocyclyloxy, whereby the above-mentioned groups, with the exception of CN and halogen, may be substituted by the same or different substituents; R4 is methyl, ethyl or cyclopropyl; R6 is hydrogen or methyl; have microbicidal, insecticidal and acaricidal activity, and may be used to control plant-pathogenic fungi, acarids and insects in agriculture and in the field of hygiene.
    • 式I的化合物,其中A是基团OCHR 4或N = CR 4; Y是O或NH,R 1是C 1 -C 6烷基; R 2是被1至5个氟原子取代的C 1 -C 6烷基或C 1 -C 6烷基; R 3是 C 1 -C 6 - 烷基,C 1 -C 6 - 烷氧基,C 3 -C 6 - 环烷基,C 3 -C 6 - 环烷氧基,C 2 -C 6 - 烯基,C 2 -C 6 - 烯氧基,C 2 -C 6 - C 6 - 烷氧基羰基,CN或卤素,芳基,杂芳基,杂环基,芳氧基,杂芳氧基或杂环氧基,其中除CN和卤素以外的上述基团可以被相同或不同的取代基取代; R4是甲基,乙基 或环丙基; R 6为氢或甲基;具有杀菌,杀虫和杀螨活性,可用于控制农业和卫生领域的植物病原真菌,螨虫和昆虫。
    • 50. 发明授权
    • O-benzyl oxime ether derivatives and their use as pesticides
    • O-苄基肟醚衍生物及其作为农药的用途
    • US5977182A
    • 1999-11-02
    • US836176
    • 1997-05-01
    • Rene ZurfluhHugo ZieglerStephan Trah
    • Rene ZurfluhHugo ZieglerStephan Trah
    • A01C1/08A01N35/10A01N37/34A01N37/50A01N37/52A01N55/10C07C251/38C07C251/48C07C251/52C07C251/54C07C251/60C07C255/62C07C255/64C07C257/06C07C257/14C07C257/22C07C317/32C07C323/47C07C327/40C07C327/58C07D213/76C07D277/10C07D277/12C07D277/28C07D295/185C07D295/30C07D521/00A01N33/24A01N43/40
    • C07D295/185A01N37/50A01N37/52C07C251/38C07C251/48C07C255/64C07C257/06C07C257/14C07C257/22C07D295/30C07C2101/02
    • Compounds of formula (I), wherein Y is hydrogen, C.sub.1 -C.sub.4 alkyl, C.sub.1 -C.sub.4 alkoxy, OH, CN, NO.sub.2, Si(CH.sub.3).sub.3, CF.sub.3 or halogen, and T is a group (a) or (b), and wherein the remaining substituents have the following definitions: X is O, S or NR.sub.13 ; A is O or NR.sub.4 ; R.sub.1 is hydrogen, C.sub.1 -C.sub.4 alkyl, halo-C.sub.1 -C.sub.4 alkyl, cyclopropyl, C.sub.1 -C.sub.4 alkoxymethyl, C.sub.1 -C.sub.4 alkoxy, C.sub.1 -C.sub.4 alkylthio or cyano; R.sub.2 is hydrogen, C.sub.1 -C.sub.6 alkyl, C.sub.3 -C.sub.6 cycloalkyl, cyano unsubstituted or substituted C.sub.1 -C.sub.6 alkoxycarbonyl, unsubstituted or substituted di(C.sub.1 -C.sub.6 alkyl)aminocarbonyl, unsubstituted or substituted C.sub.1 -C.sub.6 alkyl-S(O).sub.q, unsubstituted or substituted aryl-S(O).sub.q, unsubstituted or substituted heteroaryl, unsubstituted or substituted heterocyclyl, unsubstituted or substituted heterocyclylcarbonyl or unsubstituted or substituted phenyl; and R.sub.3 is hydrogen, unsubstituted or substituted alkyl, unsubstituted or substituted C.sub.3 -C.sub.6 cycloalkyl, unsubstituted or substituted phenyl or unsubstituted or substituted pyridyl; and wherein the remaining substituents are as defined herein, are pesticidal active ingredients. They can be used in pest control, especially as microbicides, insecticides and acaricides in agriculture, in horticulture and in the hygiene sector. ##STR1##
    • PCT No.PCT / EP95 / 04357 Sec。 371日期1997年5月1日 102(e)日期1997年5月1日PCT提交1995年11月6日PCT公布。 公开号WO96 / 16026 日期:5月30日,式(I)的化合物,其中Y为氢,C1-C4烷基,C1-C4烷氧基,OH,CN,NO2,Si(CH3)3,CF3或卤素,T为(a)或 b),其中其余取代基具有以下定义:X是O,S或NR 13; A为O或NR4; R 1是氢,C 1 -C 4烷基,卤代C 1 -C 4烷基,环丙基,C 1 -C 4烷氧基甲基,C 1 -C 4烷氧基,C 1 -C 4烷硫基或氰基; 未取代或取代的二(C 1 -C 6烷基)氨基羰基,未取代或取代的C 1 -C 6烷基-S(O)q,未取代或取代的芳基-S(O)q,C 1 -C 6烷基,C 3 -C 6环烷基,氰基未取代或取代的C 1 -C 6烷氧基羰基, (O)q,未取代或取代的杂芳基,未取代或取代的杂环基,未取代或取代的杂环基羰基或未取代或取代的苯基; 未取代或取代的烷基,未取代或取代的C 3 -C 6环烷基,未取代或取代的苯基或未取代或取代的吡啶基; 并且其中剩余的取代基如本文所定义,是杀虫活性成分。 它们可用于病虫害防治,特别是作为农业,园艺和卫生领域的杀菌剂,杀虫剂和杀螨剂。