专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明申请

US20070099842A1 Tripeptides and derivatives thereof for cosmetic application in order to improve skin structure 有权
标题翻译：用于化妆品应用的三肽及其衍生物，以改善皮肤结构
公开(公告)号：US20070099842A1
公开(公告)日：2007-05-03
申请号：US10555994
申请日：2004-05-07
申请人： Hugo Ziegler , Marc Heldi , Dominik Imfeld
发明人： Hugo Ziegler , Marc Heldi , Dominik Imfeld
IPC分类号： A61K38/05 , C07K5/08
CPC分类号： C07K7/08 , A61K8/64 , A61Q19/08
摘要： The invention relates to compounds and to the cosmetically acceptable salts thereof, which correspond to general formula (I), wherein: R1 represents H, —C(O)—R6, —SO2—R6 or —C(O)—XR6; R2 and R4, independent of one another, represent (CH2)n—NH2 or (CH2)3—NHC(NH)NH2; n equals 1 4; R3 represents linear or branched C1-C4 alkyl that is optionally substituted by hydroxy; R5 and R6, independent of one another, represent hydrogen, optionally substituted (C1-C24) alkyl, optionally substituted C2-C24 alkenyl, optionally substituted phenyl, optionally substituted phenyl-C1-C4 alkyl or 9-fluorenyl-methyl; X represents oxygen (—O—) or —NH—; or XR5 with X=O also represents the esters of a-tocopherol, tocotrienol or retinol, with the provision that R1 and R5 do not represent hydrogen and X does not represent oxygen at the same time. The invention also relates to the production of the compounds of general formula (I) and to a cosmetically active composition that contains at least one compound of formula (I).
摘要翻译：本发明涉及对应于通式（I）的化合物及其化学上可接受的盐，其中：R 1表示H，-C（O）-R 6 O >，-SO 2 -OR 6或-C（O）-XR 6; R 2和R 4彼此独立地表示（CH 2 - ）N - 2或（CH 2 2）3 -NHC（NH）NH 2; n等于1 4; R 3表示任选被羟基取代的直链或支链C 1 -C 4烷基; R 5和R 6彼此独立地表示氢，任选被取代的（C 1 -C 24 - ）烷基，任选取代的C 2 -C 24链烯基，任选取代的苯基，任选取代的苯基-C 1 -C 4 - 烷基或9-芴基 - 甲基; X表示氧（-O-）或-NH-; 或XR 5，X = O也表示α-生育酚，生育三烯酚或视黄醇的酯，其条件是R 1和R 5，不表示氢，X不同时代表氧。本发明还涉及通式（I）的化合物的生产和含有至少一种式（I）化合物的化妆品活性组合物。

2. 发明授权

US07863417B2 Tripeptides and derivatives thereof for cosmetic application in order to improve skin structure 有权
标题翻译：用于化妆品应用的三肽及其衍生物，以改善皮肤结构
公开(公告)号：US07863417B2
公开(公告)日：2011-01-04
申请号：US10555994
申请日：2004-05-07
申请人： Hugo Ziegler , Marc Heidl , Dominik Imfeld
发明人： Hugo Ziegler , Marc Heidl , Dominik Imfeld
IPC分类号： C07K5/08
CPC分类号： C07K7/08 , A61K8/64 , A61Q19/08
摘要： The invention relates to compounds and to the cosmetically acceptable salts thereof, which correspond to general formula (I), wherein: R1 represents H, —C(O)—R6, —SO2—R6 or —C(O)—XR6; R2 and R4, independent of one another, represent (CH2)n—NH2 or (CH2)3—NHC(NH)NH2; n equals 1 4; R3 represents linear or branched C1-C4 alkyl that is optionally substituted by hydroxy; R5 and R6, independent of one another, represent hydrogen, optionally substituted (C1-C24) alkyl, optionally substituted C2-C24 alkenyl, optionally substituted phenyl, optionally substituted phenyl-C1-C4 alkyl or 9-fluorenyl-methyl; X represents oxygen (—O—) or —NH—; or XR5 with X═O also represents the esters of a-tocopherol, tocotrienol or retinol, with the provision that R1 and R5 do not represent hydrogen and X does not represent oxygen at the same time. The invention also relates to the production of the compounds of general formula (I) and to a cosmetically active composition that contains at least one compound of formula (I).
摘要翻译：本发明涉及对应于通式（I）的化合物及其化学上可接受的盐，其中：R 1表示H，-C（O）-R 6，-SO 2 -R 6或-C（O）-XR 6; R 2和R 4彼此独立地表示（CH 2）n -NH 2或（CH 2）3 -NHC（NH）NH 2; n等于1 4; R3表示任选被羟基取代的直链或支链C 1 -C 4烷基; R 5和R 6彼此独立地表示氢，任选取代的（C 1 -C 24）烷基，任选取代的C 2 -C 24烯基，任选取代的苯基，任选取代的苯基-C 1 -C 4烷基或9-芴基 - 甲基; X表示氧（-O-）或-NH-; 或具有X = O的XR5也表示α-生育酚，生育三烯酚或视黄醇的酯，其条件是R1和R5不表示氢，X不同时代表氧。本发明还涉及通式（I）的化合物的生产和含有至少一种式（I）化合物的化妆品活性组合物。

3. 发明申请

US20090155347A1 Cosmetic Composition for Stimulating the Synthesis of Proteins of the Basement Membrane 有权
标题翻译：用于刺激基底膜蛋白质合成的化妆品组合物
公开(公告)号：US20090155347A1
公开(公告)日：2009-06-18
申请号：US12226191
申请日：2006-04-28
申请人： Hugo Ziegler , Dominik Imfeld , Martin Stockli , Marc Heidl
发明人： Hugo Ziegler , Dominik Imfeld , Martin Stockli , Marc Heidl
IPC分类号： A61K9/127 , C07K5/09 , A61K38/06
CPC分类号： A61Q19/08 , A61K8/64 , C07K5/0815 , C07K5/1019
摘要： Cosmetic composition which can be applied topically, comprising at least one compound of the general formula (I) in which R1 is H, C1-C20-alkyl, cycloalkyl or aryl-C1-C4-alkyl, n is 1-4, X is —O—, —NH— or —NR2— and R2H or C1-C20-alkyl; and at least one compound corresponding to the above formula (I) but in which XR1 with X having the possible meaning of —NH— is the residue of an alpha-amino acid; use of these compounds and of the composition for stimulating the synthesis of the proteins of the basement membrane; and also both those compounds of the formula (I) in which X is —NR2— and both R1 and R2 are different from H, and the compounds corresponding to formula (I) but in which XR1 with X having the possible meaning of —NH— is the residue of an alpha-amino acid, as such.
摘要翻译：可以局部施用的化妆品组合物，其包含至少一种通式（I）的化合物，其中R 1是H，C 1 -C 20 - 烷基，环烷基或芳基-C 1 -C 4 - 烷基，n是1-4，X是 -O - ， - NH-或-NR 2 - 和R 2 H或C 1 -C 20 - 烷基; 和至少一种对应于上述式（I）的化合物，但其中具有可能含义为-NH-的X的XR1为α-氨基酸的残基; 使用这些化合物和组合物刺激基底膜的蛋白质的合成; 以及其中X为-NR 2 - 且R 1和R 2不同于H的式（I）化合物以及对应于式（I）的化合物，但其中具有可能含义为-NH的X的XR1 - 是这样的α-氨基酸的残基。

4. 发明授权

US08722852B2 Cosmetic composition for stimulating the synthesis of proteins of the basement membrane 有权
标题翻译：用于刺激基底膜蛋白质合成的化妆品组合物
公开(公告)号：US08722852B2
公开(公告)日：2014-05-13
申请号：US13614337
申请日：2012-09-13
申请人： Hugo Ziegler , Dominik Imfeld , Martin Stockli , Marc Heidl
发明人： Hugo Ziegler , Dominik Imfeld , Martin Stockli , Marc Heidl
IPC分类号： C07K5/11
CPC分类号： A61Q19/08 , A61K8/64 , C07K5/0815 , C07K5/1019
摘要： Cosmetic composition which can be applied topically, comprising at least one compound of the general formula (I) in which R1 is H, C1-C20-alkyl, cycloalkyl or aryl-C1-C4-alkyl, n is 1-4, X is —O—, —NH— or —NR2— and R2H or C1-C20-alkyl; and at least one compound corresponding to the above formula (I) but in which XR1 with X having the possible meaning of —NH— is the residue of an alpha-amino acid; use of these compounds and of the composition for stimulating the synthesis of the proteins of the basement membrane; and also both those compounds of the formula (I) in which X is —NR2— and both R1 and R2 are different from H, and the compounds corresponding to formula (I) but in which XR1 with X having the possible meaning of —NH— is the residue of an alpha-amino acid, as such.
摘要翻译：可以局部施用的化妆品组合物，其包含至少一种通式（I）的化合物，其中R 1是H，C 1 -C 20 - 烷基，环烷基或芳基-C 1 -C 4 - 烷基，n是1-4，X是 -O - ， - NH-或-NR 2 - 和R 2 H或C 1 -C 20 - 烷基; 和至少一种对应于上述式（I）的化合物，但其中具有可能含义为-NH-的X的XR1为α-氨基酸的残基; 使用这些化合物和组合物刺激基底膜的蛋白质的合成; 以及其中X为-NR 2 - 且R 1和R 2不同于H的式（I）化合物以及对应于式（I）的化合物，但其中具有可能含义为-NH的X的XR1 - 是这样的α-氨基酸的残基。

5. 发明申请

US20120094919A1 USE OF TRIPEPTIDES 审中-公开
标题翻译：使用TRIPEPTIDES
公开(公告)号：US20120094919A1
公开(公告)日：2012-04-19
申请号：US13254564
申请日：2010-03-16
申请人： Remo Gräub , Marc Heidl , Dominik Imfeld , Eike Müller , Peter Wikstroem , Hugo Ziegler
发明人： Remo Gräub , Marc Heidl , Dominik Imfeld , Eike Müller , Peter Wikstroem , Hugo Ziegler
IPC分类号： A61K8/64 , A61Q19/00
CPC分类号： A61K8/64 , A61K38/06 , A61Q1/02 , A61Q1/04 , A61Q1/10 , A61Q5/02 , A61Q5/12 , A61Q19/00 , A61Q19/06 , A61Q19/08 , A61Q19/10
摘要： The present invention relates to the use of tripeptide derivatives for tightening, firming and/or moisturizing skin. Furthermore, the invention relates to a method for stimulating the synthesis of glycosaminoglycans containing a D-glucosamine and/or N-acetyl-D-glucosamine residue and/or proteoglycans by fibroblasts and/or keratinocytes such as in particular the synthesis of Hyaluronic acid and/or of the proteoglycans Decorin and/or Lumican.
摘要翻译：本发明涉及三肽衍生物用于紧固，固紧和/或保湿皮肤的用途。此外，本发明涉及用于刺激含有D-葡糖胺和/或N-乙酰基-D-葡糖胺残基和/或蛋白聚糖的成纤维细胞和/或角质形成细胞的糖胺聚糖的合成的方法，所述方法尤其是合成透明质酸和 /或蛋白聚糖Decorin和/或Lumican。

6. 发明授权

US08420778B2 Tripeptides and derivatives thereof for cosmetic application in order to improve skin structure 有权
标题翻译：用于化妆品应用的三肽及其衍生物，以改善皮肤结构
公开(公告)号：US08420778B2
公开(公告)日：2013-04-16
申请号：US12954142
申请日：2010-11-24
申请人： Hugo Ziegler , Marc Heidl , Dominik Imfeld
发明人： Hugo Ziegler , Marc Heidl , Dominik Imfeld
IPC分类号： C07K5/08
CPC分类号： C07K7/08 , A61K8/64 , A61Q19/08
摘要： The invention relates to compounds and to the cosmetically acceptable salts thereof, which correspond to general formula (I), wherein: R1 represents H, —C(O)—R6, —SO2—R6 or —C(O)—XR6; R2 and R4, independent of one another, represent (CH2)n—NH2 or (CH2)3—NHC(NH)NH2; n equals 1 4; R3 represents linear or branched C1-C4 alkyl that is optionally substituted by hydroxy; R5 and R6, independent of one another, represent hydrogen, optionally substituted (C1-C24)alkyl, optionally substituted C2-C24 alkenyl, optionally substituted phenyl, optionally substituted phenyl-C1-C4 alkyl or 9-fluorenyl-methyl; X represents oxygen (—O—) or NH—; or XR5 with X═O also represents the esters of a-tocopherol, tocotrienol or retinol, with the provision that R1 and R5 do not represent hydrogen and X does not represent oxygen at the same time. The invention also relates to the production of the compounds of general formula (I) and to a cosmetically active composition that contains at least one compound of formula (I).
摘要翻译：本发明涉及对应于通式（I）的化合物及其化学上可接受的盐，其中：R 1表示H，-C（O）-R 6，-SO 2 -R 6或-C（O）-XR 6; R 2和R 4彼此独立地表示（CH 2）n -NH 2或（CH 2）3 -NHC（NH）NH 2; n等于1 4; R3表示任选被羟基取代的直链或支链C 1 -C 4烷基; R 5和R 6彼此独立地表示氢，任选取代的（C 1 -C 24）烷基，任选取代的C 2 -C 24烯基，任选取代的苯基，任选取代的苯基-C 1 -C 4烷基或9-芴基 - 甲基; X表示氧（-O-）或NH-; 或具有X = O的XR5也表示α-生育酚，生育三烯酚或视黄醇的酯，其条件是R1和R5不表示氢，X不同时代表氧。本发明还涉及通式（I）的化合物的生产和含有至少一种式（I）化合物的化妆品活性组合物。

7. 发明授权

US08293712B2 Cosmetic composition for stimulating the synthesis of proteins of the basement membrane 有权
标题翻译：用于刺激基底膜蛋白质合成的化妆品组合物
公开(公告)号：US08293712B2
公开(公告)日：2012-10-23
申请号：US12226191
申请日：2006-04-28
申请人： Hugo Ziegler , Dominik Imfeld , Martin Stöckli , Marc Heidl
发明人： Hugo Ziegler , Dominik Imfeld , Martin Stöckli , Marc Heidl
IPC分类号： A61K38/39 , A61K38/00 , A61K31/74
CPC分类号： A61Q19/08 , A61K8/64 , C07K5/0815 , C07K5/1019
摘要： Cosmetic composition which can be applied topically, comprising at least one compound of the general formula (I) in which R1 is H, C1-C20-alkyl, cycloalkyl or aryl-C1-C4-alkyl, n is 1-4, X is —O—, —NH— or —NR2— and R2H or C1-C20-alkyl; and at least one compound corresponding to the above formula (I) but in which XR1 with X having the possible meaning of —NH— is the residue of an alpha-amino acid; use of these compounds and of the composition for stimulating the synthesis of the proteins of the basement membrane; and also both those compounds of the formula (I) in which X is —NR2— and both R1 and R2 are different from H, and the compounds corresponding to formula (I) but in which XR1 with X having the possible meaning of —NH— is the residue of an alpha-amino acid, as such.
摘要翻译：可以局部施用的化妆品组合物，其包含至少一种通式（I）的化合物，其中R 1是H，C 1 -C 20 - 烷基，环烷基或芳基-C 1 -C 4 - 烷基，n是1-4，X是 -O - ， - NH-或-NR 2 - 和R 2 H或C 1 -C 20 - 烷基; 和至少一种对应于上述式（I）的化合物，但其中具有可能含义为-NH-的X的XR1为α-氨基酸的残基; 使用这些化合物和组合物刺激基底膜的蛋白质的合成; 以及其中X为-NR 2 - 且R 1和R 2不同于H的式（I）化合物以及对应于式（I）的化合物，但其中具有可能含义为-NH的X的XR1 - 是这样的α-氨基酸的残基。

8. 发明申请

US20110142895A1 TRIPEPTIDES AND DERIVATIVES THEREOF FOR COSMETIC APPLICATION IN ORDER TO IMPROVE SKIN STRUCTURE 有权
标题翻译：用于化妆品应用的TRIPEPTIDES及其衍生物以改善皮肤结构
公开(公告)号：US20110142895A1
公开(公告)日：2011-06-16
申请号：US12954142
申请日：2010-11-24
申请人： Hugo Ziegler , Marc Heidl , Dominik Imfeld
发明人： Hugo Ziegler , Marc Heidl , Dominik Imfeld
IPC分类号： A61K8/64 , A61Q19/08 , A61K38/06 , A61Q19/04 , A61P17/10 , A61P17/18 , A61P29/00 , A61Q19/06 , A61P31/00 , A61P17/00 , A61Q17/04 , A61K8/02 , B82Y5/00
CPC分类号： C07K7/08 , A61K8/64 , A61Q19/08
摘要： The invention relates to compounds and to the cosmetically acceptable salts thereof, which correspond to general formula (I), wherein: R1 represents H, —C(O)—R6, —SO2—R6or —C(O)—XR6; R2 and R4, independent of one another, represent (CH2)n—NH2 or (CH2)3—NHC(NH)NH2; n equals 1 4; R3 represents linear or branched C1-C4 alkyl that is optionally substituted by hydroxy; R5 and R6, independent of one another, represent hydrogen, optionally substituted (C1-C24)alkyl, optionally substituted C2-C24 alkenyl, optionally substituted phenyl, optionally substituted phenyl-C1-C4 alkyl or 9-fluorenyl-methyl; X represents oxygen (—O—) or NH—; or XR5 with X═O also represents the esters of a-tocopherol, tocotrienol or retinol, with the provision that R1 and R5 do not represent hydrogen and X does not represent oxygen at the same time. The invention also relates to the production of the compounds of general formula (I) and to a cosmetically active composition that contains at least one compound of formula (I).
摘要翻译：本发明涉及对应于通式（I）的化合物及其化学上可接受的盐，其中：R 1表示H，-C（O）-R 6，-SO 2 -R 6或-C（O）-XR 6; R 2和R 4彼此独立地表示（CH 2）n -NH 2或（CH 2）3 -NHC（NH）NH 2; n等于1 4; R3表示任选被羟基取代的直链或支链C 1 -C 4烷基; R 5和R 6彼此独立地表示氢，任选取代的（C 1 -C 24）烷基，任选取代的C 2 -C 24烯基，任选取代的苯基，任选取代的苯基-C 1 -C 4烷基或9-芴基 - 甲基; X表示氧（-O-）或NH-; 或具有X = O的XR5也表示α-生育酚，生育三烯酚或视黄醇的酯，其条件是R1和R5不表示氢，X不同时代表氧。本发明还涉及通式（I）的化合物的生产和含有至少一种式（I）化合物的化妆品活性组合物。

9. 发明申请

US20160238335A1 SILENCER DEVICE 审中-公开
标题翻译：沉默器
公开(公告)号：US20160238335A1
公开(公告)日：2016-08-18
申请号：US15040845
申请日：2016-02-10
申请人： Werner Bertschinger , Hugo Ziegler
发明人： Werner Bertschinger , Hugo Ziegler
IPC分类号： F41A21/30
CPC分类号： F41A21/30
摘要： A silencer device for a firearm has a center portion including at least two substantially semi-circular chamber partition wall elements being spaced from one another in the longitudinal direction of the center portion, a housing portion into which the center portion is introduced, wherein between the at least two substantially semi-circular chamber partition wall elements and the inner wall of the housing portion at least one chamber is formed; and a positioning portion being at least connectable to the housing portion. The at least two substantially semi-circular chamber partition wall elements respectively comprise on their outer sides at least one chamfer, which form a lateral passage for explosive gases with the inner wall of the housing portion.
摘要翻译：用于枪支的消音装置具有中心部分，该中心部分包括沿中心部分的纵向方向彼此间隔开的至少两个基本上半圆形的室隔壁元件，其中引入中心部分的壳体部分，至少两个大致半圆形的室隔壁元件和壳体部分的内壁形成至少一个室; 并且至少可连接到所述壳体部分的定位部分。所述至少两个基本上为半圆形的室隔壁元件在其外侧分别包括至少一个倒角，其形成用于爆炸性气体的外部通道与壳体部分的内壁。

10. 发明授权

US08088921B2 Method for producing 3-amidinophenylalanine derivatives 有权
标题翻译：制备3-脒基苯丙氨酸衍生物的方法
公开(公告)号：US08088921B2
公开(公告)日：2012-01-03
申请号：US12905769
申请日：2010-10-15
申请人： Hugo Ziegler , Peter Wikstroem
发明人： Hugo Ziegler , Peter Wikstroem
IPC分类号： C07D295/00 , C07D213/00
CPC分类号： C07D295/205 , C07D211/60
摘要： The present invention describes a method for the synthesis of enantiomerically pure 3-amidinophenylalanine derivatives, which are used as pharmaceutically effective urokinase inhibitors, by starting from 3-cyanophenylalanine derivatives. The methods of manufacture comprising only one synthesis step lead to new intermediates, namely 3-hydroxyamidino- and 3-amidrazonophenylalanine derivatives. These intermediates or their acetyl derivatives can be reduced into the desired 3-amidino-phenylalanine derivatives under gentle conditions (H2 or ammonium formiate, Pd/C (approx. 10%), ethanol/water, room temperature, normal pressure or also H2, Pd/C, AcOH or HCl/ethanol, 1-3 bar) in excellent yields and in an enantiomeric excess of up to 99.9%.
摘要翻译：本发明描述了通过从3-氰基苯丙氨酸衍生物开始合成用作药物有效的尿激酶抑制剂的对映体纯的3-脒基苯丙氨酸衍生物的方法。仅包含一个合成步骤的制备方法导致新的中间体，即3-羟基脒基 - 和3-酰胺基苯丙氨酸衍生物。这些中间体或其乙酰基衍生物可以在温和的条件下（H2或甲酸铵，Pd / C（约10％），乙醇/水，室温，常压或还有H2），还原成所需的3-脒基 - 苯丙氨酸衍生物， Pd / C，AcOH或HCl /乙醇，1-3巴），产率高达99.9％，对映异构体过量。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式