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41. 发明申请

US20110319765A1 ENERGETIC MODULATION OF NERVES 审中-公开
标题翻译：神经的能量调节
公开(公告)号：US20110319765A1
公开(公告)日：2011-12-29
申请号：US13228366
申请日：2011-09-08
申请人： Michael Gertner , David Perozek , Jimin Zhang , Arash Sabet
发明人： Michael Gertner , David Perozek , Jimin Zhang , Arash Sabet
IPC分类号： A61B8/00 , A61N7/00
CPC分类号： A61N7/00 , A61B6/506 , A61B8/4245 , A61B8/44 , A61B8/485 , A61B90/37 , A61B2017/00106 , A61B2018/00404 , A61B2018/00434 , A61B2018/00511 , A61B2090/374 , A61N7/02 , A61N2007/003 , A61N2007/0078 , A61N2007/0095
摘要： A system for applying focused ultrasound energy to a nerve surrounding an artery of a patient includes a piezoelectric array comprising a plurality of piezoelectric elements, a controller configured to control at least a subset of the piezoelectric elements so that at least one of the piezoelectric elements in the subset is in a signal transmitting mode, in a signal sensing mode, or both, a first platform on which the piezoelectric elements are coupled and a second platform, wherein the second platform is configured to support at least a part of the patient, a programmable generator configured to generate output power for one or more of the piezoelectric elements, and a programmable processor configured to process a signal sensed by at least one of the piezoelectric elements.
摘要翻译：将聚焦超声能量施加到患者动脉周围的神经的系统包括包括多个压电元件的压电阵列，控制器，被配置为控制压电元件的至少一个子集，使得至少一个压电元件位于所述子集处于信号传输模式，信号感测模式或两者中，所述压电元件耦合在其上的第一平台和第二平台，其中所述第二平台被配置为支撑所述患者的至少一部分，可编程发生器被配置为产生一个或多个压电元件的输出功率，以及被配置为处理由至少一个压电元件感测的信号的可编程处理器。

42. 发明申请

US20110021913A1 USE OF FOCUSED ULTRASOUND FOR VASCULAR SEALING 审中-公开
标题翻译：使用聚焦超声波进行血管密封
公开(公告)号：US20110021913A1
公开(公告)日：2011-01-27
申请号：US12896740
申请日：2010-10-01
申请人： Lee Weng , David M. Perozek , Jimin Zhang
发明人： Lee Weng , David M. Perozek , Jimin Zhang
IPC分类号： A61N7/00 , A61B8/00
CPC分类号： A61B8/4422 , A61B17/0057 , A61B2017/00504 , A61B2017/00641 , A61B2017/00907 , A61B2090/062 , A61B2090/378 , A61B2090/3904 , A61B2090/3937 , A61B2562/164 , A61N7/02 , G10K11/32 , G10K11/346
摘要： An ultrasonic applicator unit (2) is used diagnostically to locate a puncture wound (316) in an artery and then therapeutically to seal the puncture wound with high intensity focused ultrasound (HIFU). A control unit (6) coupled to the applicator unit includes a processor (74) that automates the procedure, controlling various parameters of the diagnostic and therapeutic modes, including the intensity and duration of the ultrasonic energy emitted by the applicator unit. A protective, sterile acoustic shell (4), which is intended to be used with a single patient and then discarded, is slipped over the applicator unit to protect against direct contact between the applicator unit and the patient and to maintain a sterile field at the site of the puncture. The apparatus and method are particularly applicable to sealing a puncture made when inserting a catheter into an artery or other vessel. Several different procedures are described for locating the puncture wound, including imaging the vessel in which the puncture is disposed and use of a locator rod to determine the disposition of the puncture along the longitudinal axis of the artery.
摘要翻译：超声波施加器单元（2）用于诊断性地将穿刺伤口（316）定位在动脉中，然后在治疗上定位以用高强度聚焦超声（HIFU）密封穿刺伤口。耦合到施加器单元的控制单元（6）包括处理器（74），其自动化过程，控制诊断和治疗模式的各种参数，包括施加器单元发射的超声能量的强度和持续时间。旨在与单个患者一起使用然后被丢弃的保护性无菌声学外壳（4）被滑过施用器单元以防止施用器单元和患者之间的直接接触并且保持无菌区域在穿刺部位。该装置和方法特别适用于在将导管插入动脉或其他血管时进行的穿刺的密封。描述了用于定位穿刺伤口的几种不同的程序，包括对其中设置穿刺的容器进行成像，并使用定位杆来确定沿着动脉的纵向轴线的穿刺的布置。

43. 发明授权

US07754689B2 Finger-1 peptide analogs of the TGF-β superfamily 有权
标题翻译： TGF-β的Finger-1肽类似物超家族
公开(公告)号：US07754689B2
公开(公告)日：2010-07-13
申请号：US11809383
申请日：2007-06-01
申请人： Zhijian Lu , Wei Liu , Jimin Zhang , Paul John Yaworsky , Stephane H. Olland , Christopher Todd Brown , Emily Sheng-ming Shen
发明人： Zhijian Lu , Wei Liu , Jimin Zhang , Paul John Yaworsky , Stephane H. Olland , Christopher Todd Brown , Emily Sheng-ming Shen
IPC分类号： A61K38/00 , A61K38/24 , A01N37/18 , C07K1/00 , C07K14/00 , C07H21/04
CPC分类号： C07K1/22 , A61K38/00 , C07K14/475 , C07K14/495 , C07K14/51
摘要： Members of the TGF-β superfamily and peptide fragments based on member proteins are employed to purify solutions containing member proteins or as therapeutics.
摘要翻译： TGF-和bgr的成员使用基于成员蛋白的超家族和肽片段来纯化含有成员蛋白质的溶液或作为治疗剂。

44. 发明申请

US20080051340A1 Use of proteins and peptides of the TGF-Beta superfamily for purification and therapeutic methods 有权
标题翻译：使用TGF-β超家族的蛋白质和肽进行纯化和治疗
公开(公告)号：US20080051340A1
公开(公告)日：2008-02-28
申请号：US11809383
申请日：2007-06-01
申请人： Zhijian Lu , Wei Liu , Jimin Zhang , Paul Yaworsky , Stephane Olland , Christopher Brown , Emily Sheng-ming Shen
发明人： Zhijian Lu , Wei Liu , Jimin Zhang , Paul Yaworsky , Stephane Olland , Christopher Brown , Emily Sheng-ming Shen
IPC分类号： A61K38/18 , C07K1/16 , C07K14/47 , C07K14/495 , C07K14/51
CPC分类号： C07K1/22 , A61K38/00 , C07K14/475 , C07K14/495 , C07K14/51
摘要： Members of the TGF-β superfamily and peptide fragments based on member proteins are employed to purify solutions containing member proteins or as therapeutics.
摘要翻译：使用基于成员蛋白质的TGF-β超家族成员和肽片段来纯化含有成员蛋白质的溶液或作为治疗剂。

45. 发明申请

US20050215901A1 Interface for use between medical instrumentation and a patient 审中-公开
标题翻译：医疗仪器与病人之间使用的界面
公开(公告)号：US20050215901A1
公开(公告)日：2005-09-29
申请号：US11038351
申请日：2005-01-18
申请人： Thomas Anderson , Nathan Dale , Peter Edelman , John Stiggelbout , David Perozek , Lee Weng , Jimin Zhang , Robert Hubler , Paul Leonard
发明人： Thomas Anderson , Nathan Dale , Peter Edelman , John Stiggelbout , David Perozek , Lee Weng , Jimin Zhang , Robert Hubler , Paul Leonard
IPC分类号： A61B8/00 , A61B8/12 , A61B17/22
CPC分类号： A61B8/4281 , A61B8/12 , A61B2017/2253
摘要： Disclosed herein are methods, devices, compositions, and systems for providing an interface between medical instrumentation and a patient. In various embodiments, the interface provides a sterile barrier, acoustic coupler, and thermal insulator between the patient and a medical instrument. In some embodiments, an acoustic coupler interface is used between an ultrasound instrument and a patient. In some embodiments, the acoustic coupler comprises a thermoplastic elastomer (“TPE”) and in particular oil-enhanced or gelatinous TPEs that can be used in diagnostic and therapeutic (HIFU) ultrasound procedures.
摘要翻译：本文公开了用于在医疗仪器和患者之间提供界面的方法，装置，组合物和系统。在各种实施例中，界面在患者和医疗器械之间提供无菌屏障，声耦合器和热绝缘体。在一些实施例中，在超声仪器和患者之间使用声耦合器接口。在一些实施方案中，声学耦合器包括热塑性弹性体（“TPE”），特别是可用于诊断和治疗（HIFU）超声程序的油增强或凝胶状TPE。

46. 发明公开

US20230174187A1 RATCHET-DRIVEN SELF-PROPELLED SCOOTER 审中-公开
公开(公告)号：US20230174187A1
公开(公告)日：2023-06-08
申请号：US17586788
申请日：2022-01-28
申请人： Chen Zhang , Jimin Zhang
发明人： Chen Zhang , Jimin Zhang
IPC分类号： B62K17/00 , B62M1/24
CPC分类号： B62K17/00 , B62M1/24 , A63C17/12
摘要： The invention discloses a ratchet-driven self-propelled scooter, comprising a scooter body and a transmission mechanism set on the scooter body; the invention provides a manpower self-propelled scooter with simple structure, light weight and low cost; step on a driving pedal to put a driving clamp in motion, thereby a pressing arm wheel drives a ratchet arm, then a ratchet pawl leads an axle to drive the rear traveling wheels to rotate, so that the scooter body moves; after releasing the driving pedal, the driving pedal is reset through a torsion spring, likewise repeatedly stepping to increase the driving force for the scooter body; the device possesses a complete scheme, simple structure, convenient operation, low cost, which is worthy of widespread promotion.

47. 发明授权

US09005999B2 Temperature control of chemical mechanical polishing 有权
标题翻译：化学机械抛光温度控制
公开(公告)号：US09005999B2
公开(公告)日：2015-04-14
申请号：US13539344
申请日：2012-06-30
申请人： Kun Xu , Jimin Zhang , David H. Mai , Stephen Jew , Shih-Haur Walters Shen , Zhihong Wang , Thomas H. Osterheld , Wen-Chiang Tu , Gary Ka Ho Lam , Tomohiko Kitajima
发明人： Kun Xu , Jimin Zhang , David H. Mai , Stephen Jew , Shih-Haur Walters Shen , Zhihong Wang , Thomas H. Osterheld , Wen-Chiang Tu , Gary Ka Ho Lam , Tomohiko Kitajima
IPC分类号： H01L21/00 , H01L21/302 , H01L21/304
CPC分类号： H01L21/302 , B24B37/015 , H01L21/304
摘要： Methods for chemical mechanical polishing (CMP) of semiconductor substrates, and more particularly to temperature control during such chemical mechanical polishing are provided. In one aspect, the method comprises polishing the substrate with a polishing surface during a polishing process to remove a portion of the conductive material, repeatedly monitoring a temperature of the polishing surface during the polishing process, and exposing the polishing surface to a rate quench process in response to the monitored temperature so as to achieve a target value for the monitored temperature during the polishing process.
摘要翻译：提供半导体衬底的化学机械抛光（CMP）的方法，更具体地说，涉及这种化学机械抛光时的温度控制。一方面，该方法包括在抛光过程中用抛光表面抛光衬底以去除导电材料的一部分，在抛光过程中反复监测抛光表面的温度，并将抛光表面暴露于速率骤冷过程响应于所监测的温度，以便在抛光过程中达到监测温度的目标值。

48. 发明授权

US08986211B2 Energetic modulation of nerves 有权
标题翻译：神经的能量调节
公开(公告)号：US08986211B2
公开(公告)日：2015-03-24
申请号：US13048844
申请日：2011-03-15
申请人： Michael Gertner , David Perozek , Arash Sabet , Jimin Zhang , Thomas Anderson
发明人： Michael Gertner , David Perozek , Arash Sabet , Jimin Zhang , Thomas Anderson
IPC分类号： A61B5/055 , A61B5/20 , A61B5/00 , A61B6/03 , A61B8/06 , A61N5/06 , A61N7/00 , A61N7/02 , A61B5/0225 , A61B5/026 , A61B6/00 , A61B8/08 , A61B19/00 , A61B18/00
CPC分类号： A61N7/00 , A61B5/0225 , A61B5/0263 , A61B5/055 , A61B5/201 , A61B5/412 , A61B5/4528 , A61B5/4839 , A61B5/489 , A61B5/4893 , A61B6/032 , A61B6/037 , A61B6/487 , A61B6/504 , A61B6/506 , A61B8/06 , A61B8/0841 , A61B8/0891 , A61B8/4245 , A61B8/485 , A61B8/488 , A61B90/37 , A61B2018/00404 , A61B2018/00434 , A61B2018/00511 , A61B2090/374 , A61B2090/3762 , A61B2090/378 , A61N5/0601 , A61N5/062 , A61N5/0622 , A61N7/02 , A61N2005/063 , A61N2007/0026 , A61N2007/003 , A61N2007/0078
摘要： A method to deliver focused ultrasound energy from a position outside a skin of a patient to a nerve surrounding a blood vessel, includes placing the patient on a table in a substantially flat position, moving a transducer into a position inferior to ribs, superior to an iliac crest, and lateral to a spine of the patient, maintaining the transducer at the position relative to the patient, and delivering focused ultrasound energy through the skin of the patient without traversing bone, wherein the direction of the focused ultrasound is directed from a lower torso to an upper torso of the patient.
摘要翻译：将聚焦超声能量从患者皮肤外部的位置输送到血管周围的神经的方法，包括将患者放置在基本上平坦的位置的台上，将换能器移动到低于肋的位置，优于髂嵴和患者的脊柱侧面，将换能器保持在相对于患者的位置，并且将聚焦的超声波能量穿过患者的皮肤而不穿过骨骼，其中聚焦超声波的方向指向下方躯干到患者的上身。

49. 发明授权

US08372009B2 System and method for treating a therapeutic site 有权
公开(公告)号：US08372009B2
公开(公告)日：2013-02-12
申请号：US13245703
申请日：2011-09-26
申请人： Charles Emery , Larry Augustine , Robyn Lahman , David M Perozek , Jimin Zhang
发明人： Charles Emery , Larry Augustine , Robyn Lahman , David M Perozek , Jimin Zhang
IPC分类号： A61B8/00
CPC分类号： A61B8/0833 , A61B5/026 , A61B8/0841 , A61B8/12 , A61B8/4405 , A61B8/445 , A61B17/0057 , A61B18/02 , A61B34/25 , A61B50/13 , A61B2017/00557 , A61B2017/00637 , A61B2017/00641 , A61B2090/372 , A61B2090/3784 , A61B2090/3929 , A61B2090/3958 , A61B2090/397 , A61F2/82 , A61M25/10 , A61N7/02
摘要： A targeting catheter is used to locate an arteriotomy, such as is formed during a femoral artery catheterization procedure. The targeting catheter includes one or more targeting aids, such as an inflatable balloon or sensor (e.g., Doppler or temperature sensor), to locate the arteriotomy. The targeting aid may be positioned at the arteriotomy. An ultrasonic beacon on the catheter may then be located relative to a therapeutic ultrasonic applicator (e.g., by using acoustic time-of-flight) so that the focus of ultrasonic energy from the applicator can be aligned with the arteriotomy.

50. 发明申请

US20130012839A1 SYSTEM AND METHOD FOR TREATING A THERAPEUTIC SITE 审中-公开
标题翻译：治疗疗法的系统和方法
公开(公告)号：US20130012839A1
公开(公告)日：2013-01-10
申请号：US13618361
申请日：2012-09-14
申请人： Charles Emery , Larry Augustine , Robyn Lahman , David M. Perozek , Jimin Zhang
发明人： Charles Emery , Larry Augustine , Robyn Lahman , David M. Perozek , Jimin Zhang
IPC分类号： A61N7/00
CPC分类号： A61B8/0833 , A61B5/026 , A61B8/0841 , A61B8/12 , A61B8/4405 , A61B8/445 , A61B17/0057 , A61B18/02 , A61B34/25 , A61B50/13 , A61B2017/00557 , A61B2017/00637 , A61B2017/00641 , A61B2090/372 , A61B2090/3784 , A61B2090/3929 , A61B2090/3958 , A61B2090/397 , A61F2/82 , A61M25/10 , A61N7/02
摘要： A targeting catheter is used to locate an arteriotomy, such as is formed during a femoral artery catheterization procedure. The targeting catheter includes one or more targeting aids, such as an inflatable balloon or sensor (e.g., Doppler or temperature sensor), to locate the arteriotomy. The targeting aid may be positioned at the arteriotomy. An ultrasonic beacon on the catheter may then be located relative to a therapeutic ultrasonic applicator (e.g., by using acoustic time-of-flight) so that the focus of ultrasonic energy from the applicator can be aligned with the arteriotomy.
摘要翻译：靶向导管用于定位动脉切开术，例如在股动脉插管术过程中形成的。靶向导管包括一个或多个靶向辅助器，例如可充气球囊或传感器（例如，多普勒或温度传感器），以定位动脉切开术。靶向助剂可以位于动脉切开术。然后可以相对于治疗性超声波施加器（例如，通过使用声学飞行时间）来定位导管上的超声波信标，使得来自施用器的超声能量的焦点可以与动脉切开术对准。

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