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1. 发明授权

US08277398B2 Methods and devices to target vascular targets with high intensity focused ultrasound 有权
标题翻译：用高强度聚焦超声靶向血管目标的方法和装置
公开(公告)号：US08277398B2
公开(公告)日：2012-10-02
申请号：US13026108
申请日：2011-02-11
申请人： Lee Weng , David M. Perozek , Jimin Zhang
发明人： Lee Weng , David M. Perozek , Jimin Zhang
IPC分类号： A61H1/00
CPC分类号： A61B8/4422 , A61B17/0057 , A61B2017/00504 , A61B2017/00641 , A61B2017/00907 , A61B2090/062 , A61B2090/378 , A61B2090/3904 , A61B2090/3937 , A61B2562/164 , A61N7/02 , G10K11/32 , G10K11/346
摘要： An ultrasonic applicator unit (2) is used diagnostically to locate a puncture wound (316) in an artery and then therapeutically to seal the puncture wound with high intensity focused ultrasound (HIFU). A control unit (6) coupled to the applicator unit includes a processor (74) that automates the procedure, controlling various parameters of the diagnostic and therapeutic modes, including the intensity and duration of the ultrasonic energy emitted by the applicator unit. A protective, sterile acoustic shell (4), which is intended to be used with a single patient and then discarded, is slipped over the applicator unit to protect against direct contact between the applicator unit and the patient and to maintain a sterile field at the site of the puncture. The apparatus and method are particularly applicable to sealing a puncture made when inserting a catheter into an artery or other vessel. Several different procedures are described for locating the puncture wound, including imaging the vessel in which the puncture is disposed and use of a locator rod to determine the disposition of the puncture along the longitudinal axis of the artery.
摘要翻译：超声波施加器单元（2）用于诊断性地将穿刺伤口（316）定位在动脉中，然后在治疗上定位以用高强度聚焦超声（HIFU）密封穿刺伤口。耦合到施加器单元的控制单元（6）包括处理器（74），其自动化过程，控制诊断和治疗模式的各种参数，包括施加器单元发射的超声能量的强度和持续时间。旨在与单个患者一起使用然后被丢弃的保护性无菌声学外壳（4）被滑过施用器单元以防止施用器单元和患者之间的直接接触并且保持无菌区域在穿刺部位。该装置和方法特别适用于在将导管插入动脉或其他血管时进行的穿刺的密封。描述了用于定位穿刺伤口的几种不同的程序，包括对其中设置穿刺的容器进行成像，并使用定位杆来确定沿着动脉的纵向轴线的穿刺的布置。

2. 发明申请

US20110021913A1 USE OF FOCUSED ULTRASOUND FOR VASCULAR SEALING 审中-公开
标题翻译：使用聚焦超声波进行血管密封
公开(公告)号：US20110021913A1
公开(公告)日：2011-01-27
申请号：US12896740
申请日：2010-10-01
申请人： Lee Weng , David M. Perozek , Jimin Zhang
发明人： Lee Weng , David M. Perozek , Jimin Zhang
IPC分类号： A61N7/00 , A61B8/00
CPC分类号： A61B8/4422 , A61B17/0057 , A61B2017/00504 , A61B2017/00641 , A61B2017/00907 , A61B2090/062 , A61B2090/378 , A61B2090/3904 , A61B2090/3937 , A61B2562/164 , A61N7/02 , G10K11/32 , G10K11/346
摘要： An ultrasonic applicator unit (2) is used diagnostically to locate a puncture wound (316) in an artery and then therapeutically to seal the puncture wound with high intensity focused ultrasound (HIFU). A control unit (6) coupled to the applicator unit includes a processor (74) that automates the procedure, controlling various parameters of the diagnostic and therapeutic modes, including the intensity and duration of the ultrasonic energy emitted by the applicator unit. A protective, sterile acoustic shell (4), which is intended to be used with a single patient and then discarded, is slipped over the applicator unit to protect against direct contact between the applicator unit and the patient and to maintain a sterile field at the site of the puncture. The apparatus and method are particularly applicable to sealing a puncture made when inserting a catheter into an artery or other vessel. Several different procedures are described for locating the puncture wound, including imaging the vessel in which the puncture is disposed and use of a locator rod to determine the disposition of the puncture along the longitudinal axis of the artery.
摘要翻译：超声波施加器单元（2）用于诊断性地将穿刺伤口（316）定位在动脉中，然后在治疗上定位以用高强度聚焦超声（HIFU）密封穿刺伤口。耦合到施加器单元的控制单元（6）包括处理器（74），其自动化过程，控制诊断和治疗模式的各种参数，包括施加器单元发射的超声能量的强度和持续时间。旨在与单个患者一起使用然后被丢弃的保护性无菌声学外壳（4）被滑过施用器单元以防止施用器单元和患者之间的直接接触并且保持无菌区域在穿刺部位。该装置和方法特别适用于在将导管插入动脉或其他血管时进行的穿刺的密封。描述了用于定位穿刺伤口的几种不同的程序，包括对其中设置穿刺的容器进行成像，并使用定位杆来确定沿着动脉的纵向轴线的穿刺的布置。

3. 发明申请

US20110118602A1 METHODS AND APPARATUS FOR FOCUSED ULTRASOUND APPLICATION 有权
标题翻译：聚焦超声波应用的方法与装置
公开(公告)号：US20110118602A1
公开(公告)日：2011-05-19
申请号：US13011533
申请日：2011-01-21
申请人： Lee Weng , David M. Perozek , Jimin Zhang
发明人： Lee Weng , David M. Perozek , Jimin Zhang
IPC分类号： A61N7/00 , A61B8/00
CPC分类号： A61B8/4422 , A61B17/0057 , A61B2017/00504 , A61B2017/00641 , A61B2017/00907 , A61B2090/062 , A61B2090/378 , A61B2090/3904 , A61B2090/3937 , A61B2562/164 , A61N7/02 , G10K11/32 , G10K11/346
摘要： An ultrasonic applicator unit (2) is used diagnostically to locate a puncture wound (316) in an artery and then therapeutically to seal the puncture wound with high intensity focused ultrasound (HIFU). A control unit (6) coupled to the applicator unit includes a processor (74) that automates the procedure, controlling various parameters of the diagnostic and therapeutic modes, including the intensity and duration of the ultrasonic energy emitted by the applicator unit. A protective, sterile acoustic shell (4), which is intended to be used with a single patient and then discarded, is slipped over the applicator unit to protect against direct contact between the applicator unit and the patient and to maintain a sterile field at the site of the puncture. The apparatus and method are particularly applicable to sealing a puncture made when inserting a catheter into an artery or other vessel. Several different procedures are described for locating the puncture wound, including imaging the vessel in which the puncture is disposed and use of a locator rod to determine the disposition of the puncture along the longitudinal axis of the artery.
摘要翻译：超声波施加器单元（2）用于诊断性地将穿刺伤口（316）定位在动脉中，然后在治疗上定位以用高强度聚焦超声（HIFU）密封穿刺伤口。耦合到施加器单元的控制单元（6）包括处理器（74），其自动化过程，控制诊断和治疗模式的各种参数，包括施加器单元发射的超声能量的强度和持续时间。旨在与单个患者一起使用然后被丢弃的保护性无菌声学外壳（4）被滑过施用器单元以防止施用器单元和患者之间的直接接触并且保持无菌区域在穿刺部位。该装置和方法特别适用于在将导管插入动脉或其他血管时进行的穿刺的密封。描述了用于定位穿刺伤口的几种不同的程序，包括对其中设置穿刺的容器进行成像，并使用定位杆来确定沿着动脉的纵向轴线的穿刺的布置。

4. 发明授权

US06656136B1 Use of focused ultrasound for vascular sealing 有权
标题翻译：使用聚焦超声波进行血管密封
公开(公告)号：US06656136B1
公开(公告)日：2003-12-02
申请号：US09696076
申请日：2000-10-25
申请人： Lee Weng , David M. Perozek , Jimin Zhang
发明人： Lee Weng , David M. Perozek , Jimin Zhang
IPC分类号： A61H500
CPC分类号： A61B8/4422 , A61B17/0057 , A61B2017/00504 , A61B2017/00641 , A61B2017/00907 , A61B2090/062 , A61B2090/378 , A61B2090/3904 , A61B2090/3937 , A61B2562/164 , A61N7/02 , G10K11/32 , G10K11/346
摘要： A method and system for locating a vascular opening and therapeutically sealing the wound with high intensity focused ultrasound (HIFU) is disclosed. A control unit (6) coupled to an applicator unit includes a processor (74) that automates the disclosed procedure, controlling various parameters of the diagnostic and therapeutic modes, including the intensity and duration of the ultrasonic energy emitted by the applicator unit. The disclosed method and system is and then discarded, is slipped over the particularly applicable to sealing a puncture made inserting a catheter during an interventional cardiovascular procedure.
摘要翻译：公开了一种用于定位血管开口并用高强度聚焦超声（HIFU）治疗性密封伤口的方法和系统。耦合到施加器单元的控制单元（6）包括处理器（74），其使所公开的过程自动化，控制诊断和治疗模式的各种参数，包括施加器单元发射的超声能量的强度和持续时间。所公开的方法和系统然后被丢弃，特别适用于密封在介入性心血管程序期间插入导管的穿刺。

5. 发明授权

US08622937B2 Controlled high efficiency lesion formation using high intensity ultrasound 失效
标题翻译：使用高强度超声控制高效病变形成
公开(公告)号：US08622937B2
公开(公告)日：2014-01-07
申请号：US12247969
申请日：2008-10-08
申请人： Lee Weng , David M. Perozek , Jimin Zhang
发明人： Lee Weng , David M. Perozek , Jimin Zhang
IPC分类号： A61H23/00 , A61B8/00
CPC分类号： A61N7/00 , A61B8/12 , A61B8/4281 , A61B8/445 , A61B8/546 , A61B2017/4216 , A61B2090/378 , A61N7/02 , A61N7/022 , A61N2007/0052
摘要： An ultrasound system used for both imaging and delivery high intensity ultrasound energy therapy to treatment sites and a method for treating tumors and other undesired tissue within a patient's body with an ultrasound device. The ultrasound device has an ultrasound transducer array disposed on a distal end of an elongate, relatively thin shaft. In one form of the invention, the transducer array is disposed within a liquid-filled elastomeric material that more effectively couples ultrasound energy into the tumor, that is directly contacted with the device. Using the device in a continuous wave mode, a necrotic zone of tissue having a desired size and shape (e.g., a necrotic volume selected to interrupt a blood supply to a tumor) can be created by controlling at least one of the f-number, duration, intensity, and direction of the ultrasound energy administered. This method speeds the therapy and avoids continuously pausing to enable intervening normal tissue to cool.
摘要翻译：用于成像和递送高强度超声能量治疗到治疗部位的超声系统以及用超声波装置治疗患者体内的肿瘤和其它不需要的组织的方法。超声波装置具有设置在细长相对薄的轴的远端上的超声换能器阵列。在本发明的一种形式中，换能器阵列设置在液体填充的弹性体材料内，其更有效地将超声能量耦合到与装置直接接触的肿瘤中。以连续波模式使用该装置，可以通过控制至少一个f号码，来产生具有期望大小和形状的组织的坏死区（例如，被选择用于中断向肿瘤供血的坏死体积）持续时间，强度和方向。这种方法加快了治疗速度，避免了持续暂停，从而使正常组织能够平静地冷却。

6. 发明申请

US20120108966A1 USE OF FOCUSED ULTRASOUND FOR VASCULAR SEALING 审中-公开
标题翻译：使用聚焦超声波进行血管密封
公开(公告)号：US20120108966A1
公开(公告)日：2012-05-03
申请号：US13344418
申请日：2012-01-05
申请人： Lee Weng , David M. Perozek , Jimin Zhang
发明人： Lee Weng , David M. Perozek , Jimin Zhang
IPC分类号： A61B8/00 , A61N7/00
CPC分类号： A61B8/4422 , A61B17/0057 , A61B2017/00504 , A61B2017/00641 , A61B2017/00907 , A61B2090/062 , A61B2090/378 , A61B2090/3904 , A61B2090/3937 , A61B2562/164 , A61N7/02 , G10K11/32 , G10K11/346
摘要： Methods for applying heat to a region proximate a blood vessel are disclosed. In one embodiment, a method can include generating an imaging ultrasound beam adapted to image a blood vessel target and receiving a reflection of the imaging ultrasound beam. The method can also include producing an output signal in response to the reflection of the imaging ultrasonic beam and processing the output signal to identify a location of a treatment zone proximate an outer wall of the blood vessel. Therapeutic energy can be applied to the treatment zone. In some embodiments, the therapeutic ultrasound energy beam can be moved to over-scan the treatment zone. Other methods are also disclosed.
摘要翻译：公开了向靠近血管的区域施加热量的方法。在一个实施例中，一种方法可以包括产生适于对血管靶进行成像并接收成像超声波束的反射的成像超声波束。该方法还可以包括响应于成像超声波束的反射而产生输出信号并且处理输出信号以识别靠近血管外壁的治疗区域的位置。治疗能量可以应用于治疗区域。在一些实施例中，治疗性超声能量束可以被移动以过度扫描治疗区域。还公开了其它方法。

7. 发明申请

US20120059258A1 USE OF FOCUSED ULTRASOUND FOR VASCULAR SEALING 审中-公开
标题翻译：使用聚焦超声波进行血管密封
公开(公告)号：US20120059258A1
公开(公告)日：2012-03-08
申请号：US13245689
申请日：2011-09-26
申请人： Lee Weng , David M. Perozek , Jimin Zhang
发明人： Lee Weng , David M. Perozek , Jimin Zhang
IPC分类号： A61N7/00 , A61B5/00
CPC分类号： A61B8/4422 , A61B17/0057 , A61B2017/00504 , A61B2017/00641 , A61B2017/00907 , A61B2090/062 , A61B2090/378 , A61B2090/3904 , A61B2090/3937 , A61B2562/164 , A61N7/02 , G10K11/32 , G10K11/346
摘要： An ultrasonic applicator unit (2) is used diagnostically to locate a puncture wound (316) in an artery and then therapeutically to seal the puncture wound with high intensity focused ultrasound (HIFU). A control unit (6) coupled to the applicator unit includes a processor (74) that automates the procedure, controlling various parameters of the diagnostic and therapeutic modes, including the intensity and duration of the ultrasonic energy emitted by the applicator unit. A protective, sterile acoustic shell (4), which is intended to be used with a single patient and then discarded, is slipped over the applicator unit to protect against direct contact between the applicator unit and the patient and to maintain a sterile field at the site of the puncture.
摘要翻译：超声波施加器单元（2）用于诊断性地将穿刺伤口（316）定位在动脉中，然后在治疗上定位以用高强度聚焦超声（HIFU）密封穿刺伤口。耦合到施加器单元的控制单元（6）包括处理器（74），其自动化过程，控制诊断和治疗模式的各种参数，包括施加器单元发射的超声能量的强度和持续时间。旨在与单个患者一起使用然后被丢弃的保护性无菌声学外壳（4）被滑过施用器单元以防止施用器单元和患者之间的直接接触并且保持无菌区域在穿刺部位。

8. 发明授权

US06626855B1 Controlled high efficiency lesion formation using high intensity ultrasound 失效
标题翻译：使用高强度超声控制高效病变形成
公开(公告)号：US06626855B1
公开(公告)日：2003-09-30
申请号：US09721526
申请日：2000-11-22
申请人： Lee Weng , David M. Perozek , Jimin Zhang
发明人： Lee Weng , David M. Perozek , Jimin Zhang
IPC分类号： A61N700
CPC分类号： A61N7/00 , A61B8/12 , A61B8/4281 , A61B8/445 , A61B8/546 , A61B2017/4216 , A61B2090/378 , A61N7/02 , A61N7/022 , A61N2007/0052
摘要： An ultrasound system used for both imaging and delivery high intensity ultrasound energy therapy to treatment sites and a method for treating tumors and other undesired tissue within a patient's body with an ultrasound device. The ultrasound device has an ultrasound transducer array disposed on a distal end of an elongate, relatively thin shaft. In one form of the invention, the transducer array is disposed within a liquid-filled elastomeric material that more effectively couples ultrasound energy into the tumor, that is directly contacted with the device. Using the device in a continuous wave mode, a necrotic zone of tissue having a desired size and shape (e.g., a necrotic volume selected to interrupt a blood supply to a tumor) can be created by controlling at least one of the f-number, duration, intensity, and direction of the ultrasound energy administered. This method speeds the therapy and avoids continuously pausing to enable intervening normal tissue to cool.
摘要翻译：用于成像和递送高强度超声能量治疗到治疗部位的超声系统以及用超声波装置治疗患者体内的肿瘤和其它不需要的组织的方法。超声波装置具有设置在细长相对薄的轴的远端上的超声换能器阵列。在本发明的一种形式中，换能器阵列设置在液体填充的弹性体材料内，其更有效地将超声能量耦合到与装置直接接触的肿瘤中。以连续波模式使用该装置，可以通过控制至少一个f号码，来产生具有期望大小和形状的组织的坏死区（例如，被选择用于中断向肿瘤供血的坏死体积）持续时间，强度和方向。这种方法加快了治疗速度，避免了持续暂停，从而使正常组织能够平静地冷却。

9. 发明申请

US20110178445A1 METHODS AND DEVICES TO TARGET VASCULAR TARGETS WITH HIGH INTENSITY FOCUSED ULTRASOUND 有权
标题翻译：用高强度聚焦超声波靶向血管收缩的方法和装置
公开(公告)号：US20110178445A1
公开(公告)日：2011-07-21
申请号：US13026108
申请日：2011-02-11
申请人： Lee Weng , David M. Perozek , Jimin Zhang
发明人： Lee Weng , David M. Perozek , Jimin Zhang
IPC分类号： A61N7/00
CPC分类号： A61B8/4422 , A61B17/0057 , A61B2017/00504 , A61B2017/00641 , A61B2017/00907 , A61B2090/062 , A61B2090/378 , A61B2090/3904 , A61B2090/3937 , A61B2562/164 , A61N7/02 , G10K11/32 , G10K11/346
摘要： An ultrasonic applicator unit (2) is used diagnostically to locate a puncture wound (316) in an artery and then therapeutically to seal the puncture wound with high intensity focused ultrasound (HIFU). A control unit (6) coupled to the applicator unit includes a processor (74) that automates the procedure, controlling various parameters of the diagnostic and therapeutic modes, including the intensity and duration of the ultrasonic energy emitted by the applicator unit. A protective, sterile acoustic shell (4), which is intended to be used with a single patient and then discarded, is slipped over the applicator unit to protect against direct contact between the applicator unit and the patient and to maintain a sterile field at the site of the puncture. The apparatus and method are particularly applicable to sealing a puncture made when inserting a catheter into an artery or other vessel. Several different procedures are described for locating the puncture wound, including imaging the vessel in which the puncture is disposed and use of a locator rod to determine the disposition of the puncture along the longitudinal axis of the artery.
摘要翻译：超声波施加器单元（2）用于诊断性地将穿刺伤口（316）定位在动脉中，然后在治疗上定位以用高强度聚焦超声（HIFU）密封穿刺伤口。耦合到施加器单元的控制单元（6）包括处理器（74），其自动化过程，控制诊断和治疗模式的各种参数，包括施加器单元发射的超声能量的强度和持续时间。旨在与单个患者一起使用然后被丢弃的保护性无菌声学外壳（4）被滑过施用器单元以防止施用器单元和患者之间的直接接触并且保持无菌区域在穿刺部位。该装置和方法特别适用于在将导管插入动脉或其他血管时进行的穿刺的密封。描述了用于定位穿刺伤口的几种不同的程序，包括对其中设置穿刺的容器进行成像，并使用定位杆来确定沿着动脉的纵向轴线的穿刺的布置。

10. 发明申请

US20110066085A1 FORMATION OF ULTRASOUND BASED HEATING REGIONS ADJACENT BLOOD VESSELS 审中-公开
标题翻译：形成超声波加热区域邻近血液容器
公开(公告)号：US20110066085A1
公开(公告)日：2011-03-17
申请号：US12951850
申请日：2010-11-22
申请人： Lee Weng , David M. Perozek , Jimin Zhang
发明人： Lee Weng , David M. Perozek , Jimin Zhang
IPC分类号： A61N7/00
CPC分类号： A61N7/00 , A61B8/12 , A61B8/4281 , A61B8/445 , A61B8/546 , A61B2017/4216 , A61B2090/378 , A61N7/02 , A61N7/022 , A61N2007/0052
摘要： An ultrasound system used for both imaging and delivery high intensity ultrasound energy therapy to treatment sites and a method for treating tumors and other undesired tissue within a patient's body with an ultrasound device. The ultrasound device has an ultrasound transducer array disposed on a distal end of an elongate, relatively thin shaft. In one form of the invention, the transducer array is disposed within a liquid-filled elastomeric material that more effectively couples ultrasound energy into the tumor, that is directly contacted with the device. Using the device in a continuous wave mode, a necrotic zone of tissue having a desired size and shape (e.g., a necrotic volume selected to interrupt a blood supply to a tumor) can be created by controlling at least one of the f-number, duration, intensity, and direction of the ultrasound energy administered. This method speeds the therapy and avoids continuously pausing to enable intervening normal tissue to cool.
摘要翻译：用于成像和递送高强度超声能量治疗到治疗部位的超声系统以及用超声波装置治疗患者体内的肿瘤和其它不需要的组织的方法。超声波装置具有设置在细长相对薄的轴的远端上的超声换能器阵列。在本发明的一种形式中，换能器阵列设置在液体填充的弹性体材料内，其更有效地将超声能量耦合到与装置直接接触的肿瘤中。以连续波模式使用该装置，可以通过控制至少一个f号码，来产生具有期望大小和形状的组织的坏死区（例如，被选择用于中断向肿瘤供血的坏死体积）持续时间，强度和方向。这种方法加快了治疗速度，避免了持续暂停，从而使正常组织能够平静地冷却。

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