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41. 发明申请

WO2021202109A1 COMPOSITE MATERIALS AND METHODS OF PREPARATION THEREOF 审中-公开
公开(公告)号：WO2021202109A1
公开(公告)日：2021-10-07
申请号：PCT/US2021/022906
申请日：2021-03-18
申请人： BORAL IP HOLDINGS (AUSTRALIA) PTY LIMITED , CASSIDY, Edward, F. , HILL, Russell, L. , SHUGDINIS, Robert, W. , ZHANG, Xi , ZHANG, Ying
发明人： CASSIDY, Edward, F. , HILL, Russell, L. , SHUGDINIS, Robert, W. , ZHANG, Xi , ZHANG, Ying
IPC分类号： C08J9/00 , B68G11/04
摘要： Composite materials that include a structural support are described, wherein the structural support defines a plurality of cavities at least partially filled with a polymeric foam. The polymeric foam may have a density less than 5 pcf and/or the composite material may have a compressive strength of at least 60 psi.

42. 发明申请

WO2020005270A1 FOAM COMPOSITES AND METHODS OF PREPARATION THEREOF 审中-公开
公开(公告)号：WO2020005270A1
公开(公告)日：2020-01-02
申请号：PCT/US2018/040231
申请日：2018-06-29
申请人： BORAL IP HOLDINGS (AUSTRALIA) PTY LIMITED , CASSIDY, Edward, F. , ZHANG, Ying , ZHANG, Xi , MENESES, Matthew, Yatco , LAKROUT, Hamed
发明人： CASSIDY, Edward, F. , ZHANG, Ying , ZHANG, Xi , MENESES, Matthew, Yatco , LAKROUT, Hamed
IPC分类号： C08J9/00 , C08J9/14 , C08J9/12
摘要： Foam composites and methods of preparation thereof are discussed. For example, the foam composite may include a polymeric material and a particulate filler, wherein the compressive strength of the foam composite is equal to or greater than 20 psi, the density is 4 pcf to 40 pcf, and wherein the thermal conductivity is equal to or less than 0.050 W/m K. the particulate filler may include fly ash, e.g., in an amount of about of 45% to about 75% by weight with respect to the total weight of the foam composite. The foam composite may be prepared from a mixture of a polyol, an isocyanate, the particulate filler, and a liquid blowing agent having a boiling point equal to or greater than 25°C or 30°C.

43. 发明申请

WO2018162944A1 RECOMBINANT ANTIBODIES TO PROGRAMMED DEATH 1 (PD-1) AND USES THEREFOR 审中-公开
公开(公告)号：WO2018162944A1
公开(公告)日：2018-09-13
申请号：PCT/IB2017/051275
申请日：2017-03-04
申请人： SHENZHEN RUNSHIN BIOSCIENCE , ZHANG, Ying
发明人： ZHANG, Ying
IPC分类号： C07K16/28 , A61K39/395 , A61P35/00
摘要： Provided are monoclonal antibody, particularly rabbit recombinant antibody, which specifically binds to human PD-1 with biological functions and super high affinity, and methods of use. In various embodiments, the antibodies are fully humanized antibodies that bind to human PD-1. Nucleic acid molecules encoding the antibodies and methods for expressing the antibodies are also provided. In some embodiments, the antibodies are useful for inhibiting or neutralizing PD-1 activity, thus providing a means of treating, preventing and/or diagnosing a disease or disorder such as cancer or a viral infection.

44. 发明申请

WO2012122163A1 MICRONEEDLE DEVICES AND METHODS 审中-公开
标题翻译： MICRONEEDLE设备和方法
公开(公告)号：WO2012122163A1
公开(公告)日：2012-09-13
申请号：PCT/US2012/027858
申请日：2012-03-06
申请人： 3M INNOVATIVE PROPERTIES COMPANY , ZHANG, Ying , HANSEN, Kristen J. , DETERMAN, Amy S.
发明人： ZHANG, Ying , HANSEN, Kristen J. , DETERMAN, Amy S.
IPC分类号： A61K9/00 , A61M37/00
CPC分类号： A61K9/0021 , A61M37/0015 , A61M2037/0023 , A61M2037/0046 , A61M2037/0061
摘要： A medical device, comprising: an array of microneedles, and a coating disposed on the microneedles, wherein the coating comprises: a local anesthetic selected from the group consisting of lidocaine, prilocaine, and a combination thereof; and a local anesthetic dose-extending component selected from the group consisting of tetracaine, ropivacaine, bupivacaine, procaine and a combination thereof; wherein the local anesthetic is present in an amount of at least 1 wt-% based upon total weight of solids in the coating, and wherein the local anesthetic and dose-extending component are in a non-eutectic weight ratio; a medical device, comprising an array of dissolvable microneedles, the microneedles comprising: a dissolvable matrix material; at least 1 wt-% of a local anesthetic selected from the group consisting of lidocaine, prilocaine, and a combination thereof; and a local anesthetic dose-extending component selected from the group consisting of tetracaine, ropivacaine, bupivacaine, procaine and a combination thereof; wherein the local anesthetic and dose-extending component are in a non-eutectic weight ratio, and wherein wt-% is based upon total weight of solids in all portions of the dissolvable microneedles which contain the local anesthetic; a method of extending a topically delivered local anesthetic dose in mammalian tissue using the devices; and methods of making the devices are provided.
摘要翻译：一种医疗装置，包括：微针阵列和设置在所述微针上的涂层，其中所述涂层包括：选自利多卡因，丙胺卡因及其组合的局部麻醉剂; 以及选自丁卡因，罗哌卡因，布比卡因，普鲁卡因及其组合的局部麻醉剂剂量延伸组分; 其中所述局部麻醉剂以基于所述涂层中固体总重量的至少1重量％的量存在，并且其中所述局部麻醉剂和剂量延伸组分为非共晶重量比; 包括可溶性微针阵列的医疗装置，所述微针包括：可溶性基质材料; 至少1重量％的选自利多卡因，丙胺卡因及其组合的局部麻醉剂; 以及选自丁卡因，罗哌卡因，布比卡因，普鲁卡因及其组合的局部麻醉剂剂量延伸组分; 其中所述局部麻醉剂和剂量延伸组分为非共晶重量比，并且其中wt％基于含有所述局部麻醉剂的可溶性微针的所有部分中固体的总重量; 使用所述装置延长哺乳动物组织中局部递送的局部麻醉剂剂量的方法; 并提供制造设备的方法。

45. 发明申请

WO2012027687A8 MICROPOROUS THERMOPLASTIC SHEETS 审中-公开
公开(公告)号：WO2012027687A8
公开(公告)日：2012-03-01
申请号：PCT/US2011/049379
申请日：2011-08-26
申请人： CORNING INCORPORATED , DEROSA, Michael E , UPTON, Todd M , ZHANG, Ying
发明人： DEROSA, Michael E , UPTON, Todd M , ZHANG, Ying
IPC分类号： C08J7/02 , C12N5/00
摘要： Thermoplastic polymeric sheets are rendered microporous and remain substantially flat by contacting the sheet with a first fluid composition that contains or more solvents for the polymeric sheet to render the sheet microporous and then contacting the microporous sheet with a second fluid composition that is substantially free of solvents for the polymer and that contains a non-solvent that is miscible with the one or more solvents of the first composition. Contacting the microporous sheet with the second fluid composition preferably occurs prior to substantial evaporation of the first fluid compositions, or solvents thereof, from the microporous sheet.

46. 发明申请

WO2009148509A1 CELL CULTURE APPARATUS HAVING DIFFERENT MICRO-WELL TOPOGRAPHY 审中-公开
标题翻译：细胞培养装置具有不同的微观形态
公开(公告)号：WO2009148509A1
公开(公告)日：2009-12-10
申请号：PCT/US2009/003115
申请日：2009-05-20
申请人： CORNING INCORPORATED , FANG, Ye , WANG, Jianguo , ZHANG, Ying
发明人： FANG, Ye , WANG, Jianguo , ZHANG, Ying
IPC分类号： C12M1/18 , B01L3/00
CPC分类号： C12M23/16 , B01L3/5085 , B01L2300/0829 , B01L2300/0851 , B01L2300/163 , B81B2201/06 , B81B2203/0346 , B81B2203/0376 , B81C99/0085 , B81C99/009 , C12M23/12
摘要： A cell culture apparatus includes a substrate having formed therein a micro-well array, the micro-well array comprising a plurality of micro-wells. Each micro-well is defined by a curved surface which is concave. At least two of the micro-wells have different topgraphy.
摘要翻译：细胞培养装置包括其中形成有微孔阵列的基底，微孔阵列包括多个微孔。每个微孔由凹入的曲面限定。至少有两个微孔具有不同的地层。

47. 发明申请

WO2009140482A1 SILICA COATING FOR ENHANCED HYDROPHILICITY/TRANSMITTIVITY 审中-公开
标题翻译：二氧化硅涂料，用于增强疏水性/传递性
公开(公告)号：WO2009140482A1
公开(公告)日：2009-11-19
申请号：PCT/US2009/043934
申请日：2009-05-14
申请人： 3M INNOVATIVE PROPERTIES COMPANY , JING, Naiyong , BOEHMER, Roxanne, A. , CHEN, Xue-Hua , YU, Zhigang , ZHANG, Ying , XIE, Dang , XI, Bangwei
发明人： JING, Naiyong , BOEHMER, Roxanne, A. , CHEN, Xue-Hua , YU, Zhigang , ZHANG, Ying , XIE, Dang , XI, Bangwei
IPC分类号： C09D1/00 , C03C17/25 , C09D7/12
CPC分类号： C09D1/00 , C03C17/007 , C03C2217/425 , C03C2217/75 , C04B41/009 , C04B41/5089 , C04B41/85 , C04B2111/00112 , C08K3/36 , C09D7/61 , C09D7/67 , Y10T428/259 , C04B41/4922 , C04B41/5016 , C04B33/00
摘要： A coated article having a substrate coated with a layer of silica nanoparticles is provided. The coating is substantially uniform in thickness, durably adheres to the substrate, and provides antireflection and or hydrophilic surface properties to the substrate.
摘要翻译：提供了具有涂覆有二氧化硅纳米颗粒层的基底的涂覆制品。涂层的厚度基本上是均匀的，耐久地粘附到基底上，并且为基底提供抗反射和/或亲水的表面性质。

48. 发明申请

WO2009090371A1 DRILLING FLUIDS COMPRISING SUB-MICRON PRECIPITATED BARITE AS A COMPONENT OF THE WEIGHTING AGENT AND ASSOCIATED METHODS 审中-公开
标题翻译：包含作为称重剂的组分和相关方法的亚微米级精制巴比特的钻井液
公开(公告)号：WO2009090371A1
公开(公告)日：2009-07-23
申请号：PCT/GB2009/000030
申请日：2009-01-07
申请人： HALLIBURTON ENERGY SERVICES, INC. , TURNER, Craig, Robert , ZHANG, Ying
发明人： ZHANG, Ying
IPC分类号： C09K8/03
CPC分类号： C09K8/032
摘要： An embodiment of the present invention includes a method comprising circulating a drilling fluid in a well bore, wherein the drilling fluid comprises a carrier fluid; and a weighting agent that comprises precipitated barite having a weight average particle diameter below about 1 micron and a particle having a specific gravity of greater than about 2.6. Another embodiment of the present invention includes a drilling fluid comprising: a carrier fluid; and a weighting agent that comprises precipitated barite having a weight average particle diameter below about 1 micron, and a particle having a specific gravity of greater than about 2.6. Another embodiment of the present invention includes a weighting agent that comprises precipitated barite having a weight average particle diameter below about 1 micron, and a particle having a specific gravity of greater than about 2.6.
摘要翻译：本发明的一个实施例包括一种方法，包括使钻井液在井眼中循环，其中钻井液包括载体流体; 以及包含重均粒径低于约1微米的沉淀重晶石和比重大于约2.6的颗粒的加重剂。本发明的另一个实施例包括一种钻井液，包括：载体流体; 以及包含重均粒径低于约1微米的沉淀重晶石和比重大于约2.6的颗粒的加重剂。本发明的另一个实施方案包括加重剂，其包含重均粒径低于约1微米的沉淀重晶石和比重大于约2.6的颗粒。

49. 发明申请

WO2009009208A2 PATTERNING STRUCTURES USING DEFORMABLE SUBSTRATES 审中-公开
标题翻译：使用可变基底构图
公开(公告)号：WO2009009208A2
公开(公告)日：2009-01-15
申请号：PCT/US2008/061293
申请日：2008-04-23
申请人： THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA , YANG, Shu , ZHANG, Ying , KAMIEN, Randall , KIKKAWA, James, Makoto , MATSUMOTO, Elisabetta , CHANDRA, Dinesh
发明人： YANG, Shu , ZHANG, Ying , KAMIEN, Randall , KIKKAWA, James, Makoto , MATSUMOTO, Elisabetta , CHANDRA, Dinesh
IPC分类号： H01L51/00
CPC分类号： G03F7/0002 , B82Y10/00 , B82Y40/00
摘要： Aspects of the present invention describe soft imprint lithography methods capable of preparing structural features on surfaces. Disclosed methods include surmounting a deformable substrate, having an original form, with a composition, wherein the deformable substrate is capable of achieving at least one predetermined deformed state; predictably deforming said deformable substrate from its original form to the at least one predetermined deformed state; and transferring at least a portion of the composition surmounting the deformed substrate to a receiving substrate.
摘要翻译：本发明的方面描述了能够制备表面结构特征的软压印光刻方法。所公开的方法包括用组合物去除具有原始形式的可变形基底，其中可变形基底能够实现至少一个预定的变形状态; 将所述可变形基材从其原始形式预测变形为至少一个预定变形状态; 以及将所述组合物的至少一部分超过所述变形的基材转移到接收基板。

50. 发明申请

WO2013095247A1 METHOD AND ARRANGEMENT FOR FAULT ANALYSIS IN A MULTI-LAYER NETWORK 审中-公开
标题翻译：多层网络中故障分析的方法和布置
公开(公告)号：WO2013095247A1
公开(公告)日：2013-06-27
申请号：PCT/SE2012/050028
申请日：2012-01-16
申请人： TELEFONAKTIEBOLAGET L M ERICSSON (publ) , ZHANG, Ying , BEHESHTI-ZAVAREH, Neda , DEVLIC, Alisa , MEIROSU, Catalin
发明人： ZHANG, Ying , BEHESHTI-ZAVAREH, Neda , DEVLIC, Alisa , MEIROSU, Catalin
IPC分类号： H04L12/24 , G01M11/00 , H04B10/07
CPC分类号： B01D19/0404 , B01D19/04 , B01D19/0409 , H04L41/065
摘要： The invention relates to a method for fault analysis in a multi-layer network. The method includes receiving (210) a first set of performance measurements occurring in response to the fault and representing at least a first and a second layer in a multi-layer communications network. A probable set of network elements affected by the fault are localized (220). The type of fault is inferred (230) from one or more symptoms in the performance measurements. The root cause of the failure is determined (240) from a combination of the information on probable set of network elements and inferred type of fault. The invention also relates to an arrangement in a network management node for carrying out the inventive method. The arrangement includes a root cause analyzer (320) to detect affected network elements and fault type upon network failure, wherein affected network elements are determined in a spatial localization unit (320) and the fault type is determined in a fault type inference unit (350).
摘要翻译：本发明涉及一种多层网络故障分析方法。该方法包括：接收（210）响应故障而发生的第一组性能测量，并表示多层通信网络中的至少第一层和第二层。受故障影响的一组可能的网络元件本地化（220）。从性能测量中的一个或多个症状推断故障类型（230）。根据可能的网络组件信息和推断的故障类型的组合来确定故障的根本原因（240）。本发明还涉及网络管理节点中用于实现本发明方法的一种布置。该配置包括：根本原因分析器（320），用于在网络故障时检测受影响的网络元件和故障类型，其中在空间定位单元（320）中确定受影响的网络元件，并且在故障类型推理单元（350）中确定故障类型）。

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