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1. 发明申请

WO2021202109A1 COMPOSITE MATERIALS AND METHODS OF PREPARATION THEREOF 审中-公开
公开(公告)号：WO2021202109A1
公开(公告)日：2021-10-07
申请号：PCT/US2021/022906
申请日：2021-03-18
申请人： BORAL IP HOLDINGS (AUSTRALIA) PTY LIMITED , CASSIDY, Edward, F. , HILL, Russell, L. , SHUGDINIS, Robert, W. , ZHANG, Xi , ZHANG, Ying
发明人： CASSIDY, Edward, F. , HILL, Russell, L. , SHUGDINIS, Robert, W. , ZHANG, Xi , ZHANG, Ying
IPC分类号： C08J9/00 , B68G11/04
摘要： Composite materials that include a structural support are described, wherein the structural support defines a plurality of cavities at least partially filled with a polymeric foam. The polymeric foam may have a density less than 5 pcf and/or the composite material may have a compressive strength of at least 60 psi.

2. 发明申请

WO2020005270A1 FOAM COMPOSITES AND METHODS OF PREPARATION THEREOF 审中-公开
公开(公告)号：WO2020005270A1
公开(公告)日：2020-01-02
申请号：PCT/US2018/040231
申请日：2018-06-29
申请人： BORAL IP HOLDINGS (AUSTRALIA) PTY LIMITED , CASSIDY, Edward, F. , ZHANG, Ying , ZHANG, Xi , MENESES, Matthew, Yatco , LAKROUT, Hamed
发明人： CASSIDY, Edward, F. , ZHANG, Ying , ZHANG, Xi , MENESES, Matthew, Yatco , LAKROUT, Hamed
IPC分类号： C08J9/00 , C08J9/14 , C08J9/12
摘要： Foam composites and methods of preparation thereof are discussed. For example, the foam composite may include a polymeric material and a particulate filler, wherein the compressive strength of the foam composite is equal to or greater than 20 psi, the density is 4 pcf to 40 pcf, and wherein the thermal conductivity is equal to or less than 0.050 W/m K. the particulate filler may include fly ash, e.g., in an amount of about of 45% to about 75% by weight with respect to the total weight of the foam composite. The foam composite may be prepared from a mixture of a polyol, an isocyanate, the particulate filler, and a liquid blowing agent having a boiling point equal to or greater than 25°C or 30°C.

3. 发明申请

WO2017204782A1 FILLED POLYURETHANE FOAM HAVING TAILORED MICROSTRUCTURES 审中-公开
标题翻译：具有定制微结构的填充聚氨酯泡沫
公开(公告)号：WO2017204782A1
公开(公告)日：2017-11-30
申请号：PCT/US2016/033761
申请日：2016-05-23
申请人： BORAL IP HOLDINGS (AUSTRALIA) PTY LIMITED , LAKROUT, Hamed , ZHANG, Ying , CROCCO, Guy , HILL, Russell
发明人： LAKROUT, Hamed , ZHANG, Ying , CROCCO, Guy , HILL, Russell
IPC分类号： C08L75/04 , C08J9/00 , C08J9/228 , C08G18/72 , C08K7/16 , C08K7/18 , C08K7/14
摘要： Filled polyurethane foams having tailored microstructures, as well as methods of making these polyurethane foams, are described herein. By tailoring the microstructure of the polyurethane foam, composite materials having desirable mechanical properties (e.g., elastic modulus, compressive strength, or combination thereof) can be obtained.
摘要翻译：本文描述了具有定制微结构的填充聚氨酯泡沫以及制备这些聚氨酯泡沫的方法。通过调整聚氨酯泡沫的微观结构，可以获得具有期望的机械性能（例如，弹性模量，压缩强度或其组合）的复合材料。

4. 发明申请

WO2017204778A1 FILLED POLYURETHANE OR POLYISOCYANURATE FOAM AND METHOD OF MAKING SAME 审中-公开
标题翻译：填充聚氨酯或多异氰酸酯泡沫及其制备方法
公开(公告)号：WO2017204778A1
公开(公告)日：2017-11-30
申请号：PCT/US2016/033734
申请日：2016-05-23
申请人： BORAL IP HOLDINGS (AUSTRALIA) PTY LIMITED
发明人： LAKROUT, Hamed , CROCCO, Guy , ZHANG, Ying , HILL, Russell
IPC分类号： C08L75/04 , C08G18/08 , C08G18/72 , C08G18/32 , C08J9/00 , C08K7/14 , C08K7/02 , C08K7/16 , C08K7/18
CPC分类号： C08G18/7671 , C08G18/32 , C08G18/4829 , C08G18/5021 , C08G18/6204 , C08G2101/0083 , C08K7/02 , C08K7/14 , C08K7/16 , C08K7/18 , C08L75/04
摘要： Polyurethane or polyisocyanurate foam stock and methods of manufacturing are described herein. The foam stock can include (a) a polyurethane or polyisocyanurate formed by the reaction of (i) one or more isocyanates selected from the group consisting of diisocyanates, polyisocyanates, and mixtures thereof, and (ii) one or more polyols; and (b) a filler present in an amount from greater than 50% to 90% by weight, based on the total weight of the foam stock. The density of the foam stock can be from 10 lb/ft 3 to 35 lb/ft 3 . The flexural strength of the foam stock can be at least 100 psi. The resulting foam stock can be used to produce polyurethane or polyisocyanurate foam to be used in composite panels.
摘要翻译：本文描述了聚氨酯或聚异氰脲酸酯泡沫原料和制造方法。（a）通过（i）一种或多种选自二异氰酸酯，多异氰酸酯及其混合物的异氰酸酯和（ii）一种或多种多元醇的反应形成的聚氨酯或聚异氰脲酸酯; 和（b）基于泡沫原料的总重量，以大于50重量％至90重量％的量存在的填料。泡沫材料的密度可以从10磅/英尺3至35磅/英尺3 。泡沫材料的弯曲强度可以至少为100psi。生成的泡沫材料可用于生产用于复合板的聚氨酯或聚异氰脲酸酯泡沫。

5. 发明公开

EP3589652A1 RECOMBINANT ANTIBODIES TO PROGRAMMED DEATH 1 (PD-1) AND USES THEREFOR 审中-实审
公开(公告)号：EP3589652A1
公开(公告)日：2020-01-08
申请号：EP17900235.7
申请日：2017-03-04
申请人： Xiangtan Tenghua Bioscience , Zhang, Ying
发明人： ZHANG, Ying
IPC分类号： C07K16/28 , A61K39/395 , A61P35/00

6. 发明公开

EP3583127A1 ANTI-PROGRAMMED DEATH-LIGAND 1 (PD-L1) ANTIBODIES AND THERAPEUTIC USES THEREOF 审中-实审
公开(公告)号：EP3583127A1
公开(公告)日：2019-12-25
申请号：EP17896573.7
申请日：2017-02-16
申请人： Zhang, Ying , Xiangtan Tenghua Bioscience
发明人： ZHANG, Ying
IPC分类号： C07K16/28 , C12N5/10 , A61K39/395 , A61P35/00

7. 发明公开

EP3321371A1 NOVEL METHODS FOR RAPID DRUG SUSCEPTIBILITY TESTING AND DRUG SCREENS FOR GROWING AND NON-GROWING CELLS OF PROKARYOTIC AND EUKARYOTIC ORIGIN 审中-公开
标题翻译：用于快速药物敏感性试验和药物屏障的新方法用于生长和非生长的原核和真核生成细胞
公开(公告)号：EP3321371A1
公开(公告)日：2018-05-16
申请号：EP17159022.7
申请日：2017-03-02
申请人： Zhang, Ying , Feng, Jie , Yee, Rebecca , Zhang, Shuo , Zhang, Wenhong , Wang, Xiaodong
发明人： ZHANG, Ying , FENG, Jie , YEE, Rebecca , ZHANG, Wenhong , ZHANG, Shuo
IPC分类号： C12Q1/18 , G01N33/50
CPC分类号： G01N33/5014 , C12Q1/18 , Y02A50/57
摘要： The presently disclosed subject matter provides methods, compositions, and kits for extremely rapid assessment of drug susceptibility of growing as well as non-growing cells of prokaryotic and also eukaryotic origins, without the need for organism growth, which is in contrast to the current growth-dependent methods.This growth-independent new methodology achieves extremely rapid drug susceptibility testing results previously not possible. Methods for rapidly identifying compounds with inhibitory activity against both growing and non-growing cells in real-time continuous manner with previously unachievable efficiency in drug screens using the novel methodology are also provided. Cell cultures are incubated with a drug or test agent and with a staining mixture containing a first fluorescent dye indicative the emission of which is indicative of live cells (e.g. SYBR Green I) and a second fluorescent dye indicative emitting a different color, the emission of which is indicative of dead cells (e.g. Propidium iodide). The ratio of the intensities of the emitted fluorescence of the dyes is indicative of the percentage live and dead cells in the culture.
摘要翻译：本发明公开的主题提供了方法，组合物和试剂盒，用于非常快速评估原核生物和真核生物起源的生长以及非生长细胞的药物敏感性，而不需要生物体生长，这与目前的生长相反这种独立于生长的新方法实现了以前不可能的极快的药物敏感性测试结果。还提供了用实时连续方式迅速鉴定具有抑制生长和非生长细胞的活性的化合物的方法，以及使用新方法在药物筛选中以前无法实现的效率。将细胞培养物与药物或测试试剂以及含有第一荧光染料和第二荧光染料的染色混合物孵育，所述第一荧光染料指示其发射指示活细胞（例如SYBR Green I），第二荧光染料指示发射不同颜色，这是死细胞的指示（例如碘化丙锭）。染料荧光发射强度的比例表明培养物中活细胞和死细胞的百分比。

8. 发明申请

WO2018233559A1 PROCESS FOR INCREASING XYLOSE PERCENTAGE OF HYDROLYSATE 审中-公开
公开(公告)号：WO2018233559A1
公开(公告)日：2018-12-27
申请号：PCT/CN2018/091455
申请日：2018-06-15
申请人： NOVOZYMES A/S , ZHANG, Ying
发明人： ZHANG, Ying , WANG, Yun , XU, Wanghui , ZHU, Junding
IPC分类号： C07C31/24 , C07C29/09 , C07B63/02 , C12N9/24 , C12P19/02
CPC分类号： C07B63/02 , C12P19/02 , C12P19/14 , C12Y101/03
摘要： The present invention relates to a process for increasing xylose percentage of hydrolysate of a cellulosic or hemicellulosic material, comprising: (1) hydrolyzing the cellulosic or hemicellulosic material, optionally by a first enzyme composition comprising one or more enzymes having cellulase or hemicellulase activity; and (2) purifying the material of step (1) by adding a second enzyme composition comprising one or more oxidases.

9. 发明申请

WO2018150224A1 ANTI-PROGRAMMED DEATH-LIGAND 1 (PD-L1) ANTIBODIES AND THERAPEUTIC USES THEREOF 审中-公开
公开(公告)号：WO2018150224A1
公开(公告)日：2018-08-23
申请号：PCT/IB2017/050855
申请日：2017-02-16
申请人： ZHANG, Ying , SHENZHEN RUNSHIN BIOSCIENCE
发明人： ZHANG, Ying
IPC分类号： C07K16/28 , C12N5/10 , A61K39/395 , A61P35/00
摘要： Anti-programmed death-ligand l (PD-L1) antibodies, methods of using the same, therapeutic compositions thereof, and uses thereof in upregulating cell-mediated immune responses and treating T cell dysfunctional disorders are provided. The use of the anti-PD-L1 antibody as a diagnostic agent in vitro is also provided.

10. 发明申请

WO2014116547A1 SURFACE NANOFABRICATION METHODS USING SELF-ASSEMBLED POLYMER NANOMASKS 审中-公开
标题翻译：使用自组装聚合物纳米颗粒的表面纳米化方法
公开(公告)号：WO2014116547A1
公开(公告)日：2014-07-31
申请号：PCT/US2014/012228
申请日：2014-01-21
申请人： CORNING INCORPORATED , QUESADA, Mark Alejandro , WANG, Jianguo , ZHANG, Ying
发明人： QUESADA, Mark Alejandro , WANG, Jianguo , ZHANG, Ying
IPC分类号： G03F7/00
CPC分类号： B05D5/00 , B82Y10/00 , B82Y40/00 , G03F7/0002 , Y10S977/888
摘要： Methods for fabricating a nanopillared substrate surface include applying a polymer solution containing an amphiphilic block copolymer and a hydrophilic homopolymer to a substrate surface. The amphiphilic block copolymer and the hydrophilic homopolymer in the polymer solution self-assemble on the substrate surface to form a self-assembled polymer layer having hydrophobic domains adjacent to the substrate surface and hydrophilic domains extending into the self-assembled polymer layer. At least a portion of the hydrophilic domains may be removed to form a plurality of pores in the exposed surface of the self-assembled polymer layer. A protective layer may be deposited on the exposed surface as a mask for etching through the plurality of pores to form through-holes. A nanopillar-forming material may be deposited onto the substrate surface via the through-holes. Then, the remaining portion of the self-assembled polymer layer may be removed to expose a nanopillared substrate surface.
摘要翻译：用于制造纳米圆柱形基底表面的方法包括将含有两亲嵌段共聚物和亲水均聚物的聚合物溶液施加到基底表面。聚合物溶液中的两亲性嵌段共聚物和亲水均聚物自组装在基材表面上以形成具有与基材表面相邻的疏水区域和延伸到自组装聚合物层中的亲水区域的自组装聚合物层。亲水区域的至少一部分可以被去除以在自组装聚合物层的暴露表面中形成多个孔。可以在暴露的表面上沉积保护层作为用于通过多个孔蚀刻的掩模以形成通孔。可以通过通孔将纳米柱形成材料沉积到衬底表面上。然后，可以除去自组装聚合物层的剩余部分以暴露出纳米圆柱形的衬底表面。

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