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1. 发明申请

WO2012122163A1 MICRONEEDLE DEVICES AND METHODS 审中-公开
标题翻译： MICRONEEDLE设备和方法
公开(公告)号：WO2012122163A1
公开(公告)日：2012-09-13
申请号：PCT/US2012/027858
申请日：2012-03-06
申请人： 3M INNOVATIVE PROPERTIES COMPANY , ZHANG, Ying , HANSEN, Kristen J. , DETERMAN, Amy S.
发明人： ZHANG, Ying , HANSEN, Kristen J. , DETERMAN, Amy S.
IPC分类号： A61K9/00 , A61M37/00
CPC分类号： A61K9/0021 , A61M37/0015 , A61M2037/0023 , A61M2037/0046 , A61M2037/0061
摘要： A medical device, comprising: an array of microneedles, and a coating disposed on the microneedles, wherein the coating comprises: a local anesthetic selected from the group consisting of lidocaine, prilocaine, and a combination thereof; and a local anesthetic dose-extending component selected from the group consisting of tetracaine, ropivacaine, bupivacaine, procaine and a combination thereof; wherein the local anesthetic is present in an amount of at least 1 wt-% based upon total weight of solids in the coating, and wherein the local anesthetic and dose-extending component are in a non-eutectic weight ratio; a medical device, comprising an array of dissolvable microneedles, the microneedles comprising: a dissolvable matrix material; at least 1 wt-% of a local anesthetic selected from the group consisting of lidocaine, prilocaine, and a combination thereof; and a local anesthetic dose-extending component selected from the group consisting of tetracaine, ropivacaine, bupivacaine, procaine and a combination thereof; wherein the local anesthetic and dose-extending component are in a non-eutectic weight ratio, and wherein wt-% is based upon total weight of solids in all portions of the dissolvable microneedles which contain the local anesthetic; a method of extending a topically delivered local anesthetic dose in mammalian tissue using the devices; and methods of making the devices are provided.
摘要翻译：一种医疗装置，包括：微针阵列和设置在所述微针上的涂层，其中所述涂层包括：选自利多卡因，丙胺卡因及其组合的局部麻醉剂; 以及选自丁卡因，罗哌卡因，布比卡因，普鲁卡因及其组合的局部麻醉剂剂量延伸组分; 其中所述局部麻醉剂以基于所述涂层中固体总重量的至少1重量％的量存在，并且其中所述局部麻醉剂和剂量延伸组分为非共晶重量比; 包括可溶性微针阵列的医疗装置，所述微针包括：可溶性基质材料; 至少1重量％的选自利多卡因，丙胺卡因及其组合的局部麻醉剂; 以及选自丁卡因，罗哌卡因，布比卡因，普鲁卡因及其组合的局部麻醉剂剂量延伸组分; 其中所述局部麻醉剂和剂量延伸组分为非共晶重量比，并且其中wt％基于含有所述局部麻醉剂的可溶性微针的所有部分中固体的总重量; 使用所述装置延长哺乳动物组织中局部递送的局部麻醉剂剂量的方法; 并提供制造设备的方法。

2. 发明申请

WO2012122162A1 MICRONEEDLE DEVICES AND METHODS 审中-公开
标题翻译： MICRONEEDLE设备和方法
公开(公告)号：WO2012122162A1
公开(公告)日：2012-09-13
申请号：PCT/US2012/027857
申请日：2012-03-06
申请人： 3M INNOVATIVE PROPERTIES COMPANY , ZHANG, Ying , HANSEN, Kristen J. , DETERMAN, Amy S.
发明人： ZHANG, Ying , HANSEN, Kristen J. , DETERMAN, Amy S.
IPC分类号： A61K9/00 , A61M37/00
CPC分类号： A61K9/0021 , A61M37/0015 , A61M2037/0023 , A61M2037/0046 , A61M2037/0061
摘要： A medical device, comprising: an array of microneedles, and a coating disposed on the microneedles, wherein the coating comprises: a local anesthetic selected from the group consisting of lidocaine, prilocaine, and a combination thereof; and a local anesthetic dose-extending component selected from the group consisting of alpha 1 adrenergic agonists, alpha 2 adrenergic agonists, and a combination thereof; wherein the local anesthetic is present in an amount of at least 1 wt-% based upon total weight of solids in the coating, and wherein the dose-extending component/local anesthetic weight ratio is at least 0.0001; a medical device, comprising an array of dissolvable microneedles, the microneedles comprising: a dissolvable matrix material; at least 1 wt-% of a local anesthetic selected from the group consisting of lidocaine, prilocaine, and a combination thereof; and a local anesthetic dose-extending component selected from the group consisting of alpha 1 adrenergic agonists, alpha 2 adrenergic agonists, and a combination thereof; wherein the dose-extending component/local anesthetic weight ratio is at least 0.0001, and wherein wt-% is based upon total weight of solids in all portions of the dissolvable microneedles which contain the local anesthetic; a method of extending a topically delivered local anesthetic dose in mammalian tissue using the devices; and methods of making the devices are provided.
摘要翻译：一种医疗装置，包括：微针阵列和设置在所述微针上的涂层，其中所述涂层包括：选自利多卡因，丙胺卡因及其组合的局部麻醉剂; 以及选自α1肾上腺素能激动剂，α2肾上腺素能激动剂及其组合的局部麻醉剂剂量延伸组分; 其中所述局部麻醉剂以基于所述包衣中固体总重量的至少1重量％的量存在，并且其中所述剂量延长组分/局部麻醉剂重量比至少为0.0001; 包括可溶性微针阵列的医疗装置，所述微针包括：可溶性基质材料; 至少1重量％的选自利多卡因，丙胺卡因及其组合的局部麻醉剂; 以及选自α1肾上腺素能激动剂，α2肾上腺素能激动剂及其组合的局部麻醉剂剂量延伸组分; 其中所述剂量延伸组分/局部麻醉重量比为至少0.0001，并且其中wt％基于含有所述局部麻醉剂的可溶性微针的所有部分中固体的总重量; 使用所述装置延长哺乳动物组织中局部递送的局部麻醉剂剂量的方法; 并提供制造设备的方法。

3. 发明申请

WO2011150144A2 AQUEOUS FORMULATIONS FOR COATING MICRONEEDLE ARRAYS 审中-公开
标题翻译：涂层麦克风阵列的水性配方
公开(公告)号：WO2011150144A2
公开(公告)日：2011-12-01
申请号：PCT/US2011/038029
申请日：2011-05-26
申请人： 3M INNOVATIVE PROPERTIES COMPANY , DETERMAN, Amy S. , JOHNSON, Peter R. , MOSEMAN, Joan T. , WOLDT, Ryan T. , HANSEN, Kristen J.
发明人： DETERMAN, Amy S. , JOHNSON, Peter R. , MOSEMAN, Joan T. , WOLDT, Ryan T. , HANSEN, Kristen J.
IPC分类号： A61K38/00 , A61K47/32 , A61K47/36 , A61K47/38 , A61K9/08 , A61K47/10 , A61K47/18 , A61K47/22 , A61K47/26
CPC分类号： A61K9/0021 , A61K47/10 , A61K47/183 , A61K47/22 , A61K47/26 , A61K47/32 , A61K47/36 , A61K47/38 , A61M37/0015
摘要： Aqueous formulations that include at least one active pharmaceutical ingredient; and at least one excipient, wherein the aqueous formulation has a viscosity of from 500 to 30,000 centipoise when measured at a shear rate of 100s -1 and a temperature of 25° C; a surface tension that is not greater than 60 dynes/cm when measured under ambient conditions; or a contact angle on a medical grade polymeric material of 50° or greater when measured under ambient conditions. Methods of coating and coated microneedle arrays using the aqueous formulations are also disclosed herein.
摘要翻译：包含至少一种活性药物成分的水性制剂; 和至少一种赋形剂，其中当在100s -1的剪切速率和25℃的温度下测量时，所述水性制剂具有500至30,000厘泊的粘度; 当在环境条件下测量时，表面张力不大于60达因/厘米; 或在环境条件下测量时，医疗级聚合物材料的接触角为50°或更大。本文还公开了使用水性制剂的包衣和包衣微针阵列的方法。

4. 发明申请

WO2020240353A1 OPERATOR PROFICIENCY-BASED INFRASTRUCTURE ARTICLES 审中-公开
公开(公告)号：WO2020240353A1
公开(公告)日：2020-12-03
申请号：PCT/IB2020/054795
申请日：2020-05-20
申请人： 3M INNOVATIVE PROPERTIES COMPANY
发明人： HANSEN, Kristen J. , DUNN, Douglas S. , GANDRUD, Jonathan D.
IPC分类号： G08C13/00 , E01F9/553
摘要： An infrastructure article includes a signal receiver device configured to receive a wireless signal from a signal emitter device configured at an electrically powered scooter; and a controller configured to determine information, coded in the wireless signal, that is based on an operator proficiency of an operator of the electrically powered scooter; and to perform, based at least in part on the information that indicates the operator proficiency of the operator of the electrically powered scooter, at least one operation.

5. 发明申请

WO2020089747A1 CURABLE ADHESIVE, BONDING FILM, AND METHOD OF BONDING THE SAME 审中-公开
公开(公告)号：WO2020089747A1
公开(公告)日：2020-05-07
申请号：PCT/IB2019/059142
申请日：2019-10-24
申请人： 3M INNOVATIVE PROPERTIES COMPANY
发明人： CHEN, Lianzhou , HANSEN, Kristen J.
IPC分类号： C08G59/06 , C08G59/22 , C08G59/26 , C08G59/38
摘要： A curable composition comprises: 1 to 65 percent by weight of polyepoxide comprising an addition reaction product of phenolphthalein and bisphenol A diglycidyl ether; 5 to 50 percent by weight of liquid polyepoxide; and an effective amount of curative for curing the curable composition. A curable adhesive film comprising the curable composition, and method of bonding are also disclosed.

6. 发明公开

EP3977431A1 OPERATOR PROFICIENCY-BASED INFRASTRUCTURE ARTICLES 无效
公开(公告)号：EP3977431A1
公开(公告)日：2022-04-06
申请号：EP20727856.5
申请日：2020-05-20
申请人： 3M Innovative Properties Company
发明人： HANSEN, Kristen J. , DUNN, Douglas S. , GANDRUD, Jonathan D.
IPC分类号： G08C13/00 , E01F9/553

7. 发明授权

EP2575845B1 AQUEOUS FORMULATIONS FOR COATING MICRONEEDLE ARRAYS 有权
标题翻译：含水配方涂料微针FIELDS
公开(公告)号：EP2575845B1
公开(公告)日：2017-02-15
申请号：EP11727852.3
申请日：2011-05-26
申请人： 3M Innovative Properties Company
发明人： DETERMAN, Amy S. , JOHNSON, Peter R. , MOSEMAN, Joan T. , WOLDT, Ryan T. , HANSEN, Kristen J.
IPC分类号： A61K38/00 , A61K47/32 , A61K47/36 , A61K47/38 , A61K9/08 , A61K47/10 , A61K47/18 , A61K47/22 , A61K47/26
CPC分类号： A61K9/0021 , A61K47/10 , A61K47/183 , A61K47/22 , A61K47/26 , A61K47/32 , A61K47/36 , A61K47/38 , A61M37/0015

8. 发明公开

EP2683358A1 MICRONEEDLE DEVICES AND METHODS 有权
标题翻译： MICRONEEDLE设备和方法
公开(公告)号：EP2683358A1
公开(公告)日：2014-01-15
申请号：EP12709231.0
申请日：2012-03-06
申请人： 3M Innovative Properties Company
发明人： ZHANG, Ying , HANSEN, Kristen J. , DETERMAN, Amy S.
IPC分类号： A61K9/00 , A61M37/00
CPC分类号： A61K9/0021 , A61M37/0015 , A61M2037/0023 , A61M2037/0046 , A61M2037/0061
摘要： A medical device, comprising: an array of microneedles, and a coating disposed on the microneedles, wherein the coating comprises: a local anesthetic selected from the group consisting of lidocaine, prilocaine, and a combination thereof; and a local anesthetic dose-extending component selected from the group consisting of alpha 1 adrenergic agonists, alpha 2 adrenergic agonists, and a combination thereof; wherein the local anesthetic is present in an amount of at least 1 wt-% based upon total weight of solids in the coating, and wherein the dose-extending component/local anesthetic weight ratio is at least 0.0001; a medical device, comprising an array of dissolvable microneedles, the microneedles comprising: a dissolvable matrix material; at least 1 wt-% of a local anesthetic selected from the group consisting of lidocaine, prilocaine, and a combination thereof; and a local anesthetic dose-extending component selected from the group consisting of alpha 1 adrenergic agonists, alpha 2 adrenergic agonists, and a combination thereof; wherein the dose-extending component/local anesthetic weight ratio is at least 0.0001, and wherein wt-% is based upon total weight of solids in all portions of the dissolvable microneedles which contain the local anesthetic; a method of extending a topically delivered local anesthetic dose in mammalian tissue using the devices; and methods of making the devices are provided.
摘要翻译： 1。一种医疗装置，包括：微针阵列和布置在所述微针上的涂层，其中所述涂层包括：选自利多卡因，丙胺卡因及其组合的局部麻醉剂; 和选自α1肾上腺素能激动剂，α2肾上腺素能激动剂及其组合的局部麻醉剂量延长组分; 其中所述局部麻醉剂以基于涂层中固体总重量的至少1重量％的量存在，并且其中剂量增加组分/局部麻醉剂重量比至少为0.0001; 包括可溶解微针阵列的医疗装置，所述微针包括：可溶解基质材料; 至少1重量％的选自利多卡因，丙胺卡因及其组合的局部麻醉剂; 和选自α1肾上腺素能激动剂，α2肾上腺素能激动剂及其组合的局部麻醉剂量延长组分; 其中所述剂量延长组分/局部麻醉剂重量比至少为0.0001，并且其中wt-％基于含有所述局部麻醉剂的所述可溶解微针的所有部分中的固体总重量; 使用所述装置在哺乳动物组织中延长局部递送的局部麻醉剂量的方法; 并提供了制造这些装置的方法。

9. 发明公开

EP2575845A2 AQUEOUS FORMULATIONS FOR COATING MICRONEEDLE ARRAYS 有权
标题翻译： WÄSSRIGEFORMULIERUNGEN ZUR BESCHICHTUNG VON MIKRONADELFELDERN
公开(公告)号：EP2575845A2
公开(公告)日：2013-04-10
申请号：EP11727852.3
申请日：2011-05-26
申请人： 3M Innovative Properties Company
发明人： DETERMAN, Amy S. , JOHNSON, Peter R. , MOSEMAN, Joan T. , WOLDT, Ryan T. , HANSEN, Kristen J.
IPC分类号： A61K38/00 , A61K47/32 , A61K47/36 , A61K47/38 , A61K9/08 , A61K47/10 , A61K47/18 , A61K47/22 , A61K47/26
CPC分类号： A61K9/0021 , A61K47/10 , A61K47/183 , A61K47/22 , A61K47/26 , A61K47/32 , A61K47/36 , A61K47/38 , A61M37/0015
摘要： Aqueous formulations that include at least one active pharmaceutical ingredient; and at least one excipient, wherein the aqueous formulation has a viscosity of from 500 to 30,000 centipoise when measured at a shear rate of 100s
-1 and a temperature of 25° C; a surface tension that is not greater than 60 dynes/cm when measured under ambient conditions; or a contact angle on a medical grade polymeric material of 50° or greater when measured under ambient conditions. Methods of coating and coated microneedle arrays using the aqueous formulations are also disclosed herein.
摘要翻译：包含至少一种活性药物成分的水性制剂; 和至少一种赋形剂，其中当在100s -1的剪切速率和25℃的温度下测量时，所述水性制剂具有500至30,000厘泊的粘度; 当在环境条件下测量时，表面张力不大于60达因/厘米; 或在环境条件下测量时，医疗级聚合材料的接触角为50°以上。本文还公开了使用水性制剂的包衣和包衣微针阵列的方法。

10. 发明授权

EP2355887B1 HOLLOW MICRONEEDLE ARRAY 有权转让
公开(公告)号：EP2355887B1
公开(公告)日：2017-08-02
申请号：EP09828101.7
申请日：2009-11-17
申请人： 3M Innovative Properties Company
发明人： BURTON, Scott A., , FREDERICKSON, Franklyn L. , HANSEN, Kristen J. , SIMMERS, Ryan Patrick, , FENN, Percy T., , MOECKLY, Craig S.,
IPC分类号： A61B17/20 , A61K9/00 , A61M37/00 , A61B5/15
CPC分类号： A61M37/0015 , A61B5/150022 , A61B5/150106 , A61B5/150396 , A61B5/150969 , A61B5/150984 , A61B17/205 , A61K9/0021 , A61M2037/0023 , A61M2037/003 , A61M2037/0061

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