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41. 发明授权

US08846320B2 Haptens, hapten conjugates, compositions thereof and method for their preparation and use 有权
标题翻译：半抗原，半抗原共轭物，其组合物及其制备和使用方法
公开(公告)号：US08846320B2
公开(公告)日：2014-09-30
申请号：US12660017
申请日：2010-02-17
申请人： Jerome W. Kosmeder , Mark Lefever , Donald Johnson , Michael Farrell , Zhanna Zhilina , Christopher Bieniarz
发明人： Jerome W. Kosmeder , Mark Lefever , Donald Johnson , Michael Farrell , Zhanna Zhilina , Christopher Bieniarz
IPC分类号： G01N33/53 , G01N33/532 , G01N33/58
CPC分类号： G01N33/5308 , C07D495/04 , C12Q1/6804 , C12Q1/6841 , C12Q1/6886 , G01N33/532 , G01N33/533 , G01N33/58 , G01N33/582 , G01N33/583 , Y10S435/961 , Y10S530/807
摘要： A method for performing a multiplexed diagnostic assay, such as for two or more different targets in a sample, is described. One embodiment comprised contacting the sample with two or more specific binding moieties that bind specifically to two or more different targets. The two or more specific binding moieties are conjugated to different haptens, and at least one of the haptens is an oxazole, a pyrazole, a thiazole, a nitroaryl compound other than dinitrophenyl, a benzofurazan, a triterpene, a urea, a thiourea, a rotenoid, a coumarin, a cyclolignan, a heterobiaryl, an azo aryl, or a benzodiazepine. The sample is contacted with two or more different anti-hapten antibodies that can be detected separately. The two or more different anti-hapten antibodies may be conjugated to different detectable labels.
摘要翻译：描述了用于执行多路诊断测定的方法，例如样品中两种或更多种不同靶标。一个实施方案包括使样品与特异性结合两个或更多个不同靶标的两个或多个特异性结合部分接触。两个或更多个特异性结合部分与不同的半抗原结合，至少一个半抗原是恶唑，吡唑，噻唑，除二硝基苯基以外的硝基芳基化合物，苯并呋咱，三萜烯，脲，硫脲，旋叶，香豆素，环链烷醇，杂二芳基，偶氮芳基或苯并二氮杂。将样品与两种或更多种可分别检测的不同的抗半抗原抗体接触。两种或更多种不同的抗半抗原抗体可以缀合到不同的可检测标记上。

42. 发明申请

US20140154374A1 Birch Sap Beverage 审中-公开
标题翻译：桦树汁饮料
公开(公告)号：US20140154374A1
公开(公告)日：2014-06-05
申请号：US13690420
申请日：2012-11-30
申请人： Paolo Cugnasca , Michael Farrell
发明人： Paolo Cugnasca , Michael Farrell
IPC分类号： A23L2/50 , A23L2/46 , A23L2/38
CPC分类号： A23L2/38 , A23L2/46 , A23L2/50 , A23L2/56 , A23L2/60 , A23L2/72 , A23L2/74 , A23V2002/00
摘要： A birch sap beverage having an extended shelf life and process for the manufacture thereof in which a birch sap is adjusted to a standard pre-determined Brix value and then subjected to either (a) ultra-high temperature (UHT) pasteurization followed with aseptic packaging (b) packaging followed by UHT. Additional birch sap products having extended shelf life are also disclosed and claimed.
摘要翻译：具有延长的保质期的桦树汁饮料及其制造方法，其中将桦树汁调节至标准预定的白利糖度值，然后进行（a）超高温（UHT）巴氏灭菌，然后进行无菌包装（b）包装，然后是UHT。具有延长保质期的其他桦树汁产品也被公开并要求保护。

43. 发明申请

US20130034854A1 Antibody-Nanoparticle Conjugates and Methods for Making and Using Such Conjugates 有权
标题翻译：抗体纳米颗粒结合体及其制备和使用方法
公开(公告)号：US20130034854A1
公开(公告)日：2013-02-07
申请号：US13640944
申请日：2011-04-27
申请人： Julia Ashworth-Sharpe , Chol Steven Yun , Zhanna Zhilina , Adrian E. Murillo , Donald D. Johnson , Michael Farrell , Jerome W. Kosmeder , Christopher Bieniarz
发明人： Julia Ashworth-Sharpe , Chol Steven Yun , Zhanna Zhilina , Adrian E. Murillo , Donald D. Johnson , Michael Farrell , Jerome W. Kosmeder , Christopher Bieniarz
IPC分类号： C07K17/14 , G01N33/566 , G01N33/573 , G01N33/553 , C12Q1/68 , B82Y5/00
CPC分类号： G01N33/54346 , C07F9/12 , C07F9/5004 , C07F9/5022 , C07F9/5045 , C07F9/5728 , C07F9/65515 , C07F9/65517 , C07F9/65522 , G01N33/531 , G01N33/553 , G01N33/587 , G01N33/6854 , G01N2333/916
摘要： Disclosed herein are antibody-nanoparticle conjugates that include two or more nanoparticles (such as gold, palladium, platinum, silver, copper, nickel, cobalt, iridium, or an alloy of two or more thereof) directly linked to an antibody or fragment thereof through a metal-thiol bond. Methods of making the antibody-nanoparticle conjugates disclosed herein include reacting an arylphosphine-nanoparticle composite with a reduced antibody to produce an antibody-nanoparticle conjugate. Also disclosed herein are methods for detecting a target molecule in a sample that include using an antibody-nanoparticle conjugate (such as the antibody-nanoparticle conjugates described herein) and kits for detecting target molecules utilizing the methods disclosed herein.
摘要翻译：本文公开了抗体 - 纳米颗粒缀合物，其包括直接连接到抗体或其片段的两个或更多个纳米颗粒（例如金，钯，铂，银，铜，镍，钴，铱或其两种或多种的合金）金属硫醇键。制备本文公开的抗体 - 纳米颗粒缀合物的方法包括使芳基膦 - 纳米颗粒复合物与还原抗体反应以产生抗体 - 纳米颗粒缀合物。本文还公开了用于检测样品中靶分子的方法，其包括使用抗体 - 纳米颗粒缀合物（例如本文所述的抗体 - 纳米颗粒缀合物）和利用本文公开的方法检测靶分子的试剂盒。

44. 发明申请

US20110271878A1 TAILGATE-MOUNTED WORK SURFACE 审中-公开
标题翻译： TAILGATE-MOUNTED工作表面
公开(公告)号：US20110271878A1
公开(公告)日：2011-11-10
申请号：US13071903
申请日：2011-03-25
申请人： Greg Parks , John Farrell , Doug Strait , Michael Farrell
发明人： Greg Parks , John Farrell , Doug Strait , Michael Farrell
IPC分类号： A47B37/00 , A47B13/08
CPC分类号： B62D63/04 , B60P3/14 , B62D33/0273
摘要： A portable work surface for use with a vehicle having an extendable rear gate, wherein the rear gate includes first and second latches for securing the rear gate to the body of the vehicle when in a closed position, and wherein the portable work surface includes an elongated platform; a first mounting apparatus attached to one end of the elongated platform, wherein the first mounting apparatus further includes a bracket and pin assembly; a second mounting apparatus attached to the opposite end of the elongated platform, wherein the second mounting apparatus further includes a bracket and pin assembly; and wherein each pin is adapted to cooperate with one of the latches on the rear gate for securely attaching the work surface to the gate when the gate is in the open position.
摘要翻译：一种用于与具有可延伸的后门的车辆一起使用的便携式工作表面，其中所述后门包括用于在处于关闭位置时将所述后门固定到所述车身的第一和第二闩锁，并且其中所述便携式工作表面包括细长平台; 附接到所述细长平台的一端的第一安装装置，其中所述第一安装装置还包括支架和销组件; 附接到所述细长平台的相对端的第二安装装置，其中所述第二安装装置还包括支架和销组件; 并且其中每个销适于与所述后门上的所述闩锁中的一个协作，以在所述门处于打开位置时将所述工作表面牢固地附接到所述门。

45. 发明申请

US20110136130A1 METHOD FOR CHROMOGENIC DETECTION OF TWO OR MORE TARGET MOLECULES IN A SINGLE SAMPLE 有权
标题翻译：用于在单个样品中检测两种或更多种目标分子的方法
公开(公告)号：US20110136130A1
公开(公告)日：2011-06-09
申请号：US13059274
申请日：2009-08-21
申请人： Richard Gniewek , Michael Farrell , Hiroaki Nitta , Megan Lehrkamp , Jerome Kosmeder , Brian Daniel Kelly , Fabien Gaire , Mary Padilla , Thomas Grogan , Christopher Bieniarz
发明人： Richard Gniewek , Michael Farrell , Hiroaki Nitta , Megan Lehrkamp , Jerome Kosmeder , Brian Daniel Kelly , Fabien Gaire , Mary Padilla , Thomas Grogan , Christopher Bieniarz
IPC分类号： C12Q1/68 , G01N33/53
CPC分类号： C12Q1/6841 , G01N33/53 , G01N33/581 , G01N33/583
摘要： The present invention provides a method and kit for detection of two or more target molecules in a single tissue sample, such as for gene and protein dual detection in a single tissue sample. Methods comprise treating a tissue sample with a first binding moiety that specifically binds a first target molecule. Methods further comprise treating the tissue sample with a solution containing a soluble electron-rich aromatic compound prior to or concomitantly with contacting the tissue sample with a hapten-labeled binding moiety and detecting a second target molecule. In one example, the first target molecule is a protein and the second is a nucleic acid sequence, the first target molecule being detected by immunohistochemistry and the second by in situ hybridization. The disclosed method reduces background due to non-specific binding of the hapten-labeled specific binding moiety to an insoluble electron rich compound deposited near the first target molecule.
摘要翻译：本发明提供了用于检测单个组织样品中两种或更多种靶分子的方法和试剂盒，例如用于单一组织样品中的基因和蛋白质双重检测。方法包括用特异性结合第一靶分子的第一结合部分处理组织样品。方法还包括在使组织样品与半抗原标记的结合部分接触或同时检测第二靶分子之前或同时使用含有可溶于富电子的芳族化合物的溶液处理组织样品。在一个实例中，第一靶分子是蛋白质，第二个是核酸序列，第一个靶分子通过免疫组织化学检测，第二个是原位杂交。所公开的方法由于半抗原标记的特异性结合部分与沉积在第一靶分子附近的不溶性富电子化合物的非特异性结合而减少背景。

46. 发明申请

US20080057513A1 METHOD FOR PRODUCING NUCLEIC ACID PROBES 有权
标题翻译：生产核酸探针的方法
公开(公告)号：US20080057513A1
公开(公告)日：2008-03-06
申请号：US11849060
申请日：2007-08-31
申请人： Michael Farrell
发明人： Michael Farrell
IPC分类号： C12Q1/68 , C07H21/04 , C12P19/34
CPC分类号： C12Q1/6841 , C12Q1/6876 , C12Q1/6883 , C12Q1/6886 , C12Q1/701 , C12Q1/708 , C12Q2600/112 , C12Q2600/156
摘要： The present disclosure provides nucleic acid probes, as well as kits that include such probes. Methods for producing and using (for example in chromosomal in situ hybridization) the probes are also provided. Such probes in some examples are used to detect chromosomal abnormalities or the presence of a pathogen.
摘要翻译：本公开提供了核酸探针，以及包括这种探针的试剂盒。还提供了用于生产和使用（例如染色体原位杂交）探针的方法。一些实施例中的这种探针用于检测染色体异常或病原体的存在。

47. 发明申请

US20070216930A1 System and method for estimating toner usage for a printing system 有权
标题翻译：用于估计打印系统的调色剂使用的系统和方法
公开(公告)号：US20070216930A1
公开(公告)日：2007-09-20
申请号：US11374868
申请日：2006-03-14
申请人： William Jacobs , Michael Farrell
发明人： William Jacobs , Michael Farrell
IPC分类号： G06K15/00 , G06F15/00
CPC分类号： G06K15/00 , G03G15/0856 , G03G15/556 , G03G2215/0634 , G03G2221/1663
摘要： A method for determining a toner usage estimate for a print job to be performed by a printing system having at least one print engine and at least one controller includes determining a set of print conditions for the print job and selecting a set of parameters associated with the print conditions. The method further includes estimating a total amount of toner usage for each of the print job's pages. The set of parameters may include image rendering, job dependent and engine dependent parameters.
摘要翻译：一种用于确定要由具有至少一个打印引擎和至少一个打印引擎的打印系统执行的打印作业的调色剂使用估计的方法，包括确定用于所述打印作业的一组打印条件并选择与所述打印作业相关联的一组参数打印条件。该方法还包括估计每个打印作业页面的调色剂使用总量。该组参数可能包括图像渲染，依赖于作业和引擎依赖的参数。

48. 发明申请

US20070201098A1 Bleed creation for documents 有权
标题翻译：流失文件的创建
公开(公告)号：US20070201098A1
公开(公告)日：2007-08-30
申请号：US11363666
申请日：2006-02-28
申请人： Javier Morales , Michael Farrell
发明人： Javier Morales , Michael Farrell
IPC分类号： G06F3/12
CPC分类号： G06T11/60 , G06T11/001
摘要： Apparatus are provided, including a document application and a bleed creation mechanism. The bleed creation mechanism includes an image extender to automatically determine non-blank extended image information based on a location of a blank perimeter area of a page description language (PDL) file. The image extender further populates the blank perimeter area with the non-blank extended image information.
摘要翻译：提供了包括文件应用和出血创建机构的装置。出血创建机构包括图像扩展器，用于基于页面描述语言（PDL）文件的空白周边区域的位置自动确定非空白扩展图像信息。图像扩展器进一步用非空白扩展图像信息填充空白周边区域。

49. 发明申请

US20070192685A1 Document versioning based on layer content 失效
标题翻译：基于图层内容的文档版本控制
公开(公告)号：US20070192685A1
公开(公告)日：2007-08-16
申请号：US11356654
申请日：2006-02-16
申请人： Javier Morales , Michael Farrell
发明人： Javier Morales , Michael Farrell
IPC分类号： G06F17/00
CPC分类号： G06F17/2288 , G06F17/24
摘要： A document can contain multiple print layers. Different layers can be combined to produce different document versions. In this manner, a document can have an English version and a Spanish version that share graphics layers but have different text layers. A document's different layers can be difficult to track and the difficulty can lead to errors in document proofing and production. A discrimination module can automatically classify layers as common, graphics, and text containing. The text containing layers can be further grouped by native language. The layer groups can then be automatically combined to produce the desired document version specifications that can be rendered as document versions.
摘要翻译：文档可以包含多个打印图层。可以组合不同的层以产生不同的文档版本。以这种方式，文档可以具有共享图形层但具有不同文本层的英文版和西班牙文版本。文档的不同层次很难跟踪，难度可能导致文档打样和生产中的错误。辨别模块可以自动将图层分类为普通图形，图形和文本。包含图层的文本可以按本地语言进一步分组。然后，图层组可以自动组合，以产生可以呈现为文档版本的所需文档版本规范。

50. 发明申请

US20070060059A1 Method and system for automatic control in an interference cancellation device 失效
标题翻译：干扰消除装置自动控制方法及系统
公开(公告)号：US20070060059A1
公开(公告)日：2007-03-15
申请号：US11450543
申请日：2006-06-09
申请人： Andrew Kim , Edward Gebara , Bruce Schmukler , Mark Dickmann , Michael Farrell , Michael Vrazel , David Stelliga , Joy Laskar , Charles Summers
发明人： Andrew Kim , Edward Gebara , Bruce Schmukler , Mark Dickmann , Michael Farrell , Michael Vrazel , David Stelliga , Joy Laskar , Charles Summers
IPC分类号： H04B1/00 , H04B15/00
CPC分类号： H04B1/7103 , H04B1/123
摘要： Signals propagating on an aggressor communication channel can cause detrimental interference in a victim communication channel. A signal processing circuit can generate an interference cancellation signal that, when applied to the victim communication channel, cancels the detrimental interference. The signal processing circuit can dynamically adjust or update two or more aspects of the interference cancellation signal, such as an amplitude or gain parameter and a phase or delay parameter. Via the dynamic adjustments, the signal processing circuit can adapt to changing conditions, thereby maintaining an acceptable level of interference cancellation in a fluctuating operating environment. A control circuit that implements the parametric adjustments can have at least two modes of operation, one for adjusting the amplitude parameter and one for adjusting the phase parameter. The modes can be selectable or can be intermittently available, for example.
摘要翻译：在侵略者通信信道上传播的信号可能对受害者通信信道造成有害的干扰。信号处理电路可以产生干扰消除信号，当被施加到受害通信信道时，消除有害干扰。信号处理电路可以动态地调整或更新干扰消除信号的两个或多个方面，例如振幅或增益参数以及相位或延迟参数。通过动态调整，信号处理电路可以适应变化的条件，从而在波动的操作环境中保持可接受的干扰消除水平。实现参数调整的控制电路可以具有至少两种操作模式，一种用于调整幅度参数，一种用于调整相位参数。这些模式可以是可选择的，或者可以间歇地可用。

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