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41. 发明授权

US4854324A Processor-controlled angiographic injector device 失效
标题翻译：处理器控制的血管造影注射器装置
公开(公告)号：US4854324A
公开(公告)日：1989-08-08
申请号：US161434
申请日：1988-02-24
申请人： Alan D. Hirschman , David M. Reilly , Ross H. Potter , John A. Stulen , Eric M. Toft , John G. Clark
发明人： Alan D. Hirschman , David M. Reilly , Ross H. Potter , John A. Stulen , Eric M. Toft , John G. Clark
IPC分类号： A61M5/172
CPC分类号： A61M5/14546 , A61M5/172 , A61M2230/04 , Y10S128/01
摘要： An angiographic injector device for use in x-ray photography for delivering contrast media to a patient at controlled rates and pressures. A processor elicits injection parameters from an operator or a pre-programmed injection module, and on the basis of the injection parameters, calculates appropriate control signals for use in a closed-loop servo system to actuate the plunger of a syringe containing the contrast media. Injection parameters includes flow rate, volume, duration, pressure limit and rise-fall time of flow rate. The device also includes control circuits for inhibiting the injection device in response to a contrast media pressure limit, failure in the processor or injection control system, or upon reaching a predetermined volume of injected media. A mechanical stop member cooperates with the control circuit for blocking movement of the syringe plunger upon reaching the predetermined injected volume. Further, the device includes a self-test feature for checking the status of operational components thereof and a self-calibration feature for calibrating the servo system and position monitors. To improve reliability and to provide immunity from data corruption due to line power interruption, injection parameters are stored in battery-powered primary and secondary memories, and are compared and verified prior to an injection. To assist in coordinating an injection in synchronism with cardiac activity, the device monitors the ECG waveform of the patient's heart and injects a small bolus of contrast media at a given interval, such as the distolic interval. An interface also is provided for providing remote transfer of status and control information with the angiographic injector device.
摘要翻译：一种用于x射线摄影的血管造影注射器装置，用于以受控的速率和压力向患者输送造影剂。处理器从操作者或预编程的注射模块引出注射参数，并且基于注射参数，计算用于闭环伺服系统中的合适的控制信号以致动含有造影剂的注射器的柱塞。注射参数包括流量，体积，持续时间，压力极限和流速上升时间。该装置还包括用于响应于造影剂压力极限，处理器或注射控制系统中的故障或达到预定体积的注射介质而抑制注射装置的控制电路。机械止动构件与控制电路配合，以阻止注射器柱塞达到预定注射体积时的运动。此外，该装置包括用于检查其操作部件的状态的自检特征和用于校准伺服系统和位置监视器的自校准特征。为了提高可靠性并提供由于线路电源中断引起的数据损坏的免疫力，注入参数存储在电池供电的初级和次级存储器中，并在注入之前进行比较和验证。为了协调与心脏活动同步的注射，该装置监测患者心脏的心电图波形，并以给定的时间间隔（例如恶心间隔）注入小量的造影剂。还提供了用于提供与血管造影注射器装置的状态和控制信息的远程传送的界面。

42. 发明申请

US20090326370A1 INTERFACE UNIT FOR USE WITH INJECTORS AND IMAGING SYSTEMS AND RELATED DEVICES 有权
标题翻译：与注射器和成像系统及相关设备一起使用的界面单元
公开(公告)号：US20090326370A1
公开(公告)日：2009-12-31
申请号：US12534987
申请日：2009-08-04
申请人： Arthur E. Uber, III , Edward J. Rhinehart , Rosemary Almon-Martin , David M. Griffiths , Alan D. Hirschman , Francis J. Sciulli , Walter Grumski , Vera Pagano , Karen Zelenski
发明人： Arthur E. Uber, III , Edward J. Rhinehart , Rosemary Almon-Martin , David M. Griffiths , Alan D. Hirschman , Francis J. Sciulli , Walter Grumski , Vera Pagano , Karen Zelenski
IPC分类号： A61B6/00
CPC分类号： A61B8/481 , A61B6/481 , A61B6/504 , A61B8/06 , A61M5/007 , A61M5/14546 , A61M5/1723 , A61M2205/581 , A61M2205/80 , G06F19/00 , G06F19/321 , G06F19/3468
摘要： A system for producing a contrast-enhanced medical image of a patient includes a source of a contrast or enhancement medium, a pressurizing unit in fluid connection with the source of contrast or enhancement medium, an energy source operable to apply energy to a region of the patient, an imaging unit providing a visual display of an internal view of the patient based upon a signal resulting from the energy applied to the region of the patient, and a control unit. In an embodiment, the signal is affected by a condition of the contrast or enhancement medium in the patient. To control the procedures, the control unit adjusts the condition of the contrast or enhancement medium in the patient based upon the signal. A communication interface preferably enables information between an injector subsystem and an imaging subsystem.
摘要翻译：用于产生患者的对比度增强的医学图像的系统包括对比度或增强介质的源，与对比度或增强介质源流体连接的加压单元，可操作以将能量施加到所述对比度或增强介质的区域的能量源患者，成像单元，其基于由施加到患者的区域的能量产生的信号以及控制单元提供患者的内部视图的视觉显示。在一个实施例中，该信号受到患者中的对比度或增强介质的状况的影响。为了控制程序，控制单元基于该信号来调整患者的对比度或增强介质的状况。通信接口优选地实现喷射器子系统和成像子系统之间的信息。

43. 发明授权

US06397098B1 Data communication and control for medical imaging systems 有权
公开(公告)号：US06397098B1
公开(公告)日：2002-05-28
申请号：US09300326
申请日：1999-04-27
申请人： Arthur E. Uber, III , Edward J. Rhinehart , Rosemary Almon-Martin , David M. Griffiths , Alan D. Hirschman , Francis J. Sciulli , Walter Grumski , Vera Pagano , Karen Zelenski
发明人： Arthur E. Uber, III , Edward J. Rhinehart , Rosemary Almon-Martin , David M. Griffiths , Alan D. Hirschman , Francis J. Sciulli , Walter Grumski , Vera Pagano , Karen Zelenski
IPC分类号： A61B600
CPC分类号： A61B8/481 , A61B6/481 , A61B6/504 , A61B8/06 , A61M5/007 , A61M5/14546 , A61M5/1723 , A61M2205/581 , A61M2205/80 , G06F19/00 , G06F19/321 , G06F19/3468
摘要： A system for producing a contrast-enhanced medical image of a patient includes a source of a contrast or enhancement medium, a pressurizing unit in fluid connection with the source of contrast or enhancement medium, an energy source operable to apply energy to a region of the patient, an imaging unit providing a visual display of an internal view of the patient based upon a signal resulting from the energy applied to the region of the patient, and a control unit. In an embodiment, the signal is affected by a condition of the contrast or enhancement medium in the patient. To control the procedures, the control unit adjusts the condition of the contrast or enhancement medium in the patient based upon the signal. A communication interface preferably enables information between an injector subsystem and an imaging subsystem.

44. 发明授权

US5938639A Front load pressure jacket system with syringe holder 失效
公开(公告)号：US5938639A
公开(公告)日：1999-08-17
申请号：US911340
申请日：1997-08-14
申请人： David M. Reilly , Arthur E. Uber, III , Alan D. Hirschman , Eugene A. Gelblum
发明人： David M. Reilly , Arthur E. Uber, III , Alan D. Hirschman , Eugene A. Gelblum
IPC分类号： A61M5/142 , A61M5/145 , A61M37/00 , B05C17/01
CPC分类号： B05C17/01 , A61M5/14546 , A61M2005/14553 , A61M5/14566 , Y10S128/01
摘要： The pressure jacket systems of the invention are used to permit the front loading and removal of a syringe from an injector and include a first jacket segment and a second jacket segment surrounding the exterior surface of the syringe, interior surfaces comformable to the exterior surface of the syringe, a mechanism which allows movement of the first jacket segment in relation to the second jacket segment to permit insertion and removal of the syringe from the pressure jacket, and a mechanism for securing the first and second jacket segments in a fixed relationship upon insertion of the syringe.

45. 发明授权

US5899885A Front load pressure jacket system with syringe holder 失效
公开(公告)号：US5899885A
公开(公告)日：1999-05-04
申请号：US911338
申请日：1997-08-14
申请人： David M. Reilly , Arthur E. Uber, III , Alan D. Hirschman , Eugene A. Gelblum
发明人： David M. Reilly , Arthur E. Uber, III , Alan D. Hirschman , Eugene A. Gelblum
IPC分类号： A61M5/142 , A61M5/145 , A61M37/00 , B05C17/01
CPC分类号： B05C17/01 , A61M5/14546 , A61M2005/14553 , A61M5/14566 , Y10S128/01
摘要： The pressure jacket systems of the invention are used to permit the front loading and removal of a syringe from an injector and include a first jacket segment and a second jacket segment surrounding the exterior surface of the syringe, interior surfaces comformable to the exterior surface of the syringe, a mechanism which allows movement of the first jacket segment in relation to the second jacket segment to permit insertion and removal of the syringe from the pressure jacket, and a mechanism for securing the first and second jacket segments in a fixed relationship upon insertion of the syringe.

46. 发明申请

US20100114064A1 MITIGATION OF CONTRAST-INDUCED NEPHROPATHY 有权
标题翻译：对比诱导性肾病的缓解
公开(公告)号：US20100114064A1
公开(公告)日：2010-05-06
申请号：US12611172
申请日：2009-11-03
申请人： John F. Kalafut , Alan D. Hirschman , David M. Griffiths , Thomas P. Joyce , Jerry A. Stokes , Gerald W. Callan , Dennis P. Hack , Julie Gulick , Andreas R. Maihoefer , Arthur E. Uber, III
发明人： John F. Kalafut , Alan D. Hirschman , David M. Griffiths , Thomas P. Joyce , Jerry A. Stokes , Gerald W. Callan , Dennis P. Hack , Julie Gulick , Andreas R. Maihoefer , Arthur E. Uber, III
IPC分类号： A61M31/00 , A61M5/14
CPC分类号： A61M5/1723 , A61B5/055 , A61B5/201 , A61B5/411 , A61B6/481 , A61B6/482 , A61B6/504 , A61M5/007 , A61M5/142 , A61M2210/1082 , G06F19/00 , G06F19/3468 , G16H50/30
摘要： A system, includes a pressurizing mechanism to pressurize a fluid including a contrast enhancement agent for delivery to a patient; and a control system in operative connection with the pressurizing mechanism. The control system includes a system to adjust control of fluid injection based upon a measurement of renal function of the patient.
摘要翻译：一种系统，包括加压机构，用于对包括用于递送给患者的对比增强剂的流体加压; 以及与加压机构可操作地连接的控制系统。控制系统包括基于患者的肾功能的测量来调节流体注射的控制的系统。

47. 发明申请

US20080228104A1 Energy Assisted Medical Devices, Systems and Methods 审中-公开
标题翻译：能量辅助医疗器械，系统和方法
公开(公告)号：US20080228104A1
公开(公告)日：2008-09-18
申请号：US10599366
申请日：2005-03-11
申请人： Arthur E. Uber , David M. Griffiths , Alan D. Hirschman
发明人： Arthur E. Uber , David M. Griffiths , Alan D. Hirschman
IPC分类号： A61H1/00 , A61B10/02 , A61M25/06 , A61B5/15
CPC分类号： A61B10/0233 , A61B2010/0208
摘要： A device for penetrating tissue and removing a biological sample includes a biological sampling element to remove a biological sample. The biological sampling element includes a passage therethrough. The device further includes a penetrator positioned within the passage. The penetrator is energized in a repetitive manner to assist in penetrating tissue. The biological sample element can be adapted to remove a tissue sample or a biological fluid sample (for example, blood). A device for penetrating tissue and positioning a tissue resident conduit (for example, a catheter), includes a tissue resident conduit (for example, a catheter) including a passage therethrough; and a penetrator in operative connection with the catheter. A device for inserting a tissue resident conduit includes at least one component that is energized during penetration to assist in penetrating tissue. In one embodiment, the tissue resident conduit is flexible and the energized component is positioned or a forward end of the tissue resident conduit. The device can further include a mechanism for directing the penetration of the tissue resident conduit. A needle for penetrating tissue includes a first effector including a surface and at least one actuator in operative connection with the first effector. The actuator is adapted to cause motion of the first effector such that tearing of tissue takes place in regions where there is close proximity of tissue to the surface of the first effector.
摘要翻译：用于穿透组织并去除生物样品的装置包括用于去除生物样品的生物取样元件。生物采样元件包括通过其中的通道。该装置还包括定位在通道内的穿透器。穿透器以重复的方式通电以辅助穿透组织。生物样品元件可以适于去除组织样品或生物流体样品（例如血液）。用于穿透组织并定位组织驻留导管（例如导管）的装置包括组织驻留导管（例如导管），其包括穿过其中的通道; 以及与导管可操作地连接的穿透器。用于插入组织固定导管的装置包括至少一个在穿透期间被激发以帮助穿透组织的部件。在一个实施例中，组织驻留导管是柔性的，并且通电部件被定位或组织固定导管的前端。该装置还可以包括用于引导组织驻留导管穿透的机构。用于穿透组织的针包括包括表面的第一执行器和与第一执行器可操作地连接的至少一个致动器。致动器适于引起第一效应器的运动，使得组织的撕裂发生在组织靠近第一效应器的表面的区域中。

48. 发明授权

US07018363B2 Encoding and sensing of syringe information 有权
公开(公告)号：US07018363B2
公开(公告)日：2006-03-28
申请号：US09765498
申请日：2001-01-18
申请人： Kevin P. Cowan , Barry Iddon , Michael J. Yanniello , John A. Brosovich , Alan D. Hirschman
发明人： Kevin P. Cowan , Barry Iddon , Michael J. Yanniello , John A. Brosovich , Alan D. Hirschman
IPC分类号： A61M1/00 , A61M5/00 , A61M3/00
CPC分类号： G01D5/12 , A61M5/1452 , A61M5/3129 , A61M2005/3125 , A61M2205/6036 , A61M2205/6063
摘要： A syringe for use with a powered injector to inject a fluid into a patient that includes a length of material adapted to transmit or propagate electromagnetic energy therethrough. The length of material includes at least a first indicator positioned along the length of material. The first indicator is adapted to interact with at least a portion of the energy being propagated through the length of material in a manner that is detectable. The presence (or absence) of the first indicator provides or corresponds to information about the syringe configuration. The indicator(s) of the present invention can, for example, provide information about syringe configuration by the number and/or position thereof. A plurality or set of such syringes can be provided, with the configuration of each such syringe being represented by the presence or absence of indicator(s) of that syringe.

49. 发明授权

US06751500B2 Apparatuses and methods for extravasation detection 有权
标题翻译：用于外渗检测的装置和方法
公开(公告)号：US06751500B2
公开(公告)日：2004-06-15
申请号：US10233874
申请日：2002-09-03
申请人： Alan D. Hirschman
发明人： Alan D. Hirschman
IPC分类号： A61B505
CPC分类号： A61B5/0537 , A61B5/4869 , A61M5/16836
摘要： An apparatus for the detection of extravasation is positioned in a manner so that the vicinity of a site is available for palpation and is visible for visual inspection. Another embodiment of the apparatus improves the sensitivity of detection by positioning an energy source and a receiver between a first layer of a high dielectric material and a second lay of a low dielectric material. The apparatus may further include a third layer of a conductive material to shield the apparatus from stray capacitance. In addition, a system for detection of extravasation includes an array of sensors located at, adjacent to and/or remote from an injection site.
摘要翻译：用于检测外渗的装置以使得位置附近可用于触诊的方式定位，并且对于目视检查是可见的。设备的另一实施例通过将能量源和接收器定位在高介电材料的第一层和低介电材料的第二层之间来提高检测的灵敏度。该装置可以进一步包括导电材料的第三层以屏蔽该装置与杂散电容。此外，用于检测外渗的系统包括位于，邻近和/或远离注射部位的传感器阵列。

50. 发明授权

US08821450B2 Encoding and sensing of syringe information 有权
标题翻译：注射器信息的编码和感测
公开(公告)号：US08821450B2
公开(公告)日：2014-09-02
申请号：US11254061
申请日：2005-10-19
申请人： Kevin P. Cowan , Barry Iddon , Michael J. Yanniello , John A. Brosovich , Alan D. Hirschman
发明人： Kevin P. Cowan , Barry Iddon , Michael J. Yanniello , John A. Brosovich , Alan D. Hirschman
IPC分类号： A61M1/00 , A61M5/00 , A61M3/00
CPC分类号： G01D5/12 , A61M5/1452 , A61M5/3129 , A61M2005/3125 , A61M2205/6036 , A61M2205/6063
摘要： A syringe for use with a powered injector to inject a fluid into a patient that includes a length of material adapted to transmit or propagate electromagnetic energy therethrough. The length of material includes at least a first indicator positioned along the length of material. The first indicator is adapted to interact with at least a portion of the energy being propagated through the length of material in a manner that is detectable. The presence (or absence) of the first indicator provides or corresponds to information about the syringe configuration. The indicator(s) of the present invention can, for example, provide information about syringe configuration by the number and/or position thereof. A plurality or set of such syringes can be provided, with the configuration of each such syringe being represented by the presence or absence of indicator(s) of that syringe.
摘要翻译：一种与动力注射器一起使用的注射器，用于将流体注入患者体内，该注射器包括适于透过或传播电磁能量的一定长度的材料。材料的长度至少包括沿材料长度定位的第一指示器。第一指示符适于与以可检测的方式相互作用的能量的至少一部分通过材料的长度传播。第一个指示器的存在（或不存在）提供或对应于关于注射器配置的信息。例如，本发明的指示器可以通过其数量和/或位置提供关于注射器构造的信息。可以提供多个或一组这样的注射器，每个这样的注射器的构造由该注射器的指示器的存在或不存在表示。

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