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41. 发明授权

US5840026A Patient specific dosing contrast delivery systems and methods 失效
标题翻译：患者特异性给药对比剂输送系统和方法
公开(公告)号：US5840026A
公开(公告)日：1998-11-24
申请号：US309820
申请日：1994-09-21
申请人： Arthur E. Uber, III , Alan D. Hirschman , Thomas R. Welch , Rosemary Almon-Martin
发明人： Arthur E. Uber, III , Alan D. Hirschman , Thomas R. Welch , Rosemary Almon-Martin
IPC分类号： A61M5/00 , A61M5/172
CPC分类号： A61B8/06 , A61B8/481 , A61M5/007 , A61M5/1723 , G06F19/3468 , A61M2205/581 , A61M2205/80 , G06F19/321 , Y10S128/12 , Y10S128/13
摘要： This invention relates generally to the field of medical devices for delivering contrast media during medical diagnostic and therapeutic imaging procedures and more particularly, this invention relates to improved contrast media delivery systems and methods of use which allow adjustment of contrast media concentration and injection parameters either before or during an injection procedure.
摘要翻译：本发明一般涉及在医疗诊断和治疗成像过程中用于输送造影剂的医疗装置领域，更具体地说，本发明涉及改进的造影剂递送系统和使用方法，其允许在之前调节造影剂浓度和注射参数或在注射过程中。

42. 发明授权

US08747358B2 Injector system with a manual control device 有权
标题翻译：注射器系统带手动控制装置
公开(公告)号：US08747358B2
公开(公告)日：2014-06-10
申请号：US11238666
申请日：2005-09-29
申请人： Frederick W. Trombley, III , Robert M. Schmidt , David M. Reilly , Alan D. Hirschman , David M. Griffiths , Gerald W. Callan , Luis A. Pedraza , Jennie Kwo , Christopher T. Zirps , Roderick H. Beaulieu
发明人： Frederick W. Trombley, III , Robert M. Schmidt , David M. Reilly , Alan D. Hirschman , David M. Griffiths , Gerald W. Callan , Luis A. Pedraza , Jennie Kwo , Christopher T. Zirps , Roderick H. Beaulieu
IPC分类号： A61M1/00
CPC分类号： A61M5/007 , A61M5/14546 , A61M5/16827 , A61M31/005 , A61M39/22 , A61M2005/1403 , A61M2205/582 , A61M2209/01 , Y10T137/7727
摘要： An injector system includes a powered injector, a pressurizing chamber in operative connection with the powered injection, a fluid path in fluid communication with the pressurizing chamber, and a manual control in fluid connection with the fluid path. The manual control includes at least one actuator for controlling the injector through application of force by an operator. The actuator provides tactile feedback of pressure in the fluid path to the operator via a fluid connection therewith. An injection system for use in angiography includes a source of saline, a pump in fluid connection with the source of saline to pressurized the saline, a source of contrast, a contrast valve in fluid connection with the source of contrast, a powered injector in fluid connection with the contrast valve, and a pressure isolation mechanism.
摘要翻译：注射器系统包括动力注射器，与动力注射操作连接的加压室，与加压室流体连通的流体路径，以及与流体路径流体连接的手动控制。手动控制包括至少一个执行器，用于通过操作者施加力来控制喷射器。致动器通过与其的流体连接提供到操作者的流体路径中的压力的触觉反馈。用于血管造影术的注射系统包括盐水源，与盐水源流体连接的泵以加压盐水，对比源，与对比源流体连接的对比阀，流体中的动力注射器与对比度阀的连接，以及压力隔离机构。

43. 发明申请

US20080058758A1 METHOD FOR DELIVERING THERAPEUTIC AGENTS 审中-公开
标题翻译：递送治疗药物的方法
公开(公告)号：US20080058758A1
公开(公告)日：2008-03-06
申请号：US11842999
申请日：2007-08-22
申请人： ARUN RANCHOD , David M. Griffiths , Alan D. Hirschman
发明人： ARUN RANCHOD , David M. Griffiths , Alan D. Hirschman
IPC分类号： A61M31/00
CPC分类号： A61M25/007 , A61F2/013
摘要： In one form, the therapeutic agent delivery apparatus is used for infusing a therapeutic agent into a body lumen and includes a lumenal body defining a plurality of infusion ports for infusing the therapeutic agent into the body lumen, and a sensing element distal of the infusion ports and adapted to sense the amount of infused therapeutic agent or any compound derived from the therapeutic agent in the body lumen. In another form, the apparatus includes a lumenal body defining a plurality of infusion ports for infusing the therapeutic agent into the body lumen, and a filtration element distal of the infusion ports and adapted to deliver a reaction agent adapted to react with the therapeutic agent in the body lumen. A sensing element may be provided distal of the filtration element for sensing the amount of infused therapeutic agent or compounds derived therefrom in the body lumen.
摘要翻译：在一种形式中，治疗剂递送装置用于将治疗剂注入体腔，并且包括界定多个用于将治疗剂注入体腔的输注端口的腔体，以及位于输液端口远端的感测元件并且适于感测输注的治疗剂或源自体腔内的治疗剂的任何化合物的量。在另一种形式中，该装置包括限定用于将治疗剂注入体腔内的多个输注端口的腔体，以及位于输注端口远端的过滤元件，并适于递送适于与治疗剂反应的反应剂体腔。感测元件可以设置在过滤元件的远侧，用于感测在体腔中输注的治疗剂或其衍生的化合物的量。

44. 发明授权

US07315109B1 Actuators and fluid delivery systems using such actuators 有权
标题翻译：使用这种致动器的致动器和流体输送系统
公开(公告)号：US07315109B1
公开(公告)日：2008-01-01
申请号：US10916946
申请日：2004-08-12
申请人： David M. Griffiths , Amy S. Pomaybo , Alan D. Hirschman
发明人： David M. Griffiths , Amy S. Pomaybo , Alan D. Hirschman
IPC分类号： H01L41/04 , H01L41/08
CPC分类号： H01L41/042 , F03G7/065 , F04B43/043 , Y10S310/80
摘要： An actuator includes a non-magnetic, electroactive material that is suitable to impart force upon application of an electric current, a power supply to provide an electric current to the electroactive material and a controller in operative connection with the power supply to control application of electric current to the electroactive material. In one embodiment, the controller is adapted to limit rates at which electric current is applied to or removed from the electroactive material to predefined rates, thereby reducing the potential for high frequency harmonic emissions.
摘要翻译：致动器包括适于在施加电流时施加力的非磁性电活性材料，用于向电活性材料提供电流的电源以及与电源可操作地连接以控制电力的应用的控制器电流至电活性材料。在一个实施例中，控制器适于限制向电活性材料施加电流或从电活性材料移除电流的速率到预定速率，从而降低高频谐波发射的可能性。

45. 发明授权

US07204797B2 Delivery methods, systems and components for use with hazardous pharmaceutical substances 有权
标题翻译：用于危险药物的输送方法，系统和组件
公开(公告)号：US07204797B2
公开(公告)日：2007-04-17
申请号：US10893591
申请日：2004-07-16
申请人： David M. Reilly , Alan D. Hirschman , David M. Griffiths , Currie Crookston
发明人： David M. Reilly , Alan D. Hirschman , David M. Griffiths , Currie Crookston
IPC分类号： A61N5/00
CPC分类号： A61K51/1282 , A61M5/007 , A61M5/1407 , A61M5/1452 , A61M5/14546 , A61M5/1785 , G06F19/00 , G16H20/17
摘要： A method of dispensing a hazardous pharmaceutical comprising the steps of: connecting a source of flushing fluid to a first port of a fluid delivery set; connecting a pressurizing unit of a powered injector system (including a powered injector and the pressurizing unit) to a second port of the fluid delivery set; purging air from the fluid delivery set; and, after purging air from the fluid delivery set, connecting a third port of the fluid delivery set to a source of the hazardous pharmaceutical. The fluid delivery set can, for example, include a valve system or assembly to control flow of fluid through the fluid delivery set. A system for delivery of a hazardous pharmaceutical includes: a syringe in operative connection with a powered injector; a protective container to enclose the syringe during operation thereof; the protective container being adapted to protect personnel from detrimental effects of the pharmaceutical; at least one source of flushing fluid; a fluid path adapted to connect to a patient; at least one source of the pharmaceutical; and a fluid delivery set including a valve assembly to which the syringe, the source of flushing fluid, the fluid path and the source of pharmaceutical are removably connectable. The valve assembly provides flow control through the fluid delivery set such that operator contact with the fluid delivery set is not required after connection of the source of pharmaceutical to the fluid delivery set.
摘要翻译：一种分配危险药物的方法，包括以下步骤：将冲洗流体源连接到流体输送装置的第一端口; 将动力注射器系统（包括动力注射器和加压单元）的加压单元连接到流体输送组的第二端口; 从流体输送装置吹扫空气; 并且在从流体输送装置吹扫空气之后，将流体输送装置的第三端口连接到危险药物源。流体输送装置可以例如包括阀系统或组件以控制通过流体输送组的流体的流动。用于递送危险药物的系统包括：与动力注射器可操作地连接的注射器; 在操作期间包围注射器的保护容器; 保护容器适于保护人员免受药物的不利影响; 至少一个冲洗液源; 适于连接到患者的流体路径; 至少一种药物来源; 以及包括阀组件的流体输送组件，注射器，冲洗流体源，流体路径和药物源可拆卸地连接到该组件。阀组件通过流体输送组件提供流量控制，使得在将药物源连接到流体输送装置之后，操作者不需要与流体输送装置接触。

46. 发明授权

US08876754B2 Catheter with filtering and sensing elements 有权
标题翻译：带过滤和感应元件的导管
公开(公告)号：US08876754B2
公开(公告)日：2014-11-04
申请号：US11469054
申请日：2006-08-31
申请人： Arun Ranchod , David M. Griffiths , Alan D. Hirschman
发明人： Arun Ranchod , David M. Griffiths , Alan D. Hirschman
IPC分类号： A61M31/00 , A61M25/00
CPC分类号： A61M25/007 , A61F2/013
摘要： A delivery apparatus useful for infusing a therapeutic agent into a body lumen, the apparatus including a lumenal body defining at least one infusion port for infusing the therapeutic agent into the body lumen, and a sensing element which is distal of the at least one infusion port and adapted to sense the amount of infused therapeutic agent or any compound derived therefrom in the body lumen. Another embodiment of the apparatus includes a lumenal body defining at least one infusion port for infusing the therapeutic agent into the body lumen, and a filtration element which is distal of the at least one infusion port and adapted to deliver a reaction agent which may react with the therapeutic agent in the body lumen. A sensing element may be provided distal of the filtration element for sensing the amount of infused therapeutic agent or compounds derived therefrom in the body lumen.
摘要翻译：一种用于将治疗剂注入体腔中的输送装置，所述装置包括限定用于将治疗剂注入体腔的至少一个输注端口的腔体，以及位于至少一个输注端口的远端的感测元件并且适于感测输注的治疗剂或其体内衍生的任何化合物的量。该装置的另一实施例包括限定用于将治疗剂注入体腔的至少一个输注端口的腔体，以及位于该至少一个输注端口的远端的适于输送可与治疗剂在体腔内。感测元件可以设置在过滤元件的远侧，用于感测在体腔中输注的治疗剂或其衍生的化合物的量。

47. 发明申请

US20080097339A1 CATHETER WITH FILTERING AND SENSING ELEMENTS 有权
标题翻译：带过滤器和感应元件的过滤器
公开(公告)号：US20080097339A1
公开(公告)日：2008-04-24
申请号：US11469054
申请日：2006-08-31
申请人： Arun Ranchod , David M. Griffiths , Alan D. Hirschman
发明人： Arun Ranchod , David M. Griffiths , Alan D. Hirschman
IPC分类号： A61M5/168 , A61M29/00
CPC分类号： A61M25/007 , A61F2/013
摘要： In one form, the therapeutic agent delivery apparatus is used for infusing a therapeutic agent into a body lumen and includes a lumenal body defining a plurality of infusion ports for infusing the therapeutic agent into the body lumen, and a sensing element distal of the infusion ports and adapted to sense the amount of infused therapeutic agent or any compound derived from the therapeutic agent in the body lumen. In another form, the apparatus includes a lumenal body defining a plurality of infusion ports for infusing the therapeutic agent into the body lumen, and a filtration element distal of the infusion ports and adapted to deliver a reaction agent adapted to react with the therapeutic agent in the body lumen. A sensing element may be provided distal of the filtration element for sensing the amount of infused therapeutic agent or compounds derived therefrom in the body lumen.
摘要翻译：在一种形式中，治疗剂递送装置用于将治疗剂注入体腔，并且包括界定多个用于将治疗剂注入体腔的输注端口的腔体，以及位于输液端口远端的感测元件并且适于感测输注的治疗剂或源自体腔内的治疗剂的任何化合物的量。在另一种形式中，该装置包括限定用于将治疗剂注入体腔内的多个输注端口的腔体，以及位于输注端口远端的过滤元件，并适于递送适于与治疗剂反应的反应剂体腔。感测元件可以设置在过滤元件的远侧，用于感测在体腔中输注的治疗剂或其衍生的化合物的量。

48. 发明授权

US06767319B2 Delivery methods, systems and components for use with hazardous pharmaceutical substances 有权
标题翻译：用于危险药物的输送方法，系统和组件
公开(公告)号：US06767319B2
公开(公告)日：2004-07-27
申请号：US10201880
申请日：2002-07-24
申请人： David M. Reilly , Alan D. Hirschman , David M. Griffiths , Currie Crookston
发明人： David M. Reilly , Alan D. Hirschman , David M. Griffiths , Currie Crookston
IPC分类号： A61N500
CPC分类号： A61K51/1282 , A61M5/007 , A61M5/1407 , A61M5/1452 , A61M5/14546 , A61M5/1785 , G06F19/00 , G16H20/17
摘要： A method of dispensing a hazardous pharmaceutical includes the steps of: connecting a source of flushing fluid to a first port of a fluid delivery set; connecting a pressurizing unit of a powered injector system (including a powered injector and the pressurizing unit) to a second port of the fluid delivery set; purging air from the fluid delivery set; and, after purging air from the fluid delivery set, connecting a third port of the fluid delivery set to a source of the hazardous pharmaceutical. The fluid delivery set can, for example, include a valve system or assembly to control flow of fluid through the fluid delivery set. A system for delivery of a hazardous pharmaceutical includes: a syringe in operative connection with a powered injector; a protective container to enclose the syringe during operation thereof, the protective container being adapted to protect personnel from detrimental effects of the pharmaceutical; at least one source of flushing fluid; a fluid path adapted to connect to a patient; at least one source of the pharmaceutical; and a fluid delivery set including a valve assembly to which the syringe, the source of flushing fluid, the fluid path and the source of pharmaceutical are removably connectable. The valve assembly provides flow control through the fluid delivery set such that operator contact with the fluid delivery set is not required after connection of the source of pharmaceutical to the fluid delivery set.
摘要翻译：分配危险药物的方法包括以下步骤：将冲洗流体源连接到流体输送装置的第一端口; 将动力注射器系统（包括动力注射器和加压单元）的加压单元连接到流体输送组的第二端口; 从流体输送装置吹扫空气; 并且在从流体输送装置吹扫空气之后，将流体输送装置的第三端口连接到危险药物源。流体输送装置可以例如包括阀系统或组件以控制通过流体输送组的流体的流动。用于递送危险药物的系统包括：与动力注射器可操作地连接的注射器; 保护容器在操作期间封闭注射器，保护容器适于保护人员免受药物的不利影响; 至少一个冲洗液源; 适于连接到患者的流体路径; 至少一种药物来源; 以及包括阀组件的流体输送组件，注射器，冲洗流体源，流体路径和药物源可拆卸地连接到该组件。阀组件通过流体输送组件提供流量控制，使得在将药物源连接到流体输送装置之后，操作者不需要与流体输送装置接触。

49. 发明授权

US07094216B2 Injection system having a pressure isolation mechanism and/or a handheld controller 有权
标题翻译：具有压力隔离机构和/或手持控制器的注射系统
公开(公告)号：US07094216B2
公开(公告)日：2006-08-22
申请号：US09982518
申请日：2001-10-18
申请人： Frederick W. Trombley, III , Robert M. Schmidt , David M. Reilly , Alan D. Hirschman , David M. Griffiths , Gerald W. Callan , Luis A. Pedraza , Jennie Kwo , Christopher T. Zirps , Roderick H. Beaulieu
发明人： Frederick W. Trombley, III , Robert M. Schmidt , David M. Reilly , Alan D. Hirschman , David M. Griffiths , Gerald W. Callan , Luis A. Pedraza , Jennie Kwo , Christopher T. Zirps , Roderick H. Beaulieu
IPC分类号： A61M31/00
CPC分类号： A61M5/007 , A61M5/14546 , A61M5/16827 , A61M31/005 , A61M39/22 , A61M2005/1403 , A61M2205/582 , A61M2209/01 , Y10T137/7727
摘要： An injector system includes a powered injector, a pressurizing chamber in operative connection with the powered injector, a fluid path in fluid connection with the pressurizing chamber, and a manual control in fluid connection with the fluid path. The manual control includes at least one actuator for controlling the injector through application of force by an operator. The actuator provides tactile feedback of pressure in the fluid path to the operator via a fluid connection with the fluid path. An injection system for use in angiography includes a source of saline, a pump in fluid connection with the source of saline to pressurize the saline, a saline valve in fluid connection via a first port thereof with an outlet of the pump, a first connector in fluid connection with a second port of the saline valve, a source of contrast, a contrast valve in fluid connection with the source of contrast via a first port of the contrast valve, a powered injector in fluid connection with a second port of the contrast valve, a second connector in fluid connection with a third port of the contrast valve, and a pressure isolation mechanism.
摘要翻译：注射器系统包括动力注射器，与动力注射器可操作地连接的加压室，与加压室流体连接的流体路径，以及与流体路径流体连接的手动控制。手动控制包括至少一个执行器，用于通过操作者施加力来控制喷射器。致动器通过与流体路径的流体连接提供到操作者的流体路径中的压力的触觉反馈。用于血管造影术的注射系统包括盐水源，与盐水源流体连接以对盐水加压的泵，经由其第一端口与泵的出口流体连接的盐水阀，第一连接器与盐水阀的第二端口的流体连接，对比度源，通过对比度阀的第一端口与对比源流体连接的对比度阀，与对比度阀的第二端口流体连接的动力注射器与对比度阀的第三端口流体连接的第二连接器和压力隔离机构。

50. 发明授权

US07326186B2 Injector system and fluid control device providing sharp bolus injection 有权
标题翻译：喷射器系统和流体控制装置提供尖锐的推注
公开(公告)号：US07326186B2
公开(公告)日：2008-02-05
申请号：US10818748
申请日：2004-04-06
申请人： Frederick W. Trombley, III , Robert M. Schmidt , David M. Reilly , Alan D. Hirschman , David M. Griffiths , Gerald W. Callan , Luis A. Pedraza , Jennie Kwo , Christopher T. Zirps , Roderick H. Beaulieu
发明人： Frederick W. Trombley, III , Robert M. Schmidt , David M. Reilly , Alan D. Hirschman , David M. Griffiths , Gerald W. Callan , Luis A. Pedraza , Jennie Kwo , Christopher T. Zirps , Roderick H. Beaulieu
IPC分类号： A61M1/00 , A61M37/00 , F16K17/00
CPC分类号： A61M5/007 , A61M5/14546 , A61M5/16827 , A61M31/005 , A61M39/22 , A61M2005/1403 , A61M2205/582 , A61M2209/01 , Y10T137/7727
摘要： An injector system includes a source of injection fluid, a pump device, a fluid path set disposed between the source of injection fluid and the pump device, and a fluid control device operatively associated with the fluid path set. The fluid control device is adapted to permit purging of air from the fluid path set and to stop flow of the injection fluid to a patient at substantially any pressure or flow rate generated by the pump device for delivering a sharp bolus of the injection fluid to the patient. The fluid control device is preferably part of the fluid path set between the source of injection fluid and the pump device.
摘要翻译：注射器系统包括注射流体源，泵装置，设置在注射流体源和泵装置之间的流体路径组以及与流体路径组可操作地相关联的流体控制装置。流体控制装置适于允许从流体路径组清洗空气并且以基本上由泵装置产生的任何压力或流速停止注射流体到患者的流动，以将喷射流体的尖锐推注物输送到患者。流体控制装置优选地是在注射流体源和泵装置之间设置的流体路径的一部分。

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