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    • 41. 发明申请
    • Short Beam Shear Test Fixture
    • 短梁剪切试验夹具
    • US20120222491A1
    • 2012-09-06
    • US13347488
    • 2012-01-10
    • David L. Williams
    • David L. Williams
    • G01N3/02
    • G01N3/04G01N2203/0023G01N2203/0048G01N2203/0405G01N2203/0435Y10T279/1986
    • The test fixture includes a housing, a first grip, and a second grip. The first grip and the second grip are each configured to clamp onto an upper surface and lower surface of a material coupon. The test fixture also includes an upper input jaw and a lower input jaw each configured to clamp onto the material coupon near a center of the upper surface and the lower surface of the material coupon. The test fixture is configured to load the material coupon in a first direction and a second direction. The first grip and the second grip are each configured to clamp onto the material coupon at a location which accordingly results in a desired testing ratio regardless of a variation in thickness of the material coupon.
    • 测试夹具包括壳体,第一把手和第二把手。 第一把手和第二把手各自构造成夹紧在材料券的上表面和下表面上。 测试夹具还包括上部输入钳口和下部输入钳口,每个构造成在材料试件的上表面和下表面的中心附近夹紧材料试样。 测试夹具被配置为在第一方向和第二方向上装载材料试样。 第一把手和第二把手各自被配置成在相应地产生期望的测试比例的位置处夹紧到材料试样上,而不管材料试样厚度的变化如何。
    • 45. 发明申请
    • NOVEL SUBSTITUTED AZABENZOXAZOLES
    • 新型取代的AZABENZOXAZOLES
    • US20110212031A1
    • 2011-09-01
    • US13125939
    • 2009-10-21
    • Cyrille SurDavid L. Williams
    • Cyrille SurDavid L. Williams
    • A61K49/10A61P25/16A61K31/5377A61K49/00A61P25/28A61P25/18A61K31/437
    • A61K31/519A61K51/0455A61K51/0463
    • The present invention relates to novel MAO-B binding compounds and methods for measuring effects of the compounds, by measuring changes of MAO-B levels in living patients. More specifically, the present invention relates to use of the compounds of this invention as therapeutic agents for inhibition of MAO-B activity as well as a method of using the compounds of this invention as tracers in positron emission tomography (PET) imaging to study MAO-B levels in brain in vivo to allow diagnosis of Alzheimer's disease. Thus, the present invention relates to use of the novel MAO-B binding compounds as diagnostic, as we a therapeutic, agents. The invention further relates to a method of measuring clinical efficacy of Alzheimer's disease therapeutic agents. Specifically, the present invention relates to novel aryl or heteroaryl substituted azabenzoxazole derivatives, compositions, and therapeutic uses and processes for making such compounds.
    • 本发明涉及通过测量活体患者中MAO-B水平的变化来测量化合物的效果的新型MAO-B结合化合物和方法。 更具体地,本发明涉及本发明化合物作为抑制MAO-B活性的治疗剂的用途以及使用本发明化合物作为正电子发射断层摄影(PET)成像中的示踪物来研究MAO的方法 -B水平在体内,以允许诊断阿尔茨海默病。 因此,本发明涉及新型MAO-B结合化合物作为诊断的用途,作为治疗剂。 本发明还涉及测量阿尔茨海默病治疗剂的临床疗效的方法。 具体地,本发明涉及新的芳基或杂芳基取代的氮杂苯并恶唑衍生物,组合物,以及用于制备这些化合物的治疗用途和方法。
    • 48. 发明申请
    • NOVEL SUBSTITUTED AZABENZOXAZOLES
    • 新型取代的AZABENZOXAZOLES
    • US20110085985A1
    • 2011-04-14
    • US12995314
    • 2009-05-28
    • James C. BarrowScott HarrisonJames MulhearnCyrille SurDavid L. WilliamsScott Wolkenberg
    • James C. BarrowScott HarrisonJames MulhearnCyrille SurDavid L. WilliamsScott Wolkenberg
    • A61K31/437C07D498/04C07D519/00A61K31/5377A61K49/00A61K49/04A61K49/06A61P25/28A61P25/18
    • C07D498/04C07D519/00
    • The present invention relates to novel amyloid binding compounds of formula (I) and methods for measuring effects of the compounds, by measuring changes of amyloid plaque level in living patients. More specifically, the present invention relates to a method of using the compounds of this invention as tracers in positron emission tomography (PET/) imaging to study amyloid deposits in brain in vivo to allow diagnosis of Alzheimer's disease. Thus, the present invention relates to use of the novel amyloid binding compounds as a diagnostic. The invention further relates to a method of measuring clinical efficacy of Alzheimer's disease therapeutic agents. Specifically, the present invention relates to novel aryl or heteroaryl substituted azabenzoxazole derivatives, compositions, and therapeutic uses and processes for making such compounds, or a pharmaceutically acceptable salt, solvate or in vivo hydrolysable ester thereof, wherein: X is O or S; A and Y independently are N, or CH;
    • 本发明涉及式(I)的新型淀粉样蛋白结合化合物和通过测定活体患者淀粉样斑块水平的变化来测定化合物的效果的方法。 更具体地说,本发明涉及使用本发明化合物作为正电子发射断层摄影(PET /)成像中的示踪剂来研究脑中淀粉样蛋白沉积物以允许诊断阿尔茨海默病的方法。 因此,本发明涉及新型淀粉样蛋白结合化合物作为诊断用途。 本发明还涉及测量阿尔茨海默病治疗剂的临床疗效的方法。 具体地,本发明涉及新的芳基或杂芳基取代的氮杂苯并恶唑衍生物,组合物,以及用于制备这些化合物或其药学上可接受的盐,溶剂合物或体内可水解的酯的治疗用途和方法,其中:X是O或S; A和Y独立地为N或CH;
    • 50. 发明授权
    • Surgical cassette
    • 手术盒
    • US07775780B2
    • 2010-08-17
    • US11338491
    • 2006-01-24
    • Mark A. HopkinsKamran SalariDavid L. Williams
    • Mark A. HopkinsKamran SalariDavid L. Williams
    • F04B43/12
    • F04B43/14A61M1/0058A61M1/0072A61M2205/128A61M2210/0612F04B43/0054F04B43/1269
    • A cassette having an elastomeric sheet that is bonded or mechanically attached to a rigid substrate. A flow channel is molded into the rigid substrate that corresponds to a flow channel molded into the elastomeric sheet. The cassette is used in combination with a peristaltic pump having pump head rollers that are mounted radially from the axis of rotation of the pump motor so as to compress the elastomeric flow channels against the rigid substrate during operation. The flow channels molded into the rigid substrate have smooth, fluid lines free from sharp edges and abrupt direction changes and correspond with the fluid channels molded into the elastomeric sheet so as to provide a transition region with a relatively constant cross-section over its entire length that approximates the cross-sectional area of the flow channels molded into the rigid substrate and the fluid channel molded into the elastomeric sheet so that the entire fluid path is of relatively constant cross-sectional area.
    • 一种具有弹性体片材的盒子,该弹性片材粘合或机械地附接到刚性基底。 将流动通道模制到对应于模制到弹性体片材中的流动通道的刚性基底中。 该盒与具有泵头辊的蠕动泵组合使用,泵头辊从泵电动机的旋转轴线径向安装,以便在操作期间将弹性体流动通道压靠在刚性基板上。 模制到刚性基材中的流动通道具有平滑的流体管线,没有锋利的边缘和突然的方向改变,并且对应于模制到弹性体片材中的流体通道,以便提供在整个长度上具有相对恒定横截面的过渡区域 其近似于模制到刚性基底中的流动通道的横截面积和模制到弹性体片材中的流体通道,使得整个流体路径具有相对恒定的横截面积。