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41. 发明专利

IL142996A DERIVATIVES OF ERYTHROMYCIN, THEIR PREPARATION PROCESS AND THEIR USE AS MEDICAMENTS 未知
公开(公告)号：IL142996A
公开(公告)日：2006-12-10
申请号：IL14299601
申请日：2001-05-06
申请人： CONSTANTIN AGOURIDAS , DENIS ALEXIS , AVENTIS PHARMA SA , FROMENTIN CLAUDE
发明人： CONSTANTIN AGOURIDAS , DENIS ALEXIS , FROMENTIN CLAUDE
IPC分类号： A61K31/7042 , A61K31/7048 , A61K31/7056 , A61P31/04 , C07D233/54 , C07D233/64 , C07H17/08
摘要： A subject of the invention is, as new chemical products, the compounds of formula (I)in which X represents a hydrogen atom or a halogen atom and Z represents a hydrogen atom or the remainder of an acid as well as their addition salts with acids. The compounds of formula (I) have antibiotic properties.

42. 发明申请

WO2009144323A3 GOLF CLUB GRIP 审中-公开
标题翻译：高尔夫俱乐部
公开(公告)号：WO2009144323A3
公开(公告)日：2010-01-14
申请号：PCT/EP2009056682
申请日：2009-05-29
申请人： FERRIS RICHARD D , MCCARTHY DENIS ALEXIS
发明人： FERRIS RICHARD D
IPC分类号： A63B53/14
CPC分类号： A63B53/14 , A63B49/08 , A63B60/08 , A63B60/10 , A63B60/12 , A63B60/14 , A63B69/36
摘要： A golf club grip (10) for attachment to a golf club shaft (12) formed of an upper section (18) having a first outer diameter, an intermediate tapered transitional area (22) and a lower section (20) having a second outer diameter larger than the upper section outer diameter. The upper section (18) accommodates the ring finger and pinky finger of the upper hand. The intermediate tapered transitional section (22) accommodates the middle and index fingers and the thumb of the upper hand. The lower section (20) accommodates the fingers of the lower hand. The structure of the golf club grip (10) promotes better feel and allows a golfer's non-dominant upper hand to obtain a firmer and stronger grip while allowing the dominant lower hand to impart more force to the ball with the golf club.
摘要翻译：一种用于附接到由具有第一外径的上部（18）形成的高尔夫球杆杆（12）的高尔夫球杆把手（10），中间锥形过渡区域（22）和具有第二外径的下部分（20）直径大于上段外径。上部（18）容纳上手的无名指和小指。中间锥形过渡部分（22）容纳上指和右手的拇指和拇指。下部（20）容纳下指的手指。高尔夫球杆把手（10）的结构促进了更好的手感，并允许高尔夫球手的非主导优势的上手获得更坚实和更强的抓地力，同时允许优势的下手赋予高尔夫球杆更多的力。

43. 发明申请

WO2010001220A1 NEW 1,2,4-TRIAZINE DERIVATIVES AND BIOLOGICAL APPLICATIONS THEREOF 审中-公开
标题翻译：新的1,2,4-三唑衍生物及其生物应用
公开(公告)号：WO2010001220A1
公开(公告)日：2010-01-07
申请号：PCT/IB2009/006101
申请日：2009-06-29
申请人： MUTABILIS SA , DESROY, Nicolas , DENIS, Alexis , GERUSZ, Vincent , OLIVEIRA, Chrystelle , VONGSOUTHI, Vanida , MOREAU, Françoise , ESCAICH, Sonia
发明人： DESROY, Nicolas , DENIS, Alexis , GERUSZ, Vincent , OLIVEIRA, Chrystelle , VONGSOUTHI, Vanida , MOREAU, Françoise , ESCAICH, Sonia
IPC分类号： C07D417/12 , A61K31/53 , A61P31/00
CPC分类号： C07D417/12 , C07D403/12 , C07D413/12 , C07D417/14 , C07D513/04
摘要： The invention relates to new 1,2,4-triazine derivatives of formula (I): wherein A, B, R2 and Y are defined in the application, their preparation and intermediates, their use as drugs and pharmaceutical compositions and associations containing them. The compounds of formula (I) are capable of inhibiting bacterial heptose synthesis.
摘要翻译：本发明涉及式（I）的新的1,2,4-三嗪衍生物：其中A，B，R2和Y在本申请中的定义，它们的制备和中间体，它们作为药物和药物组合物的用途以及含有它们的缔合物。式（I）化合物能够抑制细菌性肝炎合成。

44. 发明申请

WO2008117225A2 NEW IMIDAZOLO-HETEROARYL DERIVATIVES AND BIOLOGICAL APPLICATIONS THEREOF 审中-公开
标题翻译：新的咪唑醇衍生物及其生物应用
公开(公告)号：WO2008117225A2
公开(公告)日：2008-10-02
申请号：PCT/IB2008/051080
申请日：2008-03-21
申请人： MUTABILIS SA , ESCAICH, Sonia , DENIS, Alexis , GERUSZ, Vincent , MOREAU, François , OXOBY, Mayalen
发明人： ESCAICH, Sonia , DENIS, Alexis , GERUSZ, Vincent , MOREAU, François , OXOBY, Mayalen
IPC分类号： C07D471/04 , C07D487/04 , G01N33/15 , A61K31/437 , A61K31/5025 , A61P31/04
CPC分类号： C07D471/04 , C07D487/04
摘要： The invention relates to Imidazolo-heteroaryl derivatives of formula (I). The compounds inhibit the activity of the Dlta enzyme of Gram-positive bacteria and are useful to treat Gram-positive bacterial infections. Furthermore the application discloses method for assessing the Dlta inhibitory activity of tested molecules and a method for measuring the efficacy of molecules in inhibiting bacteria proliferation in vitro .
摘要翻译：本发明涉及式（I）的咪唑并 - 杂芳基衍生物。这些化合物抑制革兰氏阳性菌的Dlta酶的活性，可用于治疗革兰氏阳性细菌感染。此外，本申请公开了用于评估测试分子的Dlta抑制活性的方法和用于测量分子在体外抑制细菌增殖的功效的方法。

45. 发明申请

WO2007060214A2 METHOD AND APPARATUS FOR PROCESSING AND INJECTING DRILL CUTTINGS 审中-公开
标题翻译：用于加工和注入钻孔切割的方法和装置
公开(公告)号：WO2007060214A2
公开(公告)日：2007-05-31
申请号：PCT/EP2006068860
申请日：2006-11-23
申请人： MCCARTHY DENIS ALEXIS , REDDOCH SR JEFFREY A
发明人： REDDOCH SR JEFFREY A
IPC分类号： E21B21/06
CPC分类号： E21B21/066
摘要： An improved cuttings system located adjacent a drilling rig's shale shaker system utilizing a vacuum collection /gravity fed processing system, thereby eliminating expensive and complicated cuttings transfer systems. The use of a vacuum cuttings collection system combined within a common fluid-filled open tank and submersible grinding pumps eliminate the need for extensive circulating and holding systems. Cuttings are sized and chemically prepared within the same tank and fed directly to an injection pump for discharge to cuttings transport tanks or injected down hole. Other improvements include non-restrictive cuttings sizing, filtering, and an injection pump cuttings relief system.
摘要翻译：一种利用真空收集/重力进料处理系统位于钻机的页岩振荡器系统附近的改进的切割系统，从而消除昂贵且复杂的切割传送系统。在普通流体填充的开放式罐和潜水式研磨泵中组合的真空切割收集系统的使用消除了广泛的循环和保持系统的需要。切屑的尺寸和化学方式在同一罐内准备，并直接进料到注射泵，以便排出运输罐或注入井下。其他改进措施包括非限制性切屑筛分，过滤和注射泵切割救济系统。

46. 发明申请

WO2007060211A1 METHOD AND APPARATUS FOR VACUUM COLLECTING AND GRAVITY DEPOSITING DRILL CUTTINGS 审中-公开
标题翻译：真空收集和重金属沉积钻孔切割的方法和装置
公开(公告)号：WO2007060211A1
公开(公告)日：2007-05-31
申请号：PCT/EP2006/068854
申请日：2006-11-23
申请人： MCCARTHY, Denis Alexis , REDDOCH, Jeffrey A.
发明人： REDDOCH, Jeffrey A.
IPC分类号： E21B21/06
CPC分类号： E21B21/066
摘要： A continuous open discharge vacuum chamber (24) for gravity feeding drill cuttings extracted from a cuttings source (16) by vacuum and depositing them by gravity into a fluid (26) . Embodiments include means for removing and recovery of drilling fluids, sizing the cuttings and relieving choke points and blockages .
摘要翻译：一种连续的开放式放电真空室（24），用于通过真空从重力供给从切割源（16）提取的钻屑并将其通过重力沉积到流体（26）中。实施例包括用于移除和回收钻井液的装置，调整切屑的尺寸并减轻阻塞点和阻塞。

47. 发明申请

WO2005003115A1 THIOPHENE AMINO ACID DERIVATIVES, PROCESS FOR PREPARING THEM AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM 审中-公开
标题翻译：硫代氨基酸衍生物，其制备方法及其含有的药物组合物
公开(公告)号：WO2005003115A1
公开(公告)日：2005-01-13
申请号：PCT/IB2004/002115
申请日：2004-06-21
申请人： WARNER-LAMBERT COMPANY LLC , COMPERE, Delphine , DUBLANCHET, Anne-Claude , DUCROT, Pierre , DENIS, Alexis , CLUZEAU, Philippe , COURTE, Karine , BLAIS, Stéphane
发明人： COMPERE, Delphine , DUBLANCHET, Anne-Claude , DUCROT, Pierre , DENIS, Alexis , CLUZEAU, Philippe , COURTE, Karine , BLAIS, Stéphane
IPC分类号： C07D333/38
CPC分类号： C07D333/38 , C07D409/10
摘要： Compounds of formula (I), in which: R 1 and R 2 , which may be identical or different, independently of each other, each represent a group selected from: hydrogen, halogen, cyano, nitro, halo(C 1 -C 6 )alkyl, halo(C 1 -C 6 )alkoxy, (C 1 -C 6 )alkyl, (C 2 -C 6 )alkenyl, (C 2 -C 6 )alkynyl, -OR 4 , -NR 4 R 5 , -S(O) n R 4 , -C(O)R 4 , -CO 2 R 4 , -O-C(O)R 4 , -C(O)NR 4 R 5 , -NR 5 -C(O)R 4 , -NR 5 -SO 2 R 4 , -T-CN, -T-OR 4 , -T-OCF 3 , -T-NR 4 R 5 , -T-S(O) n R 4 , -T-C(O)R 4 , -T-CO 2 R 4 , -T-O-C(O)R 4 , -T-C(O)NR 4 R 5 , -T-NR 5 -C(O)R 4 , -T-NR 5 -SO 2 R 4 , -R 6 and -T-R 6 in which n, T, R 4 , R 5 and R 6 are as defined in the description ; m represents an integer between 0 and 4 inclusive ; p represents an integer between 0 and 4 inclusive ; q represents an integer between 0 and 4 inclusive ; R 7 represents a group selected from aryl, cycloalkyl and a heterocycle, each of these groups being optionally substituted; R 8 represents a group selected from carboxyl, (C 1 -C 6 )alkoxycarbonyl, (C 1 -C 7 )acyl, hydroxy(C 1 -C 6 )alkylcarbonyl, (C 1 -C 6 )alkoxy(C 1 -C 6 )alkylcarbonyl, tetrazole, amino, aminocarbonyl and amino(C 1 -C 6 )alkylcarbonyl; the isomers thereof and the addition salts thereof with a pharmaceutically acceptable acid or base, and the pharmaceutical compositions which are useful for treating pathologies associated with an inhibition of metalloproteases.
摘要翻译：式（I）化合物，其中：R 1和R 2可以相同或不同，彼此独立地表示选自：氢，卤素，氰基，硝基，卤代（C 1 -C 6）烷基，卤代（C 1 -C 6）烷基，（C 2 -C 6）烯基，（C 2 -C 6）炔基，-OR 4，-NR 4 R 5，-S（O）n R 4，-C（O）R 4，-CO 2 R 4 ，-OC（O）R4，-C（O）NR4R5，-NR5-C（O）R4，-NR5-SO2R4，-T-CN，-T-OR4，-T-OCF3，-T-NR4R5， TS（O）n R 4，-TC（O）R 4，-T-CO 2 R 4，-TOC（O）R 4，-TC（O）NR 4 R 5，-T-NR 5 -C（O） SO2R4，-R6和-T-R6，其中n，T，R4，R5和R6如说明书中所定义; m表示0和4之间的整数，包括0和4; p表示0和4之间的整数，包括0和4; q表示0和4之间的整数，包括0和4; R7表示选自芳基，环烷基和杂环的基团，这些基团各自任选被取代; R8表示选自羧基，（C1-C6）烷氧基羰基，（C1-C7）酰基，羟基（C1-C6）烷基羰基，（C1-C6）烷氧基（C1-C6）烷基羰基，四唑，氨基，氨基羰基和氨基（C1-C6）烷基羰基; 其异构体及其与药学上可接受的酸或碱的加成盐，以及可用于治疗与金属蛋白酶抑制相关的病理学的药物组合物。

48. 发明申请

WO1998025942A1 NOVEL ERYTHROMYCIN DERIVATIVES, METHOD FOR PREPARING THEM AND THEIR USE AS MEDICINE 审中-公开
标题翻译：新型红霉素衍生物，其制备方法及其作为医学用途
公开(公告)号：WO1998025942A1
公开(公告)日：1998-06-18
申请号：PCT/FR1997002254
申请日：1997-12-10
申请人： HOECHST MARION ROUSSEL , AUGER, Jean-Michel , AGOURIDAS, Constantin , CHANTOT, Jean-François , DENIS, Alexis
发明人： HOECHST MARION ROUSSEL
IPC分类号： C07H17/08
CPC分类号： C07H17/08
摘要： The invention concerns compounds of formula (I) in which R represents an alkyl radical optionally substituted or (CH2)nAr, n representing a whole number ranging from 0 to 6 and Ar representing an aryl or heteroaryl radical optionally substituted, and Z represents a hydrogen atom or the radical of a carboxylic acid. The compounds of formula (I) have very interesting antibiotic properties.
摘要翻译：本发明涉及式（I）化合物，其中R表示任选取代的烷基或（CH 2）n Ar，n表示0至6的整数，Ar表示任选取代的芳基或杂芳基，Z表示氢原子或羧酸的基团。式（I）化合物具有非常有趣的抗生素性质。

49. 发明专利

BRPI0907097A2 Éster derivado de 2-amino-2-fenil-alcanol, processo de preparação de um derivado e composição farmacêutica 未知
公开(公告)号：BRPI0907097A2
公开(公告)日：2015-07-07
申请号：BRPI0907097
申请日：2009-01-30
申请人： OROXCELL , DENIS ALEXIS
发明人： DENIS ALEXIS , PACHOT JEAN , DINI CHRISTOPHER
IPC分类号： C07C217/48 , A61K31/135 , A61K31/24 , C07C219/22

50. 发明专利

ES2400080T3 Derivados de 2-amino-2-fenil-alcanol, su preparación y composiciones farmacéuticas que los contienen 未知
公开(公告)号：ES2400080T3
公开(公告)日：2013-04-05
申请号：ES09720924
申请日：2009-01-30
申请人： OROXCELL , DENIS ALEXIS
发明人： DENIS ALEXIS , PACHOT JEAN , DINI CHRISTOPHE
IPC分类号： C07C217/48 , A61K31/135 , A61K31/24 , C07C219/22
摘要： Un éster derivado de 2-amino-2-fenil-alcanol de fórmula general: en la que: R1 es un átomo de hidrógeno, un radical alquilo que contiene de 1 a 4 átomos de carbono en cadena recta o ramificada, un radical alquilo que contiene de C2 a C4 en cadena recta o ramificada sustituido por hidroxi, alcoxi, alquiltio, aciloxi, amino, alquilamino, dialquilamino, alquil-carbamoyl-oxi, alcoxicarbonilamino, ureido o alquiureido, R2 es un radical -CO-R en el que R es un radical alquilo, un radical arilo, heterociclilo, bencilo o heterociclilmetilo,un radical -CO- Y-R4 para el que Y es un heteroátomo elegido entre -O-, -S-, -NH-, -Nalk- para el que alk es un radicalalquilo recto o ramificado que contiene de C1 a C4, y R4 se elige entre los radicales alquilo, arilo, aralquilo o heterociclilalquilo, que pueden sustituirse por uno o varios átomos de halógeno o radicales hidroxi, alquilo con C1 a C4en cadena recta o ramificada, alcoxi, alquiltio, acilamino alquiltio, alcoxicarbonilo o acilamino cuyos restos alquilocontienen de C1 a C4 en cadena recta o ramificada, u oxo, o que pueden sustituirse por un radical R5COO- en el que R5representa un radical alquilo, eventualmente sustituido por benciloxicarbonilamino, acilamino o por el resto de unaminoácido, o representa un heterociclo, o bien R2 es un radical alquilo que contiene de C2 a C4, sustituido por hidroxi, alcoxi, alquiltio, aciloxi, amino, alquilamino,dialquilamino cuyas partes alcohilo pueden formar con el átomo de nitrógeno al que están ligados, un heterociclo de 5 ó6 eslabones que contienen, eventualmente, otro heteroátomo elegido entre el oxígeno o el nitrógeno, o sustituido poralquil-carbamoyl-oxi, alcoxicarbonilamino, ureido o alquilureido, quedando entendido que dicho radical alquilo sustituidoestá en cadena recta o ramificada y contiene al menos 2 átomos de carbono entre el átomo de nitrógeno con R2 y el sustituyente; R3 es un radical alquilo que contiene de 1 a 4 átomos de carbono en cadena recta o ramificada,en sus formas R o S o sus mezclas, así como sus sales farmacéuticamente aceptables, cuando existen.

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