专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明申请

WO2008117225A2 NEW IMIDAZOLO-HETEROARYL DERIVATIVES AND BIOLOGICAL APPLICATIONS THEREOF 审中-公开
标题翻译：新的咪唑醇衍生物及其生物应用
公开(公告)号：WO2008117225A2
公开(公告)日：2008-10-02
申请号：PCT/IB2008/051080
申请日：2008-03-21
申请人： MUTABILIS SA , ESCAICH, Sonia , DENIS, Alexis , GERUSZ, Vincent , MOREAU, François , OXOBY, Mayalen
发明人： ESCAICH, Sonia , DENIS, Alexis , GERUSZ, Vincent , MOREAU, François , OXOBY, Mayalen
IPC分类号： C07D471/04 , C07D487/04 , G01N33/15 , A61K31/437 , A61K31/5025 , A61P31/04
CPC分类号： C07D471/04 , C07D487/04
摘要： The invention relates to Imidazolo-heteroaryl derivatives of formula (I). The compounds inhibit the activity of the Dlta enzyme of Gram-positive bacteria and are useful to treat Gram-positive bacterial infections. Furthermore the application discloses method for assessing the Dlta inhibitory activity of tested molecules and a method for measuring the efficacy of molecules in inhibiting bacteria proliferation in vitro .
摘要翻译：本发明涉及式（I）的咪唑并 - 杂芳基衍生物。这些化合物抑制革兰氏阳性菌的Dlta酶的活性，可用于治疗革兰氏阳性细菌感染。此外，本申请公开了用于评估测试分子的Dlta抑制活性的方法和用于测量分子在体外抑制细菌增殖的功效的方法。

2. 发明申请

WO2008038136A2 NEW CHEMICAL INHIBITORS OF BACTERIAL HEPTOSE SYNTHESIS, METHODS FOR THEIR PREPARATION AND BIOLOGICAL APPLICATIONS OF SAID INHIBITORS 审中-公开
标题翻译：细菌肝素合成新化学抑制剂，其抑制剂的制备和生物应用方法
公开(公告)号：WO2008038136A2
公开(公告)日：2008-04-03
申请号：PCT/IB2007/003276
申请日：2007-09-25
申请人： MUTABILIS SA , ESCAICH, Sonia , DENIS, Alexis , MOREAU, François , GERUSZ, Vincent , DESROY, Nicolas
发明人： ESCAICH, Sonia , DENIS, Alexis , MOREAU, François , GERUSZ, Vincent , DESROY, Nicolas
CPC分类号： C07D417/14 , C07D401/12 , C07D405/12 , C07D417/12
摘要： The invention relates to new compounds having heptose synthesis inhibitory properties, of formula (I) or a pharmaceutically acceptable salt, or prodrug thereof, wherein A is an aryl or heterocycle, optionally substituted by one or several identical or different R such as H, C1-C10 alkyl, C1-C10 alkyl-OR 1 , C1-C10 alkyl-NR 1 R 1 , alkoxy, hydroxy, thioalkyl, aryl, heterocycle, halogen, nitro, cyano, CO 2 R 1 , NR 1 R 1 , NR 1 C(O)R 1 , C(O)NR 1 R 1 , NR 1 C(S)R 1 , C(S)NR 1 R 1 , SO 2 NR 1 R 1 , SO 2 R 1 , NR 1 SO 2 R 1 , NR 1 C(O)NR 1 R 1 , NR 1 C(O)OR 1 , NR 1 C(S)NR 1 R 1 , NR 1 C(S)OR 1 , R 1 C=NOR 1 , C(O)R 1 , aryloxy, thioaryl, alkenyl, alkynyl R1 identical or different is H or C1-C10 alkyl B 1 , B 2 , B 3 identical or not represent C, N, O, S to form a five-membered aromatic ring wherein from one to three carbon atoms are replaced by a heteroatom selected from S, O, N optionally substituted by one or several identical or different R such as defined above B 4 is C or N Y is H, C1-C10 alkyl, alkoxy, thio-alkyl, optionally substituted by one or several identical or different R such as defined above W is C, O or N, substituted or not by one or several C1-C10 alkyl radicals D is an heterocycle optionally substituted by one or several identical or different R such as defined above.
摘要翻译：本发明涉及具有式（I）的肝素合成抑制性质的新化合物或其药学上可接受的盐或前药，其中A是芳基或杂环，任选被一个或多个相同或不同的R如H，C1 -C 10烷基，C 1 -C 10烷基-OR 1，C 1 -C 10烷基-NR 1 R 1，烷氧基，羟基，硫代烷基，芳基，杂环，卤素，硝基，氰基，CO 2 R 1，NR 1 R 1，NR N， C（O）R 1，C（O）NR 1 R 1，NR 1， C（S）R 1，C（S）NR 1 R 1，SO 2 NR 3， 2个1，1个，1个，1个，2个，1个，1个，1个，1个，1个，3个， NR 1，NR 1，NR 1，NR 1，NR 1， 1个C（O）OR 1，NR 1 C（S）NR 1 R 1，，NR 1 C（S）OR 1，R 1 C = NOR 1，C（O）R 芳氧基，硫代芳基，烯基，炔基R1相同或相同不同的是H或C 1 -C 10烷基B 1，B 2，B 3 3相同或不表示C，N，O，S以形成一个五元芳环，其中一至三个碳原子被选自任选被一个或多个相同或不同的R如上面定义的R 4取代的S，O，N的杂原子取代为C 或NY为H，任选被一个或几个相同或不同的R取代的C 1 -C 10烷基，烷氧基，硫代烷基，W如C，O或N，被一个或多个C 1 -C 10烷基取代或不被 D是任选被一个或多个相同或不同的R取代的杂环，如上所定义。

3. 发明申请

WO2011061214A1 NOVEL HETEROCYCLIC ACRYLAMIDES AND THEIR USE AS PHARMACEUTICALS 审中-公开
标题翻译：新型杂环丙烯酰胺及其作为药物的用途
公开(公告)号：WO2011061214A1
公开(公告)日：2011-05-26
申请号：PCT/EP2010/067647
申请日：2010-11-17
申请人： FAB PHARMA SAS , GERUSZ, Vincent , ESCAICH, Sonia , OXOBY, Mayalen , DENIS, Alexis
发明人： GERUSZ, Vincent , ESCAICH, Sonia , OXOBY, Mayalen , DENIS, Alexis
IPC分类号： C07D401/12 , C07D471/04 , C07D471/20 , A61K31/435 , A61K31/437 , A61K31/4375
CPC分类号： C07D471/04 , C07D205/04 , C07D207/12 , C07D211/22 , C07D213/73 , C07D239/26 , C07D277/22 , C07D333/12 , C07D401/12 , C07D401/14 , C07D403/12 , C07D409/12 , C07D413/04 , C07D417/12 , C07D471/20
摘要： The invention relates to novel heterocyclic acrylamide compounds (I), to the preparation of the compounds and intermediates used therein, to the use of the compounds as antibacterial medicaments and pharmaceutical compositions containing the compounds.
摘要翻译：本发明涉及新型杂环丙烯酰胺化合物（I），用于制备其中使用的化合物和中间体，以及该化合物用作抗菌药物和含有该化合物的药物组合物。

4. 发明申请

WO2010001220A1 NEW 1,2,4-TRIAZINE DERIVATIVES AND BIOLOGICAL APPLICATIONS THEREOF 审中-公开
标题翻译：新的1,2,4-三唑衍生物及其生物应用
公开(公告)号：WO2010001220A1
公开(公告)日：2010-01-07
申请号：PCT/IB2009/006101
申请日：2009-06-29
申请人： MUTABILIS SA , DESROY, Nicolas , DENIS, Alexis , GERUSZ, Vincent , OLIVEIRA, Chrystelle , VONGSOUTHI, Vanida , MOREAU, Françoise , ESCAICH, Sonia
发明人： DESROY, Nicolas , DENIS, Alexis , GERUSZ, Vincent , OLIVEIRA, Chrystelle , VONGSOUTHI, Vanida , MOREAU, Françoise , ESCAICH, Sonia
IPC分类号： C07D417/12 , A61K31/53 , A61P31/00
CPC分类号： C07D417/12 , C07D403/12 , C07D413/12 , C07D417/14 , C07D513/04
摘要： The invention relates to new 1,2,4-triazine derivatives of formula (I): wherein A, B, R2 and Y are defined in the application, their preparation and intermediates, their use as drugs and pharmaceutical compositions and associations containing them. The compounds of formula (I) are capable of inhibiting bacterial heptose synthesis.
摘要翻译：本发明涉及式（I）的新的1,2,4-三嗪衍生物：其中A，B，R2和Y在本申请中的定义，它们的制备和中间体，它们作为药物和药物组合物的用途以及含有它们的缔合物。式（I）化合物能够抑制细菌性肝炎合成。

5. 发明申请

WO2011048153A1 NOVEL ACYLPIPERAZINONES AND THEIR USE AS PHARMACEUTICALS 审中-公开
标题翻译：新型ACYLPIPERAZINONESES及其作为药物的用途
公开(公告)号：WO2011048153A1
公开(公告)日：2011-04-28
申请号：PCT/EP2010/065811
申请日：2010-10-20
申请人： FAB PHARMA SAS , GERUSZ, Vincent , ESCAICH, Sonia , OXOBY, Mayalen , MOREAU, Francois
发明人： GERUSZ, Vincent , ESCAICH, Sonia , OXOBY, Mayalen , MOREAU, Francois
IPC分类号： C07D241/08 , A61P31/04 , A61K31/496
CPC分类号： C07D241/08 , C07C65/24
摘要： The invention relates to novel acylpiperazinone compounds, to the preparation of the compounds and intermediates used therein, to the use of the compounds as antibacterial medicaments and pharmaceutical compositions containing the compounds.
摘要翻译：本发明涉及新颖的酰基哌嗪酮化合物，用于制备其中使用的化合物和中间体，涉及使用该化合物作为抗菌药物和含有该化合物的药物组合物。

6. 发明申请

WO2008020308A2 IDENTIFICATION OF GENES IMPLICATED IN THE VIRULENCE OF STREPTOCOCCUS AGALACTIAE 审中-公开
标题翻译：毒素链霉菌侵染基因的鉴定
公开(公告)号：WO2008020308A2
公开(公告)日：2008-02-21
申请号：PCT/IB2007/002781
申请日：2007-06-19
申请人： MUTABILIS SA , ESCAICH, Sonia , MOREAU, François
发明人： ESCAICH, Sonia , MOREAU, François
IPC分类号： C12N15/09
CPC分类号： C07K14/315 , G01N33/56944
摘要： Group B streptococcus is an important cause of maternal and neonatal morbidity and mortality in many part of the world. The invention is a method of identification of novel targets for inhibitors preventing septicemic dissemination of Streptococcus agalactiae, a model of Gram positive bacteria, in order to treat bacterial infections using these virulence determinant.
摘要翻译： B组链球菌是世界许多地区孕产妇和新生儿发病率和死亡率的重要原因。本发明是一种识别抑制剂的新靶标的方法，所述抑制剂预防革兰氏阳性细菌模型的无乳链球菌的败血性播散，以便使用这些毒力决定簇治疗细菌感染。

7. 发明申请

WO2006058796A3 METHODS FOR PREPARING ENZYMATIC SUBSTRATE ANALOGS USEFUL AS INHIBITORS OF BACTERIAL HEPTOSYL-TRANSFERASES AND BIOLOGICAL APPLICATIONS OF THE INHIBITORS 审中-公开
公开(公告)号：WO2006058796A3
公开(公告)日：2006-06-08
申请号：PCT/EP2005/013970
申请日：2005-12-05
申请人： MUTABILIS SA , CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS) , ESCAICH, Sonia , VINCENT, Stéphane , MOREAU, François
发明人： ESCAICH, Sonia , VINCENT, Stéphane , MOREAU, François
IPC分类号： C07H19/10 , C07H19/20
摘要： The invention relates to a method for making osyl and hexoses derivatives of formula (1), especially 2-fluoro-2-deoxy derivatives, wherein R is a nucleoside such as adenosine, cytidine, guanosine, uridine and deoxy analogs such as 2-deoxy, X represents OH, halogen, particularly F, NH 2, Y represents H, CH 2 OH, CH 2 NH 2 , CH 2 OPO 3 , CH 2 OSO 3 , Z represents O or S, and W represents O,NH, or CH 2 , said method comprising the steps of: a) stereoselective fluorophosphorylation of tetrapivaleate 8 to give β-gluco-type fluorophosphate, b) hydrogenation and deprotection to give a monophosphate, c) coupling said glycal with (R)P-morpholidate to give crude sugar nucleotide 1 , or . alternatively, d)deacetylation then silylation of heptoglycal 7 to give tetrasilylated glycal, e)fluorophosphorylation of said glycal to give β-gluco type fluorophosphate, f) deprotection of the fluorophosphate and coupling radical R to give 1 . Use of said derivatives as inhibitors of highly virulent proteins of pathogenic bacteria.

8. 发明申请

WO2003074553A3 EXPEC-SPECIFIC PROTEINS, GENES ENCODING THEM AND USES THEREOF 审中-公开
公开(公告)号：WO2003074553A3
公开(公告)日：2003-09-12
申请号：PCT/EP2003/002925
申请日：2003-03-06
申请人： MUTABILIS SA , ESCAICH, Sonia
发明人： ESCAICH, Sonia
IPC分类号： C12N15/31
摘要： The invention relates to isolated antigenic polypeptides obtainable by a process comprising the steps of: 1- selecting on the basis of sequence analysis those of the polypeptides which are either located in the outermembrane or secreted by the bacteria, 2- identifying the genes coding for said polypeptides which are conserved in B2/D clinical isolates, 3- purifying the polypeptides identified in step 1, which are found in step 2 to be conserved in B2/D isolates, 4- testing the polypeptides for immunogenicity using animals models. Application for making vaccines compositions and immunotherapies

9. 发明申请

WO2005097823A1 COMPOSITIONS OF POLYPEPTIDES SPECIFIC TO PATHOGENIC STRAINS AND THEIR USE AS VACCINES AND IN IMMUNOTHERAPY 审中-公开
标题翻译：特异性致病菌多肽的组合物及其作为疫苗和免疫球蛋白的用途
公开(公告)号：WO2005097823A1
公开(公告)日：2005-10-20
申请号：PCT/EP2005/003972
申请日：2005-03-29
申请人： MUTABILIS , ESCAICH, Sonia
发明人： ESCAICH, Sonia
IPC分类号： C07K14/245
CPC分类号： C07K14/245 , A61K39/00 , A61K2039/505
摘要： The invention relates to compositions of polypeptides specific to pathogenic strains comprising at least one polypeptide of a first group, having a sequence selected in the group comprising the sequences of SEQ ID N° 159, or homologous sequences of polypeptides of the first group and/or the second group with a minimum of 25% of identity with the whole sequences of said polypeptides. Application for the preparation of vaccine compositions specific to E. coli extra-intestinal infections.
摘要翻译：本发明涉及对病原性菌株特异性的多肽的组合物，其包含至少一种第一组的多肽，其具有选自SEQ ID NO：159的序列或第一组的多肽的同源序列的序列和/或第二组与所述多肽的整个序列具有至少25％的同一性。用于制备特异于大肠杆菌肠外感染的疫苗组合物的应用。

10. 发明申请

WO2004005535A2 PATHOGENICITY DETERMINANTS WHICH CAN BE USED AS TARGETS FOR DEVELOPING MEANS FOR PREVENTING AND CONTROLLING BACTERIAL INFECTIONS AND/OR SYSTEMIC DISSEMINATION 审中-公开
标题翻译：可用作发展预防和控制细菌感染和/或系统发现手段的目标的致病因子决定因素
公开(公告)号：WO2004005535A2
公开(公告)日：2004-01-15
申请号：PCT/EP2003/008209
申请日：2003-07-09
申请人： MUTABILIS , ESCAICH, Sonia
发明人： ESCAICH, Sonia
IPC分类号： C12Q1/02
CPC分类号： C12Q1/18 , C12Q1/02
摘要： The invention relates to a method for identifying and selecting a gene required for the proliferation in vivo of a pathogenic microorganism, comprising :- using a strain of the pathogenic microorganism,- generating mutants for inactivation in the genes encoding these factors,- determining the virulence of these mutants on an expiremental model of infection, and their effect on enteric colonization in an axenic mouse model, and- selecting the bacterial genes essential for resistance to serum in vitro, and essential, in the host, for dissemination in the serum.Application to the screening of compounds which inhibit the products of the genes identified, and to the inhibition in vitro of the proliferation of a pathogenic microorganism in serum.
摘要翻译：本发明涉及用于鉴定和选择病原微生物体内增殖所需的基因的方法，其包括： - 使用致病微生物菌株，在编码这些因子的基因中产生灭活突变体， - 确定毒力的这些突变体在一个有效的感染模型上，以及它们对一个无效小鼠模型中对肠道定植的影响，以及 - 选择体外对血清抗性至关重要的细菌基因，并且在宿主中必不可少的用于在血清中传播。应用筛选抑制所鉴定基因产物的化合物，以及体外抑制血清中病原微生物的增殖。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式