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41. 发明授权

US3809008A Apparatus for processing tissue for electron microscope examination 失效
标题翻译：用于电子显微镜检查处理组织的装置
公开(公告)号：US3809008A
公开(公告)日：1974-05-07
申请号：US30558372
申请日：1972-11-10
申请人： SAKURA FINETECHNICAL CO LTD
发明人： TAKAHASHI K
IPC分类号： G01N1/31 , B05C11/12
CPC分类号： G01N1/31
摘要： Apparatus for processing tissue for electron microscope examination comprises a series of processing reagent containing receptacles arranged in an annular row, a rotary transfer disc for transferring a tissue-containing basket along the series of receptacles successively one by one to dip the basket and the tissue contained therein into each of the reagents in the receptacles, and means for maintaining the atmosphere surrounding some of the reagents at sub-atmospheric pressure when the basket and the tissue therein are being dipped therein for processing, the sub-atmospheric pressure improving and accelerating ingress and impregnation of the reagents into the tissue being processed.
摘要翻译：用于处理组织用于电子显微镜检查的装置包括一系列处理试剂，其中包含插入环形排列的容器，用于一个接一个地沿着一系列容器传送含组织篮的浸渍篮和所述组织的旋转传送盘其中插入容器中的每种试剂，以及用于当筐和其中的组织浸入其中进行处理时，将一些试剂的气氛保持在低于大气压的装置，次大气压改善和加速进入，以及将试剂浸渍到被处理的组织中。

42. 发明公开

US20230310706A1 BURN RESTORATION MATERIAL 审中-公开
公开(公告)号：US20230310706A1
公开(公告)日：2023-10-05
申请号：US18021864
申请日：2020-11-30
申请人： National University Corporation University of Toyama , SAKURA SEIKI CO., LTD.
发明人： Jiro OBA , Toshiko YOSHIDA , Motonori OKABE , Chika SOKO , Masahiko ARAKAWA
IPC分类号： A61L27/36 , A61L27/60
CPC分类号： A61L27/3604 , A61L27/3687 , A61L27/60
摘要： A raw amniotic membrane placed in a processing tank (10) is continuously heated by a far-IR heater (14) provided in the processing tank (10). During a decompression operation in which the interior of the processing tank (10) is placed in a decompressed state, and a recompression operation in which the pressure in the decompressed interior of the processing tank (10) is raised slightly toward atmospheric pressure, the raw amniotic membrane is dried while the water molecules present therein are subjected to energy via microwave irradiation from a microwave irradiation device (30) provided in the processing tank (10). By repeating this multiple times, the amniotic membrane is dried while cells and tissue structures are maintained. The amniotic membrane can be used on a wound site as a coating material or scaffold material after removing a necrosis layer and the like from a severe burn wound patient to retain cytokines and physiologically active substances secreted from infiltrating cells and promote favorable granulation including neoangiogenesis and growth of fibroblasts. This enhances the probability of survival of the patient and therapeutic effect (without the risk of keloid formation).

43. 发明公开

US20230288440A1 COVER SLIP STICKING DEVICE 审中-公开
公开(公告)号：US20230288440A1
公开(公告)日：2023-09-14
申请号：US18200470
申请日：2023-05-22
申请人： SAKURA SEIKI CO., LTD. , SAKURA FINETEK JAPAN CO., LTD.
发明人： Tomonori KAWAI , Yamato MIYAIRI
IPC分类号： G01N35/00 , G01N1/31 , G02B21/34
CPC分类号： G01N35/00732 , G01N1/312 , G01N35/00029 , G01N35/00663 , G01N35/00871 , G02B21/34 , G01N2035/00138 , G01N2035/00752 , G01N2035/00782 , G01N2035/00801 , G01N2035/00891
摘要： It is an object to provide a cover slip sticking device capable of improving matching between types of clearing agents and cover slips. As a means for solving the problem, a cover slip sticking device includes a dipping bath (21) in which slide glasses (22) on which specimens are attached are housed to be dipped in a clearing agent, a holder (11) having a cover slip (10) and cover slip information (14), a mounting part (C) on which the holder is mounted, a sticking part (B) sticking the cover slip (10) taken out from the holder (11) on the slide glass (22), a reading unit (62) reading the cover slip information (14), a storage unit (65) storing a type of the clearing agent and matching information between types of clearing agents and types of cover slips and a determination unit (66) comparing the cover slip information (14) read by the reading unit (62) and the type of the clearing agent stored in the storage unit (65) with the matching information to determine whether the types match with each other or not.

44. 发明申请

US20220297336A1 WORKPIECE MACHINING APPARATUS 有权
公开(公告)号：US20220297336A1
公开(公告)日：2022-09-22
申请号：US17772066
申请日：2020-10-29
申请人： Sakura Seiki Co., Ltd. , UCHIDA YOKO CO., LTD , UCHIDA YOKO GLOBAL CO., LTD.
发明人： Ippei MURAMOTO , Tomoki TAKADA
IPC分类号： B26F1/42
摘要： A pressure plate 12 has an upper surface 12a and a lower surface 12b. A blade die unit 16 for machining a workpiece by applying a pressure to a principal surface of the workpiece is arranged on the lower surface 12b. A face plate 24 has an upper surface 24a and a lower surface 24b, and is arranged such that the upper surface 24a faces the lower surface 12b with the blade die unit 16 interposed therebetween. An upper pressure roller 20 applies a pressure directed from the upper surface 12a side toward the lower surface 12b side of the pressure plate 12 to a portion of the upper surface 12a. A lower pressure roller 22 applies a pressure directed from the lower surface 24b side toward the upper surface 24a side of the face plate 24 to a portion of the lower surface 24b. A motor changes a portion that the upper pressure roller 20 pressurizes, and also, a portion that the lower pressure roller 22 pressurizes is changed such that the portion that the lower pressure roller 22 pressurizes is aligned with the portion that the upper pressure roller 20 pressurizes when viewed from a direction crossing the lower surface 24b.

45. 发明申请

US20210283306A1 REGENERATION OF TENDON AND TENDON SHEATH, RESTORATION MATERIAL, AND USE OF RESTORATION MATERIAL 有权
公开(公告)号：US20210283306A1
公开(公告)日：2021-09-16
申请号：US17257918
申请日：2019-08-30
申请人： Toshiko YOSHIDA , Motonori OKABE , Ryusuke OSADA , Mineyuki ZUKAWA , SAKURA SEIKI CO., LTD.
发明人： Toshiko YOSHIDA , Motonori OKABE , Ryusuke OSADA , Mineyuki ZUKAWA , Masahiko ARAKAWA
IPC分类号： A61L27/36
摘要： An object is to provide a dried amniotic membrane that promotes regeneration of a tendon and a tendon sheath when a tendon injury has occurred and that reduces loss of the motor function of fingers of upper limbs and lower limbs due to tendon adhesion as a novel regeneration material. As a means for resolution, a dry amniotic membrane is produced by performing a specific drying treatment, that is, during a depressurization operation in which a fresh amniotic membrane placed in a treatment tank is continuously heated by an infrared heater provided in the treatment tank, and the inside of the treatment tank is brought into a depressurized state; and a pressure recovery operation in which the pressure of the inside of the treatment tank in a depressurized state is raised slightly toward the atmospheric pressure, drying is performed while applying energy to water molecules present in the amniotic membrane by irradiating the fresh amniotic membrane with a microwave also from a microwave generator provided in the treatment tank. The dried amniotic membrane retaining of the cell and tissue structures by repeating the treatment of drying a plurality of times promotes regeneration of the motor function of fingers of upper limbs and lower limbs after tendon suture surgery and is useful as a regeneration material.

46. 发明申请

US20180305148A1 WORKPIECE CONVEYING APPARATUS 审中-公开
公开(公告)号：US20180305148A1
公开(公告)日：2018-10-25
申请号：US15765332
申请日：2016-10-07
申请人： Sakura Seiki Co., Ltd. , UCHIDA YOKO CO., LTD. , Uchida Yoko Global Limited
发明人： Ippei MURAMOTO , Toshimasa ENDO
IPC分类号： B65H3/12 , B65H3/64 , B65H3/48
CPC分类号： B65H3/128 , B65H3/12 , B65H3/48 , B65H3/64 , B65H2301/44336 , B65H2301/44514 , B65H2301/44735 , B65H2404/264 , B65H2406/31 , B65H2406/323
摘要： A guide member (14) has an upper surface assisting conveyance of workpieces (44) mounted on a table (12) and is arranged downstream of the table (12) in a workpiece conveyance direction. A belt drive mechanism (16) has pulleys (26a to 26d, 28a to 28b), and endless belts (32a to 32d) wound around these pulleys, and is arranged above the table (12) and the guide member (14) so as to stride over the table (12) and the guide member (14). A first opening portion is formed on a bottom portion of the belt drive mechanism (16) to generate an upward suction force. A second opening portion is formed on the upper surface of the guide member (14) to generate a downward suction force. A magnitude of the suction force generated in the first opening portion exceeds a magnitude of the suction force generated in the second opening portion.

47. 发明授权

US09801963B2 Steam sterilizer 有权
公开(公告)号：US09801963B2
公开(公告)日：2017-10-31
申请号：US14371555
申请日：2012-01-30
申请人： Chihiro Kinebuchi , Eiichi Minemura , Satoshi Tanaka , Haruo Machida , Akihiro Miyamoto , Kouji Tanaka , Hiroshi Karasawa
发明人： Chihiro Kinebuchi , Eiichi Minemura , Satoshi Tanaka , Haruo Machida , Akihiro Miyamoto , Kouji Tanaka , Hiroshi Karasawa
IPC分类号： A61L2/07 , F04F5/04 , F04F5/20
CPC分类号： A61L2/07 , F04F5/04 , F04F5/20
摘要： Provided is a steam sterilizer capable of performing water vapor sterilization without using a vacuum pump as a mechanism for bringing the inside of a pressure vessel into vacuum. The steam sterilizer includes a pressure vessel (32) which stores an object to be sterilized and in which sterilization is performed with water vapor supplied from a steam piping, and vacuum-generating means (34) which is connected to the pressure vessel (32) and brings the inside of the pressure vessel (32) into a vacuum state. The vacuum-generating means (34) includes a water ejector (48), a tank (50) for storing supply water supplied from an outside, and a pump (52) for supplying the supply water inside the tank (50) to the water ejector (48).

48. 发明授权

US09488553B2 Tissue piece treating apparatus and method of operating tissue piece treating apparatus 有权
标题翻译：组织片处理装置和操作组织片处理装置的方法
公开(公告)号：US09488553B2
公开(公告)日：2016-11-08
申请号：US14894952
申请日：2014-05-16
申请人： Sakura Seiki Co., Ltd. , Sakura Finetek Japan Co., Ltd.
发明人： Atsuo Ito
IPC分类号： A61B10/00 , G01N1/31 , G01N1/36
CPC分类号： G01N1/31 , G01N1/36
摘要： The present invention addresses the problem of providing a technology capable of automatically preparing a mixed liquid having a fixed ratio. To address the problem, the following processes are carried out in a tissue piece treating apparatus (10). (a) By use of a detection sensor (36), a dehydrating agent is transferred from a dehydrating agent tank (large-capacity tank (15)) to a treatment tank (11) until reaching a prescribed level. (b) By use of the detection sensor (36), an intermediate agent is transferred from an intermediate agent tank (large-capacity tank (17)) to the treatment tank (11) until reaching a prescribed level. (c) An admixture obtained by mixing the dehydrating agent by the process of (a) and the intermediate agent by the process of (b) is transferred from the treatment tank (11) to an admixture tank (14).
摘要翻译：本发明解决了提供能够自动制备具有固定比例的混合液体的技术的问题。为了解决该问题，在组织片处理装置（10）中进行以下处理。（a）通过使用检测传感器（36），将脱水剂从脱水剂槽（大容量罐（15））输送到处理槽（11）直到达到规定的水平。（b）通过使用检测传感器（36），将中间体药剂从中间体罐（大容量罐（17））转移到处理槽（11）直到达到规定的水平。（c）通过（a）的方法将脱水剂与（b）的方法混合使用的混合物从处理槽（11）输送到混合罐（14）。

49. 发明授权

US09335238B2 Device for forming tissue pieces for tissue array 有权
标题翻译：用于形成组织阵列的组织片的装置
公开(公告)号：US09335238B2
公开(公告)日：2016-05-10
申请号：US13810660
申请日：2011-07-26
申请人： Yoshiaki Nakazawa , Masaki Takano , Masahiko Arakawa , Kohji Naritake
发明人： Yoshiaki Nakazawa , Masaki Takano , Masahiko Arakawa , Kohji Naritake
IPC分类号： G01N1/30 , G01N1/28 , G01N1/36 , C12M1/33
CPC分类号： G01N1/30 , C12M45/02 , G01N1/286 , G01N1/36
摘要： The invention provides a method for forming tissue pieces which allows stable and accurate winding around a core rod in rolling a sheet-like tissue piece, and a device therefor.In the tissue pieces used as each tissue piece in a tissue array obtained by arranging the tissue pieces on a substrate in an array form, the method for forming a roll-shaped tissue piece 6 obtained by rolling a sheet-like tissue piece 8 is characterized by the facts that the sheet-like tissue piece 8 is produced by slicing a tissue block 5 obtained by embedding the tissues with an embedding medium, the sheet-like tissue piece 8 is placed on a mounting block 12, peeling means 13 which easily enables peeling of the tissue piece 8 from the mounting block 12 is applied between the mounting block 12 and the tissue piece 8, and the tissue piece 8 is wound around a core rod 11 while heating the tissue piece 8 on the mounting block 12.
摘要翻译：本发明提供了一种用于形成组织片的方法，其允许在卷绕片状组织片时围绕芯棒进行稳定和精确的缠绕，以及用于其的装置。在通过将组织块以阵列形式布置在基板上而获得的组织排列中用作每个组织片的组织片中，形成通过滚动片状组织片8获得的辊状组织片6的方法的特征在于通过切片通过用嵌入介质包埋组织获得的组织块5来生产片状组织片8，片状组织片8被放置在安装块12上，剥离装置13容易启用将组织片8从安装块12剥离施加在安装块12和组织片8之间，并且组织片8缠绕在芯棒11上，同时加热安装块12上的组织片8。

50. 发明授权

US08997615B2 Microtome and cryostat 有权
标题翻译：切片机和低温恒温器
公开(公告)号：US08997615B2
公开(公告)日：2015-04-07
申请号：US13816458
申请日：2011-07-29
申请人： Hiroyuki Minemura , Tatsuya Seki
发明人： Hiroyuki Minemura , Tatsuya Seki
IPC分类号： B26D7/10 , A01N1/02 , G01N1/06
CPC分类号： A01N1/0257 , G01N1/06 , Y10S83/9155 , Y10T83/283 , Y10T83/293
摘要： A microtome comprising a head 32 which holds a sample, an alignment mechanism 50 which aligns the head 32, a body portion 42 which is provided on a back face side of the alignment mechanism 50, a cylindrical coupling portion 41 which couples the body portion 42 with the head 32, a temperature controller 34 in the head 32, and refrigerant piping 40 and electrical wiring 46 for the temperature controller 34, and the alignment mechanism 50 includes a spherical member 68 coupled with the back face side of the head and having a spherical outer periphery and includes retainer portions 70 and 71 retaining the outer periphery of the spherical member 68 slidably along a spherical surface, the spherical member 68 has a through hole 74 which communicates with the hollow portion 43 of the coupling portion 41, the refrigerant piping 40 and the electrical wiring 46 are connected with the temperature controller 34 in the head 32 through the through hole 74 of the spherical member 68 and the hollow portion 43 of the coupling portion 41.
摘要翻译：切片机包括保持样品的头部32，对准头部32的对准机构50，设置在对准机构50的背面侧的主体部分42，连接主体部分42的圆柱形联接部分41 头32，头32中的温度控制器34和用于温度控制器34的制冷剂管道40和电线46，并且对准机构50包括与头部的背面侧联接的球形部件68，球形外周，并且包括保持部70和71，球形部件68沿着球面滑动地保持外周，球形部件68具有与联接部41的中空部43连通的通孔74，制冷剂配管 40并且电线46通过球形构件68的通孔74和中空po连接到头部32中的温度控制器34 连接部41的连接部43。

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