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1. 发明申请

US20070249620A1 Urea Derivative 审中-公开
标题翻译：尿素衍生物
公开(公告)号：US20070249620A1
公开(公告)日：2007-10-25
申请号：US11631179
申请日：2005-07-01
申请人： Hitoshi Kurata , Yoshikazu Uto , Yuko Fujibayashi , Takafumi Kohama , Tatsuo Tanimoto , Hiroshi Karasawa
发明人： Hitoshi Kurata , Yoshikazu Uto , Yuko Fujibayashi , Takafumi Kohama , Tatsuo Tanimoto , Hiroshi Karasawa
IPC分类号： A61K31/44 , A61K31/445 , A61K31/47 , A61K31/497 , A61P3/04 , C07D211/30 , C07D211/70 , C07D215/38 , C07D241/04 , C07D401/04
CPC分类号： C07D295/205 , C07D211/26 , C07D213/75 , C07D217/22 , C07D217/24 , C07D217/26 , C07D401/12 , C07D401/14 , C07D413/12 , C07D413/14 , C07D417/12 , C07D417/14
摘要： The present invention relates to a urea derivative or a pharmacologically acceptable salt thereof having an excellent DGAT inhibitory effect. A urea derivative having the formula: [wherein R1 is a C6-C10 aryl group which may be independently mono- to pentasubstituted by a group selected from Substituent Group a or others; R is a C6-C10 aryl group which may be independently mono- to pentasubstituted by a group selected from Substituent Group a or others; E is a group having the formula (II) or the formula (III) (wherein R3 is a hydrogen atom or others; R4 and R5, which are the same or different, are a hydrogen atom or others; X and U, which are the same or different, are a group represented by the formula CH or others; m and n, which are the same or different, are I or another number) or others; and A is a group represented by the formula —NH—C(═O)— or others], or a pharmacologically acceptable salt thereof.
摘要翻译：本发明涉及具有优异DGAT抑制作用的尿素衍生物或其药理学上可接受的盐。具有下式的脲衍生物：其中R 1是C 6 -C 10芳基，其可以独立地被单价五价取代的C 6 -C 10芳基选自取代基组a或其他组的组; R是可以被选自取代基组a或其它基团的基团独立地单 - 五取代的C 6 -C 10 - 芳基; E是具有式（II）或式（III）的基团（其中R 3是氢原子或其它; R 4和R 5，相同或不同的氢原子或其它基团; X和U相同或不同，为由式CH或其它基团表示的基团; m和n相同或不同是我还是其他人）或其他人; A为由式-NH-C（-O） - 或其它]表示的基团，或其药理学上可接受的盐。

2. 发明申请

US20110034481A1 NOVEL TETRAHYDROISOQUINOLINE DERIVATIVE 有权
标题翻译：新四氢喹啉衍生物
公开(公告)号：US20110034481A1
公开(公告)日：2011-02-10
申请号：US12878170
申请日：2010-09-09
申请人： Yoshikazu Uto , Hiroshi Karasawa , Kiyosumi Takaishi
发明人： Yoshikazu Uto , Hiroshi Karasawa , Kiyosumi Takaishi
IPC分类号： A61K31/497 , C07D217/22 , A61K31/472 , A61P3/10 , A61P3/04 , C07D401/12
CPC分类号： C07D217/06 , A61K31/47 , C07D401/12 , C07D413/12 , C07D417/12
摘要： The present invention relates to a compound or a pharmacologically acceptable salt thereof having an excellent DGAT inhibitory effect and feeding suppressant effect. The present invention provides a compound represented by the general formula (I), or pharmacologically acceptable salt thereof: [wherein, R1 represents a phenylaminocarbonyl group that may be substituted with 1 to 5 group(s) independently selected from Substituent Group A, a benzoxazol-2-yl group that may be substituted with 1 to 3 group(s) independently selected from Substituent Group A, or the like; R2 independently represents a C1-C6 alkyl group; R3 represents a group represented by the formula —C(═O)—O—R4 or the like; R4 represents a hydrogen atom, a C1-C6 alkyl group that may be substituted with 1 to 3 group(s) independently selected from Substituent Group B, or the like; X represents an oxygen atom, a methylene group, or a group represented by the formula —NH—, or the like; L represents a single bond, a methylene group, or the like; . . . represents a single bond or a double bond; m represents 1 or 2; n represents an integer of 0 to 5; Substituent Group A represents a halogen atom, a C1-C6 alkyl group, a C1-C6 halogenated alkyl group, a C1-C6 alkoxy group, or the like; and Substituent Group B represents a C3-C6 cycloalkyl group, a phenyl group, a carboxyl group, or the like].
摘要翻译：本发明涉及具有优异的DGAT抑制效果和抑制抑制作用的化合物或其药理学上可接受的盐。本发明提供由通式（I）表示的化合物或其药理学上可接受的盐：[其中，R 1表示可以被1至5个独立地选自取代基组A的基团取代的苯基氨基羰基，苯并恶唑可以被1至3个独立地选自取代基组A的基团取代的2-基;等等; R2独立地表示C1-C6烷基; R3表示由式-C（= O）-O-R4等表示的基团; R4表示氢原子，可以被1〜3个独立地选自取代基组B的基团取代的C1-C6烷基等; X表示氧原子，亚甲基或由式-NH-表示的基团等; L表示单键，亚甲基等; 。。。代表单键或双键; m表示1或2; n表示0〜5的整数，取代基组A表示卤素原子，C1-C6烷基，C1-C6卤代烷基，C1-C6烷氧基等; 取代基B代表C3-C6环烷基，苯基，羧基等〕。

3. 发明申请

US20100291873A1 COMMUNICATION TERMINAL DEVICE AND TRIPARTITE COMMUNICATION METHOD 审中-公开
标题翻译：通信终端设备和三通信通信方法
公开(公告)号：US20100291873A1
公开(公告)日：2010-11-18
申请号：US12766190
申请日：2010-04-23
申请人： Hiroyuki Nakai , Katsuaki Akama , Shoichi Sato , Hiroshi Fushikida , Tetsuya Murata , Hiroshi Kawasaki , Hiromi Watanabe , Hiroshi Karasawa , Tetsuya Matsuda
发明人： Hiroyuki Nakai , Katsuaki Akama , Shoichi Sato , Hiroshi Fushikida , Tetsuya Murata , Hiroshi Kawasaki , Hiromi Watanabe , Hiroshi Karasawa , Tetsuya Matsuda
IPC分类号： H04B7/00
CPC分类号： H04M1/0256 , H04M1/6008 , H04M1/6016 , H04M2250/02
摘要： A communication terminal device includes a terminal body which enables a communication with a radio communication network by a first radio communication, a separating member which may be separated from the terminal body and enables a communication with the terminal body by a second radio communication, a tripartite communication unit which enables a tripartite communication among the terminal body, the separating member, and the radio communication network when the separating member and the terminal body are separated, and a control unit which controls howling between the terminal body and the separating member when the separating member and the terminal body are close during the tripartite communication.
摘要翻译：通信终端装置包括能够通过第一无线通信与无线通信网络进行通信的终端主体，可以与终端主体分离并能够通过第二无线通信与终端主体进行通信的分离部件，三方通信单元，当所述分离构件和所述终端主体分离时，能够在所述终端主体，所述分离构件和所述无线电通信网络之间进行三方通信;以及控制单元，当所述分离构件和所述终端主体分离时，控制所述终端主体与所述分离构件之间的啸叫会员和终端机构在三方通信期间关闭。

4. 发明申请

US20120202847A1 Novel Tetrahydroisoquinoline Compounds 审中-公开
标题翻译：新型四氢异喹啉化合物
公开(公告)号：US20120202847A1
公开(公告)日：2012-08-09
申请号：US13404836
申请日：2012-02-24
申请人： Yoshikazu Uto , Hiroshi Karasawa , Kiyosumi Takaishi
发明人： Yoshikazu Uto , Hiroshi Karasawa , Kiyosumi Takaishi
IPC分类号： A61K31/47 , A61P3/04 , A61P3/00 , A61P3/06 , A61P7/00 , A61P5/48 , A61P3/08 , A61P3/10 , A61P27/12 , A61P31/14 , A61P15/00 , A61P9/10 , A61P25/02 , A61P13/12 , A61P27/02 , C07D217/26
CPC分类号： C07D217/06
摘要： The present invention relates to a compound or a pharmacologically acceptable salt thereof having an excellent DGAT inhibitory effect and feeding suppressant effect. The present invention provides trans-6-[3-(2,4-difluoro-phenyl)-ureido]-3,4-dihydro-1H-isoquinoline-2-carboxylic acid 4-carboxymethyl-cyclohexyl ester, trans-6-[3-(2-chloro-phenyl)-ureido]-3,4-dihydro-1H-isoquinoline-2-carboxylic acid 4-carboxymethyl-cyclohexyl ester, trans-6-[3-(2,3-difluoro-phenyl)-ureido]-3,4-dihydro-1H-isoquinoline-2-carboxylic acid 4-carboxymethyl-cyclohexyl ester, trans-6-[3-(2,5-difluoro-phenyl)-ureido]-3,4-dihydro-1H-isoquinoline-2-carboxylic acid 4-carboxymethyl-cyclohexyl ester, trans-6-[3-(2,6-difluoro-phenyl)-ureido]-3,4-dihydro-1H-isoquinoline-2-carboxylic acid 4-carboxymethyl-cyclohexyl ester, or the like, or a pharmacologically acceptable salt thereof.
摘要翻译：本发明涉及具有优异的DGAT抑制效果和抑制抑制作用的化合物或其药理学上可接受的盐。本发明提供反式-6- [3-（2,4-二氟 - 苯基） - 脲基] -3,4-二氢-1H-异喹啉-2-羧酸4-羧甲基 - 环己基酯，反式-6- [ 3-（2-氯 - 苯基） - 脲基] -3,4-二氢-1H-异喹啉-2-羧酸4-羧甲基 - 环己基酯，反式-6- [3-（2,3-二氟 - 苯基） - 脲基] -3,4-二氢-1H-异喹啉-2-羧酸4-羧甲基 - 环己基酯，反式-6- [3-（2,5-二氟 - 苯基） - 脲基] -3,4-二氢 -1H-异喹啉-2-羧酸4-羧甲基 - 环己基酯，反式-6- [3-（2,6-二氟 - 苯基） - 脲基] -3,4-二氢-1H-异喹啉-2-羧酸 4-羧甲基 - 环己基酯等，或其药理学上可接受的盐。

5. 发明授权

US09801963B2 Steam sterilizer 有权
公开(公告)号：US09801963B2
公开(公告)日：2017-10-31
申请号：US14371555
申请日：2012-01-30
申请人： Chihiro Kinebuchi , Eiichi Minemura , Satoshi Tanaka , Haruo Machida , Akihiro Miyamoto , Kouji Tanaka , Hiroshi Karasawa
发明人： Chihiro Kinebuchi , Eiichi Minemura , Satoshi Tanaka , Haruo Machida , Akihiro Miyamoto , Kouji Tanaka , Hiroshi Karasawa
IPC分类号： A61L2/07 , F04F5/04 , F04F5/20
CPC分类号： A61L2/07 , F04F5/04 , F04F5/20
摘要： Provided is a steam sterilizer capable of performing water vapor sterilization without using a vacuum pump as a mechanism for bringing the inside of a pressure vessel into vacuum. The steam sterilizer includes a pressure vessel (32) which stores an object to be sterilized and in which sterilization is performed with water vapor supplied from a steam piping, and vacuum-generating means (34) which is connected to the pressure vessel (32) and brings the inside of the pressure vessel (32) into a vacuum state. The vacuum-generating means (34) includes a water ejector (48), a tank (50) for storing supply water supplied from an outside, and a pump (52) for supplying the supply water inside the tank (50) to the water ejector (48).

6. 发明授权

US08735425B2 Tetrahydroisoquinoline derivative 有权
标题翻译：四氢异喹啉衍生物
公开(公告)号：US08735425B2
公开(公告)日：2014-05-27
申请号：US12878170
申请日：2010-09-09
申请人： Yoshikazu Uto , Hiroshi Karasawa , Kiyosumi Takaishi
发明人： Yoshikazu Uto , Hiroshi Karasawa , Kiyosumi Takaishi
IPC分类号： C07D217/06 , A61K31/47
CPC分类号： C07D217/06 , A61K31/47 , C07D401/12 , C07D413/12 , C07D417/12
摘要： The present invention relates to a compound or a pharmacologically acceptable salt thereof having an excellent DGAT inhibitory effect and feeding suppressant effect. The present invention provides a compound represented by the general formula (I), or pharmacologically acceptable salt thereof: [wherein, R1 represents a phenylaminocarbonyl group that may be substituted with 1 to 5 group(s) independently selected from Substituent Group A, a benzoxazol-2-yl group that may be substituted with 1 to 3 group(s) independently selected from Substituent Group A, or the like; R2 independently represents a C1-C6 alkyl group; R3 represents a group represented by the formula —C(═O)—O—R4 or the like; R4 represents a hydrogen atom, a C1-C6 alkyl group that may be substituted with 1 to 3 group(s) independently selected from Substituent Group B, or the like; X represents an oxygen atom, a methylene group, or a group represented by the formula —NH—, or the like; L represents a single bond, a methylene group, or the like; . . . represents a single bond or a double bond; m represents 1 or 2; n represents an integer of 0 to 5; Substituent Group A represents a halogen atom, a C1-C6 alkyl group, a C1-C6 halogenated alkyl group, a C1-C6 alkoxy group, or the like; and Substituent Group B represents a C3-C6 cycloalkyl group, a phenyl group, a carboxyl group, or the like].
摘要翻译：本发明涉及具有优异的DGAT抑制效果和抑制抑制作用的化合物或其药理学上可接受的盐。本发明提供由通式（I）表示的化合物或其药理学上可接受的盐：[其中，R 1表示可以被1至5个独立地选自取代基组A的基团取代的苯基氨基羰基，苯并恶唑可以被1至3个独立地选自取代基组A的基团取代的2-基;等等; R2独立地表示C1-C6烷基; R3表示由式-C（= O）-O-R4等表示的基团; R4表示氢原子，可以被1〜3个独立地选自取代基组B的基团取代的C1-C6烷基等; X表示氧原子，亚甲基或由式-NH-表示的基团等; L表示单键，亚甲基等; 。。。代表单键或双键; m表示1或2; n表示0〜5的整数，取代基组A表示卤素原子，C1-C6烷基，C1-C6卤代烷基，C1-C6烷氧基等; 取代基B代表C3-C6环烷基，苯基，羧基等〕。

7. 发明授权

US5721717A Optical disk apparatus capable of using a ROM compact disk or a magneto-optical disk 失效
标题翻译：能够使用ROM光盘或磁光盘的光盘装置
公开(公告)号：US5721717A
公开(公告)日：1998-02-24
申请号：US716738
申请日：1996-09-23
申请人： Kiyoshi Obata , Yutaka Kotoh , Hiroshi Karasawa
发明人： Kiyoshi Obata , Yutaka Kotoh , Hiroshi Karasawa
IPC分类号： G11B20/18 , G11B7/0037 , G11B7/09 , G11B11/105 , G11B19/12 , G11B7/00 , G11B3/90
CPC分类号： G11B11/10597 , G11B19/12 , G11B7/0901 , G11B7/0037
摘要： A CD and an MO cartridge are accessed by a pickup of the same optical system, thereby allowing 4-split photodetectors to receive a medium return light to obtain a tracking error detection signal. Upon recording and reproduction of the MO cartridge, a tracking error detecting circuit for MO detects a first tracking error signal by a push-pull method on the basis of light reception signals obtained from the pickup. Upon reproduction of the CD, a tracking error detecting circuit for CD detects a second tracking error signal by a heterodyne method on the basis of the light reception signals obtained from the pickup.
摘要翻译：通过同一光学系统的拾取器访问CD和MO盒，从而允许4分割光电检测器接收中等返回光以获得跟踪误差检测信号。在记录和再现MO盒时，用于MO的跟踪误差检测电路基于从拾取器获得的光接收信号通过推挽方法检测第一跟踪误差信号。在CD的再现时，用于CD的跟踪误差检测电路基于从拾取器获得的光接收信号通过外差方法检测第二跟踪误差信号。

8. 发明授权

US09381264B2 Steam sterilizer 有权
标题翻译：蒸汽灭菌器
公开(公告)号：US09381264B2
公开(公告)日：2016-07-05
申请号：US14381185
申请日：2012-03-02
申请人： Eiichi Minemura , Haruo Machida , Hiroshi Karasawa
发明人： Eiichi Minemura , Haruo Machida , Hiroshi Karasawa
IPC分类号： A61L2/07 , A61L11/00 , B09B3/00
CPC分类号： A61L2/07 , A61L11/00 , A61L2202/14 , A61L2202/15 , B09B3/0091
摘要： A steam sterilizer includes a sterilization tank configured to house an object to be sterilized and perform sterilization on the object to be sterilized by maintaining supplied steam at a predetermined temperature and under a predetermined pressure; a steam-supplying pipe configured to supply the steam into the sterilization tank; a steam-supplying pipe valve configured to control an amount of steam flow flowing through the steam-supplying pipe, wherein the steam-supplying pipe is provided so as to have a diameter that allows a pressure-increase rate of 100 kPa/min or more in the sterilization tank; and a control unit configured to control the steam-supplying pipe valve to be fully opened, in a conditioning process for repeatedly performing introduction and discharge of the steam in and from the sterilization tank and to control the steam-supplying pipe valve so as to supply a predetermined amount of steam, in a sterilization process after the conditioning process.
摘要翻译：蒸汽消毒器包括：灭菌箱，其构造成容纳待灭菌物体，并通过将供给的蒸汽维持在预定温度和预定压力下，对要灭菌的物体进行灭菌; 蒸汽供给管，其构造成将蒸汽供给到所述灭菌槽中; 蒸汽供给管阀，被配置为控制流过所述蒸汽供应管的蒸汽流量，其中所述蒸汽供应管设置成具有允许100kPa / min以上的增压速率的直径在灭菌槽中; 以及控制单元，被配置为在所述蒸汽供给管阀被完全打开的条件下进行控制，所述调节处理用于反复进行所述蒸汽进出所述灭菌槽的导入和排出，并且控制所述蒸汽供给管阀，在调节处理之后的灭菌过程中，预定量的蒸汽。

9. 发明申请

US20150023841A1 STEAM STERILIZER 有权
标题翻译：蒸汽杀菌剂
公开(公告)号：US20150023841A1
公开(公告)日：2015-01-22
申请号：US14381185
申请日：2012-03-02
申请人： Eiichi Minemura , Haruo Machida , Hiroshi Karasawa
发明人： Eiichi Minemura , Haruo Machida , Hiroshi Karasawa
IPC分类号： A61L2/07
CPC分类号： A61L2/07 , A61L11/00 , A61L2202/14 , A61L2202/15 , B09B3/0091
摘要： A steam sterilizer includes a sterilization tank configured to house an object to be sterilized and perform sterilization on the object to be sterilized by maintaining supplied steam at a predetermined temperature and under a predetermined pressure; a steam-supplying pipe configured to supply the steam into the sterilization tank; a steam-supplying pipe valve configured to control an amount of steam flow flowing through the steam-supplying pipe, wherein the steam-supplying pipe is provided so as to have a diameter that allows a pressure-increase rate of 100 kPa/min or more in the sterilization tank; and a control unit configured to control the steam-supplying pipe valve to be fully opened, in a conditioning process for repeatedly performing introduction and discharge of the steam in and from the sterilization tank and to control the steam-supplying pipe valve so as to supply a predetermined amount of steam, in a sterilization process after the conditioning process.
摘要翻译：蒸汽消毒器包括：灭菌箱，其构造成容纳待灭菌物体，并通过将供给的蒸汽维持在预定温度和预定压力下，对要灭菌的物体进行灭菌; 蒸汽供给管，其构造成将蒸汽供给到所述灭菌槽中; 蒸汽供给管阀，被配置为控制流过所述蒸汽供应管的蒸汽流量，其中所述蒸汽供应管设置成具有允许100kPa / min以上的增压速率的直径在灭菌槽中; 以及控制单元，被配置为在所述蒸汽供给管阀被完全打开的条件下进行控制，所述调节处理用于反复进行所述蒸汽进出所述灭菌槽的导入和排出，并且控制所述蒸汽供给管阀，在调节处理之后的灭菌过程中，预定量的蒸汽。

10. 发明申请

US20140363339A1 STEAM STERILIZER 有权
标题翻译：蒸汽杀菌剂
公开(公告)号：US20140363339A1
公开(公告)日：2014-12-11
申请号：US14371555
申请日：2012-01-30
申请人： Chihiro Kinebuchi , Eiichi Minemura , Satoshi Tanaka , Haruo Machida , Akihiro Miyamoto , Kouji Tanaka , Hiroshi Karasawa
发明人： Chihiro Kinebuchi , Eiichi Minemura , Satoshi Tanaka , Haruo Machida , Akihiro Miyamoto , Kouji Tanaka , Hiroshi Karasawa
IPC分类号： A61L2/07
CPC分类号： A61L2/07 , F04F5/04 , F04F5/20
摘要： Provided is a steam sterilizer capable of performing water vapor sterilization without using a vacuum pump as a mechanism for bringing the inside of a pressure vessel into vacuum. The steam sterilizer includes a pressure vessel (32) which stores an object to be sterilized and in which sterilization is performed with water vapor supplied from a steam piping, and vacuum-generating means (34) which is connected to the pressure vessel (32) and brings the inside of the pressure vessel (32) into a vacuum state. The vacuum-generating means (34) includes a water ejector (48), a tank (50) for storing supply water supplied from an outside, and a pump (52) for supplying the supply water inside the tank (50) to the water ejector (48).
摘要翻译：提供一种能够不使用真空泵进行水蒸气灭菌的蒸汽灭菌器，作为使压力容器内部成为真空的机构。蒸汽灭菌器包括：压力容器（32），其存储要被灭菌的物体，并且利用从蒸汽管道供应的水蒸气进行灭菌;以及与压力容器（32）连接的真空发生装置（34）并使压力容器（32）的内部成为真空状态。真空发生装置（34）包括水喷射器（48），用于存储从外部供应的供水的罐（50）和用于将水（50）内的供给水供应到水的泵（52）喷射器（48）。

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