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31. 发明授权

US09398877B2 Method and device for optical imaging of a turbid medium 有权
标题翻译：混浊介质的光学成像方法和装置
公开(公告)号：US09398877B2
公开(公告)日：2016-07-26
申请号：US12094670
申请日：2006-11-17
申请人： Martinus Bernardus Van Der Mark , Michael Cornelis Van Beek , Levinus Pieter Bakker
发明人： Martinus Bernardus Van Der Mark , Michael Cornelis Van Beek , Levinus Pieter Bakker
IPC分类号： A61B5/1455 , A61B5/00
CPC分类号： A61B5/4312 , A61B5/0091 , A61B5/1455 , A61B5/14551
摘要： Disclosed is a method and a device for optical imaging of a turbid medium. This method comprises a reference measurement of reference intensities of light emanating from the turbid medium at a reference blood oxygen saturation (SaO2) in the turbid medium and a reference imaging step for reconstructing a reference image of the turbid medium from the measured reference intensities. Furthermore the method comprises a contrast measurement of the contrast intensity of the light emanating from the turbid medium at a contrast blood oxygen saturation (SaO2) level in the turbid medium and a contrast imaging step for reconstructing a contrast image of the turbid medium from the measured contrast intensities. A comparison is made between the contrast image to the reference image of the turbid medium.
摘要翻译：公开了一种用于浑浊介质的光学成像的方法和装置。该方法包括在混浊介质中以参考血氧饱和度（SaO2）从混浊介质发出的光的参考光强度的参考测量值，以及用于根据测量的参考光强度重建浊度介质的参考图像的参考成像步骤。此外，该方法包括在浑浊培养基中以对比血氧饱和度（SaO2）水平从浑浊培养基发出的光的对比度强度的对比度测量，以及用于从所测量的重量中重建浑浊培养基的对比度图像的对比度成像步骤对比强度。对比图像与混浊介质的参考图像之间进行比较。

32. 发明申请

US20100258741A1 METHOD AND DEVICE FOR IMAGING AN INTERIOR OF AN OPTICALLY TURBID MEDIUM 审中-公开
标题翻译：用于成像光学涡卷介质内部的方法和装置
公开(公告)号：US20100258741A1
公开(公告)日：2010-10-14
申请号：US12741044
申请日：2008-11-03
申请人： Levinus Pieter Bakker , Michael Cornelis Van Beek , Martinus Bernardus Van Der Mark
发明人： Levinus Pieter Bakker , Michael Cornelis Van Beek , Martinus Bernardus Van Der Mark
IPC分类号： G01N21/64
CPC分类号： G01N21/6428 , A61B5/0091 , G01N21/6456 , G01N2021/1787 , G01N2021/6484
摘要： The invention relates to a method and a device (30, 125) for imaging an interior of an optically turbid medium (40). Light from a light source (35) is coupled into the turbid medium (40). Detection light emanating from the turbid medium (40) as a result of coupling (5) light from the light source (35) into the turbid medium (40) is collected. A first characteristic and a second characteristic of collected detection light are measured simultaneously. Next, the ratio of a first linear combination of the measured characteristics and a second linear combination of the measured characteristics is taken based on the recognition that the noise in both linear combinations is correlated.
摘要翻译：本发明涉及一种用于对光学混浊介质（40）的内部进行成像的方法和装置（30,125）。来自光源（35）的光被耦合到混浊介质（40）中。收集从光源（35）到混浊介质（40）的耦合（5）从混浊介质（40）发出的检测光。同时测量收集的检测光的第一特性和第二特性。接下来，基于两个线性组合中的噪声相关的认识来获得测量特性的第一线性组合与测量特性的第二线性组合的比率。

33. 发明申请

US20090231587A1 DEVICE FOR IMAGING AN INTERIOR OF A TURBID MEDIUM 审中-公开
标题翻译：用于成像涡轮介质内部的装置
公开(公告)号：US20090231587A1
公开(公告)日：2009-09-17
申请号：US12513686
申请日：2007-11-13
申请人： Levinus Pieter Bakker , Martinus Bernardus Van Der Mark , Michael Cornelis Van Beek
发明人： Levinus Pieter Bakker , Martinus Bernardus Van Der Mark , Michael Cornelis Van Beek
IPC分类号： A61B5/00
CPC分类号： A61B5/4312 , A61B5/0091
摘要： The invention relates to a device (1) for imaging an interior of a turbid medium (55) comprising a receptacle (20) with the receptacle (20) comprising a measurement volume (15) for receiving the turbid medium (55). The device (1) is adapted such that the inner surface of the receptacle (20), including at least part of the optical channels (70) is covered with a layer (80).
摘要翻译：本发明涉及一种用于对包含容器（20）的混浊介质（55）的内部成像的装置（1），所述容器（20）包括用于接收混浊介质（55）的测量体积（15）。设备（1）适于使得包括至少部分光通道（70）的容器（20）的内表面被层（80）覆盖。

34. 发明授权

US07557916B2 Spectroscopic system with multiple probes 失效
标题翻译：具有多个探针的光谱系统
公开(公告)号：US07557916B2
公开(公告)日：2009-07-07
申请号：US11570137
申请日：2005-06-22
申请人： Bernardus Leonardus Gerardus Bakker , Michael Cornelis Van Beek
发明人： Bernardus Leonardus Gerardus Bakker , Michael Cornelis Van Beek
IPC分类号： G01J3/30
CPC分类号： G01N21/65 , G01N2021/653 , G01N2021/655
摘要： The present invention provides a spectroscopic system for non invasive spectral analysis of substances or biological structures (114, 116) that are located in a plurality of various volumes of interest (110, 112). The inventive spectroscopic system makes use of a multiplicity of various probe heads (106, 108) that are connected to a base station (100) providing a spectroscopic light source (104) and spectroscopic analysis means (102) . By additionally implementing a coupling unit (132) the present invention allows to realize a spectroscopic analysis environment that makes spectroscopic analysis available in a variety of different locations, e.g. various rooms of a hospital.
摘要翻译：本发明提供了一种用于对位于多个不同感兴趣体积（110,112）中的物质或生物结构（114,116）进行无创光谱分析的光谱系统。本发明的光谱系统利用连接到提供分光光源（104）的基站（100）和光谱分析装置（102）的多个各种探头（106,108）。通过附加地实现耦合单元（132），本发明允许实现使得光谱分析在各种不同位置（例如，一间医院的各种房间。

35. 发明申请

US20090046291A1 DEVICE FOR IMAGING AN INTERIOR OF A TURBID MEDIUM 审中-公开
标题翻译：用于成像涡轮介质内部的装置
公开(公告)号：US20090046291A1
公开(公告)日：2009-02-19
申请号：US12093964
申请日：2006-10-27
申请人： Martinus Bernadus Van Der Mark , Michael Cornelis Van Beek , Levinus Pieter Bakker , arnoldus Johannes Martinus Jozeph Ras
发明人： Martinus Bernadus Van Der Mark , Michael Cornelis Van Beek , Levinus Pieter Bakker , arnoldus Johannes Martinus Jozeph Ras
IPC分类号： G01N21/49
CPC分类号： A61B5/4312 , A61B5/0073 , A61B5/0091 , A61B2562/146
摘要： The invention relates to a device (1) for imaging an interior of a turbid medium (55) comprising a receptacle (20) with the receptacle (20) comprising a measurement volume (15) for receiving the turbid medium (55). The device (1) is adapted such that the device (1) further comprises a further receptacle (60), arranged to be inserted into the receptacle (20), with the further receptacle (60) comprising a restricted measurement volume (75) for receiving the turbid medium (55).
摘要翻译：本发明涉及一种用于对包含容器（20）的混浊介质（55）的内部成像的装置（1），所述容器（20）包括用于接收混浊介质（55）的测量体积（15）。装置（1）适于使得装置（1）还包括设置成插入到容器（20）中的另一个容器（60），另外的容器（60）包括限制的测量体积（75），用于接收混浊介质（55）。

36. 发明申请

US20080278727A1 Device For Imaging an Interior of a Turbid Medium 审中-公开
标题翻译：用于成像浊度介质内部的装置
公开(公告)号：US20080278727A1
公开(公告)日：2008-11-13
申请号：US12093965
申请日：2006-11-02
申请人： Michael Cornelis Van Beek , Martinus Bernardus Van Der Mark , Levinus Pieter Bakker
发明人： Michael Cornelis Van Beek , Martinus Bernardus Van Der Mark , Levinus Pieter Bakker
IPC分类号： G01N21/59
CPC分类号： A61B5/0059 , A61B5/0073 , A61B5/0091 , A61B5/4312
摘要： The invention relates to a device for imaging an interior of a turbid medium. Said device (1) comprises a measurement volume (15) for accommodating the turbid medium. Said measurement volume (15) comprises a number of sources capable of communicating light, said sources comprising a preferred source, capable of communicating preferred light and a further source, capable of communicating further light. Said device (1) further comprises a detection unit capable of detecting composed light comprising a preferred component comprising at least a part of the preferred light and a further component comprising at least a part of the further light. The device is adapted such that the negative effect said further component in the composed light may have on detecting the preferred component also present in the composed light is counteracted. According to the invention this object is realized in that the preferred source and the further source are located such that a path followed by the preferred component from the preferred source to the detector unit and a path followed by the further component from the further source to the detector unit are substantially the same.
摘要翻译：本发明涉及一种用于对浑浊介质内部进行成像的装置。所述装置（1）包括用于容纳混浊介质的测量体积（15）。所述测量体积（15）包括能够通信光的多个光源，所述光源包括能够传送更好的光的能够传送优选光的另一光源的优选光源。所述装置（1）还包括能够检测合成光的检测单元，其包括包含至少一部分优选光的优选组分和包含至少一部分光的另外组分。该装置适于使得组合光中所述另外的组分的负面影响可能在检测到组合光中也存在的优选组分时可能被抵消。根据本发明，该目的的实现是，优选的源和进一步的源被定位成使得从优选的源到检测器单元的优选组件之后的路径以及从另一个源到另一个源的另一个组件的路径检测器单元基本相同。

37. 发明申请

US20080045817A1 Apparatus and Method for Performing Othogonal Polarized Spectral Imaging (Opsi) 审中-公开
标题翻译：用于执行正交极化光谱成像（Opsi）的装置和方法
公开(公告)号：US20080045817A1
公开(公告)日：2008-02-21
申请号：US10596562
申请日：2004-12-20
申请人： Michael Cornelis Van Beek , Egbert Lenderink , Robert Frans Maria Hendriks
发明人： Michael Cornelis Van Beek , Egbert Lenderink , Robert Frans Maria Hendriks
IPC分类号： A61B5/00
CPC分类号： A61B5/0059
摘要： Provided is a method and an apparatus for detection of objects below the surface of diffuse scattering media, in particular blood capillaries in organs such as the skin of human beings, using Orthogonal Polarized Spectral Imaging (OPSI), according to the invention comprising the steps of: imaging the object in question at at least two different angles so as to obtain a shift of position in the imaging plane; and subsequently comparing relative shifts of objects in the two images so as to obtain coordinates of the imaged objects with respect to the organ surface.
摘要翻译：提供了一种用于根据本发明使用正交偏振光谱成像（OPSI）检测漫射散射介质，特别是诸如人皮肤的器官中的毛细血管表面下方的物体的方法和装置，包括以下步骤：：以至少两个不同的角度对所讨论的物体进行成像，以获得成像平面中位置的偏移; 并且随后比较两个图像中的对象的相对偏移，以获得相对于器官表面的成像对象的坐标。

38. 发明授权

US07145641B2 Lithographic apparatus, device manufacturing method, and device manufactured thereby 失效
公开(公告)号：US07145641B2
公开(公告)日：2006-12-05
申请号：US10748751
申请日：2003-12-31
申请人： Mark Kroon , Michael Cornelis Van Beek , Peter Dirksen , Ralph Kurt , Cassandra May Owen
发明人： Mark Kroon , Michael Cornelis Van Beek , Peter Dirksen , Ralph Kurt , Cassandra May Owen
IPC分类号： G03B27/72 , G03B27/42 , G03B27/52 , G03G27/54
CPC分类号： G03F7/70983 , G03F7/70808 , G03F7/70916 , G03F7/70933
摘要： A lithographic apparatus is disclosed. The apparatus includes a radiation system that provides a beam of radiation, and a support structure that supports a patterning structure. The patterning structure is configured to pattern the beam of radiation according to a desired pattern. The apparatus also includes a substrate support that supports a substrate, and a projection system that projects the patterned beam onto a target portion of the substrate. The projection system includes an optical element that has a beam entry area and an optical element that has a beam exit area through each of which the patterned beam passes. The apparatus further includes a nucleated surface that is associated with the projection system on which a plurality of nucleation sites are provided. The surface is disposed away from at least one of the beam entry area and the beam exit area.

39. 发明授权

US07142287B2 Lithographic apparatus, device manufacturing method, and device manufactured thereby 失效
公开(公告)号：US07142287B2
公开(公告)日：2006-11-28
申请号：US11345316
申请日：2006-02-02
申请人： Mark Kroon , Michael Cornelis Van Beek , Peter Dirksen , Ralph Kurt , Cassandra May Owen
发明人： Mark Kroon , Michael Cornelis Van Beek , Peter Dirksen , Ralph Kurt , Cassandra May Owen
IPC分类号： G03B27/72 , G03B27/42 , G03B27/54
CPC分类号： G03F7/70983 , G03F7/70808 , G03F7/70916 , G03F7/70933
摘要： A lithographic apparatus is disclosed. The apparatus includes a radiation system that provides a beam of radiation, and a support structure that supports a patterning structure. The patterning structure is configured to pattern the beam of radiation according to a desired pattern. The apparatus also includes a substrate support that supports a substrate, and a projection system that projects the patterned beam onto a target portion of the substrate. The projection system includes an optical element that has a beam entry area and an optical element that has a beam exit area through each of which the patterned beam passes. The apparatus further includes a nucleated surface that is associated with the projection system on which a plurality of nucleation sites are provided. The surface is disposed away from at least one of the beam entry area and the beam exit area.

40. 发明授权

US10791932B2 Optical detection method and device for optical detection of the condition of joints 有权
公开(公告)号：US10791932B2
公开(公告)日：2020-10-06
申请号：US12992609
申请日：2009-05-20
申请人： Wouter Harry Jacinth Rensen , Michael Cornelis Van Beek , Rik Harbers
发明人： Wouter Harry Jacinth Rensen , Michael Cornelis Van Beek , Rik Harbers
IPC分类号： A61B5/00 , A61B5/02
摘要： An optical detection method is provided, wherein a body part (5) comprising at least one joint is irradiated with light. Local attenuation of the light by the body part (5) is detected as attenuation measurements (2) at the position of the at least one joint and at the position of at least one other portion of the body part (5); and wherein blood flow to and/or from the body part (5) is temporarily at least partially blocked and thereafter enabled again (3). Distinct local attenuation measurements for the at least one joint and for at least one other portion of the body part (5) are performed for at least two of the times before (I), during (II), and after (III) the blocking of blood flow.

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