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31. 发明授权

US06685927B2 Topical application of chromophores for hair removal 失效
标题翻译：用于脱毛的发色团的局部应用
公开(公告)号：US06685927B2
公开(公告)日：2004-02-03
申请号：US09965354
申请日：2001-09-27
申请人： Chryslain Sumian , Wolfgang Neuberger , Serge Mordon
发明人： Chryslain Sumian , Wolfgang Neuberger , Serge Mordon
IPC分类号： A61K715
CPC分类号： A61Q9/04 , A61K8/0241 , A61K8/49 , A61K2800/412 , A61K2800/438 , A61K2800/56 , A61K2800/81 , A61K2800/82 , A61K2800/83 , A61Q9/00
摘要： A device and method is disclosed for permanent or semi-permanent removal of hair through the activation of microparticles introduced into hair follicles. Microparticles are incorporated into a composition that is topically applied to the skin. These microparticles containing or consisting of chromophores or chemically activated molecules are of a variety of shapes and sizes. Microparticles are within a size range of 1 micron to 70 microns, and preferably between 10 and 50 microns. Microparticles of this size and variety of shapes enter hair follicles on all areas of the skin without entering other areas of the skin, such as the stratum corneum or sweat gland channels. Treatment of the skin with electromagnetic radiation, ultrasonic radiation or chemical means activates the chromophore or chemically activated compounds, thus destroying the hair follicle without damaging other areas of the skin. In another embodiment, microparticles further contain nanoparticles released further into the hair follicle by use of a solvent or other method, allowing chromophores or chemically activated molecules to penetrate deeper into the follicle and avoid structures such as the sebaceous gland.
摘要翻译：公开了通过引入毛囊的微粒的活化来永久或半永久性去除毛发的装置和方法。将微粒掺入局部施用于皮肤的组合物中。含有或由发色团或化学活化分子组成的这些微粒具有各种形状和尺寸。微粒的尺寸范围为1微米至70微米，优选为10至50微米。这种尺寸和各种形状的微粒在皮肤的所有区域都进入毛囊，而不会进入皮肤的其他区域，例如角质层或汗腺通道。用电磁辐射，超声辐射或化学方法治疗皮肤会激活发色团或化学活化的化合物，从而破坏毛囊而不损害皮肤的其他部位。在另一个实施方案中，微粒还包含通过使用溶剂或其它方法进一步释放到毛囊中的纳米颗粒，使得发色团或化学活化分子能够更深地渗入毛囊并避免诸如皮脂腺的结构。

32. 发明授权

US06574401B2 Optical fiber-handpiece combination for medical laser treatments 失效
标题翻译：用于医疗激光治疗的光纤手机组合
公开(公告)号：US06574401B2
公开(公告)日：2003-06-03
申请号：US10023326
申请日：2001-12-17
申请人： Wolfgang Neuberger , Brian Foley
发明人： Wolfgang Neuberger , Brian Foley
IPC分类号： G02B606
CPC分类号： A61B18/22 , A61B2090/0813
摘要： The present invention describes a multi-component handpiece that is both economical and practical for surgical laser treatment. A disposable optical fiber is inserted into a reusable handpiece. The distal end of the optical fiber is protected by a micro-walled protective tube to prevent the disposable fiber from chipping before and during insertion into the handpiece. Once the optical fiber is protected, it is inserted into the handpiece by threading the optical fiber through the cap, body, and cannula of the handpiece until the fiber extends slightly beyond the distal end of the needle. The micro-walled protective tube is removed from the end of the optical fiber, the optical fiber is positioned, and the cap is tightened. The cap and body of the handpiece cooperate to produce a tight friction fit that prevents longitudinal movement of the optical fiber during laser therapy. The tight friction fit holds the optical fiber in place without the use of adhesives, which allows for facilitated removal of the disposable fiber after use. Furthermore, a disposable fiber allows for convenient resterilization of the handpiece to eliminate the transmission of disease from one patient to the next without having to dispose of the entire handpiece following every laser procedure.
摘要翻译：本发明描述了一种多组分手机，其经济且实用于外科激光治疗。将一次性光纤插入可重复使用的手持件中。光纤的远端由微型壁保护管保护，以防止一次性光纤在插入手机之前和插入手机中。一旦光纤受到保护，通过将光纤穿过手持件的帽，主体和套管，将其插入到手持件中，直到纤维稍微延伸超过针的远端。从光纤端部取出微小的保护管，定位光纤，盖子被拧紧。手柄的盖子和主体配合以产生紧密的摩擦配合，防止光纤在激光治疗期间的纵向移动。紧密的摩擦配合将光纤保持在适当位置，而不需要使用粘合剂，这允许在使用后有助于去除一次性纤维。此外，一次性纤维允许方便地对手持件进行再生，以消除疾病从一个患者传播到下一个患者，而不必在每个激光程序之后处理整个手持件。

33. 发明授权

US06383179B1 Diode laser scalpel 失效
标题翻译：二极管激光手术刀
公开(公告)号：US06383179B1
公开(公告)日：2002-05-07
申请号：US09372541
申请日：1999-08-11
申请人： Wolfgang Neuberger
发明人： Wolfgang Neuberger
IPC分类号： A61B1818
CPC分类号： A61B18/22 , A61B17/3213 , A61B2018/2261
摘要： A device that simultaneously incises an area and cauterizes the desired tissue. The device incorporates laser energy by some means into a mechanical scalpel so that the incised area is cauterized as well. For example, a laser source is coupled by some means to an optically transparent blade such as a diamond knife. The diamond knife is appropriately coated so that radiation only exits at desired areas. In another example, optical fibers are embedded into a sharp edge blade scalpel with means to couple to a suitable radiation source.
摘要翻译：同时切割区域并烧灼所需组织的装置。该装置通过某种手段将激光能量并入机械解剖刀，使得切割区域也被烧灼。例如，激光源通过某种手段耦合到诸如金刚石刀的光学透明刀片上。金刚石刀被适当地涂覆，使得辐射仅在期望的区域离开。在另一示例中，光纤被嵌入到锋利的边缘刀片解剖刀中，其具有耦合到合适的辐射源的装置。

34. 发明授权

US06270342B1 Dental laser treatment hand-piece and system 失效
标题翻译：牙科激光治疗手工和系统
公开(公告)号：US06270342B1
公开(公告)日：2001-08-07
申请号：US09362378
申请日：1999-07-28
申请人： Wolfgang Neuberger , Michael Quade
发明人： Wolfgang Neuberger , Michael Quade
IPC分类号： A61C105
CPC分类号： A61C3/025 , A61C1/0046 , A61C1/0061 , A61C1/05 , A61C19/063
摘要： A handpiece is presented which utilizes fluid channels instead of electric wiring to provide power to a treatment device. These fluid channels operate a micro-turbine generator that provides electrical energy to treatment devices. Each micro-turbine generator generates electrical energy for powering at least one electricity consuming functional device; wherein said electricity consuming functional device is selected from the group; a compact laser, an electromechanical dental drill, an ultrasound generator, a microwave generator and, an activator for treatment chemicals. In particular this device provides energy to a dental hand-piece without the need for electrical wiring or optics between the hand-piece and the control apparatus. One or more fluid channels permit fluids to flow between the control apparatus and the hand-piece. This flow of fluid operates the micro-turbine, which in turn produces energy to operate a medical/dental device. The fluid channels can also be used to deliver substances in conjunction with the medical device use. The hand-piece of this apparatus can be manufactured for a specific medical/dental procedure, or the apparatus can be made compatible/interchangeable with existing hand-pieces and control apparatus. This micro-turbine energy system provides the power necessary to operate many state of the art devices. For example, the energy produced can be used to operate a laser used for various dental applications such as drilling, pre-heating of the drill area, or activation of PDT substances.
摘要翻译：提出了一种使用流体通道而不是电气布线向处理装置供电的手持件。这些流体通道操作向处理装置提供电能的微型涡轮发电机。每个微型涡轮发电机产生用于为至少一个电力消耗功能装置供电的电能; 其中所述电力消耗功能装置从所述组中选择; 紧凑型激光器，机电牙钻，超声波发生器，微波发生器和用于处理化学品的活化剂。特别地，该装置向牙科手柄提供能量，而不需要在手持件和控制装置之间的电线或光学元件。一个或多个流体通道允许流体在控制装置和手持件之间流动。该流体流动操作微型涡轮机，微型涡轮机又产生用于操作医疗/牙科设备的能量。流体通道也可用于与医疗装置的使用结合输送物质。该装置的手持件可以针对特定的医疗/牙科程序制造，或者可以使装置与现有手柄和控制装置兼容/互换。该微型涡轮机能量系统提供了操作许多现有技术装置所需的功率。例如，所产生的能量可用于操作用于各种牙齿应用的激光器，例如钻孔，钻孔区域的预加热或PDT物质的活化。

35. 发明授权

US06261310B1 Laser safe treatment system 有权
标题翻译：激光安全治疗系统
公开(公告)号：US06261310B1
公开(公告)日：2001-07-17
申请号：US09427871
申请日：1999-10-27
申请人： Wolfgang Neuberger , Michael Quade , Bolesh Skutnik
发明人： Wolfgang Neuberger , Michael Quade , Bolesh Skutnik
IPC分类号： A61N5067
CPC分类号： A61B18/20 , A61B90/40 , A61B2090/065 , A61F9/022 , A61N5/062 , A61N2005/067
摘要： In the present invention a laser treatment system is provided that can be used in any clinical environment without the necessity of personal safety equipment. Furthermore, the present invention provides a large amount of control to the operator/technician and the patient. The present invention combines mechanical and optical methods to protect operators and patients from undesired exposure to laser radiation. According to this approach, safe, portable and fixed embodiments that are useful in a large variety of applications, which are now possible. Several examples are described.
摘要翻译：在本发明中，提供了可以在任何临床环境中使用而不需要人身安全设备的激光治疗系统。此外，本发明对操作员/技术人员和患者提供了大量的控制。本发明结合机械和光学方法来保护操作者和患者免受不期望的暴露于激光辐射。根据这种方法，在现在可能的各种应用中有用的安全，便携和固定的实施例。描述几个例子。

36. 发明授权

US5771325A Modular laser system 失效
标题翻译：模块化激光系统
公开(公告)号：US5771325A
公开(公告)日：1998-06-23
申请号：US724082
申请日：1996-09-30
申请人： Wolfgang Neuberger
发明人： Wolfgang Neuberger
IPC分类号： H01S3/0941 , H01S5/068 , H01S5/40 , C02B6/36
CPC分类号： H01S3/09415 , H01S5/06825 , H01S5/4025
摘要： In a modular laser system, a plurality of laser modules are interchangeably mounted on a support rack with each laser module transmitting an output beam to a respective optical pump fiber, and the plurality of pump fibers are optically coupled to a laser rod for generating a combined output beam. A laser diode array is mounted within a sealed chamber of each module, and an output wave-guide of each module is coupled through a plurality of optical fibers to the diode array to receive the laser emissions. The other end of each output wave-guide has a first connector, and each pump fiber has a corresponding second connector permitting the output wave-guides to be interchangeably connected to the pump fibers. A control circuit of each laser module monitors the status of its laser diodes, the voltage and current supplied thereto, and the temperature conditions, and generates signals indicative of these parameters for detecting and replacing failed or defective laser modules. During replacement of a laser module, the other modules may continue to operate and generate a system output beam (albeit at a lower power level) thus permitting virtually continuous system operation.
摘要翻译：在模块化激光系统中，多个激光模块可互换地安装在支撑架上，每个激光模块将输出光束传输到相应的光泵浦光纤，并且多个泵浦光纤光学耦合到激光棒，以产生组合输出光束。激光二极管阵列安装在每个模块的密封室中，并且每个模块的输出波导通过多根光纤耦合到二极管阵列以接收激光发射。每个输出波导的另一端具有第一连接器，并且每个泵浦光纤具有相应的第二连接器，允许输出波导可互换地连接到泵浦光纤。每个激光模块的控制电路监视其激光二极管的状态，供给的激光二极管的电压和电流以及温度条件，并产生指示这些参数的信号，用于检测和更换失效或有缺陷的激光模块。在更换激光模块期间，其他模块可以继续操作并产生系统输出光束（尽管处于较低功率水平），从而允许实际上连续的系统操作。

37. 发明申请

US20210378741A1 ENCLOSED LASER MEDICAL DEVICE/SYSTEM 有权
公开(公告)号：US20210378741A1
公开(公告)日：2021-12-09
申请号：US16891656
申请日：2020-06-03
申请人： Wolfgang Neuberger
发明人： Wolfgang Neuberger
IPC分类号： A61B18/22 , A61B90/98
摘要： A fiber optic medical device/system is presented, comprising means to connect and enclose a laser source to ensure sterility and safe operation. Device includes a low cost, single use system enclosed and sterilized including laser source and with the fiber attached in a sterile tube. Another embodiment comprises hermetically sealed laser unit with simple connection system to a properly shaped fiber optic, after joining, unit comprises a hand piece and fiber for direct insertion to treat target tissue. Laser handle is aseptically packaged. In other embodiments, fiber is proximally terminated in solid funnel-shaped end to provide unique directional keyed junction with laser module. In another embodiment, unit includes fiber proximally joined to it, where a laser module can be added away from the fiber end, so that laser does not need to be sterilized but entire unit is safe for medical use in sterile fields. Enclosure also serves as a grip for pulling and/or manipulating device. In another preferred embodiment, laser unit is attached to a rigid delivery system for laparoscopic procedures.

38. 发明授权

US09693826B2 Endoluminal laser ablation device and method for treating veins 有权
公开(公告)号：US09693826B2
公开(公告)日：2017-07-04
申请号：US12395455
申请日：2009-02-27
申请人： Wolfgang Neuberger
发明人： Wolfgang Neuberger
IPC分类号： A61B18/18 , A61B18/24 , A61B17/22 , A61B18/22
CPC分类号： A61B18/24 , A61B17/22012 , A61B2018/2272
摘要： An improved method and device is provided for safe and efficient low power density endoluminal treatment of venous insufficiency. One such device emits pulsed or continuous energy radially through an optical fiber end with a conical shaped tip for 360° radial emission. In some embodiments, a conical reflective surface is distally spaced opposite to and faces the emitting tip for enhancing radial emission efficiency by reflecting out any designed or remnant forwardly transmitted energy in radial directions. Other devices include flat emitting faces sealed within protective, radiation transparent covers. Laser radiation is transmitted at a wavelength and power such that is it substantially entirely absorbed within the blood vessel wall to sufficiently damage the intravascular endothelium and, in turn, achieve blood vessel closure. Because the energy is substantially entirely absorbed within the blood vessel wall, the need for a local anesthetic along the treatment area of the blood vessel may be substantially avoided.

39. 发明授权

US09409037B2 Enhanced anti-microbial PDT 有权
标题翻译：增强抗微生物PDT
公开(公告)号：US09409037B2
公开(公告)日：2016-08-09
申请号：US13006274
申请日：2011-01-13
申请人： Volker Albrecht , Gerhard Wieland , Burkhard Gitter , Wolfgang Neuberger
发明人： Volker Albrecht , Gerhard Wieland , Burkhard Gitter , Wolfgang Neuberger
IPC分类号： A61N5/06 , A61M1/36 , A61L2/00
CPC分类号： A61N5/062 , A61L2/0029 , A61L2/0052 , A61L2202/21 , A61M1/3681 , A61M1/3686 , A61N5/0624 , A61N2005/063 , A61N2005/0652
摘要： Methods and devices to eliminate, reduce, destroy and/or inhibit undesired body fluid species, such as pathogen microbes and deteriorated or malignant cells in complex environments like blood, serum and other body fluids are provided. In preferred embodiments, an antimicrobial photodynamic therapy (PDT) treatment is given that effectively inactivates, reduces and/or destroys both Gram (−) and Gram (+) bacteria in complex body fluids. Methods to enhance antimicrobial PDT activity include administering a photosensitizer to bacteria-contaminated fluid, after a dwell time guiding bacteria-contaminated fluid with photosensitizer through a channel, emitting radiation preferably in an intermittent manner, and restoring treated body fluids to corresponding body regions. Electromagnetic radiation is preferably delivered intermittently with pulse width based on treatment parameters. Additionally, the method/device diminishes adverse host's inflammatory responses by neutralizing the biological activity of pathogenic microorganism fragments and reducing and/or removing pathogenic microorganism fragments responsible for it.
摘要翻译：提供了用于消除，减少，破坏和/或抑制诸如病原体微生物和诸如血液，血清和其他体液的复杂环境中的恶化或恶性细胞的不期望的体液物质的方法和装置。在优选的实施方案中，给出了在复合体液中有效灭活，减少和/或破坏革兰氏（ - ）和革兰氏阴性（+）细菌的抗微生物光动力疗法（PDT）治疗。增强抗微生物PDT活性的方法包括在通过通道引导细菌污染的流体与光敏剂停留时间之后，向细菌污染的流体施用光敏剂，优选以间歇方式发射辐射，并将经处理的体液恢复到相应的身体区域。基于治疗参数，电磁辐射优选间歇地以脉冲宽度递送。此外，该方法/装置通过中和致病微生物片段的生物活性并减少和/或除去负责其的病原微生物片段来减少不良宿主的炎症反应。

40. 发明授权

US09149335B2 Contact free and perforation safe endoluminal laser treatment device and method 有权
标题翻译：接触自由和穿孔安全腔内激光治疗装置及方法
公开(公告)号：US09149335B2
公开(公告)日：2015-10-06
申请号：US12951617
申请日：2010-11-22
申请人： Wolfgang Neuberger
发明人： Wolfgang Neuberger
IPC分类号： A61B18/18 , A61B18/24
CPC分类号： A61B18/24
摘要： A device and method for endovascular radiation therapy that prevents unwanted damage to blood vessels during treatment is described. The device is adapted to prevent the emission end of an energy delivery device from coming into contact with the wall of a blood vessel. The device is also adapted to sense the inputted radiation power and prevent irradiation above a preselected power or energy level. Both features serve to prevent radiation, having an overly high intensity or power density, from impacting the vessel wall and causing a puncture.
摘要翻译：描述了用于在治疗期间防止对血管的不期望的损伤的血管内放射治疗的装置和方法。该装置适于防止能量输送装置的排放端与血管的壁接触。该装置还适于感测输入的辐射功率并防止辐射高于预选的功率或能量水平。这两个特征都用于防止具有过高的强度或功率密度的辐射影响血管壁并引起穿刺。

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