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1. 发明授权

US06685927B2 Topical application of chromophores for hair removal 失效
标题翻译：用于脱毛的发色团的局部应用
公开(公告)号：US06685927B2
公开(公告)日：2004-02-03
申请号：US09965354
申请日：2001-09-27
申请人： Chryslain Sumian , Wolfgang Neuberger , Serge Mordon
发明人： Chryslain Sumian , Wolfgang Neuberger , Serge Mordon
IPC分类号： A61K715
CPC分类号： A61Q9/04 , A61K8/0241 , A61K8/49 , A61K2800/412 , A61K2800/438 , A61K2800/56 , A61K2800/81 , A61K2800/82 , A61K2800/83 , A61Q9/00
摘要： A device and method is disclosed for permanent or semi-permanent removal of hair through the activation of microparticles introduced into hair follicles. Microparticles are incorporated into a composition that is topically applied to the skin. These microparticles containing or consisting of chromophores or chemically activated molecules are of a variety of shapes and sizes. Microparticles are within a size range of 1 micron to 70 microns, and preferably between 10 and 50 microns. Microparticles of this size and variety of shapes enter hair follicles on all areas of the skin without entering other areas of the skin, such as the stratum corneum or sweat gland channels. Treatment of the skin with electromagnetic radiation, ultrasonic radiation or chemical means activates the chromophore or chemically activated compounds, thus destroying the hair follicle without damaging other areas of the skin. In another embodiment, microparticles further contain nanoparticles released further into the hair follicle by use of a solvent or other method, allowing chromophores or chemically activated molecules to penetrate deeper into the follicle and avoid structures such as the sebaceous gland.
摘要翻译：公开了通过引入毛囊的微粒的活化来永久或半永久性去除毛发的装置和方法。将微粒掺入局部施用于皮肤的组合物中。含有或由发色团或化学活化分子组成的这些微粒具有各种形状和尺寸。微粒的尺寸范围为1微米至70微米，优选为10至50微米。这种尺寸和各种形状的微粒在皮肤的所有区域都进入毛囊，而不会进入皮肤的其他区域，例如角质层或汗腺通道。用电磁辐射，超声辐射或化学方法治疗皮肤会激活发色团或化学活化的化合物，从而破坏毛囊而不损害皮肤的其他部位。在另一个实施方案中，微粒还包含通过使用溶剂或其它方法进一步释放到毛囊中的纳米颗粒，使得发色团或化学活化分子能够更深地渗入毛囊并避免诸如皮脂腺的结构。

2. 发明授权

US06287549B1 Method for removing superfluous hairs 有权
标题翻译：去除多余毛发的方法
公开(公告)号：US06287549B1
公开(公告)日：2001-09-11
申请号：US09402351
申请日：1999-12-22
申请人： Chryslain Sumian , Frank Pitre , Serge Mordon , Karine Buffard , Martine Bouclier
发明人： Chryslain Sumian , Frank Pitre , Serge Mordon , Karine Buffard , Martine Bouclier
IPC分类号： A61K7155
CPC分类号： A61Q7/02 , A61B18/203 , A61B2017/22085 , A61B2018/00452 , A61B2018/00476 , A61K8/0241 , A61K2800/412 , A61K2800/56 , A61K2800/81 , B23K26/18
摘要： A method for eliminating unwanted hairs is provided. The method includes applying an effective amount of a composition including microparticles to the surface of the skin where the hairs are situated and removing the composition remaining on the surface of the skin. The microparticles contain chromophores and a second material different from the chromophores. At least 80% by weight of the microparticles have a diameter of between 3 &mgr;m and 10 &mgr;m. A composition containing a solvent which dissolves the chromophores may then be applied to the surface of the skin. Laser radiation is then applied in one or more shots. The emitted wavelength of the laser radiation is absorbed by the chromophores. The light energy and the emission duration of the laser energy are sufficient to damage and/or kill the cells responsible for the growth of the hair.
摘要翻译：提供了一种消除不需要的毛发的方法。该方法包括将有效量的包含微粒的组合物施用于头发所在皮肤的表面，并去除残留在皮肤表面上的组合物。微粒含有发色团和不同于发色团的第二种材料。至少80重量％的微粒的直径在3μm和10μm之间。然后可以将含有溶解发色团的溶剂的组合物施用于皮肤表面。然后在一个或多个照射中施加激光辐射。激光辐射的发射波长被发色团吸收。激光能量的光能和发射持续时间足以损害和/或杀死负责头发生长的细胞。

3. 发明授权

US06340495B1 Device including a chromophoric composition to be applied to the skin, a method of fabricating such a device, and uses therefor 有权
标题翻译：包含应用于皮肤的发色组合物的装置，制造这种装置的方法及其用途
公开(公告)号：US06340495B1
公开(公告)日：2002-01-22
申请号：US09207267
申请日：1998-12-09
申请人： Chryslain Sumian , Franck Pitre , Serge Mordon
发明人： Chryslain Sumian , Franck Pitre , Serge Mordon
IPC分类号： A61B5103
CPC分类号： A61K9/7084 , A61K8/02 , A61K2800/438 , A61N5/062 , A61Q1/02
摘要： The invention relates to device making it possible to apply a chromophoric composition to the skin, said device including a chromophoric composition containing at least one chromophoric agent. The chromophoric composition is in the form of a layer of constant thickness bonded to one face of backing, at least prior to being applied to the skin, the chromophoric agent or agents being distributed uniformly in said composition, and the type of the composition being chosen such that light energy from laser radiation is transformed locally into heat and/or the chemical structure(s) of the chromophoric agent(s) is/are modified locally.
摘要翻译：本发明涉及使得可以将发色组合物施用于皮肤的装置，所述装置包括含有至少一种发色剂的发色组合物。至少在施用于皮肤之前，发色团组合物是以恒定厚度的层的形式结合到背衬的一个表面上，发色剂或试剂均匀地分布在所述组合物中，并且选择组合物的类型使得来自激光辐射的光能局部变换成热，和/或发色剂的化学结构被局部改变。

4. 发明授权

US6086580A Laser treatment/ablation of skin tissue 失效
标题翻译：激光治疗/消融皮肤组织
公开(公告)号：US6086580A
公开(公告)日：2000-07-11
申请号：US986145
申请日：1997-12-05
申请人： Serge Mordon , Chryslain Sumian , Karine Buffard , Franck Pitre , Martine Bouclier
发明人： Serge Mordon , Chryslain Sumian , Karine Buffard , Franck Pitre , Martine Bouclier
IPC分类号： A61B18/20 , A61N5/06 , A61N5/067
CPC分类号： A61N5/062 , A61B18/203 , A61B2018/00452 , A61B2018/0047 , A61N2005/067
摘要： Mammalian skin is treated and advantageously smoothed, for example to remove wrinkles, lines, warts and scars therefrom, by topically applying thereto a composition which comprises at least one laser-absorbing chromophore formulated into a physiologically acceptable carrier, diluent or vehicle therefor, and laser-irradiating the skin thus treated with an intensity sufficient to locally convert the light energy into heat energy in the applied composition and advantageously effecting tissue ablation of the surface of the treated skin, said applied composition and the thickness thereof having an absorbance at the emission wavelength of the laser such that the light energy transmitted into the skin generates no undesired irreversible tissue or cell damage.
摘要翻译：哺乳动物皮肤被处理并有利地平滑，例如通过局部施用包含至少一种配制成生理上可接受的载体，稀释剂或载体的激光吸收发色团和激光的组合物来去除皱纹，线，疣和疤痕以足以将光能局部转换成所施加的组合物中的热能并且有利地实现经处理的皮肤表面的组织消融的强度来照射如此处理的皮肤，所述施用的组合物及其厚度在发射波长处具有吸光度使得透射入皮肤的光能产生不期望的不可逆组织或细胞损伤。

5. 发明授权

US08715347B2 Devices and methods for reshaping cartilage structures 有权
标题翻译：用于整形软骨结构的装置和方法
公开(公告)号：US08715347B2
公开(公告)日：2014-05-06
申请号：US13498573
申请日：2011-04-15
申请人： Pascal Servell , Serge Mordon , Jack Savage
发明人： Pascal Servell , Serge Mordon , Jack Savage
IPC分类号： A61F2/18 , A61F5/08
CPC分类号： A61F11/004 , A61B5/1079 , A61B2017/00792 , A61F2/186 , A61F2002/183 , B33Y80/00 , H04L29/06 , H04L67/00 , H04L67/42 , H04L69/329
摘要： Described are methods of reshaping a cartilage structure. One such method comprises creating a virtual three dimensional image of the cartilage structure; manipulating the virtual three dimensional image of the cartilage structure so as to obtain a virtual three dimensional image of a desired final shape of the cartilage structure; creating a virtual prototype of a device to hold the cartilage structure in the desired final shape of the cartilage structure; manufacturing the device; lasing the cartilage structure; and fitting the manufactured device to the cartilage structure (e.g., ear).
摘要翻译：描述了重塑软骨结构的方法。一种这样的方法包括创建软骨结构的虚拟三维图像; 操纵软骨结构的虚拟三维图像，以获得软骨结构的所需最终形状的虚拟三维图像; 创建将软骨结构保持在软骨结构的所需最终形状中的装置的虚拟原型; 制造设备; 激光软骨结构; 并将制造的装置装配到软骨结构（例如，耳朵）上。

6. 发明授权

US5370119A Device for measuring the pH of a target, method for using said device and applications thereof 失效
标题翻译：用于测量靶的pH的装置，使用所述装置的方法及其应用
公开(公告)号：US5370119A
公开(公告)日：1994-12-06
申请号：US81276
申请日：1993-10-29
申请人： Serge Mordon , Vincent Maunoury , Jean-Marie Devoisselle
发明人： Serge Mordon , Vincent Maunoury , Jean-Marie Devoisselle
IPC分类号： A61B10/00 , A61B1/00 , A61B5/00 , G01N21/64 , G01N21/80 , A61B6/00
CPC分类号： A61B5/0084 , A61B5/0071 , G01N21/6428 , G01N2021/6419 , G01N2021/6434 , G01N21/80
摘要： A device for measuring the pH of an appropriate target, without direct contact with the target, includes a light source for selecting a plurality of wavelengths for excitation of fluorescence of a fluorescent marker fixed to the target. The fluorescence emission spectrum is dependent on pH, the excitation wavelength being switched from one wavelength to another. Light is transmitted from the light source to the target, and the emitted fluorescence is collected, detected and read. The pH of the target is calculated from the ratio of the emitted fluorescence signals obtained successively at least at two excitation wavelengths.
摘要翻译： PCT No.PCT / FR92 / 00006 Sec。 371日期：1993年10月29日 102（e）日期1993年10月29日PCT提交1992年1月3日PCT公布。第WO92 / 12412号公报日期：1992年7月23日。一种用于测量不与目标物直接接触的适当靶标的pH值的装置，包括用于选择多个波长的光源，用于激发固定在靶上的荧光标记物的荧光。荧光发射光谱依赖于pH，激发波长从一个波长切换到另一个波长。光从光源传输到目标，并且发射的荧光被收集，检测和读取。根据从至少两个激发波长连续获得的发射荧光信号的比值计算目标的pH。

7. 发明授权

US5330517A Device for treating tissue by pulse sequence group 失效
标题翻译：脉冲序列组治疗组织的装置
公开(公告)号：US5330517A
公开(公告)日：1994-07-19
申请号：US971987
申请日：1993-02-19
申请人： Serge Mordon , Jean-Marc Brunetaud , Hubert Guillet
发明人： Serge Mordon , Jean-Marc Brunetaud , Hubert Guillet
IPC分类号： A61B17/00 , A61B18/00 , A61B18/20 , A61B18/24 , A61N5/00
CPC分类号： A61B18/245 , A61B18/00 , A61B18/24 , A61B2017/00057 , A61B2017/0007 , A61B2017/00128 , A61B2017/00154 , A61B2017/00172 , A61B2017/0019 , A61B2018/207
摘要： The invention relates to a device for heat treatment of tissue. The device comprises a laser (20) provided with means enabling it to emit laser radiation in the form of a sufficient number of pulses to deliver a total energy that provides the heat treatment of the tissues, the device being characterized in that it includes means (30, 40) for adjusting the number and the duration of the pulses, said means enabling at least two pulse sequence groups to be emitted: a first pulse sequence group delivering about 70% to 80% of the total energy, and a second pulse sequence group delivering 30% to 20% of the total energy. The invention makes it possible to shorten the total time required for heat treatment of tissues.
摘要翻译： PCT No.PCT / FR92 / 00345 Sec。 371日期：1993年2月19日 102（e）日期1993年2月19日PCT提交1992年4月16日PCT公布。第WO92 / 18057号公报日期：1992年10月29日。本发明涉及一种用于组织热处理的装置。该装置包括具有能够以足够数量的脉冲的形式发射激光辐射的装置的激光器（20），以传送提供组织的热处理的总能量，该装置的特征在于它包括装置 30,40），用于调整所述脉冲的数量和持续时间，所述装置能够发射至少两个脉冲序列组：第一脉冲序列组，其传送总能量的约70％至80％，以及第二脉冲序列集团总能量的30％至20％。本发明可以缩短组织热处理所需的总时间。

8. 发明申请

US20060241362A1 Method and device for the mapping of intraretinal ph and device for the photocoagulation of peripheral retinal areas 审中-公开
标题翻译：用于映射外周视网膜区域的视网膜内结缔组织和装置的方法和装置
公开(公告)号：US20060241362A1
公开(公告)日：2006-10-26
申请号：US10548914
申请日：2004-03-05
申请人： Serge Mordon , Philippe Rochon
发明人： Serge Mordon , Philippe Rochon
IPC分类号： A61H33/00
CPC分类号： A61B5/14555 , A61B3/1225 , A61B5/14539 , A61F9/008 , A61F9/00821 , A61F2009/00863
摘要： The invention relates to a method of mapping the intraretinal pH of a retina which is marked by a pH-dependent fluorescent marker, in which the retina is illuminated with a first excitation radiation. According to the invention, a first image of the fluorescence emitted by the retina is formed as a bi-directional matrix of pixels at the wavelength of the peak of the fluorescence emission spectrum. Subsequently, the retina is illuminated with a second excitation radiation and a second image is formed of the fluorescence emitted thereby. Finally, the ratio at each pixel between the levels of fluorescence emitted in response to the two respective wavelengths is calculated, said ratio being representative of the pH of the retina, and a pH map of the retina is deduced.
摘要翻译：本发明涉及一种映射由pH依赖性荧光标记物标记的视网膜的视网膜内pH值的方法，其中视网膜被第一激发辐射照射。根据本发明，由视网膜发出的荧光的第一图像形成为在荧光发射光谱的峰值的波长处的像素的双向矩阵。随后，用第二激发辐射照射视网膜，并且由其发射的荧光形成第二图像。最后，计算响应于两个相应波长发射的荧光水平之间的每个像素的比率，所述比率代表视网膜的pH，并且推导出视网膜的pH图。

9. 发明申请

US20120226307A1 DEVICES AND METHODS FOR RESHAPING CARTILAGE STRUCTURES 有权
标题翻译：用于修复卡培结构的装置和方法
公开(公告)号：US20120226307A1
公开(公告)日：2012-09-06
申请号：US13498573
申请日：2001-02-09
申请人： Pascal Servell , Serge Mordon , Jack Savage
发明人： Pascal Servell , Serge Mordon , Jack Savage
IPC分类号： A61F5/00
CPC分类号： A61F11/004 , A61B5/1079 , A61B2017/00792 , A61F2/186 , A61F2002/183 , B33Y80/00 , H04L29/06 , H04L67/00 , H04L67/42 , H04L69/329
摘要： A networked system in which the majority of data bypass the server (101) to improve end-to-end performance of network access by achieving higher throughput between the network (130) and storage system (110). The apparatus consists of a network interface (120), server computer interface (240), and storage interface (250); and a switching element (201) and a high-layer protocol decoding and control unit (205). Incoming traffic is decoded and compared against a routing table. If there is a matching entry, it will be routed to the storage interface or sent to the server for further processing by default. The routing table entries are set up based on the initial nature of the applications. Subsequently, barring any changes or errors, there will be no data exchange between the server and the device. There may also be a speed matching funcion between the network and storage, load balancing function for servers, and flow control for priority and QOS purposes.
摘要翻译：网络系统，其中大部分数据绕过服务器（101），以通过在网络（130）和存储系统（110）之间实现更高的吞吐量来提高网络接入的端到端性能。该装置由网络接口（120），服务器计算机接口（240）和存储接口（250）组成。和开关元件（201）和高层协议解码和控制单元（205）。传入流量被解码并与路由表进行比较。如果有匹配的条目，它将被路由到存储接口或发送到服务器进行进一步处理。基于应用程序的初始性质设置路由表条目。随后，禁止任何更改或错误，服务器和设备之间将不会进行数据交换。在网络和存储之间也可能存在速度匹配功能，服务器的负载平衡功能以及优先级和QOS用途的流量控制。

10. 发明授权

US5336217A Process for treatment by irradiating an area of a body, and treatment apparatus usable in dermatology for the treatment of cutaneous angio dysplasias 失效
标题翻译：用于通过照射身体区域进行治疗的方法，以及可用于皮肤病学用于治疗皮肤血管发育异常的治疗装置
公开(公告)号：US5336217A
公开(公告)日：1994-08-09
申请号：US893683
申请日：1992-06-05
申请人： Bruno Buys , Jean-Pierre Sozanski , Serge Mordon , Jean-Marc Brunetaud , Yves Moschetto
发明人： Bruno Buys , Jean-Pierre Sozanski , Serge Mordon , Jean-Marc Brunetaud , Yves Moschetto
IPC分类号： A61B17/00 , A61B18/20 , A61N5/067 , B23K26/02 , B23K26/08 , A61N5/02
CPC分类号： B23K26/02 , A61B18/203 , B23K26/08 , B23K26/0884 , A61B18/20 , A61B2017/00057 , A61B2018/00452 , A61B2018/00636 , A61B2018/209 , A61N2005/067
摘要： The invention relates to a process of treatment in the field of dermatology, for the treatment of cutaneous angio dysplasias, using the energy emitted by a laser source, as well as to an apparatus for the treatment of skin angiomas implementing the process. The apparatus includes a laser source suitable for supplying laser radiation, a treatment instrument for receiving the laser radiation from the source and whereby a plurality of consecutive laser shots is effected to form a plurality of resulting impacts on the area of the body to be treated. Following each shot, the area of the body thus treated has, at the resulting impact, at least a given relaxation time. The apparatus includes a support frame, an optical fiber disposed in the frame. The optical fiber has two ends, the first of the ends being suitable for connection to the laser source via the connecting means, the second end being mobile and suitable for generating a displaceable laser spot. An automatic control unit with memory controls in time and space sequential scanning of the second end of the optical fiber, and permits a sequence of consecutive laser shots such that two consecutive laser shots form two resulting impacts, which are not contiguous, if the time lapse between the two consecutive laser shots is less than the given thermal relaxation time, and the impacts of the different consecutive laser shots completely cover the surface through the contiguous juxtaposition of the different impacts resulting from the different laser shots.
摘要翻译：本发明涉及使用激光源发射的能量以及用于治疗实施该过程的皮肤血管瘤的装置的皮肤病领域的治疗方法，用于治疗皮肤血管发育不良。该装置包括适于提供激光辐射的激光源，用于从源接收激光辐射的治疗仪器，由此实现多个连续的激光照射，以在待治疗的身体的区域上形成多个所产生的冲击。在每次射击之后，如此处理的身体的面积在所产生的影响下至少具有给定的放松时间。该装置包括支撑框架，布置在框架中的光纤。光纤具有两个端部，第一端部适于通过连接装置连接到激光源，第二端部是可移动的并且适合于产生位移激光点。一种自动控制单元，其具有对光纤的第二端进行时间和空间顺序扫描的存储器控制，并且允许连续激光照射的顺序，使得如果时间流逝，两个连续的激光照射形成不连续的两个所产生的冲击两个连续的激光照射之间的距离小于给定的热松弛时间，并且不同的激光照射的不同冲击的连续并置完全覆盖了不同的激光照射的影响。

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