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1. 发明授权

US06685927B2 Topical application of chromophores for hair removal 失效
标题翻译：用于脱毛的发色团的局部应用
公开(公告)号：US06685927B2
公开(公告)日：2004-02-03
申请号：US09965354
申请日：2001-09-27
申请人： Chryslain Sumian , Wolfgang Neuberger , Serge Mordon
发明人： Chryslain Sumian , Wolfgang Neuberger , Serge Mordon
IPC分类号： A61K715
CPC分类号： A61Q9/04 , A61K8/0241 , A61K8/49 , A61K2800/412 , A61K2800/438 , A61K2800/56 , A61K2800/81 , A61K2800/82 , A61K2800/83 , A61Q9/00
摘要： A device and method is disclosed for permanent or semi-permanent removal of hair through the activation of microparticles introduced into hair follicles. Microparticles are incorporated into a composition that is topically applied to the skin. These microparticles containing or consisting of chromophores or chemically activated molecules are of a variety of shapes and sizes. Microparticles are within a size range of 1 micron to 70 microns, and preferably between 10 and 50 microns. Microparticles of this size and variety of shapes enter hair follicles on all areas of the skin without entering other areas of the skin, such as the stratum corneum or sweat gland channels. Treatment of the skin with electromagnetic radiation, ultrasonic radiation or chemical means activates the chromophore or chemically activated compounds, thus destroying the hair follicle without damaging other areas of the skin. In another embodiment, microparticles further contain nanoparticles released further into the hair follicle by use of a solvent or other method, allowing chromophores or chemically activated molecules to penetrate deeper into the follicle and avoid structures such as the sebaceous gland.
摘要翻译：公开了通过引入毛囊的微粒的活化来永久或半永久性去除毛发的装置和方法。将微粒掺入局部施用于皮肤的组合物中。含有或由发色团或化学活化分子组成的这些微粒具有各种形状和尺寸。微粒的尺寸范围为1微米至70微米，优选为10至50微米。这种尺寸和各种形状的微粒在皮肤的所有区域都进入毛囊，而不会进入皮肤的其他区域，例如角质层或汗腺通道。用电磁辐射，超声辐射或化学方法治疗皮肤会激活发色团或化学活化的化合物，从而破坏毛囊而不损害皮肤的其他部位。在另一个实施方案中，微粒还包含通过使用溶剂或其它方法进一步释放到毛囊中的纳米颗粒，使得发色团或化学活化分子能够更深地渗入毛囊并避免诸如皮脂腺的结构。

2. 发明授权

US06340495B1 Device including a chromophoric composition to be applied to the skin, a method of fabricating such a device, and uses therefor 有权
标题翻译：包含应用于皮肤的发色组合物的装置，制造这种装置的方法及其用途
公开(公告)号：US06340495B1
公开(公告)日：2002-01-22
申请号：US09207267
申请日：1998-12-09
申请人： Chryslain Sumian , Franck Pitre , Serge Mordon
发明人： Chryslain Sumian , Franck Pitre , Serge Mordon
IPC分类号： A61B5103
CPC分类号： A61K9/7084 , A61K8/02 , A61K2800/438 , A61N5/062 , A61Q1/02
摘要： The invention relates to device making it possible to apply a chromophoric composition to the skin, said device including a chromophoric composition containing at least one chromophoric agent. The chromophoric composition is in the form of a layer of constant thickness bonded to one face of backing, at least prior to being applied to the skin, the chromophoric agent or agents being distributed uniformly in said composition, and the type of the composition being chosen such that light energy from laser radiation is transformed locally into heat and/or the chemical structure(s) of the chromophoric agent(s) is/are modified locally.
摘要翻译：本发明涉及使得可以将发色组合物施用于皮肤的装置，所述装置包括含有至少一种发色剂的发色组合物。至少在施用于皮肤之前，发色团组合物是以恒定厚度的层的形式结合到背衬的一个表面上，发色剂或试剂均匀地分布在所述组合物中，并且选择组合物的类型使得来自激光辐射的光能局部变换成热，和/或发色剂的化学结构被局部改变。

3. 发明授权

US6086580A Laser treatment/ablation of skin tissue 失效
标题翻译：激光治疗/消融皮肤组织
公开(公告)号：US6086580A
公开(公告)日：2000-07-11
申请号：US986145
申请日：1997-12-05
申请人： Serge Mordon , Chryslain Sumian , Karine Buffard , Franck Pitre , Martine Bouclier
发明人： Serge Mordon , Chryslain Sumian , Karine Buffard , Franck Pitre , Martine Bouclier
IPC分类号： A61B18/20 , A61N5/06 , A61N5/067
CPC分类号： A61N5/062 , A61B18/203 , A61B2018/00452 , A61B2018/0047 , A61N2005/067
摘要： Mammalian skin is treated and advantageously smoothed, for example to remove wrinkles, lines, warts and scars therefrom, by topically applying thereto a composition which comprises at least one laser-absorbing chromophore formulated into a physiologically acceptable carrier, diluent or vehicle therefor, and laser-irradiating the skin thus treated with an intensity sufficient to locally convert the light energy into heat energy in the applied composition and advantageously effecting tissue ablation of the surface of the treated skin, said applied composition and the thickness thereof having an absorbance at the emission wavelength of the laser such that the light energy transmitted into the skin generates no undesired irreversible tissue or cell damage.
摘要翻译：哺乳动物皮肤被处理并有利地平滑，例如通过局部施用包含至少一种配制成生理上可接受的载体，稀释剂或载体的激光吸收发色团和激光的组合物来去除皱纹，线，疣和疤痕以足以将光能局部转换成所施加的组合物中的热能并且有利地实现经处理的皮肤表面的组织消融的强度来照射如此处理的皮肤，所述施用的组合物及其厚度在发射波长处具有吸光度使得透射入皮肤的光能产生不期望的不可逆组织或细胞损伤。

4. 发明授权

US09095663B2 Biological fluid filtration unit provided with an offset inlet and/or outlet member 有权
标题翻译：设置有偏移入口和/或出口构件的生物流体过滤单元
公开(公告)号：US09095663B2
公开(公告)日：2015-08-04
申请号：US12597276
申请日：2008-04-22
申请人： Robert Duhaut , Chryslain Sumian , David Godard
发明人： Robert Duhaut , Chryslain Sumian , David Godard
IPC分类号： A61M1/36 , A61M1/02 , B29C65/02 , B29C65/04 , B29C65/00 , B29L31/14 , B29L31/00
CPC分类号： A61M1/3633 , A61M1/0209 , A61M1/0218 , A61M1/3636 , A61M1/3686 , B29C65/02 , B29C65/04 , B29C66/1122 , B29C66/12443 , B29C66/133 , B29C66/24221 , B29C66/53262 , B29C66/53263 , B29C66/71 , B29C66/80 , B29C66/81423 , B29C66/81431 , B29C66/8322 , B29C66/83221 , B29C66/8432 , B29L2031/14 , B29L2031/7148 , B29K2027/06
摘要： A filtration unit intended to allow the selective elimination of target substances from a fluid such as flood or a blood component, has an outer envelope formed from two flexible sheets joined together over their periphery along a bond line so as to define an inner volume, the envelope containing a filtering medium which delimits, on both sides of the bond line, an inlet compartment of the fluid to be filtered and an outlet compartment of the filtrate, each of the compartments being provided with an element—respectively an inlet and outlet element—for bringing the compartment into communication with the outside, the elements being connected between the sheets and comprising a flow channel that passes through the bond line, the unit being characterized in that at least one channel is offset relative to the bond line towards the compartment with which the channel is in communication.
摘要翻译：用于允许从诸如洪水或血液成分的流体中选择性地清除目标物质的过滤单元具有由两个柔性片材形成的外部封套，该两个柔性片材沿其接合线连接在一起，以便限定内部容积，包含过滤介质的封套，其在接合线的两侧限定待过滤流体的入口隔室和滤液的出口室，每个隔室设有元件，分别为入口和出口元件，为了使隔室与外部连通，元件连接在片材之间，并且包括通过接合线的流动通道，该单元的特征在于至少一个通道相对于朝向隔室的接合线偏移，通道正在通信。

5. 发明授权

US06287549B1 Method for removing superfluous hairs 有权
标题翻译：去除多余毛发的方法
公开(公告)号：US06287549B1
公开(公告)日：2001-09-11
申请号：US09402351
申请日：1999-12-22
申请人： Chryslain Sumian , Frank Pitre , Serge Mordon , Karine Buffard , Martine Bouclier
发明人： Chryslain Sumian , Frank Pitre , Serge Mordon , Karine Buffard , Martine Bouclier
IPC分类号： A61K7155
CPC分类号： A61Q7/02 , A61B18/203 , A61B2017/22085 , A61B2018/00452 , A61B2018/00476 , A61K8/0241 , A61K2800/412 , A61K2800/56 , A61K2800/81 , B23K26/18
摘要： A method for eliminating unwanted hairs is provided. The method includes applying an effective amount of a composition including microparticles to the surface of the skin where the hairs are situated and removing the composition remaining on the surface of the skin. The microparticles contain chromophores and a second material different from the chromophores. At least 80% by weight of the microparticles have a diameter of between 3 &mgr;m and 10 &mgr;m. A composition containing a solvent which dissolves the chromophores may then be applied to the surface of the skin. Laser radiation is then applied in one or more shots. The emitted wavelength of the laser radiation is absorbed by the chromophores. The light energy and the emission duration of the laser energy are sufficient to damage and/or kill the cells responsible for the growth of the hair.
摘要翻译：提供了一种消除不需要的毛发的方法。该方法包括将有效量的包含微粒的组合物施用于头发所在皮肤的表面，并去除残留在皮肤表面上的组合物。微粒含有发色团和不同于发色团的第二种材料。至少80重量％的微粒的直径在3μm和10μm之间。然后可以将含有溶解发色团的溶剂的组合物施用于皮肤表面。然后在一个或多个照射中施加激光辐射。激光辐射的发射波长被发色团吸收。激光能量的光能和发射持续时间足以损害和/或杀死负责头发生长的细胞。

6. 发明申请

US20100108596A1 BIOLOGICAL FLUID FILTRATION UNIT PROVIDED WITH AN OFFSET INLET AND/OR OUTLET MEMBER 有权
标题翻译：具有偏移入口和/或出口部件的生物流体过滤装置
公开(公告)号：US20100108596A1
公开(公告)日：2010-05-06
申请号：US12597276
申请日：2008-04-22
申请人： Robert Duhaut , Chryslain Sumian , David Godard
发明人： Robert Duhaut , Chryslain Sumian , David Godard
IPC分类号： B01D29/11 , A61J1/05 , A61M1/36
CPC分类号： A61M1/3633 , A61M1/0209 , A61M1/0218 , A61M1/3636 , A61M1/3686 , B29C65/02 , B29C65/04 , B29C66/1122 , B29C66/12443 , B29C66/133 , B29C66/24221 , B29C66/53262 , B29C66/53263 , B29C66/71 , B29C66/80 , B29C66/81423 , B29C66/81431 , B29C66/8322 , B29C66/83221 , B29C66/8432 , B29L2031/14 , B29L2031/7148 , B29K2027/06
摘要： A filtration unit intended to allow the selective elimination of target substances from a fluid such as flood or a blood component, has an outer envelope formed from two flexible sheets joined together over their periphery along a bond line so as to define an inner volume, the envelope containing a filtering medium which delimits, on both sides of the bond line, an inlet compartment of the fluid to be filtered and an outlet compartment of the filtrate, each of the compartments being provided with an element—respectively an inlet and outlet element—for bringing the compartment into communication with the outside, the elements being connected between the sheets and comprising a flow channel that passes through the bond line, the unit being characterized in that at least one channel is offset relative to the bond line towards the compartment with which the channel is in communication.
摘要翻译：用于允许从诸如洪水或血液成分的流体中选择性地清除目标物质的过滤单元具有由两个柔性片材形成的外部封套，该两个柔性片材沿其接合线连接在一起，以便限定内部容积，包含过滤介质的封套，其在接合线的两侧限定待过滤流体的入口隔室和滤液的出口室，每个隔室设有元件，分别为入口和出口元件，为了使隔室与外部连通，元件连接在片材之间，并且包括通过接合线的流动通道，该单元的特征在于至少一个通道相对于朝向隔室的接合线偏移，通道正在通信。

7. 发明申请

US20070154536A1 Drug delivery method by enhanced topical application 审中-公开
标题翻译：通过增强局部应用的药物递送方法
公开(公告)号：US20070154536A1
公开(公告)日：2007-07-05
申请号：US11706720
申请日：2007-02-15
申请人： Chryslain Sumian
发明人： Chryslain Sumian
IPC分类号： A61K9/70
CPC分类号： A61K9/06 , A61K9/70
摘要： Methods for enhancing penetration of compounds/drugs into an animal or human through their hair follicles are provided. The methods employ topical application of swellable compositions which can maintain a passage for desired drugs by either opening hair follicles and preventing them from collapsing or increasing the depth of inner lumen space of the hair follicles. The swellable composition can be polymers that are biodegradable, bioactive, encapsulated in microspheres or liposomes, and/or form microspheres. The method is useful to increase compound/drug penetration deep into a patient, to increase flux of compounds/drugs through the hair follicle, to obtain release of compounds/drugs in the tissues surrounding hair follicle or under the skin surface, and to obtain a systemic effect of the compounds/drugs after topical application. The method is also useful to increase therapeutic effects of compounds/drugs in the treatment of a wide variety of skin disorders. The method can further used to obtain permanent removing of unwanted hair by permitting the diffusion of compounds/drugs deeply into hair follicles.
摘要翻译：提供了通过其毛囊增强化合物/药物进入动物或人的渗透的方法。该方法采用局部施用可溶胀组合物，其可以通过打开毛囊并防止它们塌陷或增加毛囊内腔空间的深度来保持所需药物的通过。可溶胀组合物可以是可生物降解，生物活性，包封在微球或脂质体中的聚合物和/或形成微球体。该方法可用于增加深入患者的化合物/药物渗透，增加化合物/药物通过毛囊的通量，以获得围绕毛囊或皮肤表面的组织中化合物/药物的释放，并获得局部应用后化合物/药物的全身效应。该方法还可用于增加化合物/药物治疗各种皮肤病症的治疗效果。该方法可以进一步用于通过允许化合物/药物深入毛囊中的方式获得永久性去除不需要的毛发。

8. 发明授权

US06562025B2 Apparatus for uniting the lips of a wound, a holding piece, and a cosmetic treatment method 有权
标题翻译：用于将伤口的嘴唇，保持片和美容治疗方法结合的装置
公开(公告)号：US06562025B2
公开(公告)日：2003-05-13
申请号：US09358438
申请日：1999-07-22
申请人： Serge R. Mordon , Alexandre Capon , Chryslain Sumian
发明人： Serge R. Mordon , Alexandre Capon , Chryslain Sumian
IPC分类号： A61B1818
CPC分类号： A61B17/085 , A61B18/20 , A61B2017/00508
摘要： The apparatus for uniting the lips of a wound comprises a laser having an emission wavelength chosen such that it can perform tissue bonding and unite the lips of a wound, and a holding piece suitable for being secured to the tissue around the wound so as to keep the lips of the wound approximated, at least while the wound is being exposed to said laser radiation, the holding piece including at least one region suitable for being positioned over the wound and sufficiently transparent at the wavelength of the laser radiation for the energy from said radiation to be sufficient, after it has passed through said region, to perform the desired tissue bonding.
摘要翻译：用于结合伤口的装置的装置包括具有选择的发射波长的激光，使得其可以执行组织结合并团结伤口的唇缘，以及适于固定在伤口周围的组织的保持件，以便保持伤口的嘴唇至少在伤口暴露于所述激光辐射的同时近似，所述保持片包括适于定位在伤口上的至少一个区域，并且在激光辐射的波长处具有足够的透明度，用于来自所述激光辐射的能量在其通过所述区域之后，辐射足以进行所需的组织粘合。

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