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1. 发明授权

US06261310B1 Laser safe treatment system 有权
标题翻译：激光安全治疗系统
公开(公告)号：US06261310B1
公开(公告)日：2001-07-17
申请号：US09427871
申请日：1999-10-27
申请人： Wolfgang Neuberger , Michael Quade , Bolesh Skutnik
发明人： Wolfgang Neuberger , Michael Quade , Bolesh Skutnik
IPC分类号： A61N5067
CPC分类号： A61B18/20 , A61B90/40 , A61B2090/065 , A61F9/022 , A61N5/062 , A61N2005/067
摘要： In the present invention a laser treatment system is provided that can be used in any clinical environment without the necessity of personal safety equipment. Furthermore, the present invention provides a large amount of control to the operator/technician and the patient. The present invention combines mechanical and optical methods to protect operators and patients from undesired exposure to laser radiation. According to this approach, safe, portable and fixed embodiments that are useful in a large variety of applications, which are now possible. Several examples are described.
摘要翻译：在本发明中，提供了可以在任何临床环境中使用而不需要人身安全设备的激光治疗系统。此外，本发明对操作员/技术人员和患者提供了大量的控制。本发明结合机械和光学方法来保护操作者和患者免受不期望的暴露于激光辐射。根据这种方法，在现在可能的各种应用中有用的安全，便携和固定的实施例。描述几个例子。

2. 发明授权

US06270342B1 Dental laser treatment hand-piece and system 失效
标题翻译：牙科激光治疗手工和系统
公开(公告)号：US06270342B1
公开(公告)日：2001-08-07
申请号：US09362378
申请日：1999-07-28
申请人： Wolfgang Neuberger , Michael Quade
发明人： Wolfgang Neuberger , Michael Quade
IPC分类号： A61C105
CPC分类号： A61C3/025 , A61C1/0046 , A61C1/0061 , A61C1/05 , A61C19/063
摘要： A handpiece is presented which utilizes fluid channels instead of electric wiring to provide power to a treatment device. These fluid channels operate a micro-turbine generator that provides electrical energy to treatment devices. Each micro-turbine generator generates electrical energy for powering at least one electricity consuming functional device; wherein said electricity consuming functional device is selected from the group; a compact laser, an electromechanical dental drill, an ultrasound generator, a microwave generator and, an activator for treatment chemicals. In particular this device provides energy to a dental hand-piece without the need for electrical wiring or optics between the hand-piece and the control apparatus. One or more fluid channels permit fluids to flow between the control apparatus and the hand-piece. This flow of fluid operates the micro-turbine, which in turn produces energy to operate a medical/dental device. The fluid channels can also be used to deliver substances in conjunction with the medical device use. The hand-piece of this apparatus can be manufactured for a specific medical/dental procedure, or the apparatus can be made compatible/interchangeable with existing hand-pieces and control apparatus. This micro-turbine energy system provides the power necessary to operate many state of the art devices. For example, the energy produced can be used to operate a laser used for various dental applications such as drilling, pre-heating of the drill area, or activation of PDT substances.
摘要翻译：提出了一种使用流体通道而不是电气布线向处理装置供电的手持件。这些流体通道操作向处理装置提供电能的微型涡轮发电机。每个微型涡轮发电机产生用于为至少一个电力消耗功能装置供电的电能; 其中所述电力消耗功能装置从所述组中选择; 紧凑型激光器，机电牙钻，超声波发生器，微波发生器和用于处理化学品的活化剂。特别地，该装置向牙科手柄提供能量，而不需要在手持件和控制装置之间的电线或光学元件。一个或多个流体通道允许流体在控制装置和手持件之间流动。该流体流动操作微型涡轮机，微型涡轮机又产生用于操作医疗/牙科设备的能量。流体通道也可用于与医疗装置的使用结合输送物质。该装置的手持件可以针对特定的医疗/牙科程序制造，或者可以使装置与现有手柄和控制装置兼容/互换。该微型涡轮机能量系统提供了操作许多现有技术装置所需的功率。例如，所产生的能量可用于操作用于各种牙齿应用的激光器，例如钻孔，钻孔区域的预加热或PDT物质的活化。

3. 发明授权

US06660000B2 Device for application of radiation 有权
标题翻译：辐射装置
公开(公告)号：US06660000B2
公开(公告)日：2003-12-09
申请号：US10115662
申请日：2002-04-04
申请人： Wolfgang Neuberger , Michael Quade
发明人： Wolfgang Neuberger , Michael Quade
IPC分类号： A61B1818
CPC分类号： A61B18/203 , A61B2017/00199 , A61B2018/00452 , A61C19/004 , A61C19/066
摘要： A photonic scanning and delivery system capable of controllable transmission of light energy to an irregularly shaped treatment area are disclosed. The desired uniformity (controllability) of light energy application is ensured by a tracking device, which monitors the position of the radiation applicator and thereby prevents over- or under-radiation. The system employs a light energy delivery hand-piece. By these means, structures in the lower dermis are irradiated. Because of the large size of the treatment area, damage to surface tissue is avoided. The hand-piece can operate while in contact with the treatment surface. Treatment surfaces include non-medical work sites. Alternatively, the hand-piece can operate in a non-contact mode. The system can also be used in non-medical applications such as UV curing.
摘要翻译：公开了一种能够将光能可控地传输到不规则形状的处理区域的光子扫描和传送系统。通过跟踪装置确保光能施加的期望的均匀性（可控制性），跟踪装置监测辐射施加器的位置，从而防止辐射或辐射不足。该系统采用光能传递手段。通过这些方式，照射下层真皮中的结构。由于治疗面积大，避免了表面组织的损伤。手柄可以在与治疗表面接触的同时进行操作。治疗表面包括非医疗工作场所。或者，手持件可以以非接触模式操作。该系统也可用于非医疗应用，如紫外线固化。

4. 发明授权

US6097540A Frequency conversion combiner system for diode lasers 失效
标题翻译：二极管激光器的变频组合器系统
公开(公告)号：US6097540A
公开(公告)日：2000-08-01
申请号：US288189
申请日：1999-04-08
申请人： Wolfgang Neuberger , Michael Quade
发明人： Wolfgang Neuberger , Michael Quade
IPC分类号： G02B27/14 , G02F1/355 , H01S5/00 , H01S5/40 , G02B27/10
CPC分类号： H01S5/4025 , H01S5/005 , H01S5/1014
摘要： A frequency conversion diode beam combiner system is provided to multiplex several frequency converted laser beams and therefore keep the beam-quality of a single emitter. This multiplexing is physically impossible with free propagating beams. Both transformations, the frequency conversion and the beam multiplexing, must take place in one step in a single optical component or complex. This also aids the system to be very compact. The frequency conversion diode beam combiner system delivers a single beam which consists of several multiplexed beams from the converted radiation of the diode laser emitters. The high power high beam-quality of this device is not reachable with current diode lasers. A broad range of visible and infra-red wavelengths is possible. The frequency conversion diode beam combiner system can replace high power continuous wave (cw) solid state lasers, because its design is scaleable, small and simple.
摘要翻译：提供了一种频率转换二极管波束组合器系统来对多个频率转换的激光束进行多路复用，从而保持单个发射极的光束质量。这种多路复用对于自由传播光束物理上是不可能的。变换，频率转换和波束复用都必须在单个光学部件或复合体中一步进行。这也有助于系统非常紧凑。频率转换二极管光束组合器系统传送由二极管激光发射器的转换辐射的多个多路复用光束组成的单个光束。该器件的高功率高光束质量无法通过电流二极管激光器达到。宽范围的可见光和红外波长是可能的。变频二极管组合器系统可以代替高功率连续波（cw）固态激光器，因为其设计可扩展，小巧简单。

5. 发明授权

US6005717A Diode laser beam combiner system 失效
标题翻译：二极管激光束组合器系统
公开(公告)号：US6005717A
公开(公告)日：1999-12-21
申请号：US193742
申请日：1998-11-17
申请人： Wolfgang Neuberger , Michael Quade
发明人： Wolfgang Neuberger , Michael Quade
IPC分类号： G02B27/09 , H01S5/40 , G02B27/10 , G02B3/02 , G02B27/30
CPC分类号： G02B27/09 , H01S5/4025
摘要： A small, scalable, and inexpensive semiconductor diode laser system is described that includes a diode laser beam combiner comprising a cylindrical microlens, a lens array, and a fan window that optically combines energy outputs of at least two diode laser emitters or emitter groups. The diode laser beam combiner first collimates the diode laser energy and then optically combines the energy along a pre-determined axis, thus limiting effects due to space between the diode laser emitters. A chosen spot size and shape can be achieved by manipulating the number and size of lens array and fan window steps. Maximum power density and beam brightness available from the diode laser emitters or emitter groups is thus available at a work or treatment site.
摘要翻译：描述了一种小型，可扩展和便宜的半导体二极管激光系统，其包括二极管激光束组合器，其包括圆柱形微透镜，透镜阵列和风扇窗口，其光学地组合至少两个二极管激光发射器或发射极组的能量输出。二极管激光束组合器首先准直二极管激光能量，然后沿着预定的轴光学地组合能量，从而限制由二极管激光发射器之间的空间引起的影响。可以通过操纵透镜阵列和风扇窗台的数量和尺寸来实现所选择的光斑尺寸和形状。因此，二极管激光发射器或发射极组可获得的最大功率密度和光束亮度可在工作或处理现场获得。

6. 发明授权

US06406474B1 Device and method for application of radiation 失效
标题翻译：辐射应用的装置和方法
公开(公告)号：US06406474B1
公开(公告)日：2002-06-18
申请号：US09409358
申请日：1999-09-30
申请人： Wolfgang Neuberger , Michael Quade
发明人： Wolfgang Neuberger , Michael Quade
IPC分类号： A61B1818
CPC分类号： A61B18/203 , A61B2017/00199 , A61B2018/00452 , A61C19/004 , A61C19/066
摘要： A photonic scanning and delivery system capable of controllable transmission of light energy to an irregularly shaped treatment area are disclosed. The desired uniformity (controllability) of light energy application is ensured by a tracking device, which monitors the position of the radiation applicator and thereby prevents over- or under-radiation. The system employs a light energy delivery hand-piece. By these means, structures in the lower dermis are irradiated. Because of the large size of the treatment area, damage to surface tissue is avoided. The hand-piece can operate while in contact with the treatment surface. Treatment surfaces include non-medical work sites. Alternatively, the hand-piece can operate in a non-contact mode. The system can also be used in non-medical applications such as UV curing.
摘要翻译：公开了一种能够将光能可控地传输到不规则形状的处理区域的光子扫描和传送系统。通过跟踪装置确保光能施加的期望的均匀性（可控制性），跟踪装置监测辐射施加器的位置，从而防止辐射或辐射不足。该系统采用光能传递手段。通过这些方式，照射下层真皮中的结构。由于治疗面积大，避免了表面组织的损伤。手柄可以在与治疗表面接触的同时进行操作。治疗表面包括非医疗工作场所。或者，手持件可以以非接触模式操作。该系统也可用于非医疗应用，如紫外线固化。

7. 发明授权

US10709896B2 System and method for treating hemorrhoids 有权
公开(公告)号：US10709896B2
公开(公告)日：2020-07-14
申请号：US12976484
申请日：2010-12-22
申请人： Wolfgang Neuberger , Endrick Groenhoff
发明人： Wolfgang Neuberger , Endrick Groenhoff
IPC分类号： A61N5/06 , A61B8/12 , A61N5/067 , A61B8/00
摘要： System and method for treating hemorrhoidal piles, addressing both cause and symptoms, by endoluminal/interstitial application of energy are disclosed. The dilated blood arteries in anal/rectal region are irradiated from inside the pile using (laser) energy for minimal pain/discomfort. The center of the pile is irradiated over a certain diameter, absorbing energy; and is denatured causing volume reduction. Central vessels located in the same diameter are obliterated immediately, relieving bleeding. During treatment, new connective tissue replaces the coagulated tissue. Closing inflowing arteries further shrinks piles in weeks to three months. Complications are highly diminished. A hand-piece and a fiber with a sharp distal tip are beneficial. Including an imaging system, (ultrasound imaging, optical coherence tomography) and an intelligent system to calculate necessary laser energy parameters help address each pile individually.

8. 发明授权

US10335233B2 Myoma/polyp in-office treatment with lasers 有权
公开(公告)号：US10335233B2
公开(公告)日：2019-07-02
申请号：US13931210
申请日：2013-06-28
申请人： Martin Sabado , Wolfgang Neuberger
发明人： Martin Sabado , Wolfgang Neuberger
IPC分类号： A61B18/22 , A61B1/303 , A61B8/08 , A61B1/018 , A61B18/00 , A61B17/42 , A61B18/20
摘要： A noninvasive treatment of uterine growths such as myomas (fibroids) and polyps is presented. Treatment involves carrying out diagnostic hysteroscopy and ultrasound procedures to detect, measure, and evaluate unwanted uterine growths; then inserting optical fiber into a hysteroscope, reaching target tissue with optical fiber and eliminating said tissue or shrinking it to a size/shape for easy mechanical removal. Finally, ultrasound imaging is used to confirm success of procedure. In one embodiment, optical fiber has an off-axis firing end but can be inserted inside a conventional hysteroscopy device. In another embodiment, a laser interstitial thermal therapy (LITT) fiber is used to treat myomas found on the outside of the uterus. A high energy laser is used that can emit at wavelengths easily absorbed by water and blood, such as 980 nm and 1470 nm. Procedure is fast and can be done in the physician's office with little or no anesthesia used.

9. 发明授权

US09724069B2 Tissue resection under image guidance/control 有权
公开(公告)号：US09724069B2
公开(公告)日：2017-08-08
申请号：US12976337
申请日：2010-12-22
申请人： Wolfgang Neuberger , Manfred Kistner
发明人： Wolfgang Neuberger , Manfred Kistner
IPC分类号： A61B5/05 , A61B8/08 , A61N5/06 , A61B8/12 , A61B18/24 , A61B18/00 , A61B18/18 , A61B90/00
CPC分类号： A61B8/0841 , A61B8/12 , A61B18/24 , A61B2018/00547 , A61B2018/1807 , A61B2090/3762 , A61B2090/3764 , A61B2090/3784 , A61N5/0601
摘要： An improved method and device for accurate, efficient surgical procedures are disclosed. The disclosed system consists in simultaneously using an elongated member that conveys energy to a treatment site and imaging means to control position of the elongated member and monitor treatment progress in real-time. In a preferred embodiment, for BPH, a twister fiber with a fused cap is used and ultrasound image guidance is obtained using a rectal probe. The method consists in placing an ultrasound rectal probe, fixed by mechanical means, and an optical fiber inserted into urethra. Initial positioning of probe is done under endoscopic/ultrasound control. The twister fiber probe operates in contact-mode. Treatment is monitored, real-time, by the ultrasound device. Additional imaging technologies include Positron Emission Tomography (PET), Computed Tomography (CT) or Optical Coherence Tomography. Other applications include the removal of tumorous (hyperplasic) tissue. Sources include lasers, higher power LEDs or bright lamps and photodynamic therapy.

10. 发明授权

US08986731B2 Pegylated liposomal formulations of hydrophobic photosensitizers for photodynamic therapy 有权
标题翻译：用于光动力学治疗的疏水性光敏剂的聚乙二醇化脂质体制剂
公开(公告)号：US08986731B2
公开(公告)日：2015-03-24
申请号：US11349405
申请日：2006-02-07
申请人： Volker Albrecht , Alfred Fahr , Dietrich Scheglmann , Susanna Gräfe , Wolfgang Neuberger
发明人： Volker Albrecht , Alfred Fahr , Dietrich Scheglmann , Susanna Gräfe , Wolfgang Neuberger
IPC分类号： A61K9/127 , A61K31/407 , A61K31/555 , A61K41/00
CPC分类号： A61K9/1271 , A61K31/407 , A61K31/555 , A61K41/0071
摘要： Pharmaceutical pegylated liposomal formulations for photodynamic therapy are presented. The pegylated liposomal formulation provides therapeutically effective amounts of the photosensitizer for intravenous administration. At least one of the phospholipids in the liposomes has been linked with poly ethylene glycol (PEG) as an integral part of the phospholipids. The formed pegylated liposomes contain the hydrophobic photosensitizer within the lipid bilayer membrane. Pegylation of liposomes carrying the hydrophobic photosensitizer helps to maintain the drug level within the therapeutic window for longer time periods and provides the drug a longer circulating half life in vivo. Further the pegylated formulation of hydrophobic photosensitizers shows improved pharmacokinetics over standard non-liposomal formulations thus enhancing the efficacy of PDT with the pegylated liposomal formulations.
摘要翻译：提出了用于光动力学治疗的药物聚乙二醇化脂质体制剂。聚乙二醇化脂质体制剂提供治疗有效量的用于静脉内施用的光敏剂。脂质体中的至少一种磷脂已经与作为磷脂的组成部分的聚乙二醇（PEG）连接。形成的聚乙二醇化脂质体在脂质双层膜内含有疏水性光敏剂。携带疏水性光敏剂的脂质体的聚乙二醇化有助于在治疗窗口内维持更长时间的药物水平，并使药物在体内延长循环半衰期。此外，疏水性光敏剂的聚乙二醇化制剂显示与标准非脂质体制剂相比改善的药物代谢动力学，从而增强PDT与聚乙二醇化脂质体制剂的功效。

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