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31. 发明授权

US06586233B2 Convectively driven PCR thermal-cycling 失效
公开(公告)号：US06586233B2
公开(公告)日：2003-07-01
申请号：US09802549
申请日：2001-03-09
申请人： William J. Benett , James B. Richards , Fred P. Milanovich
发明人： William J. Benett , James B. Richards , Fred P. Milanovich
IPC分类号： C12M136
CPC分类号： B01L7/52 , B01L2400/0445
摘要： A polymerase chain reaction system provides an upper temperature zone and a lower temperature zone in a fluid sample. Channels set up convection cells in the fluid sample and move the fluid sample repeatedly through the upper and lower temperature zone creating thermal cycling.

32. 发明授权

US06503750B1 PCR thermocycler 有权
公开(公告)号：US06503750B1
公开(公告)日：2003-01-07
申请号：US09200309
申请日：1998-11-25
申请人： William J. Benett , James B. Richards
发明人： William J. Benett , James B. Richards
IPC分类号： C12M134
CPC分类号： B01L7/52 , B01J19/0093 , B01J2219/00788 , B01J2219/0081 , B01J2219/00828 , B01J2219/00873 , B01J2219/00961 , B01L3/5027 , B01L2300/1827 , B01L2300/1838
摘要： A sleeve-type silicon polymerase chain reaction (PCR) chamber or thermocycler having improved thermal performance. The silicon sleeve reaction chamber is improved in thermal performance by etched features therein that reduce thermal mass and increase the surface area of the sleeve for cooling. This improved thermal performance of the thermocycler enables an increase in speed and efficiency of the reaction chamber. The improvement is accomplished by providing grooves in the faces of the sleeve and a series of grooves on the interior surfaces that connect with grooves on the faces of the sleeve. The grooves can be anisotropically etched in the silicon sleeve simultaneously with formation of the chamber.

33. 发明授权

US6056331A Zero dead volume tube to surface seal 失效
标题翻译：零死体管到表面密封
公开(公告)号：US6056331A
公开(公告)日：2000-05-02
申请号：US711841
申请日：1996-09-12
申请人： William J. Benett , James A. Folta
发明人： William J. Benett , James A. Folta
IPC分类号： F16L19/02 , F16L21/04
CPC分类号： F16L19/02 , Y10S285/911 , Y10T29/49872
摘要： A method and apparatus for connecting a tube to a surface that creates a dead volume seal. The apparatus is composed of three components, a body, a ferrule, and a threaded fitting. The ferrule is compressed onto a tube and a seal is formed between the tube and a device retained in the body by threading the fitting into the body which provides pressure that seals the face of the ferrule to a mating surface on the device. This seal can be used at elevated temperatures depending on the materials used. While the invention has been developed for use with micro-machined silicon wafers used in Capillary Gas Chromatograph (GC), it can be utilized anywhere for making a gas or fluid face seal to the surface of a device that has near zero dead volume.
摘要翻译：一种将管连接到产生死体积密封的表面的方法和装置。该装置由三个部件组成，一个主体，一个套圈和一个螺纹接头。套圈被压缩到管上，并且通过将配件穿入主体中而将管和保持在主体中的装置之间形成密封，该压力提供将套圈的表面密封到装置上的配合表面的压力。根据所使用的材料，该密封可以在高温下使用。虽然本发明已被开发用于毛细管气相色谱（GC）中使用的微加工硅晶片，但是其可用于在具有接近零死体积的器件的表面形成气体或流体表面密封件的任何地方。

34. 发明授权

US5609608A Miniature plastic gripper and fabrication method 失效
标题翻译：微型塑料夹具及其制造方法
公开(公告)号：US5609608A
公开(公告)日：1997-03-11
申请号：US549497
申请日：1995-10-27
申请人： William J. Benett , Peter A. Krulevitch , Abraham P. Lee , Milton A. Northrup , James A. Folta
发明人： William J. Benett , Peter A. Krulevitch , Abraham P. Lee , Milton A. Northrup , James A. Folta
IPC分类号： A61B17/00 , A61B17/12 , A61B17/28
CPC分类号： A61B17/29 , A61B2017/00292 , A61B2017/00345 , A61B2017/00526 , A61B2017/12081 , A61B2017/2926 , A61B2017/2932 , Y10T29/49826
摘要： A miniature plastic gripper actuated by inflation of a miniature balloon and method of fabricating same. The gripper is constructed of either heat-shrinkable or heat-expandable plastic tubing and is formed around a mandrel, then cut to form gripper prongs or jaws and the mandrel removed. The gripper is connected at one end with a catheter or tube having an actuating balloon at its tip, whereby the gripper is opened or closed by inflation or deflation of the balloon. The gripper is designed to removably retain a member to which is connected a quantity or medicine, plugs, or micro-components. The miniature plastic gripper is inexpensive to fabricate and can be used for various applications, such as gripping, sorting, or placing of micron-scale particles for analysis.
摘要翻译：由微型气球膨胀致动的微型塑料夹具及其制造方法。夹具由热收缩或热膨胀塑料管构成，并围绕心轴形成，然后切割以形成夹爪或钳口，并移除心轴。夹具在其一端与在其尖端处具有致动气囊的导管或管连接，由此通过气囊的充气或放气来打开或闭合夹具。夹具被设计成可移除地保持连接有数量或药物，插头或微组件的构件。微型塑料夹具制造成本低廉，可用于各种应用，例如夹紧，分选或放置微米级颗粒进行分析。

35. 发明授权

US5548605A Monolithic microchannel heatsink 失效
标题翻译：单片微通道散热器
公开(公告)号：US5548605A
公开(公告)日：1996-08-20
申请号：US440595
申请日：1995-05-15
申请人： William J. Benett , Raymond J. Beach , Dino R. Ciarlo
发明人： William J. Benett , Raymond J. Beach , Dino R. Ciarlo
IPC分类号： H01S5/024 , H01S5/40 , H01S3/04
CPC分类号： H01S5/02423 , H01S5/4025
摘要： A silicon wafer has slots sawn in it that allow diode laser bars to be mounted in contact with the silicon. Microchannels are etched into the back of the wafer to provide cooling of the diode bars. To facilitate getting the channels close to the diode bars, the channels are rotated from an angle perpendicular to the diode bars which allows increased penetration between the mounted diode bars. This invention enables the fabrication of monolithic silicon microchannel heatsinks for laser diodes. The heatsinks have low thermal resistance because of the close proximity of the microchannels to the laser diode being cooled. This allows high average power operation of two-dimensional laser diode arrays that have a high density of laser diode bars and therefore high optical power density.
摘要翻译：一个硅晶片上有一个锯槽，可以使二极管激光棒安装成与硅接触。将微通道蚀刻到晶片的背面以提供二极管条的冷却。为了使通道靠近二极管条，通道从垂直于二极管条的角度旋转，这允许在安装的二极管条之间增加穿透。本发明能够制造用于激光二极管的单片硅微通道散热器。由于微通道与被冷却的激光二极管的紧密接近，散热器具有低热阻。这允许具有高密度激光二极管条并因此具有高光功率密度的二维激光二极管阵列的高平均功率操作。

36. 发明授权

US5105430A Thin planar package for cooling an array of edge-emitting laser diodes 失效
标题翻译：用于冷却边缘发射激光二极管阵列的薄平面封装
公开(公告)号：US5105430A
公开(公告)日：1992-04-14
申请号：US682770
申请日：1991-04-09
申请人： David C. Mundinger , William J. Benett
发明人： David C. Mundinger , William J. Benett
IPC分类号： H01L23/473 , H01S5/00 , H01S5/024 , H01S5/40
CPC分类号： H01S5/02423 , H01S5/4031 , H01L2224/45144 , H01L2224/48091 , H01S5/02236 , H01S5/02272
摘要： A laser diode array is disclosed that includes a plurality of planar assemblies and active cooling of each assembly. The laser diode array may be operated in a long duty cycle, or in continuous operation. A laser diode bar and a microchannel heat sink are thermally coupled in a compact, thin planar assembly having the laser diode bar located proximate to one edge. In an array, a number of such thin planar assemblies are secured together in a stacked configuration, in close proximity so that the laser diodes are spaced closely. The cooling means includes a microchannel heat sink proximate to the laser diode bar to absorb heat generated by laser operation. To provide the coolant to the microchannels, each thin planar assembly comprises passageways that connect the microchannels to inlet and outlet corridors. Each inlet passageway may comprise a narrow slot that directs coolant into the microchannels and increases the velocity of flow therethrough. The corridors comprises holes extending through each of the assemblies in the array. The inlet and outlet corridors are connected to a conventional coolant circulation system. The laser diode array with active cooling has applications as an optical pump for high power solid state lasers, or by mating the diodes with fiber optic lenses. Further, the arrays can be useful in applications having space constraints and energy limitations, and in military and space applications. The arrays can be incorporated in equipment such as communications devices and active sensors.
摘要翻译：公开了一种激光二极管阵列，其包括多个平面组件和每个组件的主动冷却。激光二极管阵列可以在长占空比或连续操作中操作。激光二极管条和微通道散热器热耦合在紧凑的薄平面组件中，其具有位于一个边缘附近的激光二极管条。在阵列中，许多这样的薄平面组件以堆叠的形式紧密地固定在一起，使得激光二极管紧密地间隔开。冷却装置包括靠近激光二极管条的微通道散热器，以吸收由激光操作产生的热量。为了将冷却剂提供给微通道，每个薄平面组件包括将微通道连接到入口和出口走廊的通道。每个入口通道可以包括狭窄的狭槽，其将冷却剂引导到微通道中并增加流过其中的流速。走廊包括延伸穿过阵列中每个组件的孔。入口和出口走廊连接到常规的冷却剂循环系统。具有主动冷却的激光二极管阵列可用作高功率固体激光器的光泵，或通过将二极管与光纤透镜配合使用。此外，阵列可以在具有空间限制和能量限制的应用中以及在军事和空间应用中是有用的。阵列可以并入设备，如通信设备和有源传感器。

37. 发明授权

US11975321B2 Multi-channel optical detection system and method for multi-chamber assays 有权
公开(公告)号：US11975321B2
公开(公告)日：2024-05-07
申请号：US16367125
申请日：2019-03-27
申请人： Lawrence C. Dugan , William J. Benett , Elizabeth K. Wheeler
发明人： Lawrence C. Dugan , William J. Benett , Elizabeth K. Wheeler
IPC分类号： B01L3/00 , G01N21/76
CPC分类号： B01L3/502715 , G01N21/76 , B01L2200/10
摘要： A multi-channel optical detection system includes a base unit adapted to receive a multi-chamber assay cartridge having a plurality of reaction chambers loaded with a sample and an optical detection reagent, and an optical detection unit having a multi-channel optical block having a plurality of detection channels each with an associated light source, and an optic sensor. The optical detection unit is connectable to the base unit so that interrogation ports of the detection channels are optically aligned with optically transparent windows of the reaction chambers of a loaded cartridge, so that upon initialization, light sources are activated to interrogate reaction products in the reaction chambers and detect the optical responses therefrom.

38. 发明授权

US07901623B2 Lateral flow strip assay 有权
标题翻译：侧流条测定
公开(公告)号：US07901623B2
公开(公告)日：2011-03-08
申请号：US11528286
申请日：2006-09-26
申请人： Robin R. Miles , William J. Benett , Matthew A. Coleman , Francesca S. Pearson , Shanavaz L. Nasarabadi
发明人： Robin R. Miles , William J. Benett , Matthew A. Coleman , Francesca S. Pearson , Shanavaz L. Nasarabadi
IPC分类号： G01N33/00
CPC分类号： G01N33/558
摘要： A lateral flow strip assay apparatus comprising a housing; a lateral flow strip in the housing, the lateral flow strip having a receiving portion; a sample collection unit; and a reagent reservoir. Saliva and/or buccal cells are collected from an individual using the sample collection unit. The sample collection unit is immersed in the reagent reservoir. The tip of the lateral flow strip is immersed in the reservoir and the reagent/sample mixture wicks up into the lateral flow strip to perform the assay.
摘要翻译：一种侧流条测定装置，包括壳体; 所述外壳中的横向流动条，所述横向流动带具有接收部分; 样本收集单元; 和试剂储存器。使用样品收集单元从个体收集唾液和/或颊细胞。样品收集单元浸入试剂容器中。横向流动条的尖端浸入储存器中，并将试剂/样品混合物吸入侧流条中以进行测定。

39. 发明申请

US20100139368A1 MICRO-OPTICAL-MECHANICAL SYSTEM PHOTOACOUSTIC SPECTROMETER 有权
标题翻译：微光机械系统光电光谱仪
公开(公告)号：US20100139368A1
公开(公告)日：2010-06-10
申请号：US12628952
申请日：2009-12-01
申请人： Jack Kotovsky , William J. Benett , Angela C. Tooker , Jennifer B. Alameda
发明人： Jack Kotovsky , William J. Benett , Angela C. Tooker , Jennifer B. Alameda
IPC分类号： G01H9/00 , G01N21/00 , G01N29/02
CPC分类号： G01N21/1702 , G01N33/0016 , G01N2021/1704
摘要： All-optical photoacoustic spectrometer sensing systems (PASS system) and methods include all the hardware needed to analyze the presence of a large variety of materials (solid, liquid and gas). Some of the all-optical PASS systems require only two optical-fibers to communicate with the opto-electronic power and readout systems that exist outside of the material environment. Methods for improving the signal-to-noise are provided and enable mirco-scale systems and methods for operating such systems.
摘要翻译：全光学光声光谱仪传感系统（PASS系统）和方法包括分析各种材料（固体，液体和气体）的存在所需的所有硬件。全光学PASS系统中的一些只需要两根光纤与存在于材料环境之外的光电和读出系统进行通信。提供了改善信噪比的方法，并且实现了用于操作这种系统的微小规模系统和方法。

40. 发明授权

US07413711B2 System for dispensing a precise amount of fluid 失效
标题翻译：用于分配精确量的流体的系统
公开(公告)号：US07413711B2
公开(公告)日：2008-08-19
申请号：US10621657
申请日：2003-07-16
申请人： William J. Benett , Peter A. Krulevitch , Steven R. Visuri , John M. Dzenitis , Kevin D. Ness
发明人： William J. Benett , Peter A. Krulevitch , Steven R. Visuri , John M. Dzenitis , Kevin D. Ness
IPC分类号： B01L3/02
CPC分类号： B01L3/0217 , B01L2400/0487 , G01N35/1016 , G01N35/1065 , G01N2035/1034
摘要： A dispensing system delivers a precise amount of fluid for biological or chemical processing and/or analysis. Dispensing means moves the fluid. The dispensing means is operated by a pneumatic force. Connection means delivers the fluid to the desired location. An actuator means provides the pneumatic force to the dispensing means. Valving means transmits the pneumatic force from the actuator means to the dispensing means.
摘要翻译：分配系统提供精确量的用于生物或化学处理和/或分析的流体。分液装置移动流体。分配装置通过气动力操作。连接装置将流体输送到所需位置。致动器装置向分配装置提供气动力。阀装置将气动力从致动器装置传递到分配装置。

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