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31. 发明申请

US20050033368A1 Implantable cardiac device for and method of monitoring progression or regression of heart disease by quantifying morphological features 失效
标题翻译：通过量化形态学特征可植入心脏装置和监测心脏病进展或消退的方法
公开(公告)号：US20050033368A1
公开(公告)日：2005-02-10
申请号：US10094929
申请日：2001-12-06
申请人： Matthew Fishler , Eric Falkenberg , Drew Hoffman
发明人： Matthew Fishler , Eric Falkenberg , Drew Hoffman
IPC分类号： A61B5/00 , A61B5/0452 , A61N1/372 , A61N1/362
CPC分类号： A61B5/0031 , A61B5/0006 , A61B5/0452
摘要： An implantable cardiac device and method provides for monitoring a progression or regression in heart disease during an extended time period. A sensor generates an electrogram signal representing electrical activity of a patient's heart. From the generated electrogram signal, a processor determines morphology measurements wherein the morphology measurements indicate a progression or regression in the heart disease. The morphology measurements are stored in a memory during the extended period of time. A telemetry circuit transmits the stored morphology measurements to an external receiver for retrieval or display. The morphology measurements may be of electrogram intrinsic activity or evoked response activity characteristics.
摘要翻译：可植入心脏装置和方法提供在延长的时间段内监测心脏病的进展或消退。传感器产生表示患者心脏的电活动的电描记图信号。根据生成的电描记图信号，处理器确定形态学测量，其中形态学测量指示心脏病的进展或消退。形态测量在长时间内存储在存储器中。遥测电路将存储的形态测量值传输到外部接收器以进行检索或显示。形态学测量可以是电描记图内在活性或诱发反应活性特征。

32. 发明授权

US06760619B1 Two lead universal defibrillation, pacing and sensing system 失效
标题翻译：双引线通用除颤，起搏和感应系统
公开(公告)号：US06760619B1
公开(公告)日：2004-07-06
申请号：US09945449
申请日：2001-08-31
申请人： John R. Helland , Gene A. Bornzin , Eric Falkenberg
发明人： John R. Helland , Gene A. Bornzin , Eric Falkenberg
IPC分类号： A61N1368
CPC分类号： A61N1/3627 , A61N1/3684 , A61N1/3918 , A61N1/395
摘要： An implantable cardiac stimulation system senses electrical activity of all four chambers of the heart and delivers pacing and defibrillation pulses to all four chambers of the heart. The system includes a lead system consisting of first and second leads. The first lead includes a right ventricular pacing electrode, a right ventricular defibrillation electrode, and a right atrial defibrillation lead. The second lead is implantable in the coronary sinus of the heart and includes a left ventricular pacing electrode, a left ventricular defibrillation electrode, a left atrial pacing electrode, and a left atrial defibrillation electrode. A right atrial pacing electrode is carried by one of the first and second leads. The system further includes a cardiac stimulation device including a pulse generator that delivers defibrillation pulses between any combination of the defibrillation electrodes and pacing pulses to any one of the pacing electrodes and a sensing circuit that senses cardiac electrical activity with any one of the pacing electrodes.
摘要翻译：植入式心脏刺激系统感测心脏的所有四个腔室的电活动，并将心脏起搏和除颤脉冲输送到心脏的所有四个腔室。该系统包括由第一和第二引线组成的引导系统。第一个引线包括右心室起搏电极，右心室除颤电极和右心房除颤引线。第二引线可植入心脏的冠状窦内，包括左心室起搏电极，左心室除颤电极，左心房起搏电极和左心房除颤电极。右心房起搏电极由第一和第二引线之一承载。该系统还包括心脏刺激装置，其包括脉冲发生器，该脉冲发生器将除颤电极和起搏脉冲的任何组合之间的除颤脉冲传送到任何一个起搏电极，以及感测电路，其用任何一个起搏电极感测心脏电活动。

33. 发明授权

US06748268B1 Three lead universal pacing and shocking system 失效
标题翻译：三主控通用起搏和震动系统
公开(公告)号：US06748268B1
公开(公告)日：2004-06-08
申请号：US09945079
申请日：2001-08-31
申请人： John R. Helland , Gene A. Bornzin , Eric Falkenberg
发明人： John R. Helland , Gene A. Bornzin , Eric Falkenberg
IPC分类号： A61N1368
CPC分类号： A61N1/0563 , A61N1/3918 , A61N1/395 , A61N2001/0585
摘要： A three lead implantable cardiac stimulation system is capable of delivering stimulation pulses to any one chamber or combination of chambers of a heart. The system includes a first lead for implant in the right ventricle and having a right ventricular defibrillation electrode, a second lead for implant in the coronary sinus and having a left ventricular defibrillation electrode, and a third lead for implant in the coronary sinus and having a left atrial defibrillation electrode. One of the leads further including a right atrial defibrillation electrode for placement in one of the right atrium and superior vena cava. The system further includes an implantable cardiac stimulation device including a programmable pulse generator that delivers defibrillation pulses to any one of the defibrillation electrodes or to any combination of the defibrillation electrodes. The leads may further provide at least one pacing electrode for each chamber of the heart and the device is programmable to provide pacing pulses to any one of the pacing electrodes.
摘要翻译：三引线可植入心脏刺激系统能够将刺激脉冲输送到心脏的任何一个腔室或腔室的组合。该系统包括用于植入右心室并具有右心室除颤电极的第一引线，用于在冠状窦内植入并具有左心室除颤电极的第二引线和用于植入在冠状窦中的第三引线，并具有左心房除颤电极。其中一个引线还包括右心房除颤电极，用于放置在右心房和上腔静脉中的一个。该系统还包括可植入心脏刺激装置，其包括将除颤脉冲输送到除颤电极中的任何一个或除颤电极的任何组合的可编程脉冲发生器。引线还可以为心脏的每个腔室提供至少一个起搏电极，并且该装置可编程以将起搏脉冲提供给任何一个起搏电极。

34. 发明授权

US08065001B1 Use of implantable body position and body movement sensors 有权
标题翻译：使用植入式身体位置和身体运动传感器
公开(公告)号：US08065001B1
公开(公告)日：2011-11-22
申请号：US11681047
申请日：2007-03-01
申请人： Yelena Nabutovsky , Eric Falkenberg
发明人： Yelena Nabutovsky , Eric Falkenberg
IPC分类号： A61N1/08
CPC分类号： A61N1/08 , A61N1/05
摘要： Implantable systems, and methods for use therewith, are provided for using an implantable sensor for detecting body position and/or body movement, and using what is learned therefrom to improve accuracy of an implantable sensor that is sensitive to at least one of body position and/or body movement. Also provided are implantable systems, and methods for use therewith, that detect body position and/or body movement in order to monitor a condition and/or detect specific episodes. Other embodiments are also provided.
摘要翻译：提供了可植入系统及其使用的方法，用于使用用于检测身体位置和/或身体运动的可植入传感器，并且使用从其中学到的内容来提高可植入式传感器的精度，所述可植入系统对于身体位置和/ /或身体运动。还提供了可植入系统及其使用的方法，其检测身体位置和/或身体运动以便监视病症和/或检测特定发作。还提供了其他实施例。

35. 发明授权

US07881810B1 Cardiac access methods and apparatus 有权
标题翻译：心脏存取方法和装置
公开(公告)号：US07881810B1
公开(公告)日：2011-02-01
申请号：US11753484
申请日：2007-05-24
申请人： Yougandh Chitre , Gene A. Bornzin , John R. Helland , Eric Falkenberg , Kevin L. Morgan , Sheldon Williams , Michael Yang , Andrew W. McGarvey
发明人： Yougandh Chitre , Gene A. Bornzin , John R. Helland , Eric Falkenberg , Kevin L. Morgan , Sheldon Williams , Michael Yang , Andrew W. McGarvey
IPC分类号： A61N1/05
CPC分类号： A61F2/2478 , A61B17/00 , A61B17/0057 , A61N1/0587
摘要： A chamber or vasculature of a heart may be accessed via the pericardial space of the heart. Initially, the pericardial space may be accessed via a transmyocardial approach or a subxiphoid approach. A lead or other implantable apparatus may thus be routed into the pericardial space, through myocardial tissue and into the chamber or vasculature. The lead or other apparatus may be used to sense activity in or provide therapy to the heart.
摘要翻译：可以通过心脏的心包空间访问心脏的腔室或脉管系统。最初，心包空间可以通过心肌的方法或亚型的方法进行。因此，引线或其它可植入装置可通过心肌组织进入心包空间并进入腔室或脉管系统。铅或其他装置可用于感测心脏的活动或提供对心脏的治疗。

36. 发明授权

US07630767B1 System and method for communicating information using encoded pacing pulses within an implantable medical system 失效
标题翻译：用于在可植入医疗系统内使用编码的起搏脉冲传送信息的系统和方法
公开(公告)号：US07630767B1
公开(公告)日：2009-12-08
申请号：US11440723
申请日：2006-05-24
申请人： John W. Poore , Gene A. Bornzin , Eric Falkenberg
发明人： John W. Poore , Gene A. Bornzin , Eric Falkenberg
IPC分类号： A61N1/372
CPC分类号： A61N1/37288 , A61N1/3627 , A61N1/368 , A61N1/3684 , A61N1/3727
摘要： Techniques are provided for delivering cardiac pacing therapy to the heart of a patient using an epicardial left ventricular satellite pacing device in conjunction with primary pacemaker having at least a right ventricular pacing lead. In one embodiment described herein, right ventricular pulses generated by the primary pacemaker are detected by the satellite pacer and analyzed to determine the timing pattern employed by the primary pacemaker. The timing pattern is then used to specify the delivery times of epicardial left ventricular pulses so as to be synchronized with right ventricular pulses. In another embodiment described herein, the primary pacemaker modulates the right ventricular pulses to encode timing information, which is then detected and decoded by the satellite pacemaker. In this manner, biventricular pacing therapy, such as cardiac resynchronization therapy, may be conveniently delivered using a non-biventricular pacemaker in combination with an epicardial satellite pacer.
摘要翻译：提供技术用于使用心外膜左心室卫星起搏装置与具有至少右心室起搏引线的主起搏器一起向患者的心脏递送心脏起搏治疗。在本文描述的一个实施例中，由主起搏器产生的右心室脉冲由卫星起搏器检测并分析以确定主要起搏器采用的定时模式。然后使用定时模式来指定心外膜左心室脉冲的递送时间，以便与右心室脉冲同步。在本文所述的另一个实施例中，主起搏器调制右心室脉冲以编码定时信息，然后由卫星起搏器检测和解码定时信息。以这种方式，可以使用非心室起搏器与心外膜卫星踏板组合地方便地进行双心室起搏治疗，例如心脏再同步治疗。

37. 发明授权

US07403819B1 Parasympathetic nerve stimulation for control of AV conduction 有权
标题翻译：副交感神经刺激用于控制AV传导
公开(公告)号：US07403819B1
公开(公告)日：2008-07-22
申请号：US10460145
申请日：2003-06-11
申请人： Anne M. Shelchuk , Gene A. Bornzin , Eric Falkenberg
发明人： Anne M. Shelchuk , Gene A. Bornzin , Eric Falkenberg
IPC分类号： A61N1/34 , A61N1/368
CPC分类号： A61N1/3622 , A61N1/36114
摘要： Exemplary methods for affecting conduction and/or operation of the AV node and/or AV bundle. Various exemplary methods include delivery of one or more stimulation pulses to affect conduction and/or operation of an AV node and/or AV bundle. Such delivery optionally stimulates nerves and/or tissue. Nerve stimulation optionally includes parasympathetic nerve stimulation to decrease conduction of the AV node and/or AV bundle. Tissue stimulation optionally causes tissue to enter a refractory period. Various exemplary methods include delivering one or more stimulation pulses during postinspiration. Other exemplary methods and/or devices are also disclosed.
摘要翻译：用于影响AV节点和/或AV束的传导和/或操作的示例性方法。各种示例性方法包括递送一个或多个刺激脉冲以影响AV节点和/或AV束的传导和/或操作。这种递送可选地刺激神经和/或组织。神经刺激任选地包括副交感神经刺激以减少AV结和/或AV束的传导。组织刺激任选地使组织进入不应期。各种示例性方法包括在后吸烟期间递送一个或多个刺激脉冲。还公开了其它示例性方法和/或设备。

38. 发明申请

US20050165457A1 Tiered therapy for respiratory oscillations characteristic of Cheyne-Stokes respiration 有权
标题翻译： Cheyne-Stokes呼吸特征的分层治疗呼吸振荡
公开(公告)号：US20050165457A1
公开(公告)日：2005-07-28
申请号：US10968730
申请日：2004-10-18
申请人： Michael Benser , Eric Falkenberg
发明人： Michael Benser , Eric Falkenberg
IPC分类号： A61N1/36 , A61N1/365 , A61N1/08 , A61N1/10
CPC分类号： A61N1/36514 , A61N1/3601
摘要： An exemplary method includes delivering a maintenance therapy that aims to prevent occurrence of apnea, sensing information, based at least in part on the information, determining if apnea exists and, if apnea exists, delivering a termination therapy that aims to terminate the apnea. An exemplary implantable device includes an input for information pertaining to respiration and control logic to call for overdrive pacing at a first rate that aims to minimize occurrence of a respiratory condition, to analyze the information for occurrence of the respiratory condition and, upon occurrence of the respiratory condition, to call for overdrive pacing at a higher rate. Other exemplary methods, devices, systems, etc., are also disclosed.
摘要翻译：一种示例性方法包括：至少部分地基于信息来确定是否存在呼吸暂停，并且如果存在呼吸暂停，则提供旨在防止呼吸暂停发生的感测信息，感测信息，传递旨在终止呼吸暂停的终止疗法。示例性可植入装置包括用于与呼吸和控制逻辑相关的信息的输入，以以旨在最小化呼吸状况发生的第一速率来呼叫超速起搏，分析呼吸状况发生的信息，并且在出现呼吸状况，以更高的速度呼叫超速起搏。还公开了其它示例性方法，装置，系统等。

39. 发明授权

US06745081B1 Coronary Sinus Cardiac Lead For Stimulating and Sensing The Atria of the Right and Left Heart and System 有权
标题翻译：冠状动脉窦心脏铅刺激和感应右心左心房系统
公开(公告)号：US06745081B1
公开(公告)日：2004-06-01
申请号：US09944683
申请日：2001-08-31
申请人： John R. Helland , Gene A. Bornzin , Eric Falkenberg
发明人： John R. Helland , Gene A. Bornzin , Eric Falkenberg
IPC分类号： A61N1372
CPC分类号： A61N1/056 , A61N1/3684 , A61N2001/0585
摘要： An implantable cardiac stimulation system including a single atrial dedicated lead provides sensing electrical activity of and delivering stimulation pulses to the right and left atria of the heart. The single lead is implantable in the coronary sinus of the heart and includes a distal left atrial pacing electrode, and a right atrial pacing electrode. The electrodes are spaced apart on the lead so that when the left atrial pacing electrode is in electrical contact with and adjacent the left atrium within the coronary sinus, the right atrial pacing electrode is in electrical contact with the right atrium and adjacent to the ostium of the coronary sinus within the coronary sinus. The system further includes an implantable cardiac stimulation device including a pulse generator and a sensing circuit that is coupled to the left and right pacing electrodes. They may further include one or more defibrillation coil electrodes.
摘要翻译：包括单个心房专用线的可植入心脏刺激系统提供对心脏的右心房和左心房的感测电活动并将刺激脉冲递送给心脏。单个引线可植入心脏的冠状窦，并且包括左心房起搏电极和右心房起搏电极。电极在引线上间隔开，使得当左心房起搏电极与冠状窦内的左心房电接触并邻近时，右心房起搏电极与右心房电接触并邻近于冠状窦内冠状窦内。该系统还包括可植入心脏刺激装置，其包括脉冲发生器和耦合到左右起搏电极的感测电路。它们还可以包括一个或多个除颤线圈电极。

40. 发明授权

US08702616B2 Determination of diastolic heart failure 有权
标题翻译：舒张性心力衰竭的测定
公开(公告)号：US08702616B2
公开(公告)日：2014-04-22
申请号：US12943653
申请日：2010-11-10
申请人： Jong Gill , Xiaoyi Min , Gene A. Bornzin , Eric Falkenberg
发明人： Jong Gill , Xiaoyi Min , Gene A. Bornzin , Eric Falkenberg
IPC分类号： A61B5/0205
CPC分类号： A61B5/0215 , A61B5/042 , A61B5/0464 , A61B5/053 , A61B7/00 , A61N1/36578
摘要： An exemplary method includes detecting a change in state of a cardiac valve, detecting elongation of the left ventricle substantially along its major axis, determining a time difference between the change in state of the cardiac valve and the elongation of the left ventricle and, based at least in part on the time difference, deciding whether a diastolic abnormality exists. Other exemplary methods, devices, systems, etc., are also disclosed.
摘要翻译：示例性方法包括检测心脏瓣膜的状态变化，检测左心室基本上沿其长轴的伸长，确定心脏瓣膜状态变化与左心室伸长之间的时间差，并基于至少部分地基于时间差，决定是否存在舒张异常。还公开了其它示例性方法，装置，系统等。

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