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31. 发明申请

US20160130390A1 HYPERBRANCHED AMINO ACID-BASED POLY(ESTER UREA)S FOR REGENERATIVE MEDICINE AND DRUG DELIVERY 审中-公开
标题翻译：用于再生医药和药物递送的超级基于氨基酸的聚合物（ESTER UREA）S
公开(公告)号：US20160130390A1
公开(公告)日：2016-05-12
申请号：US14939216
申请日：2015-11-12
申请人： Matthew Becker , Jiayi Yu
发明人： Matthew Becker , Jiayi Yu
IPC分类号： C08G63/685
CPC分类号： C08G63/685 , C08G83/005
摘要： One or more embodiments of the present invention provide a hyperbranched amino-acid-based PEU polymer for use in regenerative medicine and/or drug delivery applications has tunable mechanical and thermal properties, but is sufficiently stable to permit such things as ethyloxide sterilization without degradation and/or significant loss of function. These hyperbranched amino acid-based poly(ester urea) (PEU) by interfacial polycondensation between linear and branched amino acid-based polyester monomers and a urea forming material such as trisphosgene or phosgene. By controlling the amount of branched monomer incorporated into the copolymer, the mechanical properties and water uptake abilities of the resulting hyperbranched amino acid-based PEUs may be tuned. The hyperbranched PEUs nanofibers are sterilizable with ETO and are stable for long periods of ETO sterilization, elevated temperature and exposure to aqueous environments. In various embodiments, these hyperbranched amino acid-based PEUs are also biodegradable and can be formed into fibers.
摘要翻译：本发明的一个或多个实施方案提供了用于再生医学和/或药物递送应用中的超支化氨基酸基PEU聚合物具有可调节的机械和热性质，但是足够稳定以允许诸如乙酸氧化酶灭菌而不降解， /或显着的功能丧失。这些超支化氨基酸基聚（酯脲）（PEU）通过直链和支链氨基酸类聚酯单体之间的界面缩聚和尿素形成材料如三光气或光气。通过控制掺入共聚物中的支化单体的量，可以调节所得到的超支化氨基酸基PEU的机械性能和吸水能力。超支化PEU纳米纤维可以用ETO进行灭菌，对于长时间的ETO灭菌，升高的温度和暴露于水性环境是稳定的。在各种实施方案中，这些基于超支化氨基酸的PEU也是可生物降解的并且可以形成纤维。

32. 发明申请

US20150183988A1 Strain-Promoted Crosslinking of PEG-based Hydrogels via Copper-Free Cycloaddition 审中-公开
标题翻译：通过无铜环加成的PEG基水凝胶的应变促进交联
公开(公告)号：US20150183988A1
公开(公告)日：2015-07-02
申请号：US14418507
申请日：2013-07-31
申请人： Matthew Becker , Robert A. Weiss
发明人： Matthew Becker , Robert A. Weiss
IPC分类号： C08L71/00 , C08L89/00
CPC分类号： C08L71/00 , A61K9/06 , A61K47/34 , C08G65/325 , C08G65/33389 , C08L71/02 , C08L89/00 , C08L2205/02
摘要： The present invention is directed to a covalently crosslinked hydrogel comprising the strain-promoted reaction product of an 8-member cycloalkyne functionalized polyalkylene glycol and a multi-arm glycerol exytholate triazide and methods for making them. Because the precursor materials can be manipulated without causing crosslinking, provided the strain threshold is not reached, these hydrogels permit mechanical control over when (and where) cross linking occurs and are easier to use than prior strain-activated or temperature-activated systems. These novel hydrogels do not require a catalyst to cross link, thus avoiding the biocompatibility problems common to many catalysts. Nor is the crosslinking process affected by the presence of catalysts or other substances, which have interfered with crosslinking in known strain induced hydrogels. Because of their crosslinking reaction kinetics, these novel hydrogels can encapsulate and transport highly sensitive cells and other biological additives and have no known toxic byproducts.
摘要翻译：本发明涉及一种共价交联的水凝胶，其包含8-元环炔官能化聚亚烷基二醇和多臂甘油异戊酸三叠氮化物的应变促进反应产物及其制备方法。因为前体材料可以在不引起交联的情况下被操纵，只要未达到应变阈值，这些水凝胶允许机械控制何时发生交联（并且在何处发生），并且比以前的应变活化或温度激活的系统更容易使用。这些新颖的水凝胶不需要催化剂交联，从而避免许多催化剂常见的生物相容性问题。交联过程也不受催化剂或其他物质的存在的影响，这些物质干扰已知应变诱导的水凝胶中的交联。由于它们的交联反应动力学，这些新颖的水凝胶可以包封和输送高敏感性细胞和其他生物添加剂，并且没有已知的有毒副产物。

33. 发明申请

US20090243638A1 Receiver for recovering and retiming electromagnetically coupled data 有权
标题翻译：用于恢复和重新定位电磁耦合数据的接收器
公开(公告)号：US20090243638A1
公开(公告)日：2009-10-01
申请号：US12080262
申请日：2008-04-01
申请人： Matthew Becker , Zibing Yang , Qiang Zhang , Todd Hinck , Larry Tate
发明人： Matthew Becker , Zibing Yang , Qiang Zhang , Todd Hinck , Larry Tate
IPC分类号： G01R31/302
CPC分类号： H04L25/05 , G06F11/2733
摘要： In one embodiment, the present invention includes a system having an electromagnetic coupler probe to electromagnetically sample signals from a device under test or a link under test and a receiver, e.g., configured as an integrated circuit that is to receive the sampled electromagnetic signals from the probe and output digital signals corresponding thereto. Other embodiments are described and claimed.
摘要翻译：在一个实施例中，本发明包括具有电磁耦合器探针以对来自被测器件或被测链路的信号进行电磁采样的系统，以及接收器，例如被配置为集成电路，该集成电路将从探测和输出与之对应的数字信号。描述和要求保护其他实施例。

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