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31. 发明授权

US07081192B1 Methods for manipulating moieties in microfluidic systems 有权
公开(公告)号：US07081192B1
公开(公告)日：2006-07-25
申请号：US09636104
申请日：2000-08-10
申请人： Xiaobo Wang , Lei Wu , Jing Cheng , Weiping Yang , Junquan Xu
发明人： Xiaobo Wang , Lei Wu , Jing Cheng , Weiping Yang , Junquan Xu
IPC分类号： G01N27/447 , G01N33/48 , C12Q1/00
CPC分类号： G01N33/54386 , B01L3/502761 , B01L2200/0647 , B01L2200/0668 , B01L2300/0816 , B01L2300/0864 , B01L2400/0415 , B01L2400/0424 , B01L2400/043 , B01L2400/0436 , B01L2400/0439 , B01L2400/0454 , B01L2400/0496 , B03C5/028 , B03C2201/26 , G01N27/745 , G01N33/569
摘要： This invention relates generally to the field of moiety or molecule manipulation in a chip format. In particular, the invention provides a method for manipulating a moiety in a microfluidic application, which method comprises: a) coupling a moiety to be manipulated onto surface of a binding partner of said moiety to form a moiety-binding partner complex; and b) manipulating said moiety-binding partner complex with a physical force in a chip format, wherein said manipulation is effected through a combination of a structure that is external to said chip and a structure that is built-in in said chip, thereby said moiety is manipulated.

32. 发明授权

US06900013B1 Methods and compositions for identifying nucleic acid molecules using nucleolytic activities and hybridization 失效
标题翻译：用核酸分解活性和杂交鉴定核酸分子的方法和组合物
公开(公告)号：US06900013B1
公开(公告)日：2005-05-31
申请号：US09648081
申请日：2000-08-25
申请人： Guoqing Wang , Lei Wu , Xiaobo Wang , Jing Cheng , WeiPing Yang
发明人： Guoqing Wang , Lei Wu , Xiaobo Wang , Jing Cheng , WeiPing Yang
IPC分类号： C07H21/02 , C07H21/04 , C12M1/34 , C12P19/34 , C12Q1/68
CPC分类号： C12Q1/6816 , C07H21/04 , C12Q1/6827 , C12Q1/6837 , C12Q2521/101 , C12Q2533/101 , C12Q2563/107 , C12Q2521/327 , C12Q2537/143 , C12Q2565/501
摘要： The present invention recognizes that identifying genes expressed during developmental processes, stress responses, and disease states can advance understanding of these biological functions, and can contribute to identifying targets for therapeutic drugs. In addition, the present invention recognizes that rapid and reliable profiling of genetic variations, such as mutations and SNPs, is of increasing importance to diagnostics, prognostics, forensics, heredity determinations, and pharmacogenetics. One aspect of the present invention provides a method of identifying one or more nucleic acid molecules that are expressed under a given set of conditions based on their complementarity to known sequences, or one or more mutations or SNPs in a population of nucleic acid molecules. The method includes: contacting at least one probe nucleic acid molecule with a survey population of nucleic acid molecules under conditions that promote nucleic acid hybridization to generate a probe-survey population mixture of nucleic acid molecules, treating the probe-survey population mixture of nucleic acid molecules with a nucleolytic activity, such that nucleolytic activity-sensitive nucleic acid molecules are digested, and contacting the resulting mixture of nucleolytic activity-protected nucleic acid molecules with a solid support comprising one or more attached nucleic acid molecules to generate attached nucleic acid molecule/nucleolytic activity-protected nucleic acid molecule complexes, and identifying one or more of the attached nucleic acid molecules or one or more of the nucleolytic activity-protected nucleic acid molecules in one or more attached nucleic acid molecule/nucleolytic activity-protected nucleic acid molecule complexes.
摘要翻译：本发明认识到，在发育过程，应激反应和疾病状态期间表达的鉴定基因可以促进对这些生物功能的理解，并且可以有助于鉴定治疗药物的靶标。此外，本发明认识到，遗传变异的快速和可靠的分析，例如突变和SNP，对于诊断，预后，取证，遗传测定和药物遗传学是越来越重要的。本发明的一个方面提供了鉴定一种或多种核酸分子的方法，所述核酸分子基于它们与已知序列的互补性或核酸分子群体中的一个或多个突变或SNP在给定条件下表达。该方法包括：在促进核酸杂交以产生核酸分子的探针 - 调查群体混合物的条件下使至少一个探针核酸分子与核酸分子的调查群体接触，处理核酸的探针 - 调查群体混合物具有核分解活性的分子，使得消解活性敏感的核酸核酸分子，并使得到的核分解活性保护的核酸分子的混合物与包含一个或多个连接的核酸分子的固体支持物接触，以产生附着的核酸分子/ 核分解活性保护的核酸分子复合物，以及鉴定一个或多个连接的核酸分子/核酸分解活性保护的核酸分子复合物中所附连的核酸分子或一个或多个核裂解活性保护的核酸分子。

33. 发明授权

US06716642B1 Individually addressable micro-electromagnetic unit array chips in horizontal configurations 有权
标题翻译：水平配置的单独寻址微电磁单元阵列芯片
公开(公告)号：US06716642B1
公开(公告)日：2004-04-06
申请号：US09685410
申请日：2000-10-10
申请人： Lei Wu , Xiaobo Wang , Jing Cheng , Weiping Yang , YuXiang Zhou , LiTian Liu , Junquan Xu
发明人： Lei Wu , Xiaobo Wang , Jing Cheng , Weiping Yang , YuXiang Zhou , LiTian Liu , Junquan Xu
IPC分类号： G01N33543
CPC分类号： B01L3/502792 , B01J19/0046 , B01J2219/00468 , B01J2219/005 , B01J2219/00585 , B01J2219/00596 , B01J2219/00605 , B01J2219/0061 , B01J2219/00612 , B01J2219/00614 , B01J2219/00619 , B01J2219/00626 , B01J2219/0063 , B01J2219/00637 , B01J2219/00641 , B01J2219/00648 , B01J2219/00653 , B01J2219/00655 , B01J2219/00659 , B01J2219/00702 , B01J2219/00722 , B01J2219/00725 , B01J2219/00731 , B01J2219/00734 , B01J2219/0074 , B01J2219/00743 , B01L3/5025 , B01L3/502761 , B01L2200/0647 , B01L2200/0668 , B01L2300/0636 , B01L2300/0816 , B01L2300/0819 , B01L2300/0877 , B01L2300/089 , B01L2400/043 , C40B40/06 , C40B40/10 , C40B40/12 , C40B60/14 , G01N35/0098 , H01F17/0006
摘要： The present invention provides electromagnetic chips and electromagnetic biochips having arrays of individually addressable micro-electromagnetic units, as well as methods of utilizing these chips for directed manipulation of micro-particles and micro-structures such as biomolecules and chemical reagents.
摘要翻译：本发明提供具有单独寻址的微电磁单元的阵列的电磁芯片和电磁生物芯片，以及利用这些芯片来定向操纵微粒和微结构如生物分子和化学试剂的方法。

34. 发明授权

US06596143B1 Apparatus for switching and manipulating particles and method of use thereof 有权
标题翻译：用于切换和操纵颗粒的装置及其使用方法
公开(公告)号：US06596143B1
公开(公告)日：2003-07-22
申请号：US09678263
申请日：2000-10-03
申请人： Xiao-Bo Wang , Weiping Yang , Junquan Xu , Jing Cheng , Lei Wu
发明人： Xiao-Bo Wang , Weiping Yang , Junquan Xu , Jing Cheng , Lei Wu
IPC分类号： G01N2726
CPC分类号： H02N11/006 , B01D57/02 , B03C5/028 , H02N1/004
摘要： A device acts as a particle switch to transport and/or re-direct microparticles which are in a fluid suspension. The switch comprises at least three structural branches and the branches may be connected at a common junction. Particles can be transported along the branches as a result of the forces generated along that branch. Particles are transported into or out of the particle switch via the ends of the branches. Particles can be switched from one branch into one of the other branches. Depending on the properties of the particles, the transportation mechanism may be traveling-wave-dielectrophoresis or traveling-wave-electrophoresis.
摘要翻译：装置用作颗粒开关以运输和/或重新引导处于流体悬浮液中的微粒。开关包括至少三个结构分支，并且分支可以在公共接头处连接。由于沿该分支产生的力，颗粒可以沿着分支运输。颗粒通过分支的末端被输送进出颗粒开关。颗粒可以从一个分支切换到其他分支之一。根据颗粒的性质，运输机制可以是行波介电电泳或行波电泳。

35. 发明授权

US06309601B1 Scanning optical detection system 失效
标题翻译：扫描光学检测系统
公开(公告)号：US06309601B1
公开(公告)日：2001-10-30
申请号：US08846876
申请日：1997-05-01
申请人： Robert D. Juncosa , William F. Butler , Lei Wu , Robert H. Cormack
发明人： Robert D. Juncosa , William F. Butler , Lei Wu , Robert H. Cormack
IPC分类号： G01N1500
CPC分类号： G01N21/6458 , B01J19/0046 , B01J19/0093 , B01J2219/00315 , B01J2219/00317 , B01J2219/00527 , B01J2219/00585 , B01J2219/0059 , B01J2219/00596 , B01J2219/00605 , B01J2219/00612 , B01J2219/00614 , B01J2219/00621 , B01J2219/00653 , B01J2219/00659 , B01J2219/00686 , B01J2219/00689 , B01J2219/00713 , B01J2219/0072 , B01J2219/00722 , B01J2219/00725 , B01J2219/00731 , B01L3/5027 , B01L3/502761 , B01L3/5085 , B01L2200/025 , B01L2200/143 , B01L2300/0636 , B01L2300/0645 , B01L2300/0816 , B01L2300/0838 , B01L2300/0877 , B01L2400/0421 , B82Y5/00 , B82Y10/00 , C07B2200/11 , C07H21/00 , C07K1/04 , C07K1/045 , C07K1/047 , C12Q1/6813 , C12Q1/6816 , C12Q1/6825 , C12Q1/6837 , C40B40/06 , C40B40/10 , C40B40/12 , C40B60/14 , G01N21/6452 , G01N21/76 , G11C13/0014 , G11C13/0019 , G11C13/04 , G11C19/00 , H01L25/50 , H01L2924/0002 , C12Q2565/515 , C12Q2565/607 , H01L2924/00
摘要： An optical detection system is adapted for detection of biological reactions. An excitation source illuminates a portion of an object to be examined, the portion preferably comprising one microlocation out of an array of microlocations. An intervening optical detection platform serves to direct the excitation radiation to the portion of the object to be illuminated. A detector receives the emitted radiation from the object to be examined, the detector being characterized in that the diameter of the region examined by the detector is the same as or smaller than the diameter of the illuminated region, and comprises less than the entire surface of the object to be examined, and most preferably images a whole or a part of a single microlocation. In operation, a microscopy system is formed in which the excitation radiation is substantially in focus at the surface of the object to be examined. In one aspect of this invention, the optical detection platform includes an excitation detector that measures reflected excitation radiation from the object to be examined. This information is compared to prestored information regarding the location of the microlocations and interstitial regions on the object to be examined, whereby alignment information is obtained. The excitation radiation may then be precisely directed to a given microlocation or portion thereof to perform the examining through the system.
摘要翻译：光学检测系统适用于生物反应的检测。激发源照亮待检查对象的一部分，该部分优选地包括微位置阵列中的一个微位置。中间光学检测平台用于将激发辐射引导到被照射物体的部分。检测器接收来自待检测物体的发射的辐射，检测器的特征在于检测器检查的区域的直径等于或小于照射区域的直径，并且包括小于整个表面要检查的对象，最优选地，图像是单个微位置的全部或一部分。在操作中，形成显微镜系统，其中激发辐射基本上在待检查对象的表面上聚焦。在本发明的一个方面，光学检测平台包括一个激励检测器，该激励检测器测量被检测物体的反射激发辐射。将该信息与关于待检查对象上的微位置和间质区域的位置的预先存储的信息进行比较，从而获得对准信息。然后可以将激发辐射精确地引导到给定的微定位或其部分以通过系统进行检查。

36. 发明申请

US20200249351A1 Multi-line, High-definition LiDAR Device and Method with Integrated Direct Spatial Reference 审中-公开
公开(公告)号：US20200249351A1
公开(公告)日：2020-08-06
申请号：US16104129
申请日：2018-08-16
申请人： Wei Chen , Shan Zhong , Jin Zhang , Zhonghua Zhu , Lei Wu
发明人： Wei Chen , Shan Zhong , Jin Zhang , Zhonghua Zhu , Lei Wu
IPC分类号： G01S17/36 , G01S7/4912 , G01S7/4911 , G01S17/58
摘要： The present disclosure relates to a FMCW Light Detection and Ranging system, a wave train of carrier frequency is modulated in narrow-band sequence, an delay interferometer with in-phase and quadrature outputs extracts the phase of this frequency modulation, and a coherent receiver with in-phase and quadrature outputs detects the phase of reflected light from a remote object, the ratio between two phases determines the distance of the remote object.

37. 发明申请

US20180192898A1 Novel optical interferometric scanning detector for cardiovascular function monitoring 审中-公开
公开(公告)号：US20180192898A1
公开(公告)日：2018-07-12
申请号：US15403184
申请日：2017-01-11
申请人： Jin Zhang , Shan Zhong , Wei Chen , Zhonghua Zhu , Lei Wu
发明人： Jin Zhang , Shan Zhong , Wei Chen , Zhonghua Zhu , Lei Wu
IPC分类号： A61B5/024 , A61B5/00 , A61B5/021 , A61B7/04
CPC分类号： A61B7/04 , A61B5/0022 , A61B5/0064 , A61B5/02108 , A61B5/02133 , A61B5/02444 , A61B5/1102
摘要： The object of the present invention is to disclose a novel optical miniaturized handheld medical device for convenient monitoring and/or data collection of detailed signals on human cardiovascular function. The implementation consists of a number of advanced technologies, including interferometric detection, phase controlled focusing beam steering, auto-tracking scheme and algorism, and integrated optical chip assembly to enhance the device's performance and miniaturization. Briefly, this handheld medical device directs a single or dual output laser beam(s) onto certain skin surface to detect the surface vibration velocity at the point where the laser hits the surface. The skin surface vibrates in response to cardiovascular signals, such as blood pressure pulses, turbulent blood flow through narrowed arteries, pumping actions of the heart, or the closure of the heart valves etc. The miniaturized apparatus thus is capable of detecting these signals for the assessment of cardiovascular functions in both healthy and disease conditions.

38. 发明授权

US09370300B2 Ophthalmic optical coherence tomography system and method for quick switching to realize anterior and posterior eye segments imaging 有权
标题翻译：眼科光学相干断层扫描系统及快速切换方法，实现前后眼部成像
公开(公告)号：US09370300B2
公开(公告)日：2016-06-21
申请号：US14124030
申请日：2012-04-24
申请人： Shoudong Cai , Peng Li , Shuguang Guo , Xiangsong Dai , Lei Wu
发明人： Shoudong Cai , Peng Li , Shuguang Guo , Xiangsong Dai , Lei Wu
IPC分类号： A61B3/10 , G01B9/02
CPC分类号： A61B3/102 , G01B9/02091
摘要： An ophthalmic optical coherence tomography system and a method for quick switching to realize anterior and posterior eye segments imaging are provided, the system includes: an OCT interferometer primary module and a sample arm module, the OCT interferometer primary module includes an OCT light source, a fiber coupler, a reference arm, a detection module, an X-direction scanning unit, and a Y-direction scanning unit; the sample arm module includes an anterior eye segment imaging module and a posterior eye segment imaging module; the Y-direction scanning unit is rotatable; when the Y-direction scanning unit is at a first rotation angle, the Y-direction scanning unit reflects the light received by the X-direction scanning unit into the anterior eye segment imaging module; when the Y-direction scanning unit is at a second rotation angle, the Y-direction scanning unit reflects the light received by the X-direction scanning unit into the posterior eye segment imaging module.
摘要翻译：提供了一种眼科光学相干断层摄影系统和快速切换以实现前后眼部成像的方法，该系统包括：OCT干涉仪主模块和样本臂模块，OCT干涉仪主模块包括OCT光源，光纤耦合器，参考臂，检测模块，X方向扫描单元和Y方向扫描单元; 所述样本臂模块包括前眼部成像模块和后眼部成像模块; Y方向扫描单元可旋转; 当Y方向扫描单元处于第一旋转角时，Y方向扫描单元将由X方向扫描单元接收的光反射到前眼部成像模块中; 当Y方向扫描单元处于第二旋转角时，Y方向扫描单元将由X方向扫描单元接收的光反射到后眼段成像模块中。

39. 发明授权

US08980568B2 Methods and compositions for detecting non-hematopoietic cells from a blood sample 有权
公开(公告)号：US08980568B2
公开(公告)日：2015-03-17
申请号：US11264413
申请日：2005-10-31
申请人： Ping Lin , Douglas T. Yamanishi , Paul G. Hujsak , Sara F. Snyder , George Walker , Junquan Xu , Mingxian Huang , Guoliang Tao , Lei Wu , Xiaobo Wang , Joe Ouyang , Charina Schmitigal , Jing Cheng , Elizabeth Kwok , Jia Xu
发明人： Ping Lin , Douglas T. Yamanishi , Paul G. Hujsak , Sara F. Snyder , George Walker , Junquan Xu , Mingxian Huang , Guoliang Tao , Lei Wu , Xiaobo Wang , Joe Ouyang , Charina Schmitigal , Jing Cheng , Elizabeth Kwok , Jia Xu
IPC分类号： C12Q1/24 , G01N33/574 , B01D71/04 , B01D71/02 , G01N1/40 , G01N15/05 , B01D67/00 , B01D57/02 , A61M1/36 , G01N33/569 , G01N15/02 , G01N1/34 , B01L3/00 , C12Q1/68 , B01D61/18 , G01N15/00 , G01N15/06
CPC分类号： G01N1/4077 , A61B5/150755 , A61M1/36 , A61M1/3618 , A61M1/362 , A61M1/3679 , B01D57/02 , B01D61/18 , B01D67/0034 , B01D67/0062 , B01D71/02 , B01D71/027 , B01D71/04 , B01D2325/021 , B01L3/502 , B01L3/5027 , B01L3/502753 , B01L3/502761 , B01L2200/10 , B01L2300/0627 , B01L2300/0681 , B01L2300/0816 , B01L2300/0861 , B01L2400/0409 , B01L2400/0415 , B01L2400/0457 , B01L2400/0478 , B01L2400/0644 , B01L2400/065 , C12Q1/6841 , C12Q1/6881 , G01N1/34 , G01N1/40 , G01N15/0272 , G01N15/05 , G01N33/56966 , G01N33/57407 , G01N35/026 , G01N35/04 , G01N35/1002 , G01N2001/4016 , G01N2001/4083 , G01N2001/4088 , G01N2015/0073 , G01N2015/0288 , G01N2015/0294 , G01N2015/0681 , G01N2035/0406 , G01N2333/4724 , Y10T436/25375
摘要： The present invention recognizes that diagnosis and prognosis of many conditions can depend on the enrichment of rare cells, especially tumor cells, from a complex fluid sample such as a blood sample. In particular, the present invention is directed to methods and compositions for detecting a non-hematopoietic cell, e.g., a non-hematopoietic tumor cell, in a blood sample via, inter alia, removing red blood cells (RBCs) from a blood sample using a non-centrifugation procedure, removing white blood cells (WBCs) from said blood sample to enrich a non-hematopoietic cell, if any, from said blood sample; and assessing the presence, absence and/or amount of said enriched non-hematopoietic cell.

40. 发明授权

US08457400B2 Patch-based texture histogram coding for fast image similarity search 有权
标题翻译：基于贴图的纹理直方图编码，用于快速图像相似性搜索
公开(公告)号：US08457400B2
公开(公告)日：2013-06-04
申请号：US12147832
申请日：2008-06-27
申请人： Lei Wu , Mingjing Li
发明人： Lei Wu , Mingjing Li
IPC分类号： G06K9/00
CPC分类号： H04N21/835 , G06F17/30247 , G06K9/4642 , G06T7/44 , G06T7/97 , G06T2207/10008 , G06T2207/20021 , H04N21/44008 , H04N21/44236
摘要： Techniques for identifying copied images based on an original image are described. The identifying copied image is based on creating unique and identifiable features that in turn are used to generate multiple histograms. The histograms are generated by patches of the image, where the patches are created by equally dividing the image. The combined patch histograms are representative of the image.
摘要翻译：描述了基于原始图像识别复制图像的技术。识别复制的图像基于创建唯一且可识别的特征，其又被用于生成多个直方图。直方图由图像的补丁生成，其中通过均匀分割图像来创建补丁。组合的斑块直方图代表图像。

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