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1. 发明授权

US06824670B2 Sample discriminating method 有权
标题翻译：样本识别方法
公开(公告)号：US06824670B2
公开(公告)日：2004-11-30
申请号：US09890097
申请日：2001-10-29
申请人： Hiroyuki Tokunaga , Shoji Miyazaki , Hideyuki Baba , Yoichi Inoue , Kazuo Iketaki , Katsumi Hamamoto
发明人： Hiroyuki Tokunaga , Shoji Miyazaki , Hideyuki Baba , Yoichi Inoue , Kazuo Iketaki , Katsumi Hamamoto
IPC分类号： G01N2726
CPC分类号： G01N27/3274 , Y10T436/11
摘要： A glucose sensor system comprising the steps of using as a sample discriminating parameter a ratio (I/&Dgr;I) of a measured current value I to the time-differential value of the current value &Dgr;I, defining a discrimination function that discriminates whether a sample is blood or control fluid and uses the discriminating parameter as an independent variable, quantitating as a discriminating index a numeric value obtained by substituting a discriminating parameter value into this discrimination function, and automatically discriminating, based on this index, whether the sample is blood or a control fluid, whereby a kind of the sample can be automatically quantitated by measuring electric current when a sensor system is used for quantitating the concentration of an analysis object in the sample.
摘要翻译：一种葡萄糖传感器系统，包括以下步骤：将测量电流值I与当前值ΔI的时间微分值的比值（I / DeltaI）用作样本鉴别参数，所述差分值定义了鉴别样品是否为血液的鉴别功能或控制流体，并将鉴别参数用作独立变量，作为鉴别指标，将通过将鉴别参数值代入该鉴别函数而获得的数值，并根据该指标自动鉴别样品是血液还是控制流体，从而当使用传感器系统来定量样品中的分析对象的浓度时，可以通过测量电流来自动量化样品的种类。

2. 发明授权

US06797152B2 Sensors and sensing methods for detecting analytes based on changes in pKa of a sensing polymer 有权
标题翻译：基于传感聚合物的pKa变化检测分析物的传感器和传感方法
公开(公告)号：US06797152B2
公开(公告)日：2004-09-28
申请号：US09919657
申请日：2001-07-31
申请人： Michael S. Freund , Eiichi Shoji
发明人： Michael S. Freund , Eiichi Shoji
IPC分类号： G01N2726
CPC分类号： G01N21/78 , G01N21/80 , G01N27/3277
摘要： Sensor systems and sensing methods for detecting one or more analytes in a fluid. A sensor includes a polymer capable of undergoing a proton-coupled redox reaction. The polymer includes a plurality of reactive substituents capable of undergoing a reaction with an analyte. Upon exposure of the sensor to a fluid containing the analyte, a response is detected based on a change in the pKa of the polymer.
摘要翻译：用于检测流体中一种或多种分析物的传感器系统和感测方法。传感器包括能够进行质子耦合的氧化还原反应的聚合物。聚合物包括能够与分析物发生反应的多个反应性取代基。当将传感器暴露于含有分析物的流体时，基于聚合物的pKa的变化来检测响应。

3. 发明授权

US06793791B2 Variable-volume disposable isoelectric focusing cell and method of isoelectric focusing 失效
标题翻译：可变体积一次性等电聚焦电池和等电聚焦方法
公开(公告)号：US06793791B2
公开(公告)日：2004-09-21
申请号：US10374943
申请日：2003-02-26
申请人： Milan Bier
发明人： Milan Bier
IPC分类号： G01N2726
CPC分类号： G01N27/44795
摘要： An elastomeric cell is used as the disposable part of an apparatus for isoelectric focusing in free solution (without gels) in the 0.5 to 5 ml volume range. An inlet port is used for priming the cell and end-connectors for coupling with electrodes. A grid of parallel rods compresses the cell against a cold plate, thereby causing swelling of the skin of the cell between pairs of rods and forming contiguous fluid bubble-compartments for IEF separation. Before collection of separated fractions, the gap between the rods and the plate is further reduced so as to create distinct fluid compartments which now contain discrete products of separation. The separated fractions are collected by syringe-like devices by puncturing the elastomer skin. The plate, rods and deformable cell are capable of rotation or gentle rocking motion around the cell's main axis to avoid gravitational convection during the focusing process.
摘要翻译：使用弹性体电池作为在0.5至5ml体积范围内的游离溶液（不含凝胶）中的等电聚焦装置的一次性部分。入口用于引发电池和端接头，用于与电极耦合。平行杆的格栅将细胞压在冷板上，从而导致细胞在成对的杆之间膨胀，并形成连续的液体气泡隔室以进行IEF分离。在收集分离的馏分之前，进一步减少棒和板之间的间隙，以便产生不同的流体隔室，其现在包含离散的分离产物。通过注射弹性体皮肤通过注射器状装置收集分离的级分。板，杆和可变形单元能够围绕单元的主轴旋转或缓和摇摆运动，以避免聚焦过程中的重力对流。

4. 发明授权

US06787111B2 Apparatus and method for filling and cleaning channels and inlet ports in microchips used for biological analysis 有权
标题翻译：用于生物分析的微芯片中填充和清洁通道和入口的装置和方法
公开(公告)号：US06787111B2
公开(公告)日：2004-09-07
申请号：US09737675
申请日：2000-12-13
申请人： David J. Roach , Robert T. Loder, Jr. , Thomas M. Armstrong , Dennis W. Harris , Stevan B. Jovanovich , Richard F. Johnston
发明人： David J. Roach , Robert T. Loder, Jr. , Thomas M. Armstrong , Dennis W. Harris , Stevan B. Jovanovich , Richard F. Johnston
IPC分类号： G01N2726
CPC分类号： G01N27/44791 , B01J2219/0099 , B01L3/5027 , B01L99/00 , G01N27/44704 , G01N27/44743 , G01N27/44782 , G01N35/0099 , G01N35/1074 , G01N2035/00059 , G01N2035/00158 , G01N2035/0437
摘要： An apparatus for filling and cleaning channels and inlet ports of a microchip substrate is disclosed. A device of the apparatus comprising an array of tubes is inserted into each of the inlet ports of the microchip. The array of tubes of the device comprises a plurality of pressure tubes, surrounded by a plurality of vacuum tubes. In conjunction with this, pressurized solutions such as matrix or wash are introduced into common openings on the microchip that provide a passage to microchannels of the microchip with the use of pressure tip injectors of the apparatus. As matrix or wash solutions are pumped through the common openings and microchannels of the microchip substrate, wash solutions are pumped through the plurality of pressure tubes and everything is vacuumed through the plurality of vacuum tubes surrounding the plurality of pressure tubes. Various reservoirs of solutions are selected and allowed to flow by proper valve actuation. This process can be performed manually or easily automated by utilizing appropriate valves and control hardware/software.
摘要翻译：公开了一种用于填充和清洁微芯片衬底的通道和入口的装置。将包括管阵列的装置的装置插入到微芯片的每个入口端口中。该装置的管阵列包括由多个真空管包围的多个压力管。与此同时，诸如基质或洗涤剂的加压溶液被引入到微芯片上的共同的开口中，通过使用该装置的压头喷射器提供通向微芯片的微通道的通道。当将基质或洗涤溶液泵送通过微芯片衬底的共同的开口和微通道时，将洗涤溶液泵送通过多个压力管，并且通过围绕多个压力管的多个真空管将一切都抽真空。选择各种储存的溶液并通过适当的阀驱动使其流动。该过程可以通过使用适当的阀门和控制硬件/软件手动或容易地进行自动化。

5. 发明授权

US06726817B1 Chlorinator controller 有权
标题翻译：氯化器控制器
公开(公告)号：US06726817B1
公开(公告)日：2004-04-27
申请号：US09312473
申请日：1999-05-17
申请人： Glenn Gruett
发明人： Glenn Gruett
IPC分类号： G01N2726
CPC分类号： B01J49/85 , B01J49/60 , C02F1/42 , C02F2209/006 , C02F2303/16
摘要： An apparatus for determining ions strength in a solution. In relation to a chlorinator, a control circuit senses the strength of the brine by determining current flow through an associated chlorinator. Depending on the level of current flow, different signal configurations occur to advise of the status of the apparatus.
摘要翻译：用于测定溶液中离子强度的装置。关于氯化器，控制电路通过确定通过相关氯化器的电流来感测盐水的强度。根据电流的水平，发生不同的信号配置来提示设备的状态。

6. 发明授权

US06709559B2 Microfabricated structures for facilitating fluid introduction into microfluidic devices 有权
标题翻译：用于促进流体引入微流体装置的微型结构
公开(公告)号：US06709559B2
公开(公告)日：2004-03-23
申请号：US10209493
申请日：2002-07-30
申请人： Steven A. Sundberg , J. Wallace Parce , Calvin Y. H. Chow
发明人： Steven A. Sundberg , J. Wallace Parce , Calvin Y. H. Chow
IPC分类号： G01N2726
CPC分类号： G01N27/44791 , B01J19/0093 , B01J2219/00783 , B01J2219/00826 , B01J2219/00831 , B01J2219/00833 , B01J2219/00853 , B01J2219/00891 , B01J2219/00909 , B01L3/0244 , B01L3/0262 , B01L3/5025 , B01L3/50255 , B01L3/5027 , B01L3/502715 , B01L3/502723 , B01L3/50273 , B01L3/502753 , B01L2200/027 , B01L2300/0681 , B01L2300/0816 , B01L2300/0819 , B01L2300/0864 , B01L2400/0406 , B01L2400/0418 , B01L2400/0421 , B01L2400/0487 , B01L2400/0688 , G01N27/44743 , G01N2035/00237 , G01N2035/1037 , Y10T436/25125 , Y10T436/25375 , Y10T436/2575
摘要： Fluid introduction is facilitated through the use of a port which extends entirely through a microfluidic substrate. Capillary forces can be used to retain the fluid within the port, and a series of samples or other fluids may be introduced through a single port by sequentially blowing the fluid out through the substrate and replacing the removed fluid with an alternate fluid, or by displacing the fluid in part with additional fluid. In another aspect, microfluidic substrates have channels which varying in cross-sectional dimension so that capillary action spreads a fluid only within a limited portion of the channel network. In yet another aspect, the introduction ports may include a multiplicity of very small channels leading from the port to a fluid channel, so as to filter out particles or other contaminants which might otherwise block the channel at the junction between the channel and the introduction port.
摘要翻译：通过使用完全延伸通过微流体衬底的端口来促进流体引入。可以使用毛细管力将流体保持在端口内，并且可以通过单个端口引入一系列样品或其它流体，通过依次将流体通过基底吹出并用替代流体代替去除的流体，或通过置换流体部分附加流体。在另一方面，微流体衬底具有在横截面尺寸上变化的通道，使得毛细管作用仅在通道网络的有限部分内扩散流体。在另一方面，引入端口可以包括从端口引导到流体通道的多个非常小的通道，以便过滤除了通道和引入端口之间的连接处可能阻挡通道的颗粒或其它污染物。

7. 发明授权

US06630063B1 Uniform laser excitation and detection in capillary array electrophoresis system and method 有权
标题翻译：毛细管阵列电泳系统和方法的均匀激光激发和检测
公开(公告)号：US06630063B1
公开(公告)日：2003-10-07
申请号：US09413355
申请日：1999-10-06
申请人： Qingbo Li , Songsan Zhou , Changsheng Liu
发明人： Qingbo Li , Songsan Zhou , Changsheng Liu
IPC分类号： G01N2726
CPC分类号： G01N27/44721 , G01N27/44782
摘要： A capillary electrophoresis system comprises capillaries positioned in parallel to each other forming a plane. The capillaries are configured to allow samples to migrate. A light source is configured to illuminate the capillaries and the samples therein. This causes the samples to emit light. A lens is configured to receive the light emitted by the samples and positioned directly over a first group of the capillaries and obliquely over a second group of the capillaries. The light source is further configured to illuminate the second group of capillaries more than the first group of the capillaries such that amount of light received by the lens from the first group of capillaries is substantially identical to amount of light received from the second group of capillaries when an identical amount of the samples is migrating through the first and second group capillaries.
摘要翻译：毛细管电泳系统包括彼此平行地形成平面的毛细管。毛细管被配置为允许样品迁移。光源被配置为照亮毛细管和其中的样品。这样会使样品发光。透镜被配置为接收由样品发射的光并且直接定位在第一组毛细管上并且倾斜地位于第二组毛细管上。光源还被配置为比第一组毛细管照亮第二组毛细管，使得透镜从第一组毛细管接收的光量与从第二组毛细血管接收的光量基本相同当相同量的样品通过第一和第二组毛细管迁移时。

8. 发明授权

US06627446B1 Robotic microchannel bioanalytical instrument 失效
标题翻译：机器人微通道生物分析仪器
公开(公告)号：US06627446B1
公开(公告)日：2003-09-30
申请号：US09109676
申请日：1998-07-02
申请人： David J. Roach , Robert T. Loder, Jr. , Thomas M. Armstrong , Dennis W. Harris , Stevan B. Jovanovich , Richard F. Johnston
发明人： David J. Roach , Robert T. Loder, Jr. , Thomas M. Armstrong , Dennis W. Harris , Stevan B. Jovanovich , Richard F. Johnston
IPC分类号： G01N2726
CPC分类号： G01N27/44704 , B01L3/5027 , B01L99/00 , G01N27/44743 , G01N27/44782 , G01N27/44791 , G01N35/0099 , G01N35/1074 , G01N2035/00059 , G01N2035/00158 , G01N2035/0437 , Y10T436/11 , Y10T436/110833 , Y10T436/25 , Y10T436/2575
摘要： A substrate with a plurality of microchannels is movably deployed with other movable objects that will load sample into the microchannels, stimulate molecular migration, read the results of the migration, remove and replace the substrate, and prepare for a new run. The other objects include a gripper for engaging and moving the substrate, an electrode array of fine wires suitable for fitting into the microchannels for electromigration, and a scanning detector for reading migration results. A sequence of automatic operations is established so that one substrate after another may be moved into position, loaded with sample, stimulated for molecular migration, read with a beam, and then removed and replaced with a fresh substrate.
摘要翻译：具有多个微通道的基板可移动地与其他可移动物体一起展开，其中可移动物体将样品载入微通道，刺激分子迁移，读取迁移结果，去除和替换基底，并准备新的运行。其他目的包括用于接合和移动衬底的夹持器，适于安装到用于电迁移的微通道中的细线的电极阵列，以及用于读取迁移结果的扫描检测器。建立了一系列自动操作，使得一个接一个的衬底可以移动到位置，装载样品，刺激分子迁移，用光束读取，然后移除并用新鲜的底物代替。

9. 发明授权

US06610185B2 Electrochemical corrosion potential sensor and method of making 失效
标题翻译：电化学腐蚀电位传感器及其制作方法
公开(公告)号：US06610185B2
公开(公告)日：2003-08-26
申请号：US09682725
申请日：2001-10-10
申请人： Young-Jin Kim , Reed Roeder Corderman , Peter Louis Andresen , Scott Andrew Weaver , Paul Joseph Martiniano
发明人： Young-Jin Kim , Reed Roeder Corderman , Peter Louis Andresen , Scott Andrew Weaver , Paul Joseph Martiniano
IPC分类号： G01N2726
CPC分类号： G01N17/02 , Y10S29/004 , Y10T29/49002 , Y10T29/49826 , Y10T29/49888
摘要： A sensor for measuring electrochemical corrosion potential, and a method for manufacturing a sensor, the sensor comprising a tubular ceramic probe having a closed tip at one end, the probe at least partially filled with a powder comprising metal and metal oxide; a metal support tube having one end receiving an opposite end of the probe, and joined thereto by a braze joint therewith; an electrical conductor extending through the support tube and into the probe, and having an end buried in the powder for electrical contact therewith; and a protective band bridging the probe and tube at the joint for sealing thereof, the protective band consisting essentially of a metallic coating.
摘要翻译：一种用于测量电化学腐蚀电位的传感器，以及一种用于制造传感器的方法，所述传感器包括管状陶瓷探针，所述管状陶瓷探针的一端具有封闭的尖端，所述探针至少部分地填充有包含金属和金属氧化物的粉末; 金属支撑管，其一端容纳探针的相对端，并通过其钎焊接头与其接合; 延伸穿过支撑管并进入探针的电导体，并且具有掩埋在粉末中的端部与其电接触; 以及在接头处将探针和管桥接的密封件的保护带，该保护带主要由金属涂层组成。

10. 发明授权

US06603987B2 Hollow microneedle patch 失效
公开(公告)号：US06603987B2
公开(公告)日：2003-08-05
申请号：US09877519
申请日：2001-06-11
申请人： Robert C. Whitson
发明人： Robert C. Whitson
IPC分类号： G01N2726
CPC分类号： A61M37/0015 , A61B5/14514 , A61B5/14532 , A61B5/150022 , A61B5/150358 , A61B5/150755 , A61B5/150969 , A61B5/150984 , A61B5/15142 , A61B5/15186 , A61B5/157 , A61M2037/0023 , A61M2037/003 , G01N33/528
摘要： A test strip is provided for use in the determination of the concentration of an a chemical in blood. The test strip comprises a plurality of microneedles and a test area. Each microneedle is adapted to puncture skin and to draw blood. The test area is in fluid communication with the microneedles. The test area contains a reagent adapted to produce a reaction indicative of the concentration of the chemical in blood.

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