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    • 3. 发明申请
    • AUTOMATIC INJECTION DEVICE FOR MICROARRAY CHIP AND AUTOMATIC INJECTION HYBRIDIZATION MICROARRAY CHIP
    • 微胶囊自动注射装置和自动注射微胶囊芯片
    • US20140011703A1
    • 2014-01-09
    • US14006488
    • 2012-02-10
    • Jiaming YePinhong WangGuoqing WangWanli Xing
    • Jiaming YePinhong WangGuoqing WangWanli Xing
    • G01N1/10
    • G01N1/10C12Q1/6813C40B30/04C40B40/06C40B40/10C40B40/12G01N33/543G01N33/68G01N35/1095
    • An automatic injection device comprises at least an injection unit (1). The said injection unit (1) is formed by sealing a cover plate layer (3) with hydrophilic surfaces and a microfluid layer (4). The said cover plate layer (3) is provided with at least two through holes (5). he said microfluid layer (4) is provided with a hollow-out hybridization chamber (7) and at least two hollow-out microfluid channels (6). One end of each channel (6) is connected with the hybridization chamber (7), and the other end is connected with a through hole (5) of the cover plate layer (3) respectively. Taking advantage of the hydrophilicity of the cover plate, the automatic injection device makes a solution automatically enter and fill the hybridization chamber (7) and the microfluid channels (6) by the driving force of liquid surface tension. The flow uniformity of sample solution in microarray chip is achieved by the structural design of the hybridization chamber (7) and the microfluid channels (6). The automatic injection device has advantages of simple manufacture, easy operation, high hybridization efficiency, low sample cost, and automatic quantificational injection.
    • 自动注射装置至少包括注射单元(1)。 所述注射单元(1)通过密封具有亲水表面的盖板层(3)和微流体层(4)而形成。 所述盖板层(3)设置有至少两个通孔(5)。 他表示微流体层(4)设置有中空杂交室(7)和至少两个中空的微流体通道(6)。 每个通道(6)的一端与杂交室(7)连接,另一端分别与盖板层(3)的通孔(5)连接。 利用盖板的亲水性,自动注射装置通过液面张力的驱动力使溶液自动进入并填充杂交室(7)和微流体通道(6)。 微阵列芯片中样品溶液的流动均匀性通过杂交室(7)和微流体通道(6)的结构设计来实现。 自动注射装置制造简单,操作简便,杂交效率高,样品成本低,自动定量注射等优点。
    • 4. 发明申请
    • ETHYLENE CRACKING FURNACE
    • 乙烯开裂炉
    • US20120020852A1
    • 2012-01-26
    • US13124590
    • 2009-10-15
    • Xiou HeGuoqing WangChangli LiLljun ZhangJinke LiChen ShaoGuang LiYuping Guo
    • Xiou HeGuoqing WangChangli LiLljun ZhangJinke LiChen ShaoGuang LiYuping Guo
    • B01J19/00
    • C07C4/02C10G2400/20
    • An ethylene cracking furnace comprising a high pressure steam drum (1), a convection section (2), a radiant section (3), multiple groups of radiant coils (4) arranged vertically in the firebox of radiant section, burners (5) and transfer line exchangers (6), each radiant coil comprising a first-pass tube (7), a second-pass tube (8) and a connection member (9); feedstocks being introduced into an inlet end of the first-pass tube and outflow from an outlet end of the second-pass tube, said first-pass tube (7) and said second-pass tube (8) are non-split coils, and the centerlines of the respective radiant tubes (7, 8) are within a common plane; said connection member (9) is a tridimensional structural member comprising an inlet bending tube (10), a return bending tube (11) and an outlet bending tube (12); said inlet bending tubes (10) and said outlet bending tubes (12) are arranged at two sides of the plane containing the centerlines of said first-pass tubes (7) and said second-pass tubes (8), respectively; the projections of the respective connection members (9) in a side view are the same curve line that is symmetrical, continuous and closed; the inner diameters of said radiant coils (7, 8) is varied at least once along the length of the tubes.
    • 一种乙烯裂解炉,包括高压蒸汽桶(1),对流部分(2),辐射部分(3),在辐射部分的火箱中垂直布置的多组辐射线圈(4),燃烧器(5)和 传输线交换器(6),每个辐射线圈包括第一通道管(7),第二通管(8)和连接构件(9); 原料被引入第一管的入口端并从第二通管的出口端流出,所述第一通管(7)和所述第二通管(8)是非分裂线圈,并且 各辐射管(7,8)的中心线在公共平面内; 所述连接构件(9)是包括入口弯曲管(10),返回弯管(11)和出口弯管(12)的立体结构构件; 所述入口弯管(10)和出口弯管(12)分别布置在包含所述第一通管(7)和所述第二通管(8)的中心线的平面的两侧; 各连接构件(9)的侧视图的突起是对称的,连续的和闭合的相同的曲线; 所述辐射线圈(7,8)的内径沿着管的长度改变至少一次。
    • 6. 发明授权
    • Methods and compositions for identifying nucleic acid molecules using nucleolytic activities and hybridization
    • 用核酸分解活性和杂交鉴定核酸分子的方法和组合物
    • US06900013B1
    • 2005-05-31
    • US09648081
    • 2000-08-25
    • Guoqing WangLei WuXiaobo WangJing ChengWeiPing Yang
    • Guoqing WangLei WuXiaobo WangJing ChengWeiPing Yang
    • C07H21/02C07H21/04C12M1/34C12P19/34C12Q1/68
    • C12Q1/6816C07H21/04C12Q1/6827C12Q1/6837C12Q2521/101C12Q2533/101C12Q2563/107C12Q2521/327C12Q2537/143C12Q2565/501
    • The present invention recognizes that identifying genes expressed during developmental processes, stress responses, and disease states can advance understanding of these biological functions, and can contribute to identifying targets for therapeutic drugs. In addition, the present invention recognizes that rapid and reliable profiling of genetic variations, such as mutations and SNPs, is of increasing importance to diagnostics, prognostics, forensics, heredity determinations, and pharmacogenetics. One aspect of the present invention provides a method of identifying one or more nucleic acid molecules that are expressed under a given set of conditions based on their complementarity to known sequences, or one or more mutations or SNPs in a population of nucleic acid molecules. The method includes: contacting at least one probe nucleic acid molecule with a survey population of nucleic acid molecules under conditions that promote nucleic acid hybridization to generate a probe-survey population mixture of nucleic acid molecules, treating the probe-survey population mixture of nucleic acid molecules with a nucleolytic activity, such that nucleolytic activity-sensitive nucleic acid molecules are digested, and contacting the resulting mixture of nucleolytic activity-protected nucleic acid molecules with a solid support comprising one or more attached nucleic acid molecules to generate attached nucleic acid molecule/nucleolytic activity-protected nucleic acid molecule complexes, and identifying one or more of the attached nucleic acid molecules or one or more of the nucleolytic activity-protected nucleic acid molecules in one or more attached nucleic acid molecule/nucleolytic activity-protected nucleic acid molecule complexes.
    • 本发明认识到,在发育过程,应激反应和疾病状态期间表达的鉴定基因可以促进对这些生物功能的理解,并且可以有助于鉴定治疗药物的靶标。 此外,本发明认识到,遗传变异的快速和可靠的分析,例如突变和SNP,对于诊断,预后,取证,遗传测定和药物遗传学是越来越重要的。 本发明的一个方面提供了鉴定一种或多种核酸分子的方法,所述核酸分子基于它们与已知序列的互补性或核酸分子群体中的一个或多个突变或SNP在给定条件下表达。 该方法包括:在促进核酸杂交以产生核酸分子的探针 - 调查群体混合物的条件下使至少一个探针核酸分子与核酸分子的调查群体接触,处理核酸的探针 - 调查群体混合物 具有核分解活性的分子,使得消解活性敏感的核酸核酸分子,并使得到的核分解活性保护的核酸分子的混合物与包含一个或多个连接的核酸分子的固体支持物接触,以产生附着的核酸分子/ 核分解活性保护的核酸分子复合物,以及鉴定一个或多个连接的核酸分子/核酸分解活性保护的核酸分子复合物中所附连的核酸分子或一个或多个核裂解活性保护的核酸分子 。
    • 8. 发明申请
    • SYSTEMS AND METHODS FOR PROVIDING IMPROVED TCAS BEARING MEASUREMENT
    • 用于提供改进的TCAS轴承测量的系统和方法
    • US20130325314A1
    • 2013-12-05
    • US13985189
    • 2011-02-25
    • Guoqing WangJianqiang Xuan
    • Guoqing WangJianqiang Xuan
    • G08G5/04
    • G08G5/04G01S3/48G01S13/74G01S13/9303H01Q1/28H01Q3/267H01Q21/20H01Q21/293
    • Systems and methods for improving bearing accuracy in a Traffic Collision Avoidance System (TCAS) environment. An interrogation signal is transmitted from an array of antenna elements. A response to the transmitted interrogation signal from a target is received at a first pair of elements of the array. The first pair of elements is separated by at most ½λ of the response signal. A processor determines coarse bearing of the received response. A second pair of elements of the array of antenna elements receives a response to the interrogation signal. The second pair of elements is separated by approximately Nλ of the response signal. N is an integer not equal to zero. A first bearing value to the target is determined based on the determined coarse bearing and the received response at the second pair of elements. The array is mounted on an aircraft or on a ground installation.
    • 提高交通碰撞避免系统(TCAS)环境中轴承精度的系统和方法。 从天线元件的阵列发送询问信号。 在阵列的第一对元件处接收对来自目标的发送的询问信号的响应。 第一对元件被响应信号的最多1/2分开。 处理器确定接收到的响应的粗略方位。 天线元件阵列的第二对元件接收对询问信号的响应。 第二对元件被响应信号的大约Nlambda分开。 N是不等于零的整数。 基于确定的粗略轴承和在第二对元件处的接收响应来确定到目标​​的第一轴承值。 阵列安装在飞机上或地面上。
    • 10. 发明申请
    • PROCESS FOR PRODUCING OLEFINS
    • 生产油脂的方法
    • US20100274063A1
    • 2010-10-28
    • US12669269
    • 2008-07-18
    • Guoqing WangZhaobin ZhangShuo ChenLijun Zhang
    • Guoqing WangZhaobin ZhangShuo ChenLijun Zhang
    • C07C4/06
    • C10G35/09C10G11/05C10G11/18
    • The present invention discloses a process for producing olefins from petroleum saturated hydrocarbons. The process of the present invention comprises: contacting a preheated petroleum saturated hydrocarbons feedstock with a dehydrogenation catalyst in a dehydrogenation reaction zone of a reaction system to obtain a petroleum hydrocarbon stream containing unsaturated hydrocarbon compounds, in which the dehydrogenation reaction has a conversion rate of at least 20%; and contacting the obtained petroleum hydrocarbon stream containing the unsaturated hydrocarbon compounds with olefins cracking catalyst in an olefin cracking zone of the reaction system to obtain a product stream containing olefins with a reduced number of carbon atoms.
    • 本发明公开了一种从石油饱和烃生产烯烃的方法。 本发明的方法包括:使预热的石油饱和烃原料与脱氢催化剂在反应体系的脱氢反应区中接触,得到含有不饱和烃化合物的石油烃流,其中脱氢反应的转化率为 至少20%; 并将所得到的含有不饱和烃化合物的石油烃物流与烯烃裂化催化剂在反应体系的烯烃裂化区中接触,得到含有碳原子数减少的烯烃的产物流。