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31. 发明授权

US06723112B2 Bioactive three loop coil 失效
标题翻译：生物活性三环线圈
公开(公告)号：US06723112B2
公开(公告)日：2004-04-20
申请号：US09828452
申请日：2001-04-06
申请人： Hanh Ho , Kenneth W. Quan, Jr. , Clifford Teoh , Robert M. Abrams , Joseph C. Eder , Paul C. Slaikeu , Michael P. Wallace , James Barry
发明人： Hanh Ho , Kenneth W. Quan, Jr. , Clifford Teoh , Robert M. Abrams , Joseph C. Eder , Paul C. Slaikeu , Michael P. Wallace , James Barry
IPC分类号： A61M2900
CPC分类号： A61L31/044 , A61B17/12022 , A61B17/12113 , A61B17/12145 , A61B17/1215 , A61B17/12172 , A61B17/12177 , A61B2017/12063 , A61F2/0077 , A61L31/06 , A61L31/10 , A61L31/16 , A61L2300/412 , A61L2430/36 , C08L67/04 , C08L65/04
摘要： One aspect of the present invention pertains to an implantable medical device for at least partially obstructing a neck portion of a vascular aneurysm. The device includes an occlusion subassembly comprising a base section and at least one lateral protrusion fixedly attached to the base section. A therapeutic agent is disposed upon at least one portion of at least one lateral protrusion.
摘要翻译：本发明的一个方面涉及用于至少部分地阻塞血管动脉瘤的颈部的可植入医疗装置。该装置包括闭塞子组件，其包括基部和至少一个固定地连接到基部的侧向突出部。治疗剂设置在至少一个侧向突起的至少一部分上。

32. 发明授权

US06569179B2 Bioactive three loop coil 有权
公开(公告)号：US06569179B2
公开(公告)日：2003-05-27
申请号：US09931662
申请日：2001-08-16
申请人： Clifford Teoh , Hanh Ho , Kenneth W. Quan, Jr.
发明人： Clifford Teoh , Hanh Ho , Kenneth W. Quan, Jr.
IPC分类号： A61M2900
CPC分类号： A61B17/12022 , A61B17/12113 , A61B17/12145 , A61B17/1215 , A61B17/12172 , A61B17/12177 , A61B90/39 , A61B2017/12063 , A61F2/0077 , A61L31/044 , A61L31/06 , A61L31/10 , A61L31/16 , A61L2430/36 , C08L67/04 , C08L65/04
摘要： One aspect of the present invention pertains to an implantable medical device for at least partially obstructing a neck portion of a vascular aneurysm. The implantable medical device includes an occlusion subassembly having a central tubular member and at least one lateral protrusion fixedly attached to the central tubular member. The lateral protrusion(s) and the central tubular member are of a size and overall flexibility to lodge at the neck portion of the vascular aneurysm. A coil is attached to the lateral protrusion.

33. 发明授权

US06544275B1 Vaso-occlusive coils with selectively flattened areas 有权
标题翻译：具有选择性平坦区域的血管闭塞线圈
公开(公告)号：US06544275B1
公开(公告)日：2003-04-08
申请号：US09637714
申请日：2000-08-11
申请人： Clifford Teoh
发明人： Clifford Teoh
IPC分类号： A61B1708
CPC分类号： A61B17/12145 , A61B17/12022 , A61B17/1215 , A61B2017/1205
摘要： Vaso-occlusive devices with selectively flattened surfaces are described. Also described are methods of making and using these devices.
摘要翻译：描述具有选择性平坦表面的血管闭塞装置。还描述了制造和使用这些装置的方法。

34. 发明授权

US06379369B1 Intracorporeal device with NiTi tubular member 失效
标题翻译：具有NiTi管状构件的体内装置
公开(公告)号：US06379369B1
公开(公告)日：2002-04-30
申请号：US08982725
申请日：1997-12-02
申请人： Robert M. Abrams , Randy S. Chan , Janet Walsh Burpee , Clifford Teoh
发明人： Robert M. Abrams , Randy S. Chan , Janet Walsh Burpee , Clifford Teoh
IPC分类号： A61M2500
CPC分类号： A61M25/09 , A61L31/022 , A61L31/14 , A61L2400/16 , A61M2025/09008 , A61M2025/09083 , A61M2025/09141 , A61M2025/09175 , A61M2205/0266 , C22C14/00 , C22C30/00 , C22F1/006
摘要： An improved guidewire for advancing a catheter within a body lumen which has a high strength proximal portion, a distal portion formed of superelastic alloy and a connector formed of superelastic alloy to provide torque transmitting coupling between the distal end of the proximal portion and the proximal end of the distal portion. The superelastic alloy elements are preferably cold worked and then heat treated at a temperature well above the austenite-to-martensite transformation temperature, while being subjected to longitudinal stresses equal to about 5 to about 50% of the room temperature yield stress to impart to the metal a straight “memory.” The guiding member using such improved material exhibits a stress induced austenite-to-martensite phase transformation at an exceptionally high constant yield strength of at least 70 ksi for solid members and at least 50 ksi for tubular members with a broad recoverable strain of at least about 4% during the phase transformation.
摘要翻译：一种用于将导管推进在具有高强度近端部分的体腔内的改进的导丝，由超弹性合金形成的远端部分和由超弹性合金形成的连接器，以在近端部分的远端和近端之间提供扭矩传递联接的远端部分。超弹性合金元素优选是冷加工的，然后在远高于奥氏体 - 马氏体转变温度的温度下进行热处理，同时经受等于室温屈服应力的约5至约50％的纵向应力，以赋予金属直“记忆”。使用这种改进的材料的引导构件在固体构件具有至少70ksi的异常高的恒定屈服强度和至少50ksi的管状构件的情况下表现出应力诱导的奥氏体 - 马氏体相变，其具有至少大约的可恢复应变在相变期间为4％。

35. 发明授权

US06344041B1 Aneurysm closure device assembly 有权
标题翻译：动脉瘤闭合装置组装
公开(公告)号：US06344041B1
公开(公告)日：2002-02-05
申请号：US09699267
申请日：2001-10-26
申请人： David Kupiecki , Clifford Teoh , Hong Doan , Son M. Gia , Erik T. Engelson , Uriel Hiram Chee , Mehran Bashiri , Joseph C. Eder
发明人： David Kupiecki , Clifford Teoh , Hong Doan , Son M. Gia , Erik T. Engelson , Uriel Hiram Chee , Mehran Bashiri , Joseph C. Eder
IPC分类号： A61B1804
CPC分类号： A61F2/88 , A61B17/12022 , A61B17/12118 , A61B17/12145 , A61B17/12154 , A61B2017/1205 , A61B2017/12063 , A61F2002/30092 , A61F2210/0014 , A61F2250/0039 , A61F2310/00023
摘要： This is an artificial occlusion kit for implanting and retaining an artificial occlusion device in a body space adjacent to and extending from a body lumen in a mammal. The includes at least one occlusion device and a retaining device for blocking the migration of the occlusion device out of the occlusion site. The retaining device is radially expandable at a retaining site adjacent the body space to be occluded to a diameter that is sufficient to engage the body lumen wall at the retaining site and form a barrier across the entrance zone of the body space to be occluded. The expanded retaining device also forms a lumen for flow through body lumen at the retaining site. At least one semi-penetrable space may also be provided in the retaining device, allowing introduction of occlusion devices into the body space to be occluded, but preventing subsequent migration of the occlusion devices out of the body space. This semi-penetrable space may also be distensible to allow for delivery of occlusion devices therethrough. An introducer wire or a tapered-tip delivery catheter may be used to distend the distensible space and deliver the occlusion devices. The retaining device structure may further include a radiopaque metal wire wound into a primary helix over an inner core member made of a superelastic alloy of nickel and titanium. An implantable medical device assembly is also provided, having the structure described for the retaining device of the novel artificial occlusion kit, and which is attached to an elongate pusher via a sacrificial link that is electrolytically dissolvable.
摘要翻译：这是一种用于将人工闭塞装置植入和保持在与哺乳动物的体腔相邻并从其延伸的身体空间中的人造闭塞套件。包括至少一个闭塞装置和用于阻挡闭塞装置移出闭塞部位的保持装置。保持装置可以在靠近身体空间的保持位置处径向展开，以被阻塞到直径足以与保持位置处的身体腔壁接合并形成穿过要被遮挡的身体空间的入口区域的屏障。扩张的保持装置还形成用于在保留位置处流过体腔的流明。还可以在保持装置中设置至少一个半透入空间，从而允许将遮挡装置引入身体空间以被阻塞，但是防止闭塞装置随后从身体空间中移出。这种半透入空间也可以是可扩张的，以允许通过其中的封闭装置的输送。导引线或锥形输送导管可用于扩张可扩张空间并输送遮挡装置。保持装置结构还可以包括在由镍和钛的超弹性合金制成的内芯构件上缠绕到主螺旋中的不透射线金属线。还提供了一种植入式医疗装置组件，其具有针对新型人造阻塞套件的保持装置所述的结构，并且经由电解可溶解的牺牲连接件连接到细长推动器。

36. 发明授权

US6139564A Minimally occlusive flow disruptor stent for bridging aneurysm necks 失效
标题翻译：用于桥接动脉瘤颈部的微小闭塞性流动破坏支架
公开(公告)号：US6139564A
公开(公告)日：2000-10-31
申请号：US98124
申请日：1998-06-16
申请人： Clifford Teoh
发明人： Clifford Teoh
IPC分类号： A61B17/00 , A61B17/12 , A61F2/82 , A61B17/04
CPC分类号： A61F2/966 , A61B17/0057 , A61B17/12022 , A61B17/12113 , A61B17/12131 , A61B2017/12063 , A61F2/958 , A61F2002/823
摘要： This is a device for bridging the neck of a wide-necked or narrow-necked aneurysm in the vasculature. In general, it is a device used to stabilize aneurysms found in the vasculature by at least partially closing the opening to that aneurysm with consequent limiting of the amount of blood flowing into and out of the chamber. The device is generally made of a metallic or polymeric sheet and is of a shape which may be deployed using a catheter. The device typically has three major components: the central closure area, the centrifugal stabilizers, and the axial stabilizers. The device is intended to be a permanent implant and may be used with or without occlusive devices and materials placed inside the aneurysm volume.
摘要翻译：这是用于桥接脉管系统中的宽颈或窄颈动脉瘤的颈部的装置。通常，它是用于通过至少部分地关闭该动脉瘤的开口来稳定在脉管系统中发现的动脉瘤的装置，从而限制血液流入和流出腔室的量。该装置通常由金属或聚合物片制成并且具有可以使用导管展开的形状。该装置通常具有三个主要部件：中心封闭区域，离心稳定器和轴向稳定器。该装置旨在是永久植入物，并且可以与放置在动脉瘤体积内的闭塞装置和材料一起使用。

37. 发明授权

US5695111A Method of soldering TI containing alloys 失效
标题翻译：焊接含TI合金的方法
公开(公告)号：US5695111A
公开(公告)日：1997-12-09
申请号：US276082
申请日：1994-07-15
申请人： Leonard Nanis , Robert M. Abrams , Randy S. Chan , Janet Walsh Burpee , Clifford Teoh
发明人： Leonard Nanis , Robert M. Abrams , Randy S. Chan , Janet Walsh Burpee , Clifford Teoh
IPC分类号： A61L31/02 , A61M25/09 , C22C14/00 , C22C30/00 , C22F1/00 , B23K103/14 , B23K31/02
CPC分类号： A61L31/14 , A61L31/022 , A61M25/09 , C22C14/00 , C22C30/00 , C22F1/006 , A61L2400/16 , A61M2025/09083 , A61M2025/09141 , A61M2025/09175 , A61M2205/0266
摘要： An improved guidewire for advancing a catheter within a body lumen which has a high strength proximal portion, a distal portion formed of superelastic alloy and a connector formed of superelastic alloy to provide torque transmitting coupling between the distal end of the proximal portion and the proximal end of the distal portion. The superelastic alloy elements are preferably cold worked and then heat treated at a temperature well above the austenite-to-martensite transformation temperature, while being subjected to longitudinal stresses equal to about 5 to about 50% of the room temperature yield stress to impart to the metal a straight "memory." The guiding member using such improved material exhibits a stress induced austenite-to-martensite phase transformation at an exceptionally high constant yield strength of at least 70 ksi for solid members and at least 50 ksi for tubular members with a broad recoverable strain of at least about 4% during the phase transformation.
摘要翻译：一种用于将导管推进在具有高强度近端部分的体腔内的改进的导丝，由超弹性合金形成的远端部分和由超弹性合金形成的连接器，以在近端部分的远端和近端之间提供扭矩传递联接的远端部分。超弹性合金元素优选是冷加工的，然后在远高于奥氏体 - 马氏体转变温度的温度下进行热处理，同时经受等于室温屈服应力的约5至约50％的纵向应力，以赋予金属直“记忆”。使用这种改进的材料的引导构件在固体构件具有至少70ksi的异常高的恒定屈服强度和至少50ksi的管状构件的情况下表现出应力诱导的奥氏体 - 马氏体相变，其具有至少大约的可恢复应变在相变期间为4％。

38. 发明授权

US09636115B2 Vaso-occlusive delivery device with kink resistant, flexible distal end 有权
公开(公告)号：US09636115B2
公开(公告)日：2017-05-02
申请号：US11423934
申请日：2006-06-13
申请人： William S. Henry , Charles Daly , Russell Ford , Michael D. Williams , Hanh Duong , Hughie Devaney , Kamal Ramzipoor , Clifford Teoh , Richard Murphy , Andrew Huffmaster , Scott McGill
发明人： William S. Henry , Charles Daly , Russell Ford , Michael D. Williams , Hanh Duong , Hughie Devaney , Kamal Ramzipoor , Clifford Teoh , Richard Murphy , Andrew Huffmaster , Scott McGill
IPC分类号： A61M29/00 , A61B17/12 , A61M25/09
CPC分类号： A61B17/12022 , A61B17/12109 , A61B17/12113 , A61B17/12154 , A61B2017/1205 , A61B2017/12054 , A61B2017/12063 , A61M25/09 , A61M2025/09133
摘要： A device for delivering an occlusive element includes an elongate sheath having a lumen therein. An elongate core member is disposed within the lumen and is formed from a proximal portion and distal portion connected via a joint. The distal portion of the elongate member includes a severable junction secured to the occlusive element. A marker coil is coaxially arranged around the distal portion of the elongate core member and is partially disposed inside the sheath lumen. A coil member is coaxially arranged around the distal portion of the elongate core member and coaxially arranged around at least a portion of the marker coil extending outside the lumen of the sheath. The coil member is secured at a distal end thereof to the distal portion of the elongate core member. The device resists axial compression while allowing for radial bending.

39. 发明授权

US08226660B2 Vaso-occlusive coils with non-overlapping sections 有权
标题翻译：具有非重叠部分的血管闭塞线圈
公开(公告)号：US08226660B2
公开(公告)日：2012-07-24
申请号：US12353477
申请日：2009-01-14
申请人： Clifford Teoh , Michael P. Wallace
发明人： Clifford Teoh , Michael P. Wallace
IPC分类号： A61B17/24
CPC分类号： A61B17/12113 , A61B17/12022 , A61B17/12145 , A61B2017/00526
摘要： A vaso-occlusive implant has a primary helical-coil shape that defines a primary axis and a three-dimensional secondary shape. The secondary shape includes a substantially helical section and a second section having a plurality of non-overlapping loops or loop sections. Each loop defines a plane that is oriented at an angle from about 30-150 degrees relative to a plane defined by an immediately preceding or immediately succeeding loop along the primary axis. The coil sections or loops can be generally circular loops or other smooth shapes.
摘要翻译：血管闭塞植入体具有限定主轴线和三维二次形状的初级螺旋线圈形状。次级形状包括基本上螺旋的部分和具有多个非重叠环或环部分的第二部分。每个环限定了相对于由紧邻的前一个或紧随其后的环沿主轴定义的平面以大约30-150度的角度定向的平面。线圈段或环可以是大体圆环或其它平滑形状。

40. 发明授权

US07892248B2 Occlusive cinching devices and methods of use 有权
标题翻译：闭塞装置及使用方法
公开(公告)号：US07892248B2
公开(公告)日：2011-02-22
申请号：US11748221
申请日：2007-05-14
申请人： Tri Tran , Kim Nguyen , Hanh Ho , My Doan , Richard Murphy , Michael P Wallace , Clifford Teoh
发明人： Tri Tran , Kim Nguyen , Hanh Ho , My Doan , Richard Murphy , Michael P Wallace , Clifford Teoh
IPC分类号： A61B17/08
CPC分类号： A61B17/12113 , A61B17/12022 , A61B17/12172 , A61B17/12186 , A61B17/1219 , A61B2017/1205 , A61B2017/12063
摘要： Methods and devices for blocking orifices and occluding cavities within a patient are provided. The device in one variation comprises first and second tubular members attached to a collapsible sealing element. The device can be placed through an orifice and the collapsible sealing element can be collapsed to seal the orifice. An embolic may be introduced distal to the sealing element to occlude a cavity. The device may incorporate a locking mechanism which can be engaged to lock the sealing element into the collapsed position. The device may incorporate a valve to prevent flow through the tubular members, for example to prevent egress of the embolic from a cavity. The device can be detached to provide a permanent seal of the orifice, and can retain the embolic within the cavity. The device may be used in conjunction with a stent or other retention device to assist the sealing element in maintaining the seal.
摘要翻译：提供了用于阻断患者内的孔和闭塞腔的方法和装置。一个变型中的装置包括附接到可折叠密封元件的第一和第二管状构件。该装置可以通过孔口放置，并且可折叠密封元件可以折叠以密封孔口。可以在密封元件的远侧引入栓塞以封闭空腔。该装置可以包括可以接合以将密封元件锁定到折叠位置的锁定机构。该装置可以包括阀以防止流过管状构件，例如以防止栓塞从空腔排出。该装置可以被拆卸以提供孔口的永久性密封，并且可以将栓塞保持在空腔内。该装置可以与支架或其它保持装置结合使用以帮助密封元件保持密封。

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