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    • 33. 发明授权
    • FET-type biosensor with surface modification
    • 具有表面改性的FET型生物传感器
    • US08735077B2
    • 2014-05-27
    • US11336110
    • 2006-01-20
    • Jeo-young ShimSu-hyeon KimKyu-tae YooSung-ouk JungJoon-shik Park
    • Jeo-young ShimSu-hyeon KimKyu-tae YooSung-ouk JungJoon-shik Park
    • G01N33/53
    • B82Y30/00B82Y15/00G01N27/4145
    • Provided is a field effect transistor (FET) type biosensor including a source electrode, a gate, and a drain electrode. A ligand that can bind to a side of a nucleic acid is added to the surface of the gate. In a conventional FET type biosensor, it is difficult to detect a signal within the debye length because a target nucleic acid is directly fixed to the surface of a gate of the conventional FET. However, in the present invention, this problem can be overcome and the debye length can be increased by treating the surface of a gate of an FET sensor with a ligand that can bind to a side of a nucleic acid. The ligand can be adsorbed onto the surface of the gate. In this case, the nucleic acid is adsorbed parallel to the surface of the gate, not perpendicular to the surface of the gate, thus generating an effective depletion region. In addition, hybridization efficiency can be increased because a hybridized sample can be injected into an FET sensor at high ionic strength.
    • 提供了包括源电极,栅极和漏电极的场效应晶体管(FET)型生物传感器。 可以结合核酸一侧的配体加入到门的表面。 在传统的FET型生物传感器中,由于目标核酸直接固定在常规FET的栅极表面,难以检测德拜长度内的信号。 然而,在本发明中,可以克服这个问题,并且可以通过用可以结合核酸一侧的配体处理FET传感器的栅极的表面来增加德拜长度。 配体可以吸附在栅极的表面上。 在这种情况下,核酸被平行于栅极的表面吸附,而不垂直于栅极的表面,从而产生有效的耗尽区域。 此外,杂交效率可以提高,因为杂化样品可以以高离子强度注入FET传感器。
    • 37. 发明申请
    • SENSING SWITCH AND DETECTING METHOD USING THE SAME
    • 感应开关及其检测方法
    • US20100329931A1
    • 2010-12-30
    • US12833095
    • 2010-07-09
    • Kyu-tae YOOJoon-ho KIMJun-hong MINSung-ouk JUNGJi-na NAMGOONGKui-hyun KIMJeo-young SHIMKak NAMKOONG
    • Kyu-tae YOOJoon-ho KIMJun-hong MINSung-ouk JUNGJi-na NAMGOONGKui-hyun KIMJeo-young SHIMKak NAMKOONG
    • G01N27/00
    • G01N33/54373
    • Provided are a sensing switch and a sensing method using the same. The sensing switch includes: a substrate; a supporter on the substrate; a sensing plate that is connected to a side of the supporter and is in parallel with the substrate by a predetermined distance; a receptor binding region on an upper surface of an end portion of the sensing plate; an electric or magnetic field generation device that induces deflection of the sensing plate when a receptor bound to the receptor binding region is selectively bound to an electrically or magnetically active ligand; and a pair of switching electrodes that are separated by a predetermined distance and is connected when the sensing plate contacts the substrate due to the deflection of the sensing plate. A target material need not be labelled, a signal processing of a fluorescent or electrical detection signal using an analysis apparatus is not required, and a signal can be directly decoded by confirming whether a current flows through the switch.
    • 提供了一种感测开关和使用该感测开关的感测方法。 感测开关包括:基板; 底物上的支撑物; 感测板,其与所述支撑体的一侧连接并且与所述基板平行预定距离; 在感测板的端部的上表面上的受体结合区域; 当与受体结合区结合的受体选择性地结合到电或磁性活性配体时,引起感测板偏转的电场或磁场产生装置; 以及一对分离预定距离的开关电极,并且当感测板由于感测板的偏转而与基板接触时被连接。 目标材料不需要标注,不需要使用分析装置的荧光或电检测信号的信号处理,并且可以通过确认电流是否流过开关直接解码信号。
    • 38. 发明申请
    • SENSING SWITCH AND DETECTING METHOD USING THE SAME
    • 感应开关及其检测方法
    • US20090170211A1
    • 2009-07-02
    • US12272183
    • 2008-11-17
    • Kyu-tae YOOJoon-ho KIMJun-hong MINSung-ouk JUNGJi-na NAMGOONGKui-hyun KIMJeo-young SHIMKak NAMKOONG
    • Kyu-tae YOOJoon-ho KIMJun-hong MINSung-ouk JUNGJi-na NAMGOONGKui-hyun KIMJeo-young SHIMKak NAMKOONG
    • G01N27/00
    • G01N33/54373
    • Provided are a sensing switch and a sensing method using the same. The sensing switch includes: a substrate; a supporter on the substrate; a sensing plate that is connected to a side of the supporter and is in parallel with the substrate by a predetermined distance; a receptor binding region on an upper surface of an end portion of the sensing plate; an electric or magnetic field generation device that induces deflection of the sensing plate when a receptor bound to the receptor binding region is selectively bound to an electrically or magnetically active ligand; and a pair of switching electrodes that are separated by a predetermined distance and is connected when the sensing plate contacts the substrate due to the deflection of the sensing plate. A target material need not be labelled, a signal processing of a fluorescent or electrical detection signal using an analysis apparatus is not required, and a signal can be directly decoded by confirming whether a current flows through the switch.
    • 提供了一种感测开关和使用该感测开关的感测方法。 感测开关包括:基板; 底物上的支撑物; 感测板,其与所述支撑体的一侧连接并且与所述基板平行预定距离; 在感测板的端部的上表面上的受体结合区域; 当与受体结合区结合的受体选择性地结合到电或磁性活性配体时,引起感测板偏转的电场或磁场产生装置; 以及一对分离预定距离的开关电极,并且当感测板由于感测板的偏转而与基板接触时被连接。 目标材料不需要标注,不需要使用分析装置的荧光或电检测信号的信号处理,并且可以通过确认电流是否流过开关直接解码信号。