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31. 发明申请

US20080021080A1 5-LIPOXYGENASE INHIBITORS 失效
标题翻译： 5-LIPOXYGENASE抑制剂
公开(公告)号：US20080021080A1
公开(公告)日：2008-01-24
申请号：US11685892
申请日：2007-03-14
申请人： Ashwani Verma , Sanjay Malhotra , Abhijit Ray , Shirumalla Kumar
发明人： Ashwani Verma , Sanjay Malhotra , Abhijit Ray , Shirumalla Kumar
IPC分类号： A61K31/41 , A61P11/00 , C07D249/00
CPC分类号： C07D405/12 , C07D405/14 , C07D413/14
摘要： The present invention relates to 5-lipoxygenase inhibitors. Compounds disclosed herein can be useful in the treatment of bronchial asthma, chronic obstructive pulmonary disorder, arthritis, type I diabetes, multiple sclerosis, allograft rejection, psoriasis, inflammatory bowel disease, ulcerative colitis, acne, atherosclerosis, cancer, pruritis, urticaria, atopic dermatitis, allergic rhinitis, other inflammatory and autoimmune diseases. Processes for the preparation of disclosed compounds, pharmaceutical compositions containing the disclosed compounds and their use as 5-lipoxygenase inhibitors are also provided.
摘要翻译：本发明涉及5-脂氧合酶抑制剂。本文公开的化合物可用于治疗支气管哮喘，慢性阻塞性肺病，关节炎，I型糖尿病，多发性硬化，同种异体移植排斥，牛皮癣，炎性肠病，溃疡性结肠炎，痤疮，动脉粥样硬化，癌症，瘙痒症，荨麻疹，特应性皮炎，过敏性鼻炎，其他炎性和自身免疫性疾病。还提供了制备所公开的化合物的方法，含有所公开的化合物的药物组合物及其作为5-脂氧合酶抑制剂的用途。

32. 发明授权

US06476666B1 Bootstrapped charge pump 失效
标题翻译：自举电荷泵
公开(公告)号：US06476666B1
公开(公告)日：2002-11-05
申请号：US09873017
申请日：2001-05-30
申请人： Chaitanya Palusa , Abhijit Ray
发明人： Chaitanya Palusa , Abhijit Ray
IPC分类号： G05F302
CPC分类号： H02M3/073 , H02M2003/077
摘要： The diode drops associated with the output voltage from a conventional charge pump are eliminated in the present invention with a dual-chain charge pump that utilizes the pumped voltages from each charge pump chain to drive the gates of the other charge pump chain. As a result, the voltages on the gates of the transistors are pumped up to a level such that there is no threshold voltage drop across the transistor, and thus, making it behave like an ideal switch.
摘要翻译：在本发明中，与使用来自每个电荷泵链的泵浦电压驱动另一个电荷泵链的栅极的双链电荷泵相反，在常规电荷泵中与二极管相关的输出电压降低。结果，晶体管的栅极上的电压被泵送到一个水平，使得晶体管两端没有阈值电压降，从而使其像理想的开关一样工作。

33. 发明授权

US6097179A Temperature compensating compact voltage regulator for integrated circuit device 有权
标题翻译：用于集成电路器件的温度补偿紧凑型稳压器
公开(公告)号：US6097179A
公开(公告)日：2000-08-01
申请号：US264092
申请日：1999-03-08
申请人： Abhijit Ray , Raghava Madhu
发明人： Abhijit Ray , Raghava Madhu
IPC分类号： G05F3/24 , G05F3/08 , G05F1/10 , H03K17/00
CPC分类号： G05F3/245 , Y10S323/907
摘要： A voltage regulator circuit (100), coupled between a high power supply voltage (VCC) and a lower power supply voltage (VSS), provides a regulated voltage (XDD) that is greater than the high power supply voltage (VCC). The voltage regulator circuit (100) includes a temperature compensating detect circuit (102) which activates a trigger signal when the XDD voltage exceeds a predetermined level. In response to an active trigger signal, a shunt circuit (104) couples the regulated voltage (XDD) to the high power supply voltage (VCC). The regulated voltage (XDD) is translated to the detect circuit (102) by the regulated voltage (XDD) being applied to the gate of a transistor (N112) disposed between the high power supply voltage (VCC) and a detect node (108). This arrangement allows monitoring of the regulated voltage (XDD) level without loading the regulated voltage (XDD).
摘要翻译：耦合在高电源电压（VCC）和较低电源电压（VSS）之间的稳压器电路（100）提供大于高电源电压（VCC）的调节电压（XDD）。电压调节器电路（100）包括温度补偿检测电路（102），其在XDD电压超过预定电平时激活触发信号。响应于有源触发信号，分流电路（104）将调节电压（XDD）耦合到高电源电压（VCC）。调节电压（XDD）被施加到设置在高电源电压（VCC）和检测节点（108）之间的晶体管（N112）的栅极的调节电压（XDD）转换到检测电路（102）。这种布置允许监视调节电压（XDD）电平而不加载调节电压（XDD）。

34. 发明授权

US6016270A Flash memory architecture that utilizes a time-shared address bus scheme and separate memory cell access paths for simultaneous read/write operations 失效
标题翻译：闪存架构利用时间共享地址总线方案和单独的存储单元访问路径，用于同时读/写操作
公开(公告)号：US6016270A
公开(公告)日：2000-01-18
申请号：US36558
申请日：1998-03-06
申请人： Damodar Reddy Thummalapally , Abhijit Ray
发明人： Damodar Reddy Thummalapally , Abhijit Ray
IPC分类号： G11C16/08 , G11C16/10 , G11C16/26 , G11C16/04
CPC分类号： G11C16/26 , G11C16/08 , G11C16/10 , G11C2216/22
摘要： A flash memory architecture relies on a single, time-shared address bus to enable a read operation to be performed simultaneously with an algorithm operation when the read operation is targeted for a memory cell block that is not currently tagged for an algorithm operation. After a read address has been latched into the array block selected for the read operation, the address bus is "free" for the remainder of the read operation cycle. During this free time, the address bus can be used for algorithm operations to load the counter address into an active tagged block in the array. Separate global data I/O lines are provided to facilitate simultaneous read and algorithm operations.
摘要翻译：闪速存储器架构依赖于单个时间共享的地址总线，以使得当读操作针对当前未被标记用于算法操作的存储器单元块时，可以与算法操作同时执行读操作。在读取地址被锁存到为读操作选择的数组块之后，地址总线在读操作周期的其余部分是“空闲的”。在这个空闲时间期间，地址总线可用于算法操作，以将计数器地址加载到阵列中的活动标记块中。提供单独的全局数据I / O线以便于同时读取和算法操作。

35. 发明授权

US09434610B2 HPMA—docetaxel conjugates and uses therefore 有权
标题翻译：因此，HPMA-多西紫杉醇缀合物和用途
公开(公告)号：US09434610B2
公开(公告)日：2016-09-06
申请号：US12575276
申请日：2009-10-07
申请人： Young B. Lee , Deog J. Kim , Chang H. Ahn , Anjan Nan , Hamidreza Ghandehari , Abhijit Ray
发明人： Young B. Lee , Deog J. Kim , Chang H. Ahn , Anjan Nan , Hamidreza Ghandehari , Abhijit Ray
IPC分类号： A61K47/48 , A61P35/00 , B82Y5/00
CPC分类号： B82Y5/00 , A61K47/551 , A61K47/58 , A61K47/64 , A61K47/65
摘要： Disclosed are water-soluble compositions of gemcitabine and docetaxel formed by conjugating the gemcitabine or docetaxel to a water-soluble polymer such as N-2-hydroxypropyl methacrylamide (HPMA). Also disclosed are methods of using the compositions of the invention for the treatment of cancer.
摘要翻译：公开了通过将吉西他滨或多西他赛与诸如N-2-羟丙基甲基丙烯酰胺（HPMA）的水溶性聚合物缀合而形成的吉西他滨和多西紫杉醇的水溶性组合物。还公开了使用本发明的组合物治疗癌症的方法。

36. 发明申请

US20140052464A1 METHOD AND SYSTEM FOR REMOTE PATIENT MONITORING 审中-公开
标题翻译：远程患者监测方法与系统
公开(公告)号：US20140052464A1
公开(公告)日：2014-02-20
申请号：US13969245
申请日：2013-08-16
申请人： Abhijit Ray
发明人： Abhijit Ray
IPC分类号： G06F19/00
CPC分类号： G06F19/3418
摘要： A system for remotely monitoring a patient, the system comprises a plurality of input sources operable to acquire information corresponding to a well-being condition of a patient, an external database for storing analytical models and medical data, and a central controller being operable to receive the signal from the input sources, perform an algorithm to select an analytical model from the database based on the information and the data, perform an algorithm on the information and the data with the model to determine a state of the patient and formulate a health prediction, determine a recommendation as a result of the state and the health prediction, and transmit the recommendation to at least one external entity for providing support and assistance to the patient or to a caregiver of the patient.
摘要翻译：一种用于远程监测患者的系统，所述系统包括可操作以获取与患者的健康状况相对应的信息的多个输入源，用于存储分析模型和医疗数据的外部数据库，以及可操作以接收来自输入源的信号，基于信息和数据，执行从数据库中选择分析模型的算法，利用模型对信息和数据执行算法，以确定患者的状态并制定健康预测确定由于状态和健康预测的结果的推荐，并将该建议传送到至少一个外部实体，以向患者或患者的照料者提供支持和帮助。

37. 发明申请

US20130177523A1 GOLD PARTICLES AND METHODS OF MAKING AND USING THE SAME IN CANCER TREATMENT 审中-公开
标题翻译：金颗粒及其在癌症治疗中的使用方法
公开(公告)号：US20130177523A1
公开(公告)日：2013-07-11
申请号：US13809595
申请日：2011-07-13
申请人： Hamid Ghandehari , Adam Gormley , Abhijit Ray , Nate Larson
发明人： Hamid Ghandehari , Adam Gormley , Abhijit Ray , Nate Larson
IPC分类号： A61K41/00 , A61N5/06 , C08G65/48
CPC分类号： A61K41/0052 , A61K9/0019 , A61K31/095 , A61K31/192 , A61K31/203 , A61K31/4196 , A61K31/519 , A61K31/53 , A61K31/661 , A61K31/69 , A61K31/706 , A61K33/00 , A61K45/06 , A61K47/6811 , A61K47/6851 , A61K47/6923 , A61N5/062 , C08G65/48 , Y10T428/298 , Y10T428/2982
摘要： Described herein are gold particles that can be used to reduce tumor proliferation and treat cancer. In certain aspects, the gold particles can be modified in order to enhance selectivity and uptake of the particles by cancer cells. In certain aspects, the modified gold particles have a targeting group attached to the particle via a linker. The gold particles described herein can be used in combination with other anti-cancer agents in order to enhance overall cancer treatment. Methods for making and using the gold particles are also described herein.
摘要翻译：本文描述了可用于减少肿瘤增殖和治疗癌症的金颗粒。在某些方面，可以修饰金颗粒以增强癌细胞对颗粒的选择性和摄取。在某些方面，修饰的金颗粒具有通过连接体连接到颗粒上的靶向基团。本文所述的金颗粒可以与其它抗癌剂组合使用，以增强整体癌症治疗。本文还描述了制备和使用金颗粒的方法。

38. 发明申请

US20110130403A1 PYRAZOLO [3, 4-B] PYRIDINE DERIVATIVES AS PHOSPHODIESTERASE INHIBITORS 审中-公开
标题翻译：吡咯并[3,4-B]吡啶衍生物作为磷酸二酯酶抑制剂
公开(公告)号：US20110130403A1
公开(公告)日：2011-06-02
申请号：US12531045
申请日：2008-03-13
申请人： Sonali Rudra , Nidhi Gupta , Lalit Kumar Baregama , Ritu Agarwal , Mandadapu Raghuramaiah , Vinayak Vasantrao Khairnar , Venkata P. Palle , Sarala Balachandran , Abhijit Ray , Sunada G. Dastidar , Lalitha Vijaykrishnan
发明人： Sonali Rudra , Nidhi Gupta , Lalit Kumar Baregama , Ritu Agarwal , Mandadapu Raghuramaiah , Vinayak Vasantrao Khairnar , Venkata P. Palle , Sarala Balachandran , Abhijit Ray , Sunada G. Dastidar , Lalitha Vijaykrishnan
IPC分类号： A61K31/437 , C07D471/04 , A61K31/444 , A61K31/497 , A61K31/506 , A61K31/53 , A61P29/00 , A61P37/06 , A61P25/00
CPC分类号： C07D471/04
摘要： The present invention relates to phosphodiesterase (PDE) type 4, phosphodiesterase (PDE) type 7 and dual PDE type 4/PDE type 7 inhibitors. Compounds disclosed hereinf having the structure of Formula I: can be useful in the treatment, prevention, inhibition or suppression of CNS diseases, for example, multiple sclerosis; various pathological conditions such as diseases affecting the immune system, including AIDS, rejection of transplant, auto-immune disorders such as T-cell related diseases, for example, rheumatoid arthritis; inflammatory diseases such as respiratory inflammation diseases including chronic obstructive pulmonary disease (COPD), asthma, bronchitis, allergic rhinitis, adult respiratory distress syndrome (ARDS) and other inflammatory diseases including but not limited to psoriasis, shock, atopic dermatitis, eosinophilic granuloma, allergic conjunctivitis, osteoarthritis; gastrointestinal inflammation diseases such as Crohn's disease, colitis, pancreatitis as well as different types of cancers including leukaemia; especially in humans. Processes for the preparation of disclosed compounds, pharmaceutical compositions containing the disclosed compounds and their use as PDE type 4, PDE type 7 and dual PDE t e 4/PDE t e 7 inhibitors are rovided.
摘要翻译：本发明涉及磷酸二酯酶（PDE）4型，磷酸二酯酶（PDE）7型和双重PDE型4 / PDE型7型抑制剂。本文公开的具有式I结构的化合物可用于治疗，预防，抑制或抑制CNS疾病，例如多发性硬化; 各种病理状况如影响免疫系统的疾病，包括艾滋病，移植排斥反应，自身免疫性疾病如T细胞相关疾病，例如类风湿性关节炎; 炎性疾病如呼吸道炎症疾病，包括慢性阻塞性肺疾病（COPD），哮喘，支气管炎，过敏性鼻炎，成人呼吸窘迫综合征（ARDS）和其他炎性疾病，包括但不限于银屑病，休克，特应性皮炎，嗜酸性肉芽肿，过敏性结膜炎，骨关节炎; 胃肠道炎症性疾病如克罗恩病，结肠炎，胰腺炎以及不同类型的癌症，包括白血病; 特别是在人类。制备所公开的化合物的方法，包含所公开的化合物的药物组合物及其作为PDE 4型，PDE型7和双重PDE 4 / PDE 7抑制剂的用途是有争议的。

39. 发明申请

US20100292196A1 PYRAZOLO (3, 4-B) PYRIDINE DERIVATIVES AS PHOSPHODIESTERASE INHIBITORS 有权
标题翻译：吡咯烷（3,4-B）吡啶衍生物作为磷酸二酯酶抑制剂
公开(公告)号：US20100292196A1
公开(公告)日：2010-11-18
申请号：US12531043
申请日：2008-03-14
申请人： Sonali Rudra , Nidhi Gupta , Lalit Kumar Baregama , Ritu Agarwal , Vinayak Vasantrao Khairnar , Mandadapu Raghu Ramaiah , Venkata P. Palle , Sarala Balachandran , Atul Kondaskar , Manohar Salla , Abhijit Ray , Sunanda G. Dastidar , Lalitha Vijaykrishnan
发明人： Sonali Rudra , Nidhi Gupta , Lalit Kumar Baregama , Ritu Agarwal , Vinayak Vasantrao Khairnar , Mandadapu Raghu Ramaiah , Venkata P. Palle , Sarala Balachandran , Atul Kondaskar , Manohar Salla , Abhijit Ray , Sunanda G. Dastidar , Lalitha Vijaykrishnan
IPC分类号： A61K31/573 , C07D519/00 , A61K31/437 , C07D471/04 , A61P17/00 , A61P19/00 , A61P11/00 , A61P35/00
CPC分类号： C07D471/04 , C07D519/00
摘要： The present invention relates to phosphodiesterase (PDE) type 4, phosphodiesterase (PDE) type 7 and dual PDE type 4/PDE type 7 inhibitors. Compounds disclosed herein having the structure of Formula 1: can be useful in the treatment, prevention, inhibition or suppression of CNS diseases, for example, multiple sclerosis; various pathological conditions such as diseases affecting the immune system, including AIDS, rejection of transplant, auto-immune disorders such as T-cell related diseases, for example, rheumatoid arthritis; inflammatory diseases such as respiratory inflammation diseases including chronic obstructive pulmonary disease (COPD), asthma, bronchitis, allergic rhinitis, adult respiratory distress syndrome (ARDS) and other inflammatory diseases including but not limited to psoriasis, shock, atopic dermatitis, eosinophilic granuloma, allergic conjunctivitis, osteoarthritis; gastrointestinal inflammation diseases such as Crohn's disease, colitis, pancreatitis as well as different types of cancers including leukaemia; especially in humans. Processes for the preparation of disclosed compounds, pharmaceutical compositions containing the disclosed compounds and their use as PDE type 4, PDE type 7 and dual PDE type 4/PDE type 7 inhibitors are provided.
摘要翻译：本发明涉及磷酸二酯酶（PDE）4型，磷酸二酯酶（PDE）7型和双重PDE型4 / PDE型7型抑制剂。本文公开的具有式1结构的化合物可用于治疗，预防，抑制或抑制CNS疾病，例如多发性硬化; 各种病理状况如影响免疫系统的疾病，包括艾滋病，移植排斥反应，自身免疫性疾病如T细胞相关疾病，例如类风湿性关节炎; 炎性疾病如呼吸道炎症疾病，包括慢性阻塞性肺疾病（COPD），哮喘，支气管炎，过敏性鼻炎，成人呼吸窘迫综合征（ARDS）和其他炎性疾病，包括但不限于银屑病，休克，特应性皮炎，嗜酸性肉芽肿，过敏性结膜炎，骨关节炎; 胃肠道炎症性疾病如克罗恩病，结肠炎，胰腺炎以及不同类型的癌症，包括白血病; 特别是在人类。提供了制备所公开的化合物的方法，含有所公开的化合物的药物组合物及其作为PDE 4型，PDE型7和双重PDE型4 / PDE 7型抑制剂的用途。

40. 发明申请

US20100144801A1 MUSCARINIC RECEPTOR ANTAGONISTS 审中-公开
标题翻译：肌肉受体拮抗剂
公开(公告)号：US20100144801A1
公开(公告)日：2010-06-10
申请号：US12443838
申请日：2007-10-02
申请人： Naresh Kumar , Jaskiran Kaur , Abhijit Ray , Suman Gupta , Shivani Malhotra , Rajkumar Shirumalla
发明人： Naresh Kumar , Jaskiran Kaur , Abhijit Ray , Suman Gupta , Shivani Malhotra , Rajkumar Shirumalla
IPC分类号： A61K31/44 , C07D213/55 , C07D233/54 , A61K31/4164 , A61P11/00 , A61P13/00 , A61P1/00 , A61P3/00
CPC分类号： C07D233/64 , C07D211/70 , C07D213/30
摘要： The present invention generally relates to muscarinic receptor antagonists of formula I, which are useful, among other uses, for the treatment of various diseases of the respiratory, urinary and gastrointestinal systems mediated through muscarinic receptors. The invention also relates to the process for the preparation of disclosed compounds, pharmaceutical compositions containing the disclosed compounds, and the methods for treating diseases mediated through muscarinic receptors. Formula (I) wherein Het: is heterocyclyl or heteroaryl X: O, S or NR1 and the other substituents are defined as in the claims.
摘要翻译：本发明一般涉及式I的毒蕈碱受体拮抗剂，其可用于治疗通过毒蕈碱受体介导的呼吸，泌尿和胃肠系统的各种疾病，以及其它用途。本发明还涉及制备所公开的化合物的方法，含有所公开的化合物的药物组合物，以及用于治疗通过毒蕈碱受体介导的疾病的方法。式（I）其中Het：是杂环基或杂芳基X：O，S或NR1，其它取代基如权利要求中所定义。

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