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1. 发明申请

US20100099644A1 HPMA - DOCETAXEL OR GEMCITABINE CONJUGATES AND USES THEREFORE 有权
标题翻译： HPMA - DOCETAXEL或GEMCITABINE CONJUGATES及其用途
公开(公告)号：US20100099644A1
公开(公告)日：2010-04-22
申请号：US12575276
申请日：2009-10-07
申请人： Young B. Lee , Deog J. Kim , Chang H. Ahn , Anjan Nan , Hamidreza Ghandehari , Abhijit Ray
发明人： Young B. Lee , Deog J. Kim , Chang H. Ahn , Anjan Nan , Hamidreza Ghandehari , Abhijit Ray
IPC分类号： A61K47/48
CPC分类号： B82Y5/00 , A61K47/551 , A61K47/58 , A61K47/64 , A61K47/65
摘要： Disclosed are water-soluble compositions of gemcitabine and docetaxel formed by conjugating the gemcitabine or docetaxel to a water-soluble polymer such as N-2-hydroxypropyl methacrylamide (HPMA). Also disclosed are methods of using the compositions of the invention for the treatment of cancer.
摘要翻译：公开了通过将吉西他滨或多西他赛与诸如N-2-羟丙基甲基丙烯酰胺（HPMA）的水溶性聚合物缀合而形成的吉西他滨和多西紫杉醇的水溶性组合物。还公开了使用本发明的组合物治疗癌症的方法。

2. 发明授权

US09434610B2 HPMA—docetaxel conjugates and uses therefore 有权
标题翻译：因此，HPMA-多西紫杉醇缀合物和用途
公开(公告)号：US09434610B2
公开(公告)日：2016-09-06
申请号：US12575276
申请日：2009-10-07
申请人： Young B. Lee , Deog J. Kim , Chang H. Ahn , Anjan Nan , Hamidreza Ghandehari , Abhijit Ray
发明人： Young B. Lee , Deog J. Kim , Chang H. Ahn , Anjan Nan , Hamidreza Ghandehari , Abhijit Ray
IPC分类号： A61K47/48 , A61P35/00 , B82Y5/00
CPC分类号： B82Y5/00 , A61K47/551 , A61K47/58 , A61K47/64 , A61K47/65
摘要： Disclosed are water-soluble compositions of gemcitabine and docetaxel formed by conjugating the gemcitabine or docetaxel to a water-soluble polymer such as N-2-hydroxypropyl methacrylamide (HPMA). Also disclosed are methods of using the compositions of the invention for the treatment of cancer.
摘要翻译：公开了通过将吉西他滨或多西他赛与诸如N-2-羟丙基甲基丙烯酰胺（HPMA）的水溶性聚合物缀合而形成的吉西他滨和多西紫杉醇的水溶性组合物。还公开了使用本发明的组合物治疗癌症的方法。

3. 发明申请

US20060014695A1 Hpma-polyamine conjugates and uses therefore 审中-公开
标题翻译：因此，Hpma-聚胺共轭物和用途
公开(公告)号：US20060014695A1
公开(公告)日：2006-01-19
申请号：US10502985
申请日：2003-01-31
申请人： Hamidreza Ghandehari , Martin Woodle , Puthupparampil Scaria , Anjan Nan
发明人： Hamidreza Ghandehari , Martin Woodle , Puthupparampil Scaria , Anjan Nan
IPC分类号： A61K48/00 , A61K39/395
CPC分类号： C07K5/021 , A61K31/74 , A61K47/58 , C07K5/1008 , C07K5/1027 , C12N15/87 , C12N2810/405
摘要： The inventions provide compositions and methods for nucleic acid delivery comprising IIPMA conjugated to a polyamine. These compositions have the benefit of the steric hindrance of HPMA and the nucleic acid binding capability of a polyamine. Useful polyamines for this purpose include spermine, spermidine and their analogues, and DFMO. These polyamines have the ability not only to bind nucleic acids, but also have anti-cancer effects themselves. The compounds provided can also include ligand binding domains, such as vascular endothelial growth factors, somatostatin and somatostatin analogs, transferring, melanotropin, ApoE and ApoE peptides, von Willebrand's factor and von Willebrand's factor peptides, adenoviral fiber protein and adenoviral fiber protein peptides, PD 1 and PD 1 peptides, EGF and EGF peptides, RGD peptides, CCK peptides, antibody and antibody fragments, folate, pyridoxyl and sialyl-LewisX and chemical analogs. Methods for using these compositions to achieve a therapeutic effect, including for vaccination, are also provided.
摘要翻译：本发明提供了包含与多胺缀合的IIPMA的核酸递送的组合物和方法。这些组合物具有HPMA的空间位阻和多胺的核酸结合能力的益处。有用的多胺用于此目的包括精胺，亚精胺及其类似物，以及DFMO。这些多胺不仅具有结合核酸的能力，而且还具有抗癌作用。所提供的化合物还可以包括配体结合域，例如血管内皮生长因子，生长抑素和生长抑素类似物，转移，黑素素，ApoE和ApoE肽，血管性血友病因子和血管性血友病因子肽，腺病毒纤维蛋白和腺病毒纤维蛋白肽，PD 1和PD 1肽，EGF和EGF肽，RGD肽，CCK肽，抗体和抗体片段，叶酸，吡哆醛和唾液酸-LXXX和化学类似物。还提供了使用这些组合物来实现治疗效果的方法，包括用于疫苗接种。

4. 发明申请

US20120197060A1 RADIATION ENHANCED MACROMOLECULAR DELIVERY OF THERAPEUTIC AGENTS FOR CHEMOTHERAPY TECHNOLOGY 审中-公开
标题翻译：用于化疗技术的治疗药物的辐射增强大分子递送
公开(公告)号：US20120197060A1
公开(公告)日：2012-08-02
申请号：US13378731
申请日：2010-06-17
申请人： Abhijit Ray , Hamidreza Ghandehari
发明人： Abhijit Ray , Hamidreza Ghandehari
IPC分类号： A61M37/00 , A61P35/00 , C07F15/00 , C08F222/38 , C07H23/00
CPC分类号： A61K41/00 , A61K31/337 , A61K31/4745 , A61K31/704 , A61K33/24 , A61K41/0085 , A61K47/58 , A61K47/595 , A61K47/60 , A61K47/65 , A61K47/6905 , A61N5/10 , C07F15/0093 , C07H23/00
摘要： Described herein are anti-cancer compounds composed of a macromolecule comprising (1) at least one anti-cancer agent directly or indirectly bonded to the macromolecule and (2) at least one high Z element directly or indirectly bonded to the macromolecule that is capable of producing Auger electrons upon exposure to X-ray energy. When the compounds are exposed to low energy X-ray (e.g., kilo electron volts KeV) Auger electrons are produced by the high Z elements present in the compound. Because lower energy is required when compared to typical radiotherapy, which uses therapeutic X-ray energy in the million electron volt range (MeV), the subject experiences lower collateral damage when compared to radiation therapy. Additionally, the presence of the anti-cancer agent provides a second mechanism for killing cancer cells. Methods for making and using the anti cancer compounds are also described herein.
摘要翻译：本文描述了由大分子组成的抗癌化合物，其包含（1）直接或间接结合到大分子上的至少一种抗癌剂，和（2）至少一个直接或间接结合到大分子上的高Z元素，其能够在暴露于X射线能量时产生俄歇电子。当化合物暴露于低能量X射线（例如，千电子伏特KeV）时，由化合物中存在的高Z元素产生俄歇电子。因为与使用百万电子伏范围（MeV）中的治疗性X射线能量的典型放射治疗相比，需要较低的能量，与放射治疗相比，受试者经历较低的附带损伤。此外，抗癌剂的存在提供了杀死癌细胞的第二种机制。本文还描述了制备和使用抗癌化合物的方法。

5. 发明申请

US20220081570A1 BIODEGRADABLE HOLLOW NANOPARTICLES AND METHODS AND APPARATUS FOR MANUFACTURING THE SAME 有权
公开(公告)号：US20220081570A1
公开(公告)日：2022-03-17
申请号：US17486825
申请日：2021-09-27
申请人： Christopher Hendrickson , Landon Bunderson , Seyyed Pouya Hadipour Moghaddam , Hamidreza Ghandehari
发明人： Christopher Hendrickson , Landon Bunderson , Seyyed Pouya Hadipour Moghaddam , Hamidreza Ghandehari
IPC分类号： C09C1/30 , C05G5/30
摘要： Hollow nanoparticles for time-release delivery of a payload. A composition include a mesoporous hollow nanoparticle and a degradation agent, wherein the degradation agent includes one or more of a reducing agent, an acid, or an acidifier. The mesoporous hollow nanoparticle degrades in a presence of the degradation agent for time-release of a payload.

6. 发明申请

US20080193377A1 Radiolabeled Nanohybrids Targeting Solid Tumor Neovasculature and Method of Using Same 审中-公开
标题翻译：靶向实体肿瘤新生血管的放射性标记纳米抗体及其使用方法
公开(公告)号：US20080193377A1
公开(公告)日：2008-08-14
申请号：US11571340
申请日：2005-06-28
申请人： Bruce R. Line , Beth Line , Hamidreza Ghandehari , Sergey Baklanov
发明人： Bruce R. Line , Beth Line , Hamidreza Ghandehari , Sergey Baklanov
IPC分类号： A61K51/06 , C07K7/64 , C07F19/00 , A61K51/00 , C07C233/09 , C07F13/00
CPC分类号： A61K51/065 , A61K51/082 , A61K51/088
摘要： Nanohybrid polymer conjugates that provide a “platform” delivery system is disclosed. The delivery platform provides a multi-focused therapeutic regimen that may be tailored to combat a host of cancers, including advanced-stage, therapy-resistant tumors. The nanohybrids of the instant invention incorporate a configurable polymeric backbone, are multivalent (e.g., may incorporate several targeting ligands), and have the capacity to carry multiple classes of “payloads” (e.g., alpha-, beta-, gamma- and positron-emitting isotopes). The polymer conjugates comprise a single molecular species that can be useful not only in diagnostic assessment, but also in tailoring therapies to suit a variety of cancers.
摘要翻译：公开了提供“平台”输送系统的纳米杂交聚合物共轭物。递送平台提供多重治疗方案，其可以针对大量癌症，包括晚期，耐药性肿瘤。本发明的纳米纤维结合了可配置的聚合物主链，是多价的（例如，可并入若干靶向配体），并具有承载多种类型的“有效载荷”的能力（例如，α，β，γ和正电子 - 发射同位素）。聚合物共轭物包括单一分子种类，其不仅可用于诊断评估，而且可用于适合各种癌症的定制疗法。

7. 发明申请

US20070098702A1 Recombinant protein polymer vectors for systemic gene delivery 审中-公开
标题翻译：用于全身基因递送的重组蛋白质聚合物载体
公开(公告)号：US20070098702A1
公开(公告)日：2007-05-03
申请号：US11357499
申请日：2006-02-17
申请人： Zaki Megeed , Arash Hatefi , Hamidreza Ghandehari
发明人： Zaki Megeed , Arash Hatefi , Hamidreza Ghandehari
IPC分类号： A61K48/00 , C12N15/82 , C12N15/74
CPC分类号： C12N15/87 , A61K48/00
摘要： The present invention relates to genetically engineered non-viral vectors for delivering a nucleic acid such as a therapeutic gene to a target cell. The vectors are suitable for systemic administration to an animal. In the simplest embodiment the non-viral vector is a nucleic acid-binding protein-based polymer (NABP) having at least one tandem repeat of a genetically engineered cationic amino acid-containing monomer (CAACM) containing lysine, arginine or a combination thereof, which confers on the NABP the ability to bind a nucleic acid that is intended for delivery to a target cell. Because the NABP is genetically engineered and transcribed from a single gene, its structure and function can be precisely controlled. The vectors optionally have additional functionalities including endosome disrupting moieties, targeting ligands and subcellular localization sequences.
摘要翻译：本发明涉及用于将核酸如治疗基因递送至靶细胞的遗传工程非病毒载体。载体适合于全身给予动物。在最简单的实施方案中，非病毒载体是具有含有赖氨酸，精氨酸或其组合的经遗传工程化的含阳离子氨基酸的单体（CAACM）的至少一个串联重复的基于核酸结合蛋白质的聚合物（NABP）其赋予NABP结合用于递送至靶细胞的核酸的能力。因为NABP是从单个基因进行遗传工程和转录的，所以其结构和功能可以被精确控制。载体任选具有额外的功能，包括内体破坏部分，靶向配体和亚细胞定位序列。

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