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31. 发明申请

WO1988005781A1 NOVEL ANDROST-4-ENE-3,17-DIONE DERIVATIVES AND PROCESS FOR THEIR PREPARATION 审中-公开
标题翻译：新型安慰剂4-ENE-3,17-Dione衍生物及其制备方法
公开(公告)号：WO1988005781A1
公开(公告)日：1988-08-11
申请号：PCT/JP1988000114
申请日：1988-02-05
申请人： SNOW BRAND MILK PRODUCTS CO., LTD. , YOSHIHAMA, Makoto , TAMURA, Koji , MIYATA, Nobuo , NAKAYAMA, Shoji , NAKAKOSHI, Masamichi
发明人： SNOW BRAND MILK PRODUCTS CO., LTD.
IPC分类号： C07J01/00
CPC分类号： C07J1/0011 , C12P33/06
摘要： Compounds of formula (I), wherein X represents =O or H(alpha)OR(beta), Y represents H2 or OH(alpha)H(beta), Z represents H or OH(alpha), and R represents H, COCH3, COCH2CH3, COCH(CH3)2 or COC(CH3)3, which are prepared by bringing androst-4-ene-3,17-dione into contact with microorganisms belonging to the genus Acremonium. These compounds are effective in inhibiting estrogen synthetase of human placenta origin.

32. 发明申请

WO1998007840A1 NOVEL DNAS AND PROCESS FOR PRODUCING PROTEINS BY USING THE SAME 审中-公开
标题翻译：用于生产蛋白质的新型DNA和方法
公开(公告)号：WO1998007840A1
公开(公告)日：1998-02-26
申请号：PCT/JP1997002859
申请日：1997-08-19
申请人： SNOW BRAND MILK PRODUCTS CO., LTD. , NAKAGAWA, Nobuaki , YASUDA, Hisataka , MORINAGA, Tomonori
发明人： SNOW BRAND MILK PRODUCTS CO., LTD.
IPC分类号： C12N15/00
CPC分类号： C07K14/52 , A61K38/00
摘要： DNAs represented by Sequence Listings (1 and 2) and a process for producing proteins which comprises inserting these DNAs into expression vectors to thereby produce proteins having molecular weights of about 60 kD (under reductive conditions) and about 60 kD and about 120 kD (under nonreductive conditions) and being capable of inhibiting the formation of osteoclasts. These proteins are useful in the treatment of osteoporosis and rheumatism.
摘要翻译：由序列表（1和2）表示的DNA和产生蛋白质的方法，其包括将这些DNA插入表达载体中，从而产生分子量为约60kD（还原条件）和约60kD和约120kD（下）的蛋白质非还原条件），并且能够抑制破骨细胞的形成。这些蛋白质可用于治疗骨质疏松症和风湿病。

33. 发明申请

WO1997041248A1 NOVEL ANTIBIOTICS RK-1061 AND PROCESS FOR PREPARING THE SAME 审中-公开
标题翻译：新型抗生素RK-1061及其制备方法
公开(公告)号：WO1997041248A1
公开(公告)日：1997-11-06
申请号：PCT/JP1997001466
申请日：1997-04-25
申请人： SNOW BRAND MILK PRODUCTS CO., LTD. , KIMURA, Ken-ichi , IKEDA, Yoshikazu , KAGAMI, Shinobu , TAKAHASHI, Hidetoshi , TAKAHASHI, Kousaku , YOSHIHAMA, Makoto , UBUKATA, Makoto , ISONO, Kiyoshi
发明人： SNOW BRAND MILK PRODUCTS CO., LTD.
IPC分类号： C12P17/16
CPC分类号： C07H19/06 , C12P19/385
摘要： Antibiotics RK-1061 having a novel chemical structure and a process for preparing the same. They have a structural formula represented by general formula (I) wherein A represents R1 or R1CH(OR2)CH2, R2 represents a 3-methylglutaric acid residue and R3 represents a sulfate group or a hydrogen atom. The process comprises culturing a ray fungus belonging to the genus Streptomyces and isolating RK-1061 from the culture. Streptomyces sp.SN-1061M (FERM BP-5800) is capable of stably producing RK-1061 at a high productivity.
摘要翻译：具有新化学结构的抗生素RK-1061及其制备方法。它们具有由通式（I）表示的结构式，其中A表示R 1或R 1CH（OR 2）CH 2，R 2表示3-甲基戊二酸残基，R 3表示硫酸基或氢原子。该方法包括培养属于链霉菌属的射线真菌，并从培养物中分离RK-1061。 Streptomyces sp.SN-1061M（FERM BP-5800）能够以高生产率稳定地生产RK-1061。

34. 发明申请

WO1997002832A1 LYOPHILIZED HGF PREPARATIONS 审中-公开
标题翻译： LYOPHILIZED HGF制剂
公开(公告)号：WO1997002832A1
公开(公告)日：1997-01-30
申请号：PCT/JP1996001898
申请日：1996-07-08
申请人： SNOW BRAND MILK PRODUCTS CO., LTD. , SUMITOMO PHARMACEUTICALS CO., LTD. , TANAKA, Katsumi , HIGASHIO, Kanji , KUMAZAWA, Eitaro
发明人： SNOW BRAND MILK PRODUCTS CO., LTD. , SUMITOMO PHARMACEUTICALS CO., LTD.
IPC分类号： A61K38/18
CPC分类号： A61K9/0019 , A61K9/19 , A61K38/1833 , A61K47/02 , A61K47/12 , A61K47/183 , A61K47/26 , A61K47/36
摘要： A lyophilized HGF preparation prepared by lyophilizing an aqueous HGF solution, and a lyophilized HGF preparation further containing a stabilizer, sodium chloride, a buffer and/or a surfactant, or other additive(s). The lyophilized preparations can stabilize HGF and enables long-term storage.
摘要翻译：通过冻干HGF水溶液制备的冻干HGF制剂和进一步含有稳定剂，氯化钠，缓冲液和/或表面活性剂或其它添加剂的冻干HGF制剂。冻干制剂可以稳定HGF并能长期保存。

35. 发明申请

WO1994019375A1 IRON-LACTOFERRIN COMBINATION AND PROCESS FOR PRODUCING THE SAME 审中-公开
标题翻译： IRON-LACTOFERRIN组合及其生产方法
公开(公告)号：WO1994019375A1
公开(公告)日：1994-09-01
申请号：PCT/JP1994000233
申请日：1994-02-16
申请人： SNOW BRAND MILK PRODUCTS CO., LTD. , DOSAKO, Shunichi , SAKURAI, Toshio , KOBAYASHI, Naomichi
发明人： SNOW BRAND MILK PRODUCTS CO., LTD.
IPC分类号： C07K15/14
CPC分类号： C07K14/79
摘要： A heat-resistant carbonate and/or bicarbonate-iron-lactoferrin combination wherein at least 15 iron molecules are bonded to one lactoferrin molecule via carbonate and/or bicarbonate. The production process comprises adding an alkali carbonate and/or bicarbonate to a solution containing a lactoferrin and an iron salt having a pH value of 4 or less when dissolved in water to thereby adjust the pH value to 7 or less, or adding a solution containing an iron salt and a lactoferrin to a solution containing a carbonate and/or bicarbonate, or adding an iron salt or a solution thereof to a solution containing a carbonate and/or a bicarbonate and further a lactoferrin. The combination has a high heat resistance and is useful as the starting material of food, drug, feed, cosmetic, and so forth.
摘要翻译：耐热碳酸盐和/或碳酸氢铁 - 铁 - 乳铁蛋白组合，其中至少15个铁分子通过碳酸盐和/或碳酸氢盐与一个乳铁蛋白分子结合。制备方法包括在溶解于水中时，向含有乳铁蛋白和pH值为4以下的铁盐的溶液中添加碱金属碳酸盐和/或碳酸氢盐，从而将pH值调节至7以下，或者添加含有将铁盐和乳铁蛋白加到含有碳酸盐和/或碳酸氢盐的溶液中，或将铁盐或其溶液加入到含有碳酸盐和/或碳酸氢盐的溶液中，再加入乳铁蛋白。该组合具有高耐热性，可用作食品，药物，饲料，化妆品等的原料。

36. 发明申请

WO1994014845A1 MODIFIED TCF 审中-公开
标题翻译：修改TCF
公开(公告)号：WO1994014845A1
公开(公告)日：1994-07-07
申请号：PCT/JP1993001905
申请日：1993-12-27
申请人： SNOW BRAND MILK PRODUCTS CO., LTD. , YAMAGUCHI, Kyoji , SHIMA, Nobuyuki , MURAKAMI, Akihiko , GOTO, Masaaki , TSUDA, Eisuke , MASUNAGA, Hiroaki , TAKAHIRA, Reiko , OOGAKI, Fumiko , UEDA, Masatsugu , HIGASHIO, Kanji
发明人： SNOW BRAND MILK PRODUCTS CO., LTD.
IPC分类号： C07K15/00
CPC分类号： C07K14/4753 , A61K38/00
摘要： Modified TCF in which amino-acid residue(s) of the wild-type TCF responsible for glycosylation is (are) substituted or deleted so that at least one N-linked oligosaccharide chain is removed. The modified TCF have longer biological half-lives without loss of its biological activities. The modified TCFs are therapeutically important as agents for liver diseases or as anti-cancer drugs.
摘要翻译：修饰的TCF，其中负责糖基化的野生型TCF的氨基酸残基被取代或缺失，使得至少一个N-连接的糖链被除去。改良型TCF具有较长的生物半衰期，不丧失生物活性。修饰的TCF作为肝脏疾病或抗癌药物具有治疗作用。

37. 发明申请

WO1993012807A1 BONE REINFORCING FACTOR, AND FOOD AND DRINK CONTAINING SAID FACTOR 审中-公开
标题翻译：骨质增强因子，食物和饮料含有因素
公开(公告)号：WO1993012807A1
公开(公告)日：1993-07-08
申请号：PCT/JP1992001699
申请日：1992-12-25
申请人： SNOW BRAND MILK PRODUCTS CO., LTD. , TAKADA, Yukihiro , KOBAYASHI, Naomichi , YAHIRO, Masatoshi
发明人： SNOW BRAND MILK PRODUCTS CO., LTD.
IPC分类号： A61K37/02
CPC分类号： C07K14/4705 , A61K38/00 , C07K14/51 , Y10S426/80 , Y10S426/807
摘要： An osteoblast growth promoting and bone reinforcing factor comprising either a precipitate prepared by adjusting the pH of whey or an aqueous solution of whey proteins to 2 to 6 and the concentration of ethanol to 10 % or above, or a water-soluble component prepared by dissolving the precipitate in water and having a molecular weight of 5,000-28,000 Da. The above factor having a molecular weight of 5,000-28,000 Da and an isoelectric point of 4 to 9 and obtained from a supernatant of heated whey or aqueous solution of whey proteins, a precipitate formed by treating the same with sodium chloride or a permeate formed by the ultrafiltration thereof. Food, medicine and feed containing the above factor and useful for preventing and treating osteoarthropathy.

38. 发明申请

WO1991019718A1 REVEROMYCIN A, PRODUCTION THEREOF, AND ANTITUMOR DRUG AND FUNGICIDE 审中-公开
标题翻译：抗生素A，其制造方法和抗真菌药物和杀真菌剂
公开(公告)号：WO1991019718A1
公开(公告)日：1991-12-26
申请号：PCT/JP1991000772
申请日：1991-06-07
申请人： RIKAGAKU KENKYUSHO , SNOW BRAND MILK PRODUCTS CO., LTD. , ISONO, Kiyoshi , OSADA, Hiroyuki , TAKAHASHI, Hidetoshi , KAWANISHI, Gosei
发明人： RIKAGAKU KENKYUSHO , SNOW BRAND MILK PRODUCTS CO., LTD.
IPC分类号： C07D493/10
CPC分类号： C07D493/10 , C12P17/181
摘要： A novel antibiotic reveromycin A of structural formula (I), which is useful because it has antitumor and fungicidal activities. The production process comprises culturing a streptomyces which produces an antibiotic reveromycin A, i.e., Streptomyces sp. SN-593, and isolating the produced reveromycin A from the culture product.

39. 发明申请

WO1988008006A1 PROCESS FOR SEPARATING AND PURIFYING LACTOFERRIN FROM MILK USING SULFATE COMPOUND 审中-公开
标题翻译：使用硫酸盐化合物从乳汁中分离和纯化LACTOFERRIN的方法
公开(公告)号：WO1988008006A1
公开(公告)日：1988-10-20
申请号：PCT/JP1988000353
申请日：1988-04-07
申请人： SNOW BRAND MILK PRODUCTS CO., LTD. , KAWAKAMI, Hiroshi , TANIMOTO, Morimasa , DOUSAKO, Shunichi
发明人： SNOW BRAND MILK PRODUCTS CO., LTD.
IPC分类号： C07K15/22
CPC分类号： C07K14/79 , Y10S530/832
摘要： A process for separating and purifying lactoferrin from milk using a sulfate compound, which comprises adsorbing a sulfate compound of a polysaccharide by lactoferrin-containing raw milk and eluting the adsorbed lactoferrin. The elution of the adsorbed lactoferrin is preferably conducted using a buffer containing 0.4 to 1.5 M common salt.

40. 发明申请

WO1988005782A1 NOVEL 7'beta'-HYDROXY-4-PREGNENE-3,20-DIONE DERIVATIVES AND PROCESS FOR THEIR PREPARATION 审中-公开
标题翻译：新型7（BETA） - 羟基-4-丙氨酸-3,20-二酮衍生物及其制备方法
公开(公告)号：WO1988005782A1
公开(公告)日：1988-08-11
申请号：PCT/JP1988000115
申请日：1988-02-05
申请人： SNOW BRAND MILK PRODUCTS CO., LTD. , YOSHIHAMA, Makoto , TAMURA, Koji , MIYATA, Nobuo , NAKAKOSHI, Masamichi
发明人： SNOW BRAND MILK PRODUCTS CO., LTD.
IPC分类号： C07J07/00
CPC分类号： C12P33/06 , C07J7/002 , C07J7/0045
摘要： Compounds of formula (I), wherein X represents =O or H(alpha)OH(beta), and Y represents H(alpha) or OH(alpha), which are prepared by bringing 4-pregnene-3,20-dione into contact with microorganisms belonging to the genus Acremonium. These compounds possess an activity of inducing cell differentiation.

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