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1. 发明申请

WO1997041248A1 NOVEL ANTIBIOTICS RK-1061 AND PROCESS FOR PREPARING THE SAME 审中-公开
标题翻译：新型抗生素RK-1061及其制备方法
公开(公告)号：WO1997041248A1
公开(公告)日：1997-11-06
申请号：PCT/JP1997001466
申请日：1997-04-25
申请人： SNOW BRAND MILK PRODUCTS CO., LTD. , KIMURA, Ken-ichi , IKEDA, Yoshikazu , KAGAMI, Shinobu , TAKAHASHI, Hidetoshi , TAKAHASHI, Kousaku , YOSHIHAMA, Makoto , UBUKATA, Makoto , ISONO, Kiyoshi
发明人： SNOW BRAND MILK PRODUCTS CO., LTD.
IPC分类号： C12P17/16
CPC分类号： C07H19/06 , C12P19/385
摘要： Antibiotics RK-1061 having a novel chemical structure and a process for preparing the same. They have a structural formula represented by general formula (I) wherein A represents R1 or R1CH(OR2)CH2, R2 represents a 3-methylglutaric acid residue and R3 represents a sulfate group or a hydrogen atom. The process comprises culturing a ray fungus belonging to the genus Streptomyces and isolating RK-1061 from the culture. Streptomyces sp.SN-1061M (FERM BP-5800) is capable of stably producing RK-1061 at a high productivity.
摘要翻译：具有新化学结构的抗生素RK-1061及其制备方法。它们具有由通式（I）表示的结构式，其中A表示R 1或R 1CH（OR 2）CH 2，R 2表示3-甲基戊二酸残基，R 3表示硫酸基或氢原子。该方法包括培养属于链霉菌属的射线真菌，并从培养物中分离RK-1061。 Streptomyces sp.SN-1061M（FERM BP-5800）能够以高生产率稳定地生产RK-1061。

2. 发明申请

WO1988005782A1 NOVEL 7'beta'-HYDROXY-4-PREGNENE-3,20-DIONE DERIVATIVES AND PROCESS FOR THEIR PREPARATION 审中-公开
标题翻译：新型7（BETA） - 羟基-4-丙氨酸-3,20-二酮衍生物及其制备方法
公开(公告)号：WO1988005782A1
公开(公告)日：1988-08-11
申请号：PCT/JP1988000115
申请日：1988-02-05
申请人： SNOW BRAND MILK PRODUCTS CO., LTD. , YOSHIHAMA, Makoto , TAMURA, Koji , MIYATA, Nobuo , NAKAKOSHI, Masamichi
发明人： SNOW BRAND MILK PRODUCTS CO., LTD.
IPC分类号： C07J07/00
CPC分类号： C12P33/06 , C07J7/002 , C07J7/0045
摘要： Compounds of formula (I), wherein X represents =O or H(alpha)OH(beta), and Y represents H(alpha) or OH(alpha), which are prepared by bringing 4-pregnene-3,20-dione into contact with microorganisms belonging to the genus Acremonium. These compounds possess an activity of inducing cell differentiation.

3. 发明申请

WO1995015398A1 METHOD OF EXAMINING HORMONE-DEPENDENT TUMOR 审中-公开
标题翻译：检查激素依赖性肿瘤的方法
公开(公告)号：WO1995015398A1
公开(公告)日：1995-06-08
申请号：PCT/JP1994000779
申请日：1994-05-13
申请人： SNOW BRAND MILK PRODUCTS CO., LTD. , NAKAMURA, Junji , YOSHIHAMA, Makoto
发明人： SNOW BRAND MILK PRODUCTS CO., LTD.
IPC分类号： C12Q01/25
CPC分类号： G01N33/57407 , C12Q1/25 , G01N33/743
摘要： A method of examining hormone-dependent tumors which comprises culturing tumor tissues in each of (a) a medium, (b) a medium containing a hormone synthetase substrate, and (c) a medium containing both a hormone synthetase substrate and a hormone synthetase inhibitor, measuring the growth rate of tumor cells in each medium, determining (i) the ratio of the growth rate of tumor cells in the presence of a hormone synthetase substrate to that in a medium alone and (ii) the ratio of the growth rate of tumor cells in the presence of both a hormone synthetase substrate and a hormone synthetase inhibitor to that in a medium alone. This method enables judging whether there are any hormone synthetase and hormone-dependent growth of hormone-dependent tumors readily at the same time. Further it can be employed for developing a new method of classifying tumors and selecting a guide line for tumor therapy.
摘要翻译：一种检查激素依赖性肿瘤的方法，包括在（a）培养基，（b）含有激素合成酶底物的培养基中培养肿瘤组织，和（c）含有激素合成酶底物和激素合成酶抑制剂的培养基测量每个培养基中肿瘤细胞的生长速率，确定（i）在激素合成酶底物存在下肿瘤细胞的生长速率与单独培养基中肿瘤细胞的生长速率的比例，以及（ii）在激素合成酶底物和激素合成酶抑制剂存在的情况下，肿瘤细胞与单独的培养基相同。该方法能够同时判断激素依赖性肿瘤是否具有激素合成酶和激素依赖性生长。此外，它可用于开发一种新的肿瘤分类方法和选择肿瘤治疗的指导线。

4. 发明申请

WO1993000361A1 NOVEL PROLYL ENDOPEPTIDASE INHIBITORS SNA-115 AND SNA-115T, PRODUCTION THEREOF, AND STRAIN WHICH PRODUCES SAID INHIBITORS 审中-公开
标题翻译：新型内切酶抑制剂SNA-115和SNA-115T，其生产和生产所述抑制剂的菌株
公开(公告)号：WO1993000361A1
公开(公告)日：1993-01-07
申请号：PCT/JP1992000784
申请日：1992-06-19
申请人： SNOW BRAND MILK PRODUCTS CO., LTD. , KIMURA, Kenichi , KANOU, Fumiko , TAKAHASHI, Hidetoshi , KUROSAWA, Kazuhiko , YOSHIHAMA, Makoto
发明人： SNOW BRAND MILK PRODUCTS CO., LTD.
IPC分类号： C07K07/54
CPC分类号： C07K7/56 , A61K38/00
摘要： A prolyl endopeptidase inhibitor SNA-115, which is a peptide represented by C113H142N26O27. An SNA-115 producing bacterium belonging to Microbispora sp. A process for producing SNA-115 by culturing the SNA-115 producing bacterium. A prolyl endopeptidase inhibitor SNA-115T, which is a peptide represented by C113H144N26O28 and produced by hydrolyzing SNA-115 with trypsin. SNA-115 and SNA-115T have a prolyl endopeptidase inhibiting activity and are useful as an active ingredient for preventing and treating amnesia, acquired immunodeficiency syndrome (AIDS) and HIV diseases.

5. 发明申请

WO1988005781A1 NOVEL ANDROST-4-ENE-3,17-DIONE DERIVATIVES AND PROCESS FOR THEIR PREPARATION 审中-公开
标题翻译：新型安慰剂4-ENE-3,17-Dione衍生物及其制备方法
公开(公告)号：WO1988005781A1
公开(公告)日：1988-08-11
申请号：PCT/JP1988000114
申请日：1988-02-05
申请人： SNOW BRAND MILK PRODUCTS CO., LTD. , YOSHIHAMA, Makoto , TAMURA, Koji , MIYATA, Nobuo , NAKAYAMA, Shoji , NAKAKOSHI, Masamichi
发明人： SNOW BRAND MILK PRODUCTS CO., LTD.
IPC分类号： C07J01/00
CPC分类号： C07J1/0011 , C12P33/06
摘要： Compounds of formula (I), wherein X represents =O or H(alpha)OR(beta), Y represents H2 or OH(alpha)H(beta), Z represents H or OH(alpha), and R represents H, COCH3, COCH2CH3, COCH(CH3)2 or COC(CH3)3, which are prepared by bringing androst-4-ene-3,17-dione into contact with microorganisms belonging to the genus Acremonium. These compounds are effective in inhibiting estrogen synthetase of human placenta origin.

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