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21. 发明专利

AT259056T 未知
公开(公告)号：AT259056T
公开(公告)日：2004-02-15
申请号：AT97946893
申请日：1997-11-06
申请人： SEQUENOM INC
发明人： O'DONNELL MARYANNE J , CANTOR CHARLES R , LITTLE DANIEL P , KOSTER HUBERT
IPC分类号： G01N27/62 , B01J19/00 , B01L3/02 , C07B61/00 , C07F9/24 , C07H21/00 , C12M1/00 , C12N15/09 , C12Q1/68 , C40B40/06 , C40B40/10 , C40B60/14 , G01N33/53 , G01N33/566 , G01N35/00 , G01N35/10 , G01N37/00 , G01N1/00
摘要： The invention provides a method for analyzing a material, comprising: providing a vesicle suitable for carrying a fluid having said material therein, disposing said vesicle adjacent a first location of a surface of a substrate, controlling said vesicle to deliver a nanoliter volume of the fluid to provide a defined and controlled volume of said fluid at said first location of said surface of the substrate, moving said vesicle to a second position adjacent a second location on said surface of the substrate to dispense a defined and controlled volume of said material along an array of locations on said substrate surface, and performing mass spectrometry analysis for said material at each location of said array.

22. 发明专利

AU745624B2 High density immobilization of nucleic acids 未知
公开(公告)号：AU745624B2
公开(公告)日：2002-03-28
申请号：AU5198098
申请日：1997-11-06
申请人： SEQUENOM INC
发明人： O'DONNELL MARYANNE J , CANTOR CHARLES R , LITTLE DANIEL P , KOSTER HUBERT
IPC分类号： G01N27/62 , B01J19/00 , B01L3/02 , C07B61/00 , C07F9/24 , C07H21/00 , C12M1/00 , C12N15/09 , C12Q1/68 , C40B40/06 , C40B40/10 , C40B60/14 , G01N33/53 , G01N33/566 , G01N35/00 , G01N35/10 , G01N37/00

23. 发明专利

AU9134501A High density immobilization of nucleic acids 未知
公开(公告)号：AU9134501A
公开(公告)日：2002-01-03
申请号：AU9134501
申请日：2001-11-14
申请人： SEQUENOM INC
发明人： O'DONNELL MARYANNE , KOSTER HUBERT , LITTLE DANIEL P , CANTOR CHARLES R
IPC分类号： B01J19/00 , C07H21/00 , C12Q1/68

24. 发明专利

AU6960300A DNA diagnostics based on mass spectrometry 未知
公开(公告)号：AU6960300A
公开(公告)日：2001-02-08
申请号：AU6960300
申请日：2000-10-27
申请人： SEQUENOM INC
发明人： KOSTER HUBERT , BRAUN ANDREAS , HIGGINS G SCOTT , LITTLE DANIEL P
IPC分类号： C12Q1/68

25. 发明专利

AU722218B2 DNA diagnostics based on mass spectrometry 未知
公开(公告)号：AU722218B2
公开(公告)日：2000-07-27
申请号：AU5365196
申请日：1996-03-18
申请人： SEQUENOM INC
发明人： KOSTER HUBERT , TANG KAI , FU DONG-JING , SIEGIRT CARSTEN W , LITTLE DANIEL P , HIGGINS G SCOTT , BRAUN ANDREAS , DARNHOFER-DEMAR BRIGITTE , JURINKE CHRISTIAN
IPC分类号： G01N27/62 , C12N15/09 , C12Q1/68 , C12Q1/70 , G01N33/50 , G01N35/10 , G01N30/72 , H01J49/00
摘要： The invention provides fast and highly accurate mass spectrometer based processes for detecting a particular nucleic acid sequence in a biological sample. Depending on the sequence to be detected, the processes can be used, for example, to diagnose a genetic disease or chromosomal abnormality; a predisposition to a disease or condition, infection by a pathogenic organism, or for determining identity or heredity.

26. 发明专利

CA2214359A1 DNA DIAGNOSTICS BASED ON MASS SPECTROMETRY 未知
公开(公告)号：CA2214359A1
公开(公告)日：1996-09-26
申请号：CA2214359
申请日：1996-03-18
申请人： SEQUENOM INC
发明人： TANG KAI , LITTLE DANIEL P , FU DONG-JING , HIGGINS G SCOTT , BRAUN ANDREAS , JURINKE CHRISTIAN , K STER HUBERT , SIEGIRT CARSTEN W , DARNOFER-DEMAR BRIGITTE
IPC分类号： G01N27/62 , C12N15/09 , C12Q1/68 , C12Q1/70 , G01N33/50 , G01N35/10
摘要： The invention provides fast and highly accurate mass spectrometer based processes for detecting a particular nucleic acid sequence in a biological sample. Depending on the sequence to be detected, the processes can be used, for example, to diagnose a genetic disease or chromosomal abnormality; a predisposition to a disease or condition, infection by a pathogenic organism, or for determining identity or heredity.

27. 发明专利

CA2702219C HIGH DENSITY IMMOBILIZATION OF NUCLEIC ACIDS 未知
公开(公告)号：CA2702219C
公开(公告)日：2013-01-08
申请号：CA2702219
申请日：1997-11-06
申请人： SEQUENOM INC
发明人： O'DONNELL MARYANNE J , CANTOR CHARLES R , LITTLE DANIEL P , KOSTER HUBERT
IPC分类号： C40B50/14 , G01N27/62 , B01J19/00 , B01L3/02 , C07B61/00 , C07F9/24 , C07H21/00 , C12M1/00 , C12N15/09 , C12Q1/68 , C40B40/00 , C40B40/06 , C40B40/10 , C40B60/14 , G01N33/53 , G01N33/566 , G01N35/00 , G01N35/10 , G01N37/00
摘要： Processes and kits for immobilizing a high density of nucleic acids on an insoluble surface, which are particularly useful for mass spectrometric detection of nucleic acids, are disclosed. Arrays containing the immobilized nucleic acids and use of the immobilized nucleic acids in a variety of solid phase nucleic acid chemistry applications, including nucleic acid synthesis (chemical and enzymatic), hybridization and/or extension, and sequencing, are provided. Serial and parallel dispensing tools that can deliver defined volumes of fluid to generate multi-element arrays of sample material on a substrate surface are further provided. Tools provided herein can include an assembly of vesicle elements, or pins, wherein each of the pins can include a narrow interior chamber suitable for holding nanoliter volumes of fluid. Methods for dispensing tools that can be employed to generate multi-element arrays of sample material on a substrate surface are also provided. The tool can dispense a spot of fluid to a substrate surface by spraying the fluid from the pin, contacting the substrate surface or forming a drop that touches against the substrate surface. The tool can form an array of sample material by dispensing sample material in a series of steps, while moving the pin to different locations above the substrate surface to form the sample array. The prepared sample arrays may be passed to a plate assembly that disposes the sample arrays for analysis by mass spectrometry.

28. 发明专利

AT433112T 未知
公开(公告)号：AT433112T
公开(公告)日：2009-06-15
申请号：AT02025544
申请日：1998-09-02
申请人： SEQUENOM INC
发明人： HIGGINS SCOTT , KOESTER HUBERT , LITTLE DANIEL P , LOUGH DAVID
IPC分类号： G01N27/62 , G01N33/68 , G01N33/58
摘要： A process for determining the identity of a target polypeptide using mass spectroscopy is provided. Depending on the target polypeptide to be identified, a process as disclosed can be used, for example, to diagnose a genetic disease or chromosomal abnormality, a predisposition to a disease or condition, or infection by a pathogenic organism; or for determining identity or heredity.

29. 发明专利

DE69738206D1 未知
公开(公告)号：DE69738206D1
公开(公告)日：2007-11-22
申请号：DE69738206
申请日：1997-11-06
申请人： SEQUENOM INC
发明人： KOESTER HUBERT , LITTLE DANIEL P , BRAUN ANDREAS , JURINKE CHRISTIAN , VAN DEN BOOM DIRK , XIANG GUOBING , LOUGH DAVID M , RUPPERT ANDREAS , HILLENKAMP FRANZ
IPC分类号： C12Q1/68 , B01J19/00 , B01L3/02 , C07B61/00 , C07F9/24 , C07H21/00 , C40B40/06 , C40B40/10 , C40B60/14 , G01N35/00 , G01N35/10
摘要： Fast and highly accurate mass spectrometry-based processes for detecting a particular nucleic acid sequence in a biological sample are provided. Depending on the sequence to be detected, the processed can be used, for example, to diagnose a genetic disease or chromosomal abnormality; a predisposition to a disease or condition, infection by a pathogenic organism, or for determining identity or heredity. A method and apparatus for creating multiple branch wells from a parent well is disclosed. A multiple branching sub is provided for placement at a branching node of a well. Such sub includes a branching chamber and a plurality of branching outlet members. The outlet members during construction of the branching sub, have previously been distorted into oblong shapes so that all of the branching outlet members fit within an imaginary cylinder which is coaxial with and substantially the same radius as the branching chamber. After deployment of the branching sub via a parent casing in the well, a forming tool is lowered to the interior of the sub. The outlet members are extended outwardly by the forming tool and simultaneously formed into substantially round tubes. Next, each outlet member is plugged with cement, after which each branch well is drilled through a respective outlet member. If desired, each branch may be lined with casing and sealed to a branching outlet by means of a casing hanger. A manifold placed in the branching chamber controls the production of each branch well to the parent well.

30. 发明专利

DE69735112D1 未知
公开(公告)号：DE69735112D1
公开(公告)日：2006-04-06
申请号：DE69735112
申请日：1997-11-06
申请人： SEQUENOM INC
发明人： O'DONNELL MARYANNE J , LITTLE DANIEL P , CANTOR CHARLES R , KOESTER HUBERT
IPC分类号： C07H21/00 , B01J19/00 , G01N27/62 , B01L3/02 , C07B61/00 , C07F9/24 , C12M1/00 , C12N15/09 , C12Q1/68 , C40B40/06 , C40B40/10 , C40B60/14 , G01N33/53 , G01N33/566 , G01N35/00 , G01N35/10 , G01N37/00
摘要： The invention provides a method for analyzing a material, comprising: providing a vesicle suitable for carrying a fluid having said material therein, disposing said vesicle adjacent a first location of a surface of a substrate, controlling said vesicle to deliver a nanoliter volume of the fluid to provide a defined and controlled volume of said fluid at said first location of said surface of the substrate, moving said vesicle to a second position adjacent a second location on said surface of the substrate to dispense a defined and controlled volume of said material along an array of locations on said substrate surface, and performing mass spectrometry analysis for said material at each location of said array.

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