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1. 发明专利

DE69836488D1 未知
公开(公告)号：DE69836488D1
公开(公告)日：2007-01-04
申请号：DE69836488
申请日：1998-09-02
申请人： SEQUENOM INC
发明人： LITTLE DANIEL , KOESTER HUBERT , HIGGINS SCOTT , LOUGH DAVID
IPC分类号： G01N27/62 , G01N33/68
摘要： A process for determining the identity of a target polypeptide using mass spectroscopy is provided. Depending on the target polypeptide to be identified, a process as disclosed can be used, for example, to diagnose a genetic disease or chromosomal abnormality, a predisposition to a disease or condition, or infection by a pathogenic organism; or for determining identity or heredity.

2. 发明专利

AT433112T 未知
公开(公告)号：AT433112T
公开(公告)日：2009-06-15
申请号：AT02025544
申请日：1998-09-02
申请人： SEQUENOM INC
发明人： HIGGINS SCOTT , KOESTER HUBERT , LITTLE DANIEL P , LOUGH DAVID
IPC分类号： G01N27/62 , G01N33/68 , G01N33/58
摘要： A process for determining the identity of a target polypeptide using mass spectroscopy is provided. Depending on the target polypeptide to be identified, a process as disclosed can be used, for example, to diagnose a genetic disease or chromosomal abnormality, a predisposition to a disease or condition, or infection by a pathogenic organism; or for determining identity or heredity.

3. 发明专利

CA2237946A1 METHOD AND APPARATUS FOR MALDI ANALYSIS 未知
公开(公告)号：CA2237946A1
公开(公告)日：1998-03-26
申请号：CA2237946
申请日：1997-09-19
申请人： SEQUENOM INC
发明人： HIGGINS SCOTT , HILLENKAMP FRANZ , REUTER DIRK , LOUGH DAVID M
IPC分类号： G01N27/62 , B01D59/44 , C40B60/14 , G01N27/64 , H01J49/00 , H01J49/04 , H01J49/10 , H01J49/16
摘要： Matrix assisted laser desorption/ionization is performed in a manner to thermalize large analyte ions in a plume of desorbed material for spectroscopic analysis. The thermalized ions have a low or zero mean velocity and are presented at a well-defined instant in time, reducing artifacts and sharpening the spectral peaks. In one embodiment the light is delivered to a matrix or sample holder having a cover, baffle or compartment. The baffle or compartment impedes or contains a plume of desorbed material and the analyte undergoes collisions to lower its mean velocity and directionality. Thus "thermalized", the analyte ions are passed to a mass analysis instrument. In a preferred embodiment, an optical fiber butts up against a thin transparent plate on which the specimen resides, with the matrix side in a vacuum acceleration chamber. A mechanical stage moves the specimen in both the x- and y-directions to select a point on the specimen which is to receive the radiation. The use of a fiber optic illuminator allows the entire stage assembly to be subsumed essentially within the dimensions of a conventional stage.

4. 发明专利

DE69840878D1 未知
公开(公告)号：DE69840878D1
公开(公告)日：2009-07-16
申请号：DE69840878
申请日：1998-09-02
申请人： SEQUENOM INC
发明人： HIGGINS SCOTT , KOESTER HUBERT , LITTLE DANIEL P , LOUGH DAVID
IPC分类号： G01N27/62 , G01N33/68 , G01N33/58
摘要： A process for determining the identity of a target polypeptide using mass spectroscopy is provided. Depending on the target polypeptide to be identified, a process as disclosed can be used, for example, to diagnose a genetic disease or chromosomal abnormality, a predisposition to a disease or condition, or infection by a pathogenic organism; or for determining identity or heredity.

5. 发明专利

CA2237946C METHOD AND APPARATUS FOR MALDI ANALYSIS 未知
公开(公告)号：CA2237946C
公开(公告)日：2003-06-17
申请号：CA2237946
申请日：1997-09-19
申请人： SEQUENOM INC
发明人： LOUGH DAVID M , HIGGINS SCOTT , REUTER DIRK , HILLENKAMP FRANZ
IPC分类号： G01N27/62 , B01D59/44 , C40B60/14 , G01N27/64 , H01J49/00 , H01J49/04 , H01J49/10 , H01J49/16
摘要： Matrix assisted laser desorption/ionization is performed in a manner to thermalize large analyte ions in a plume of desorbed material for spectroscopic analysis. The thermalized ions have a low or zero mean velocit y and are presented at a well-defined instant in time, reducing artifacts and sharpening the spectral peaks. In one embodiment the light is delivered to a matrix or sample holder having a cover, baffle or compartment. The baffle or compartment impedes or contains a plume of desorbed material and the analyte undergoes collisions to lower its mean velocity and directionality. Thus "thermalized", the analyte ions are passed to a mass analysis instrument. In a preferred embodiment, an optical fiber butts up against a thin transparent plate on which the specimen resides, with the matrix side in a vacuum acceleration chamber. A mechanical stage moves the specimen in both the x- a nd y-directions to select a point on the specimen which is to receive the radiation. The use of a fiber optic illuminator allows the entire stage assembly to be subsumed essentially within the dimensions of a conventional stage.

6. 发明专利

AU724884B2 Method and apparatus for maldi analysis 未知
公开(公告)号：AU724884B2
公开(公告)日：2000-10-05
申请号：AU4342397
申请日：1997-09-19
申请人： SEQUENOM INC
发明人： HILLENKAMP FRANZ , HIGGINS SCOTT , LOUGH DAVID M , REUTER DIRK
IPC分类号： G01N27/62 , B01D59/44 , C40B60/14 , G01N27/64 , H01J49/00 , H01J49/04 , H01J49/10 , H01J49/16
摘要： Matrix assisted laser desorption/ionization is performed in a manner to thermalize large analyte ions in a plume of desorbed material for spectroscopic analysis. The thermalized ions have a low or zero mean velocity and are presented at a well-defined instant in time, reducing artifacts and sharpening the spectral peaks. In one embodiment the light is delivered to a matrix or sample holder having a cover, baffle or compartment. The baffle or compartment impedes or contains a plume of desorbed material and the analyte undergoes collisions to lower its mean velocity and directionality. Thus "thermalized" the analyte ions are passed to a mass analysis instrument. In a preferred embodiment an optical fiber butts up against a thin transparent plate on which the specimen resides, with the matrix side in a vacuum acceleration chamber. A mechanical stage moves the specimen in both the x- and y- directions to select a point on the specimen which is to receive the radiation. The use of a fiber optic illuminator allows the entire stage assembly to be subsumed essentially within the dimensions of a conventional stage. In other embodiments, a thermalizing compartment is provided in a capillary tube about the end of the illumination fiber and the sample matrix is deposited along the inner cylindrical wall of the tube, so the capillary forms a migration path to the outlet for thermalization of the desorbed analyte. In other embodiments microstructures having the shape of a small lean-to, overhang or perforated cover plate, or providing a high aspect surface texture, provide the necessary containment to promote thermalization of the released analyte. A thin layer or cover of fibrous or permeable material may also be used to thermalize the analyte before mass analysis, and in another embodiment this material may also act as the substrate. An automated instrument may include a fixed array of illumination fibers which are illuminated at different times to eject samples from a corresponding array of points on the specimen.

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