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3. 发明专利

AU1918799A Mass spectrometric methods for sequencing nucleic acids 未知
公开(公告)号：AU1918799A
公开(公告)日：1999-07-05
申请号：AU1918799
申请日：1998-12-15
申请人： SEQUENOM INC , KOREA ADVANCED INST SCI & TECH , DONNELL MARYANNE J O
发明人： O'DONNELL MARYANNE J , KANG CHANGWON , KWON YOUNG-SOO , KIM YOUNG TAE , KOSTER HUBERT , LITTLE DANIEL P , XIANG GUOBING , LOUGH DAVID M , CANTOR CHARLES
IPC分类号： C12N15/09 , C12Q1/68 , C40B40/06 , C40B60/14
摘要： A mass spectrometric method for sequencing nucleic acids using RNA polymerases, including DNA-dependent and RNA-dependent RNA polymerases, is provided. The methods use a modified Sanger sequencing strategy in which RNA polymerase is used to generate a set of nested RNA transcripts obtained by base-specific chain termination. These are analyzed by mass spectrometry. A method of identifying transcriptional terminator sequences or attenuator sequences is also provided.

4. 发明专利

CA2270132A1 DNA DIAGNOSTICS BASED ON MASS SPECTROMETRY 未知
公开(公告)号：CA2270132A1
公开(公告)日：1998-05-14
申请号：CA2270132
申请日：1997-11-06
申请人： SEQUENOM INC
发明人： VAN DEN BOOM DIRK , KOESTER HUBERT , JURINKE CHRISTIAN , LITTLE DANIEL P , RUPPERT ANDREAS , XIANG GUOBING , LOUGH DAVID M , BRAUN ANDREAS
IPC分类号： B01J19/00 , B01L3/02 , C07B61/00 , C07F9/24 , C07H21/00 , C12Q1/68 , C40B40/06 , C40B40/10 , C40B60/14 , G01N35/00 , G01N35/10
摘要： Fast and highly accurate mass spectrometry-based processes for detecting a particular nucleic acid sequence in a biological sample are provided. Depending on the sequence to be detected, the processes can be used, for example, to diagnose a genetic disease or chromosomal abnormality; a predisposition to a disease or condition, infection by a pathogenic organism, or for determining identity or heredity.

5. 发明专利

DE69738206D1 未知
公开(公告)号：DE69738206D1
公开(公告)日：2007-11-22
申请号：DE69738206
申请日：1997-11-06
申请人： SEQUENOM INC
发明人： KOESTER HUBERT , LITTLE DANIEL P , BRAUN ANDREAS , JURINKE CHRISTIAN , VAN DEN BOOM DIRK , XIANG GUOBING , LOUGH DAVID M , RUPPERT ANDREAS , HILLENKAMP FRANZ
IPC分类号： C12Q1/68 , B01J19/00 , B01L3/02 , C07B61/00 , C07F9/24 , C07H21/00 , C40B40/06 , C40B40/10 , C40B60/14 , G01N35/00 , G01N35/10
摘要： Fast and highly accurate mass spectrometry-based processes for detecting a particular nucleic acid sequence in a biological sample are provided. Depending on the sequence to be detected, the processed can be used, for example, to diagnose a genetic disease or chromosomal abnormality; a predisposition to a disease or condition, infection by a pathogenic organism, or for determining identity or heredity. A method and apparatus for creating multiple branch wells from a parent well is disclosed. A multiple branching sub is provided for placement at a branching node of a well. Such sub includes a branching chamber and a plurality of branching outlet members. The outlet members during construction of the branching sub, have previously been distorted into oblong shapes so that all of the branching outlet members fit within an imaginary cylinder which is coaxial with and substantially the same radius as the branching chamber. After deployment of the branching sub via a parent casing in the well, a forming tool is lowered to the interior of the sub. The outlet members are extended outwardly by the forming tool and simultaneously formed into substantially round tubes. Next, each outlet member is plugged with cement, after which each branch well is drilled through a respective outlet member. If desired, each branch may be lined with casing and sealed to a branching outlet by means of a casing hanger. A manifold placed in the branching chamber controls the production of each branch well to the parent well.

6. 发明专利

DE69820111D1 未知
公开(公告)号：DE69820111D1
公开(公告)日：2004-01-08
申请号：DE69820111
申请日：1998-12-15
申请人： SEQUENOM INC , KOREA ADVANCED INST SCI & TECH
发明人： O'DONNELL MARYANNE J , KANG CHANGWON , KWON YOUNG-SOO , KIM YOUNG TAE , KOESTER HUBERT , LITTLE P , XIANG GUOBING , LOUGH DAVID M , CANTOR CHARLES
IPC分类号： C12N15/09 , C12Q1/68 , C40B40/06 , C40B60/14
摘要： A mass spectrometric method for sequencing nucleic acids using RNA polymerases, including DNA-dependent and RNA-dependent RNA polymerases, is provided. The methods use a modified Sanger sequencing strategy in which RNA polymerase is used to generate a set of nested RNA transcripts obtained by base-specific chain termination. These are analyzed by mass spectrometry. A method of identifying transcriptional terminator sequences or attenuator sequences is also provided.

7. 发明专利

AT255168T 未知
公开(公告)号：AT255168T
公开(公告)日：2003-12-15
申请号：AT98963969
申请日：1998-12-15
申请人： SEQUENOM INC , KOREA ADVANCED INST SCI & TECH
发明人： O'DONNELL MARYANNE J , KANG CHANGWON , KWON YOUNG-SOO , KIM YOUNG TAE , KOESTER HUBERT , LITTLE DANIEL P , XIANG GUOBING , LOUGH DAVID M , CANTOR CHARLES
IPC分类号： C12N15/09 , C12Q1/68 , C40B40/06 , C40B60/14
摘要： A mass spectrometric method for sequencing nucleic acids using RNA polymerases, including DNA-dependent and RNA-dependent RNA polymerases, is provided. The methods use a modified Sanger sequencing strategy in which RNA polymerase is used to generate a set of nested RNA transcripts obtained by base-specific chain termination. These are analyzed by mass spectrometry. A method of identifying transcriptional terminator sequences or attenuator sequences is also provided.

8. 发明专利

AU7613101A DNA diagnostics based on mass spectrometry 未知
公开(公告)号：AU7613101A
公开(公告)日：2002-01-03
申请号：AU7613101
申请日：2001-09-27
申请人： SEQUENOM INC
发明人： KOSTER HUBERT , LITTLE DANIEL P , BRAUN ANDREAS , LOUGH DAVID M , XIANG GUOBING , BOOM DIRK VAN DEN , JURINKE CHRISTIAN
IPC分类号： C07H21/02 , C12N15/11 , C12Q1/68 , H01J49/34 , H01J49/40

9. 发明专利

NO20003058L 未知
公开(公告)号：NO20003058L
公开(公告)日：2000-08-15
申请号：NO20003058
申请日：2000-06-14
申请人： SEQUENOM INC , KOREA ADVANCED INST SCI & TECH
发明人： KOESTER HUBERT , LOUGH DAVID M , O'DONNELL MARYANNE J , CANTOR CHARLES R , KANG CHANGWON , KWON YOUNG-SOO , KIM YOUNG-TAE , LITTLE DANIEL P , XIANG GUOBING
IPC分类号： C12N15/09 , C12Q1/68 , C40B40/06 , C40B60/14
摘要： A mass spectrometric method for sequencing nucleic acids using RNA polymerases, including DNA-dependent and RNA-dependent RNA polymerases, is provided. The methods use a modified Sanger sequencing strategy in which RNA polymerase is used to generate a set of nested RNA transcripts obtained by base-specific chain termination. These are analyzed by mass spectrometry. A method of identifying transcriptional terminator sequences or attenuator sequences is also provided.

10. 发明专利

CA2314906A1 MASS SPECTROMETRIC METHODS FOR SEQUENCING NUCLEIC ACIDS 未知
公开(公告)号：CA2314906A1
公开(公告)日：1999-06-24
申请号：CA2314906
申请日：1998-12-15
申请人： KOREA ADVANCED INST SCI & TECH , SEQUENOM INC
发明人： O'DONNELL MARYANNE J , KANG CHANGWON , KWON YOUNG-SOO , CANTOR CHARLES , LOUGH DAVID M , LITTLE DANIEL P , KOSTER HUBERT , KIM YOUNG TAE , XIANG GUOBING
IPC分类号： C12N15/09 , C12Q1/68 , C40B40/06 , C40B60/14
摘要： A mass spectrometric method for sequencing nucleic acids using RNA polymerases, including DNA-dependent and RNA-dependent RNA polymerases, is provided. The methods include use the RNA polymerase is to generate a set of nested RNA transcripts, which are analyzed mass spectrometry. A method of identifying transcriptional terminator sequences or attenuator sequences is also provided.

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