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21. 发明申请

US20080234772A1 METHOD AND DEVICE FOR MYOCARDIAL STRESS REDISTRIBUTION 有权
标题翻译：用于心肌应激再分配的方法和装置
公开(公告)号：US20080234772A1
公开(公告)日：2008-09-25
申请号：US11689032
申请日：2007-03-21
申请人： Allan C. Shuros , Rodney W. Salo , Shantha Arcot-Krishnamurthy
发明人： Allan C. Shuros , Rodney W. Salo , Shantha Arcot-Krishnamurthy
IPC分类号： A61N1/362
CPC分类号： A61N1/3627
摘要： Methods and devices are described for delivering electrical stimulation to the heart in a manner that advantageously redistributes myocardial stress during systole for therapeutic purposes in the treatment of, for example, post-MI and HF patients. Pre-excitation pacing may be applied to deliberately de-stress a particular myocardial region that may be expected to undergo deleterious remodeling, such an the area around a myocardial infarct or a hypertrophying region or to deliberately stress a region remote from the pre-excitation pacing site in order to exert a cardioprotective conditioning effect, similar to the beneficial effects of exercise. Pre-excitation pacing may be advantageously combined with inotropic electrical stimulation applied to the stressed region.
摘要翻译：描述了将方法和装置以有效地将收缩期内的心肌应力重新分配到治疗目的的治疗目的的心脏和心脏病和心脏病患者的方式，以向心脏递送电刺激。预激发起搏可用于故意减压可能预期会发生有害重塑的特定心肌区域，例如心肌梗塞或肥大区域周围的区域，或故意压迫远离预激励起搏的区域为了发挥心脏保护性调理作用，类似于运动的有益效果。预激发起搏可以有利地与施加到应激区域的变力电刺激组合。

22. 发明申请

US20080195174A1 SYSTEMS AND METHODS FOR ELECTRICAL STIMULATION OF BLOOD VESSELS 失效
标题翻译：血管电刺激系统与方法
公开(公告)号：US20080195174A1
公开(公告)日：2008-08-14
申请号：US11674463
申请日：2007-02-13
申请人： Joseph Walker , Rodney W. Salo , Anand Iyer , Joseph M. Pastore , Eric Mokelke
发明人： Joseph Walker , Rodney W. Salo , Anand Iyer , Joseph M. Pastore , Eric Mokelke
IPC分类号： A61N1/36
CPC分类号： A61N1/36114 , A61N1/36117
摘要： Disclosed herein, among other things, is a system for electrical stimulation of blood vessels. An embodiment of the system includes at least one electrode having electrical contact with a blood vessel. The embodiment also includes a stimulation circuit electrically connected to the electrode, the circuit adapted to provide stimulation to the vessel. The embodiment further includes a controller connected to the circuit, the controller adapted to select frequency and voltage parameters for the stimulation circuit to selectively affect vascular therapy, including constriction of the vessel and dilation of the vessel. According to various embodiments, the stimulation circuit and controller are contained within an implantable medical device (IMD). The system also includes a sensor connected to the controller, and the controller initiates and adjusts therapy based on a signal received from the sensor, in varying embodiments.
摘要翻译：此处公开的是用于电刺激血管的系统。该系统的一个实施例包括至少一个与血管电接触的电极。该实施例还包括电连接到电极的刺激电路，该电路适于向容器提供刺激。该实施例还包括连接到电路的控制器，所述控制器适于选择用于刺激电路的频率和电压参数，以选择性地影响血管治疗，包括容器收缩和血管扩张。根据各种实施例，刺激电路和控制器被包含在可植入医疗装置（IMD）内。该系统还包括连接到控制器的传感器，并且在不同的实施例中，控制器基于从传感器接收的信号来启动和调整治疗。

23. 发明申请

US20080188730A1 DEVICE FOR MONITORING FLUID STATUS 有权
标题翻译：用于监测流体状态的装置
公开(公告)号：US20080188730A1
公开(公告)日：2008-08-07
申请号：US12098644
申请日：2008-04-07
申请人： Robert J. Sweeney , Julio C. Spinelli , Rodney W. Salo
发明人： Robert J. Sweeney , Julio C. Spinelli , Rodney W. Salo
IPC分类号： A61B5/05
CPC分类号： A61B5/0538 , A61B5/053 , A61B5/14535 , A61N1/36521
摘要： A technique for determining a patient's hematocrit by an electrical impedance measurement is described. An implantable device may be configured to utilize the technique in order to assess a cardiac patient's fluid status. In order to determine the hematocrit, the electrical impedance of the blood is measured and mapped by a mapping function to a corresponding hematocrit value.
摘要翻译：描述了通过电阻抗测量来确定患者的血细胞比容的技术。可植入装置可被配置为利用该技术来评估心脏病人的流体状态。为了确定血细胞比容，测量血液的电阻抗并通过映射函数映射到相应的血细胞比容值。

24. 发明申请

US20080086036A1 METHOD AND APPARATUS FOR CONTROLLING CARDIAC THERAPY USING ULTRASOUND TRANSDUCER 有权
标题翻译：使用超声波传感器控制心脏治疗的方法和装置
公开(公告)号：US20080086036A1
公开(公告)日：2008-04-10
申请号：US11539939
申请日：2006-10-10
申请人： Jesse W. Hartley , Joseph M. Pastore , Rodney W. Salo , Andrew P. Kramer , Jeffrey E. Stahmann
发明人： Jesse W. Hartley , Joseph M. Pastore , Rodney W. Salo , Andrew P. Kramer , Jeffrey E. Stahmann
IPC分类号： A61N1/08
CPC分类号： A61N1/3627 , A61N1/36528
摘要： A cardiac rhythm management (CRM) system provides for post-myocardial infarction (MI) therapy with closed-loop control using one or more ultrasound transducers sensing one or more ultrasound signals indicative of cardiac dimensions. Cardiac size parameters are produced using the one or more ultrasound signals to represent, for example, cardiac chamber diameter, cardiac chamber volume, cardiac wall thickness, infarct size, and degree of change in any of these parameters over time or between measurements. In various embodiments, such cardiac size parameters provide for titration, safety check, and acute optimization of the post-MI therapy.
摘要翻译：心律控制（CRM）系统通过使用一个或多个超声换能器感测一个或多个指示心脏尺寸的超声信号，通过闭环控制提供心肌梗死后心肌梗死（MI）治疗。使用一个或多个超声信号产生心脏尺寸参数，以表示例如心脏室直径，心室容积，心壁厚度，梗塞面积以及随时间或测量之间的任何这些参数的变化程度。在各种实施方案中，这种心脏尺寸参数提供滴定，安全性检查和MI后治疗的急性优化。

25. 发明授权

US07194307B2 Pacing method and device for preserving native conduction system 失效
标题翻译：起搏方法和保存天然传导系统的装置
公开(公告)号：US07194307B2
公开(公告)日：2007-03-20
申请号：US10744952
申请日：2003-12-22
申请人： Rodney W. Salo , Bruce H. KenKnight , Joseph M. Pastore , Steven D. Girouard
发明人： Rodney W. Salo , Bruce H. KenKnight , Joseph M. Pastore , Steven D. Girouard
IPC分类号： A61N1/368
CPC分类号： A61N1/3627 , A61N1/3684
摘要： An implantable device for delivering cardiac pacing therapy in order to improve cardiac function is programmed to allow some amount of intrinsic activity to occur without otherwise the disturbing the pacing algorithm used to deliver therapy. Intrinsic cardiac cycles utilize the heart's native conduction system and thus serve to prevent the atrophy which may otherwise result from continuous pacing.
摘要翻译：用于递送心脏起搏治疗以改善心脏功能的可植入装置被编程为允许发生一定量的内在活动，而无需另外打扰用于递送治疗的起搏算法。内在心脏周期利用心脏的天然传导系统，从而用于预防由连续起搏引起的萎缩。

26. 发明授权

US07177688B2 Cardiac rhythm management system with optimization of cardiac performance using heart rate 有权
标题翻译：心脏节律管理系统使用心率优化心脏性能
公开(公告)号：US07177688B2
公开(公告)日：2007-02-13
申请号：US11018124
申请日：2004-12-21
申请人： Rodney W. Salo , Kenneth L. Baker , Lawrence S. Baumann
发明人： Rodney W. Salo , Kenneth L. Baker , Lawrence S. Baumann
IPC分类号： A61N1/18
CPC分类号： A61N1/3702 , A61N1/3627 , A61N1/3682 , A61N1/3684 , A61N1/3688
摘要： A method of optimizing inter-site delay is disclosed for a cardiac rhythm management device that includes a dual chamber pacemaker, especially designed for treating congestive heart failure by pacing a plurality of sites. A microcontroller is operative to adjust the pacing mode and inter-site delay of the pacemaker so as to achieve optimum hemodynamic performance. Atrial cycle lengths measured during transient (immediate) time intervals following a change in the mode inter-site delay are signal processed and a determination can then be made as to which particular configuration yields the optimum performance. Performance is optimized when the patient is at rest and when the patient exercises so that a rate-adapted dynamic value of the optimum performance can be applied.
摘要翻译：公开了一种用于心脏节律管理装置的优化站间延迟的方法，其包括双室起搏器，其特别设计用于通过起搏多个部位来治疗充血性心力衰竭。微控制器可用于调节起搏器的起搏模式和站间延迟，以达到最佳的血流动力学性能。信号处理后的瞬时（即时）时间间隔内测量的心房周期长度被信号处理，然后可以确定哪个特定配置产生最佳性能。当患者处于静止状态并且患者锻炼时优化性能，以便可以应用最佳性能的速率适应动态值。

27. 发明授权

US06829506B2 Linear stimulation of the heart for improved hemodynamic benefit 有权
标题翻译：心脏的线性刺激改善血液动力学效益
公开(公告)号：US06829506B2
公开(公告)日：2004-12-07
申请号：US09915088
申请日：2001-07-25
申请人： Joseph M. Pastore , Qingsheng Zhu , Rodney W. Salo
发明人： Joseph M. Pastore , Qingsheng Zhu , Rodney W. Salo
IPC分类号： A61N1362
CPC分类号： A61N1/3627 , A61N1/3684
摘要： A method and apparatus for linear stimulation of the heart to resynchronize contraction for improved hemodynamic benefit. Linear stimulation may be accomplished using a linear source, which may comprise an elongated electrode or plurality of electrodes arranged so as to linearly stimulate the heart. A linear source may be coupled to the left ventricle, and one or more additional electrodes may be positioned so as to stimulate a separate region of the left ventricle or one or more additional chambers of the heart as well. Application of an electrical stimulus by the linear source may function to stimulate a larger region of the heart, thereby enhancing the resynchronization effect as well as providing other hemodynamic benefits.
摘要翻译：用于线性刺激心脏以重新同步收缩以改善血液动力学益处的方法和装置。线性刺激可以使用线性源实现，线性源可以包括细长电极或多个电极，其布置成线性刺激心脏。线性源可以耦合到左心室，并且可以定位一个或多个附加电极，以便也刺激心脏的左心室或一个或多个另外的腔室的单独区域。通过线性源的电刺激的应用可以起到刺激心脏的较大区域的作用，从而增强再同步效应以及提供其它血液动力学优点。

28. 发明授权

US06278894B1 Multi-site impedance sensor using coronary sinus/vein electrodes 有权
标题翻译：多站阻抗传感器使用冠状窦/静脉电极
公开(公告)号：US06278894B1
公开(公告)日：2001-08-21
申请号：US09336449
申请日：1999-06-21
申请人： Rodney W. Salo , V. A. Kadhiresan , Kevin G. Nugent
发明人： Rodney W. Salo , V. A. Kadhiresan , Kevin G. Nugent
IPC分类号： A61B505
CPC分类号： A61N1/36521 , A61N1/3627 , A61N1/3682 , A61N1/3684
摘要： A method and apparatus for performing impedance plethysmography on a living heart for diagnostic and therapy purposes involves placement of plural leads where at least one is disposed within a coronary vein traversing the myocardium on the left side of the heart with another lead having plural electrodes thereon disposed in the right ventricle. By appropriate selection of electrodes on the first and second leads for driving with an AC carrier signal and other such electrodes coupled to a sensing amplifier, an impedance vs. time signal can be derived that when signal processed provides useful information concerning cardiac performance. The multi-site impedance sensing has been found to yield more robust data especially in patients having CHF.
摘要翻译：用于诊断和治疗目的的用于在活的心脏上进行阻抗体积描记术的方法和装置包括放置多个引线，其中至少一个引线设置在穿过心脏左侧的心肌的冠状静脉内，另一引线上设置有多个电极在右心室。通过适当选择第一和第二引线上的电极用AC载波信号进行驱动并且其它这样的电极耦合到感测放大器，可以导出阻抗对时间信号，当信号被处理时提供关于心脏性能的有用信息。已经发现多位点阻抗感测可以产生更强健的数据，特别是在具有CHF的患者中。

29. 发明授权

US5700283A Method and apparatus for pacing patients with severe congestive heart failure 失效
标题翻译：用于起搏患者严重充血性心力衰竭的方法和装置
公开(公告)号：US5700283A
公开(公告)日：1997-12-23
申请号：US754932
申请日：1996-11-25
申请人： Rodney W. Salo
发明人： Rodney W. Salo
IPC分类号： A61N1/362 , A61N1/365 , A61N1/368
CPC分类号： A61N1/36564 , A61N1/3627 , A61N1/36585 , A61N1/3682
摘要： An implantable cardiac pacemaker especially designed for treatment of CHF includes an accelerometer for sensing heart sounds and processing circuitry for deriving from the heart sound information the mechanical AV delay of the patient's heart. The pacemaker's applied AV delay is then adjusted until the measured mechanical AV delay falls in a range of between 180 ms and 250 ms. Further optimization of the heart as a pump can then be achieved by incrementally adjusting the pacemaker's applied AV delay interval until a point is reached where a measure of cardiac performance such as aortic pulse pressure is optimized.
摘要翻译：特别设计用于治疗CHF的可植入心脏起搏器包括用于感测心脏声音的加速度计和用于从心脏声音信息导出患者心脏的机械AV延迟的处理电路。然后调整起搏器应用的AV延迟，直到所测量的机械AV延迟在180ms和250ms之间的范围内。然后可以通过逐渐调整心脏起搏器应用的AV延迟间隔直到达到如心脏性能测量（例如主动脉脉压）被优化为止的点来实现心脏作为泵的进一步优化。

30. 发明授权

US5423870A Rate responsive cardiac pacemaker 失效
标题翻译：速率响应心脏起搏器
公开(公告)号：US5423870A
公开(公告)日：1995-06-13
申请号：US155482
申请日：1993-11-22
申请人： Arthur L. Olive , Rodney W. Salo
发明人： Arthur L. Olive , Rodney W. Salo
IPC分类号： A61N1/365 , A61N1/36
CPC分类号： A61N1/36585
摘要： A cardiac pacemaker having an automatic pulse rate response gain factor responsive to at least one cardiac-related physiological characteristic of a patient. The pacemaker includes a rate controller that comprises a detector for detecting a plurality of individual measurements of at least one physiological characteristic over each of a plurality of pre-determined time periods, with each of the individual measurements being an average of values detected over each of a respective multiple number of incremental time periods occurring within each of the pre-determined time periods. The pacemaker saves the highest measurement from one incremental time period of each of several consecutive pre-determined time periods, and these highest measurements are averaged. Thereafter, the rate controller adjusts the rate response gain factor or slope of the pulse rate in relation to the physiological characteristic measurement and a pre-determined target pulse rate. In a preferred embodiment, two physiological characteristics are measured, with high values averaged of only one characteristic when that characteristic exceeds a threshold level of the other characteristic. One embodiment is pulse rate responsive to minute volume measurement in combination with accelerometer measurement, with accelerometer measurement requiring a threshold value over an increment of time prior to minute volume recordation for input toward rate response gain factor.
摘要翻译：一种心脏起搏器，其具有响应于患者的至少一个心脏相关生理特征的自动脉搏响应增益因子。起搏器包括速率控制器，其包括用于在多个预定时间段中的每一个上检测至少一个生理特性的多个单独测量值的检测器，其中每个单独测量值是在在每个预定时间周期内出现的相应的多个增量时间段。起搏器从几个连续预定时间段的每个增量时间段节省最高测量值，并对这些最高测量值进行平均。此后，速率控制器相对于生理特征测量和预定的目标脉率调节脉率的速率响应增益因子或斜率。在优选实施例中，测量两个生理特征，当该特征超过另一个特征的阈值水平时，仅测量一个特征的高值。一个实施例是响应于微小体积测量的脉冲速率与加速度计测量结合，加速度计测量需要在微小体积记录之前的时间上增加阈值，以便向速率响应增益因子输入。

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