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1. 发明申请

US20080195174A1 SYSTEMS AND METHODS FOR ELECTRICAL STIMULATION OF BLOOD VESSELS 失效
标题翻译：血管电刺激系统与方法
公开(公告)号：US20080195174A1
公开(公告)日：2008-08-14
申请号：US11674463
申请日：2007-02-13
申请人： Joseph Walker , Rodney W. Salo , Anand Iyer , Joseph M. Pastore , Eric Mokelke
发明人： Joseph Walker , Rodney W. Salo , Anand Iyer , Joseph M. Pastore , Eric Mokelke
IPC分类号： A61N1/36
CPC分类号： A61N1/36114 , A61N1/36117
摘要： Disclosed herein, among other things, is a system for electrical stimulation of blood vessels. An embodiment of the system includes at least one electrode having electrical contact with a blood vessel. The embodiment also includes a stimulation circuit electrically connected to the electrode, the circuit adapted to provide stimulation to the vessel. The embodiment further includes a controller connected to the circuit, the controller adapted to select frequency and voltage parameters for the stimulation circuit to selectively affect vascular therapy, including constriction of the vessel and dilation of the vessel. According to various embodiments, the stimulation circuit and controller are contained within an implantable medical device (IMD). The system also includes a sensor connected to the controller, and the controller initiates and adjusts therapy based on a signal received from the sensor, in varying embodiments.
摘要翻译：此处公开的是用于电刺激血管的系统。该系统的一个实施例包括至少一个与血管电接触的电极。该实施例还包括电连接到电极的刺激电路，该电路适于向容器提供刺激。该实施例还包括连接到电路的控制器，所述控制器适于选择用于刺激电路的频率和电压参数，以选择性地影响血管治疗，包括容器收缩和血管扩张。根据各种实施例，刺激电路和控制器被包含在可植入医疗装置（IMD）内。该系统还包括连接到控制器的传感器，并且在不同的实施例中，控制器基于从传感器接收的信号来启动和调整治疗。

2. 发明授权

US08442639B2 Systems and methods for electrical stimulation of blood vessels 失效
标题翻译：电刺激血管的系统和方法
公开(公告)号：US08442639B2
公开(公告)日：2013-05-14
申请号：US11674463
申请日：2007-02-13
申请人： Joseph Walker , Rodney W. Salo , Anand Iyer , Joseph M. Pastore , Eric Mokelke
发明人： Joseph Walker , Rodney W. Salo , Anand Iyer , Joseph M. Pastore , Eric Mokelke
IPC分类号： A61N1/00 , A61B5/04
CPC分类号： A61N1/36114 , A61N1/36117
摘要： Disclosed herein, among other things, is a system for electrical stimulation of blood vessels. An embodiment of the system includes at least one electrode having electrical contact with a blood vessel. The embodiment also includes a stimulation circuit electrically connected to the electrode, the circuit adapted to provide stimulation to the vessel. The embodiment further includes a controller connected to the circuit, the controller adapted to select frequency and voltage parameters for the stimulation circuit to selectively affect vascular therapy, including constriction of the vessel and dilation of the vessel. According to various embodiments, the stimulation circuit and controller are contained within an implantable medical device (IMD). The system also includes a sensor connected to the controller, and the controller initiates and adjusts therapy based on a signal received from the sensor, in varying embodiments.
摘要翻译：此处公开的是用于电刺激血管的系统。该系统的一个实施例包括至少一个与血管电接触的电极。该实施例还包括电连接到电极的刺激电路，该电路适于向容器提供刺激。该实施例还包括连接到电路的控制器，所述控制器适于选择用于刺激电路的频率和电压参数，以选择性地影响血管治疗，包括容器收缩和血管扩张。根据各种实施例，刺激电路和控制器被包含在可植入医疗装置（IMD）内。该系统还包括连接到控制器的传感器，并且在不同的实施例中，控制器基于从传感器接收的信号来启动和调整治疗。

3. 发明申请

US20090036938A1 METHOD AND SYSTEM FOR EXTERNAL COUNTERPULSATION THERAPY 审中-公开
标题翻译：用于外部计数治疗的方法和系统
公开(公告)号：US20090036938A1
公开(公告)日：2009-02-05
申请号：US11830508
申请日：2007-07-30
申请人： Robert Shipley , Guy Alvarez , Rodney W. Salo , Anand Iyer , Joseph M. Pastore , Joseph Walker
发明人： Robert Shipley , Guy Alvarez , Rodney W. Salo , Anand Iyer , Joseph M. Pastore , Joseph Walker
IPC分类号： A61N1/04
CPC分类号： A61N1/36003 , A61H9/0078 , A61H2201/165 , A61H2230/06 , A61H2230/20 , A61H2230/30 , A61N1/36017 , A61N1/36114
摘要： An improved system for delivering external counterpulsation therapy is described. The system employs muscle stimulation transducers such as cutaneous electrodes in order to stimulate skeletal muscle and/or vascular smooth muscle in synchronization with the cardiac cycle in a manner that increases the fluid pressure within veins and/or arteries during cardiac diastole.
摘要翻译：描述了用于递送外部反搏疗法的改进系统。该系统采用肌肉刺激换能器，例如皮肤电极，以便以心脏舒张期内增加静脉和/或动脉内的流体压力的方式与心脏周期同步地刺激骨骼肌和/或血管平滑肌。

4. 发明授权

US07953485B2 Therapy control based on the rate of change of intracardiac impedance 有权
标题翻译：基于心内阻抗变化率的治疗控制
公开(公告)号：US07953485B2
公开(公告)日：2011-05-31
申请号：US12105219
申请日：2008-04-17
申请人： Rodney W. Salo , Joseph M. Pastore , Jeffrey E. Stahmann , Jesse W. Hartley
发明人： Rodney W. Salo , Joseph M. Pastore , Jeffrey E. Stahmann , Jesse W. Hartley
IPC分类号： A61N1/362
CPC分类号： A61N1/36521 , A61N1/30
摘要： A system comprising a medical device that includes an impedance measurement circuit adapted to be coupled to implantable electrodes to obtain an intracardiac impedance signal between electrodes, a therapy circuit operable to deliver a therapy to a subject, and a controller circuit coupled to the impedance measurement circuit and the therapy circuit. The controller circuit determines a time rate of change of the intracardiac impedance signal and adjusts at least one parameter related to therapy in a manner that alters the rate of change.
摘要翻译：一种包括医疗装置的系统，该医疗装置包括阻抗测量电路，该阻抗测量电路适于耦合到可植入电极以获得电极之间的心内阻抗信号，可操作以将治疗递送给受试者的治疗电路，以及耦合到所述阻抗测量电路和治疗电路。控制器电路确定心内阻抗信号的时间变化率，并且以改变变化率的方式调节与治疗相关的至少一个参数。

5. 发明申请

US20100274306A1 METHOD AND APPARATUS FOR DEVICE CONTROLLED GENE EXPRESSION FOR CARDIAC PROTECTION 失效
标题翻译：用于设备控制的基因表达用于心脏保护的方法和装置
公开(公告)号：US20100274306A1
公开(公告)日：2010-10-28
申请号：US12830534
申请日：2010-07-06
申请人： Joseph M. Pastore , Jeffrey Ross , Tamara Colette Baynham , Rodney W. Salo , Andrew P. Kramer , Julio C. Spinelli
发明人： Joseph M. Pastore , Jeffrey Ross , Tamara Colette Baynham , Rodney W. Salo , Andrew P. Kramer , Julio C. Spinelli
IPC分类号： A61M37/00 , A61N1/00
CPC分类号： A61N1/3627 , A61K48/0083 , A61N1/36514
摘要： A gene regulatory system detects ischemia events and is capable of delivering a biologic therapy in response to the detection of an ischemic event or the reception of a command. The biologic therapy protects the heart from ischemic damage by regulating the expression of an exogenously introduced gene product. In one embodiment, the gene regulatory system includes an implantable system that emits at least one gene regulatory signal in response to the detection of the ischemic event or the reception of the command. The gene regulatory signal directly or indirectly regulates gene expression of the gene product.
摘要翻译：基因调控系统检测缺血事件，并且能够响应于缺血事件的检测或命令的接收而递送生物疗法。生物治疗通过调节外源基因产物的表达来保护心脏免于缺血性损伤。在一个实施方案中，基因调控系统包括可植入系统，其可以响应于缺血事件的检测或命令的接收而发射至少一个基因调节信号。基因调控信号直接或间接调控基因产物的基因表达。

6. 发明申请

US20100145401A1 MYOCARDIUM CONDITIONING USING MYOCARDIAL AND PARASYMPATHETIC STIMULATION 有权
公开(公告)号：US20100145401A1
公开(公告)日：2010-06-10
申请号：US12703382
申请日：2010-02-10
申请人： Joseph M. Pastore , Tamara Colette Baynham , Andrew P. Kramer , Julio C. Spinelli , Jeffrey Ross , Rodney W. Salo
发明人： Joseph M. Pastore , Tamara Colette Baynham , Andrew P. Kramer , Julio C. Spinelli , Jeffrey Ross , Rodney W. Salo
IPC分类号： A61N1/362
CPC分类号： A61N1/36114 , A61N1/3627 , A61N1/37211 , A61N1/3956
摘要： Various system embodiments comprise a neural stimulator, a pulse generator, and a controller. The neural stimulator is adapted to generate a neural stimulation signal. The pulse generator is adapted to generate a pacing signal to provide myocardium pacing. The controller is adapted to control the neural stimulator and the pulse generator to provide a cardioprotective conditioning therapy. The conditioning therapy includes neural stimulation to elicit a parasympathetic response and myocardium pacing. Other aspects and embodiments are provided herein.
摘要翻译：各种系统实施例包括神经刺激器，脉冲发生器和控制器。神经刺激器适于产生神经刺激信号。脉冲发生器适用于产生起搏信号以提供心肌起搏。控制器适用于控制神经刺激器和脉冲发生器以提供心脏保护性调理疗法。调理疗法包括神经刺激以引发副交感神经反应和心肌起搏。本文提供了其它方面和实施例。

7. 发明申请

US20090143835A1 Method and apparatus for delivering pacing pulses using a coronary stent 审中-公开
标题翻译：使用冠状动脉支架输送起搏脉冲的方法和装置
公开(公告)号：US20090143835A1
公开(公告)日：2009-06-04
申请号：US12322382
申请日：2009-02-02
申请人： Joseph M. Pastore , Andrew P. Kramer , Julio C. Spinelli , Rodney W. Salo , Tamara Colette Baynham , Jeffrey Ross , Frits W. Prinzen , Ward Y. R. Vanagt , Richard N. Cornelussen
发明人： Joseph M. Pastore , Andrew P. Kramer , Julio C. Spinelli , Rodney W. Salo , Tamara Colette Baynham , Jeffrey Ross , Frits W. Prinzen , Ward Y. R. Vanagt , Richard N. Cornelussen
IPC分类号： A61N1/365
CPC分类号： A61N1/056 , A61N1/3627 , A61N1/36557 , A61N1/37205 , A61N1/3787 , A61N2001/0585
摘要： An implantable cardiac protection pacing system delivers pacing pulses to protect the heart from injuries associated with ischemia and myocardial infarction. The system includes an implantable pulse generator (PG) that delivers the pacing pulses and a coronary stent electrically connected to the implantable PG to function as a pacing electrode through which the pacing pulses are delivered. In one embodiment, an intravascular lead provides the electrical connection between the coronary stent and the implantable PG to allow the implantable PG to be implanted in the femoral region. In another embodiment, the coronary stent and the implantable PG are integrated into an intravascular pulse generator-stent.
摘要翻译：可植入心脏保护起搏系统提供起搏脉冲，以保护心脏免受与缺血和心肌梗塞相关的损伤。该系统包括输送起搏脉冲的可植入脉冲发生器（PG）和电连接到可植入PG的冠状动脉支架，起到起搏电极的作用，起搏电极通过该起搏电极被输送。在一个实施例中，血管内引线提供冠状支架和可植入PG之间的电连接，以允许将可植入PG植入股骨区域。在另一个实施例中，冠状动脉支架和可植入PG集成到血管内脉冲发生器 - 支架中。

8. 发明申请

US20080249583A1 THERAPY CONTROL BASED ON THE RATE OF CHANGE OF INTRACARDIAC IMPEDANCE 有权
标题翻译：基于内皮抑素变化率的治疗控制
公开(公告)号：US20080249583A1
公开(公告)日：2008-10-09
申请号：US12105219
申请日：2008-04-17
申请人： Rodney W. Salo , Joseph M. Pastore , Jeffrey E. Stahmann , Jesse W. Hartley
发明人： Rodney W. Salo , Joseph M. Pastore , Jeffrey E. Stahmann , Jesse W. Hartley
IPC分类号： A61N1/368
CPC分类号： A61N1/36521 , A61N1/30
摘要： A system comprising a medical device that includes an impedance measurement circuit adapted to be coupled to implantable electrodes to obtain an intracardiac impedance signal between electrodes, a therapy circuit operable to deliver a therapy to a subject, and a controller circuit coupled to the impedance measurement circuit and the therapy circuit. The controller circuit determines a time rate of change of the intracardiac impedance signal and adjusts at least one parameter related to therapy in a manner that alters the rate of change.
摘要翻译：一种包括医疗装置的系统，该医疗装置包括阻抗测量电路，该阻抗测量电路适于耦合到可植入电极以获得电极之间的心内阻抗信号，可操作以将治疗递送给受试者的治疗电路，以及耦合到所述阻抗测量电路和治疗电路。控制器电路确定心内阻抗信号的时间变化率，并且以改变变化率的方式调节与治疗相关的至少一个参数。

9. 发明授权

US07366567B2 Method for treating myocardial infarction 有权
公开(公告)号：US07366567B2
公开(公告)日：2008-04-29
申请号：US11088231
申请日：2005-03-23
申请人： Qingsheng Zhu , Joseph M. Pastore , Rodney W. Salo
发明人： Qingsheng Zhu , Joseph M. Pastore , Rodney W. Salo
IPC分类号： A61N1/365
CPC分类号： A61N1/368 , A61N1/0587 , A61N1/3627 , A61N1/36564 , A61N1/3682 , A61N1/3684
摘要： A method for treating patients after a myocardial infarction which includes pacing therapy is disclosed. A cardiac rhythm management device is configured to deliver pre-excitation pacing to one or more sites in proximity to an infarcted region of the ventricular myocardium. Such pacing acts to minimize the remodeling process to which the heart is especially vulnerable immediately after a myocardial infarction.

10. 发明授权

US08731677B2 Myocardium conditioning using myocardial and parasympathetic stimulation 有权
标题翻译：心肌调理使用心肌和副交感神经刺激
公开(公告)号：US08731677B2
公开(公告)日：2014-05-20
申请号：US12703382
申请日：2010-02-10
申请人： Joseph M. Pastore , Tamara Colette Baynham , Andrew P. Kramer , Julio C. Spinelli , Jeffrey Ross , Rodney W. Salo
发明人： Joseph M. Pastore , Tamara Colette Baynham , Andrew P. Kramer , Julio C. Spinelli , Jeffrey Ross , Rodney W. Salo
IPC分类号： A61N1/00
CPC分类号： A61N1/36114 , A61N1/3627 , A61N1/37211 , A61N1/3956
摘要： Various system embodiments comprise a neural stimulator, a pulse generator, and a controller. The neural stimulator is adapted to generate a neural stimulation signal. The pulse generator is adapted to generate a pacing signal to provide myocardium pacing. The controller is adapted to control the neural stimulator and the pulse generator to provide a cardioprotective conditioning therapy. The conditioning therapy includes neural stimulation to elicit a parasympathetic response and myocardium pacing. Other aspects and embodiments are provided herein.
摘要翻译：各种系统实施例包括神经刺激器，脉冲发生器和控制器。神经刺激器适于产生神经刺激信号。脉冲发生器适于产生起搏信号以提供心肌起搏。控制器适用于控制神经刺激器和脉冲发生器以提供心脏保护性调理疗法。调理疗法包括神经刺激以引发副交感神经反应和心肌起搏。本文提供了其它方面和实施例。

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